26 September 2008
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Transcript of 26 September 2008
26 September 2008Finish Chapter 6 Section B Membrane Potentials
Begin Section C: Synapses
Test # 1 Monday (includes to Ch. 6B)Start promptly at 8:30 am (Get here early!)Test Study Guide to be posted to Website.
Figure 6.22
Action Potential conduction in non-myelinated axons(0.5 m/sec in small diameter unmyelinated axons)
Axon diameter and AP CVEnergy Requirements
Changes in concentration of Na+ and K+ only with long lasting period of high frequency action potentials.
Initial experiments with squid giant axon (1mm diameter) lead to knowledge of APs.
Figure 6.23
AP CV (up to 100 m/s)Location of channelsEnergy RequirementsAxon diameter
Who Cares?Multiple sclerosis and episodic
degeneration of myelin by immune disorder.
Important Information
End of Material For Test # 1
Begin Material For Test # 2
Figure 6.24Two categories of Synapses: Electrical (rare in nervous system) & Chemical
Figure 6.25UnidirectionalRelease, diffusion, binding,Post-synaptic Receptor Types: Inotropic or Metabotropic
Classification:Excitatory (closer to threshold for AP)OrInhibitory (stabilizes or hyperpolarizes)
Inotropic receptor Metabotropic receptor
Some ion channels are permeable to both Na+ and K+
Preview of coming attraction: the nicotinic Acetylcholine receptor so named for its agonist.
Synapses named for NT used: -ergic
Examples:CholinergicAdrenergicSerotonergicPeptidergic
Figure 6.27 Vesicle release proportional to Ca++ influx
Fates of neurotransmitters:1) Diffusion away from synapse,2) Enzymatic degradation (e.g. AChE and MAO)3) Reuptake into presynaptic terminal (SSRI)
Tetanus toxin & Botulinum toxin disrupt SNARE function.
Figure 6.28
EPSPs :which ion moving in which direction?Duration of PSP vs APSynaptic delay
Ion Channels that allow flux of Na+ and K+ simultaneously.
Figure 6.29
IPSPs :which ion moving in which direction?
Some IPSPs result in no change in membrane potential by opening Chloride channels that stabilize membrane potential at resting value or in cells that actively transport Cl- out.
Figure 6.31
Summation and Synaptic Integration