2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

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2018 SPRING INDUSTRY ADVISORY BOARD MEETING April 12-13 | Houston, Texas 1

Transcript of 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Page 1: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

2018 SPRING INDUSTRY ADVISORY BOARD MEETING April 12-13 | Houston, Texas

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CHOT 2018 SPRING INDUSTRY ADVISORY BOARD MEETING AGENDA

Thursday, April 12

7:30—8:30 Check-In & Continental Breakfast

8:30—9:30 Welcome & Introductions

Welcome: Dr. Bita Kash, Texas A&M University, CHOT Center Director and Dr. Thomas Ferris, Texas A&M University, CHOT Center Co-Director

State of the Center: Dr. Bita Kash, CHOT Center Director and Dr. Thomas Ferris, CHOT Center Co-Director

LIFE Form Review: Dr. Craig Scott, NSF I/UCRC Evaluator

Meeting Overview: Lauren Irlinger, CHOT Managing Director

9:30—10:00 Keynote Presentation

Dr. M. Michael Shabot, Executive Vice President & System Chief Clinical Officer, Memorial Hermann Health System

10:00—10:15 Break

10:15—11:15 CHOT Research Impact and Insight Presentations from Completed Projects

11:15—11:45 Proposal Presentations: Population Health

Theme Champion: Dr. Conrad Tucker, Pennsylvania State University

Pop 1 Comprehensive Analysis on Impact of Social Determinants to Improve Care Across Populations

Pop 2 Participating in a Community Health Improvement Network

Pop 3 The Effectiveness of Substance Abuse Treatment Services in Combating Opioid Crisis

11:45—12:00 IAB Member Discussant Panel & LIFE Forms

12:00—1:00 Networking Lunch

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CHOT 2018 SPRING INDUSTRY ADVISORY BOARD MEETING AGENDA

Thursday, April 12

1:00—1:30 Proposal Presentations: Care Coordination

Theme Champion: Dr. Christina Mastrangelo, University of Washington

Care 1 Measuring Patient Experience and the Effects of Community Factors on Value-based Reimbursement across the Continuum of Care

Care 2 Developing a Risk Prediction Model for Hospital Acquired Clostridium Difficile Infection

1:30—1:45 IAB Member Discussant Panel & LIFE Forms

1:45—2:15 Proposal Presentations: Analytics and Innovative Technologies

Theme Champion: Dr. Eva Lee, Georgia Institute of Technology

Tech 1 HIE Project for Chronic Disease and Workflow Management

Tech 2 Leveraging technology to enhance communication in healthcare

Tech 3 Data-driven analytics and machine learning for improving healthcare outcomes

2:15—2:30 IAB Member Discussant Panel & LIFE Forms

2:30—2:45 Break

2:45—3:15 Proposal Presentations: Patient Experience

Theme Champion: Dr. Nancy Borkowski & Robert Weech-Maldonado, University of Alabama at Birmingham

Patient 1 Care Coordination Activities for Individuals with Spinal Cord Injury

Patient 2 Generating Tailored Recommendations Automatically with Explanations via an Interactive Dialog-based system

Patient 3 Embedding Routine, Informal Family Caregiver Assessment of Delirium Superimposed on Dementia into Acute Care

3:15—3:30 IAB Member Discussant Panel & LIFE Forms

3:30—4:30 Education & Engaged Scholarship Program

Dr. Norma Padron

4:30—4:45 Day Debrief

4:45—6:00 Networking Reception

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CHOT 2018 SPRING INDUSTRY ADVISORY BOARD MEETING AGENDA

Friday, April 13

7:30—9:30 Breakfast and Check-in

8:00—9:00 Closed Door IAB Meeting

9:00—9:15 Break

9:15—9:45 Proposal Presentations: Access to Care

Theme Champion: Dr. Christopher Johnson, University of Louisville

Access 1 Telemedicine in Primary Care and in the Management of Chronic Conditions: Exploring Patient & Provider Perspectives

Access 2 Ask Me 3®: A Home Health Intervention to Address Health Literacy Barriers, Increase Patient Engagement, and Improve Patient Experience and Outcomes

9:45—10:00 IAB Member Discussant Panel & LIFE Forms

10:00—10:30 LIFE Feedback Discussion Panel

Dr. Craig Scott, NSF I/UCRC Evaluator

10:30—10:45 Break

10:45—11:45 Grand Challenge Planning Grant Results & Next Steps

Dr. Bita Kash, CHOT Center Director

Dr. Marc Garbey, Center Director for the Center for Cyber-Physical Systems for the Hospital Operating Room (CyBHOR)

11:45—12:00 Debrief & Adjourn

12:00 Box Lunches Available for Pick-up

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CHOT 2018 SPRING INDUSTRY ADVISORY BOARD MEETING

Key Meeting Contact Information

If you have any questions or need assistance during the meeting, please do not hesitate to contact one of the following:

Bita Kash Center Director [email protected] (979) 575-6768

Lauren Irlinger Center Managing Director [email protected] (407) 506-9757

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  2018 SPRING IAB MEETING PARTICIPANTS April 12-13 | Houston, Texas

Participant List as of April 4th, 2018

Craig Scott [email protected] NSF - University of Washington

Casey Stallsmith [email protected] NSF - Hosparus Health

Thomas Miller [email protected] American Society of Anesthesiologists

Bob Bernstein [email protected] Avizia (formerly Carena)Rachele Misiti [email protected] Central Texas VADorothy Sanders [email protected] Central Texas VAJamey Gigliotti [email protected] HighmarkDustin Dew [email protected] Lakeshore FoundationNorma Padron [email protected] Main Line Health

Kenneth [email protected]

Opelousas General Health System

Thomas Tracy [email protected] State Health Hershey Medical Center

Christopher Hall [email protected] Philips HealthcareChris Juday [email protected] SanofiChris Juday [email protected] Sanofi

Christian [email protected]

Siemens Healthineers

Steven Brown [email protected] A&M University Health Science Center

J.J. Schmidt [email protected] York Risk Services

Jessica Autrey [email protected] AT&TMarc Garbey [email protected] CyBHORMatthew Gibson [email protected] Erlanger Health System

Michael [email protected]

Memorial Hermann Health System

Jill Bell [email protected] Passport Health Plan

Melissa Boltz [email protected] Penn State Hershey Medical Center

Jerome Jourquin [email protected] Susan G Komen

Bita Kash [email protected] CHOT Center

Lauren Irlinger [email protected] CHOT Center

Ankur Agarwal [email protected] Florida Atlantic University

Eva Lee [email protected] Georgia Institute of Technology

Conrad Tucker [email protected] Penn State University

Thomas Ferris [email protected] Texas A&M University

National Science Foundation

IAB Members

Guests

University Faculty & Administration

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  2018 SPRING IAB MEETING PARTICIPANTS April 12-13 | Houston, Texas

Participant List as of April 4th, 2018

Georges Naufal [email protected] Texas A&M University

Nancy Borkowski [email protected] University of Alabama at Birmingham

Robert Weech-Maldonado [email protected] University of Alabama at Birmingham

J'Aime Jennings [email protected] University of LouisvilleChristopher Johnson [email protected] University of LouisvilleTiffany Robinson [email protected] University of LouisvilleJoseph Heim [email protected] University of WashingtonChristina Mastrangelo [email protected] University of Washington

Guanlin Chen [email protected] Georgia Institute of TechnologyQixuan Hou [email protected] Georgia Institute of TechnologyZhuonan Li [email protected] Georgia Institute of Technology

Di Liu [email protected] Georgia Institute of Technology

Joshua Morgan [email protected] Georgia Institute of Technology

Heather Patrick [email protected] Georgia Institute of TechnologyCody Wang [email protected] Georgia Institute of TechnologyZixing Wang [email protected] Georgia Institute of TechnologyLinxi Xiao [email protected] Georgia Institute of TechnologyPeijue Zhang [email protected] Georgia Institute of TechnologyPavan Thaker [email protected] Georgia Institute of Technology Christian Lopez [email protected] Penn State UniversityPreston Blackburn [email protected] Texas A&M UniversityKesler Brock [email protected] Texas A&M University

Abigail Gonzalez [email protected] Texas A&M University

Johnathan McKenzie [email protected] Texas A&M UniversityHannah Meirink [email protected] Texas A&M UniversitySahinya Susindar [email protected] Texas A&M University

Neeraj Puro [email protected] University of Alabama at Birmingham

Reena Joseph [email protected] University of Alabama at Birmingham

Mohamed Ahmed [email protected] University of Louisville

Molly O'Keefe [email protected] University of Louisville

Larissa Prates Guimaraes Petroianu

[email protected] University of Washington

University Faculty & Administration

Students

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chotnsf.orgNSF CENTER FOR HEALTH ORGANIZATION TRANSFORMATION

As a National Science Foundation industry-university cooperative research center (I/UCRC), CHOT follows a model of an industry-

Industry Advisory Board (IAB) to conduct research that supports the implementation of evidence-based transformational

Pooled Members

$

NSF Funds

Institutional Support

RESEARCH PROJECTS

Innovations in Healthcare Delivery

INVESTIGATE VALIDATEInnovations and prototypes

IMPLEMENT

Value Created

INDUSTRY ADVISORY BOARD (IAB)

INDUSTRY MEMBERSHIP

= $50,000

CHOT’s research model relies on the knowledge and experience of healthcare leaders to guide academic research to ensure that it is meaningful and applicable to the healthcare industry and provides immediate decision support.

CORE FUNDS &

SUPPLEMENTAL FUNDS

$700,000

CHOT UNIVERSITY SITES:

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CHOT PRESENT INDUSTRY MEMBERS

chotnsf.org

Central Texas Veterans Health Care System

Last Best Chance

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T

colla

bora

tions

and

like

-m

inde

d ce

nter

s fo

r la

rge-

scal

e pr

ojec

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nts/

initi

ativ

esH

ealt

h &

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um

an

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yste

ms

En

gin

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ng

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cu

lty,

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den

t re

sea

rch

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PR

OP

OS

AL

CU

LTIV

AT

ION

PR

OC

ES

S

Ste

p 1

: Id

entif

y re

sear

ch th

emes

from

dis

cuss

ions

with

IAB

mem

bers

at

the

IAB

Fal

l Mee

ting

Ste

p 2

: fa

cilit

ate

colla

bora

tion

acro

ss C

HO

T s

ites

and

amon

g in

dust

ry m

embe

rs

Ste

p 3

: C

ham

pion

s cr

eate

3-4

col

labo

rativ

e pr

ojec

t pro

posa

ls p

er

rese

arch

them

e to

pre

sent

at t

he IA

B S

prin

g M

eetin

g

Ste

p 4

: E

nsur

e th

at c

olla

bora

tive

proj

ect p

ropo

sals

add

ress

all

spec

ific

aim

s id

entif

ied

and

enco

mpa

ss IA

B r

esea

rch

inte

rest

s

All

colla

bora

tive

proj

ect

team

s in

clud

e r

esea

rche

rs fr

om m

ultip

le

CH

OT

uni

vers

ity s

ites

and

enga

ge m

ultip

le IA

B m

embe

rs b

ase

d on

sk

ill s

et,

natu

re o

f co

ntri

butio

n to

pro

ject

aim

s, a

nd c

apac

ity.

2018

20

19 R

esea

rch

The

mes

Pop

ulat

ion

Hea

lth

Car

e C

oord

inat

ion

Acc

ess

to C

are

Ana

lytic

s an

d In

nova

tive

Tech

nolo

gies

Pat

ient

Exp

erie

nce

15

Page 16: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

2016

-201

7 P

roje

ct P

rop

osa

l V

etti

ng

Pro

cess

28B

rain

sto

rmin

g id

eas

for

pro

ject

p

rop

osa

ls w

ith

Ind

ust

ry m

emb

ers

(Jan

. 201

8) 13P

roje

ct p

rop

osa

ls v

ia

coo

rdin

ated

vet

tin

g b

y IA

B

Mem

ber

s an

d S

ite

Dir

ecto

rs

(Mar

ch 2

018)

2018

-201

9 P

roje

ct P

rop

osa

l V

etti

ng

Pro

cess

Co

mm

un

icat

eC

oo

rdin

ate

Co

llab

ora

teC

reat

e

2018

20

19 P

roje

ct P

ropo

sals Po

pu

lati

on

Hea

lth

Pro

po

sals

Po

p1:

Com

preh

ensi

ve A

naly

sis

on I

mpa

ct o

f S

ocia

l Det

erm

inan

ts to

Im

pro

ve C

are

Acr

oss

Pop

ulat

ions

Po

p 2

: P

artic

ipat

ing

in a

Com

mu

nity

Hea

lth Im

pro

vem

ent N

etw

ork

Po

p 3

: Th

e E

ffec

tiven

ess

of S

ubst

anc

e A

buse

Tre

atm

ent

Ser

vice

s in

Com

bat

ing

Op

ioid

Cris

is

Car

e C

oo

rdin

atio

n P

rop

osa

lsC

are

1:

Car

e C

oord

inat

ion

and

Pa

tient

Exp

erie

nce

acro

ss t

he C

ont

inuu

m o

f C

are:

A V

alue

Bas

ed

Rei

mbu

rsem

ent P

ersp

ectiv

e

Car

e 2

: D

evel

opin

g a

Ris

k P

redi

ctio

n M

odel

for

Hos

pita

l Acq

uire

d C

lost

ridiu

m D

iffic

ile In

fect

ion

An

alyt

ics

and

Inn

ova

tive

Tec

hn

olo

gie

s P

rop

osa

lsTe

ch 1

: In

tegr

ate

d C

hro

nic

Car

e M

ana

gem

ent

Sys

tem

for

Mo

nito

ring

and

Fac

ilita

ting

Com

preh

ensi

veC

linic

al D

eci

sio

n S

upp

ort

Tech

2:

Leve

ragi

ng T

ech

nol

ogy

to E

nha

nce

Com

mu

nica

tion

in H

ealth

care

Tech

3:

Dat

a-dr

iven

Ana

lytic

s an

d M

ach

ine

Lea

rnin

g fo

r Im

pro

ving

Hea

lthca

re O

utco

mes

2018

20

19 P

roje

ct P

ropo

sals Pat

ien

t E

xper

ien

ce P

rop

osa

lsP

atie

nt

1: C

are

Coo

rdin

atio

n A

ctiv

ities

fo

r In

div

idua

ls w

ith S

pina

l Cor

d In

jury

Pat

ien

t 2

: G

ene

ratin

g Ta

ilore

d R

eco

mm

enda

tions

Au

tom

atic

ally

with

Exp

lan

atio

ns v

ia a

n In

tera

ctiv

eD

ialo

g-ba

sed

Sys

tem

Pat

ien

t 3

: E

mb

eddi

ng R

outin

e In

form

al,

Fa

mily

Car

egiv

er A

sse

ssm

ent

of

De

liriu

m S

upe

rim

pos

ed o

n D

eme

ntia

into

Acu

te C

are

Acc

ess

to C

are

Pro

po

sals

Ac

ces

s 1

:Te

lem

edic

ine

in P

ract

ice:

Mu

ltidi

scip

linar

y U

tiliz

atio

n of

Te

lehe

alth

an

d R

emot

e P

atie

nt

Mon

itori

ng S

yste

ms

Ac

ces

s 2

:An

Inte

rven

tion

to A

ddre

ss H

ealth

Lite

racy

Ba

rrie

rs,

Incr

ease

Pat

ient

En

gage

men

t, a

nd

Impr

ove

Pa

tient

Exp

erie

nce

and

Out

com

es

CH

OT

WE

BS

ITE

ch

otn

sf.

org

16

Page 17: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Mem

ber

s O

nly

Sec

tio

nS

pri

ng

201

6 M

eeti

ng

Att

end

ance

Tota

l Reg

iste

red

Att

ende

es a

s o

f 04

.04.

18

Tota

l Att

end

ees:

61

Sp

rin

g 2

018

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tin

g A

tten

dan

ce

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eN

um

ber

of

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end

ees

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iver

sity

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e A

dm

inis

trat

or

2

Fac

ult

y / R

esea

rch

er13

NS

F R

epre

sen

tati

ve1

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Mem

ber

16

Gu

ests

6

Gra

du

ate

& U

nd

erg

rad

uat

e S

tud

ent

23

Mee

tin

g A

gen

da

ME

ET

ING

AG

EN

DA

Mee

tin

g A

gen

da

ME

ET

ING

AG

EN

DA

17

Page 18: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Thu

rsda

y, O

ctob

er 1

1 &

Fri

day,

Oct

ober

12,

201

8

Hos

ted

by G

eorg

ia I

nstit

ute

of T

echn

olog

y

at t

he M

ITR

E F

acili

ty in

McL

ean,

VA

Fal

l 201

8 IA

B M

EE

TIN

G

McL

ean

, VA

H.E

. Luc

cock

18

Page 19: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

CH

OT

Res

earc

h Im

pac

t &

Insi

gh

t:E

ffect

iven

ess

of W

orkp

lace

Hea

lth

Pro

mot

ion

Pro

gram

sP

roje

ct L

eade

rs: G

eorg

e N

aufa

l

Co-

lead

ers:

Ohb

etC

heon

, Bit

aA

. Kas

h

Stud

ent

Nam

e(s)

: N/A

Enga

ged

IAB

mem

bers

: HEB

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Texa

s A&

M

Uni

vers

ity

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Ob

ject

ive:

•H

ow e

ffect

ive

is a

wor

kpla

ce h

ealth

pro

mot

ion

prog

ram

•P

rovi

des

empi

rical

evi

denc

e on

initi

ativ

es a

ddre

ssin

g he

alth

org

aniz

atio

n m

anag

emen

t an

d se

rvic

e

•E

valu

ate

diffe

rent

hea

lth p

rom

otio

n in

terv

entio

ns,

larg

e ad

min

istr

ativ

e da

ta

Par

tner

s / R

elev

ance

:

•P

rovi

des

empi

rical

evi

denc

e fr

om a

larg

e da

ta s

et

•In

vite

s ot

her

indu

stry

par

tner

s to

con

side

r si

mila

r in

itiat

ives

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

escr

iptio

n of

Pro

ject

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Wh

at p

rob

lem

is

this

pro

ject

see

kin

g t

o

add

ress

?

•C

ost

of in

sura

nce

prem

ium

s an

d em

ploy

ee

com

pens

atio

n cl

aim

s co

ntin

ue t

o ris

e; w

orkp

lace

he

alth

pro

mot

ion

prog

ram

can

cut

dow

n th

ese

cost

s (b

oth

heal

th a

nd m

anag

emen

t co

sts)

•M

ost

full-

time

empl

oyee

s sp

end

mor

e th

an 1

/3 o

f th

eir

time

at th

e w

orkp

lace

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

hP

roje

ct O

verv

iew

an

d D

escr

ipti

on

Res

earc

h P

ersp

ecti

ve

•A

hea

lth p

rogr

am p

rom

otio

n th

at a

ll st

akeh

olde

rs

bene

fit fr

om

–E

mpl

oyee

–be

tter

hea

lth o

utco

mes

and

low

er

heal

th p

rem

ium

s

–P

rovi

der –

heal

thie

r em

ploy

ees

(bet

ter

prod

uctiv

ity, l

ess

abse

ntee

ism

), lo

wer

hea

lth

and

man

agem

ent

cost

s

–H

ealth

sys

tem

–le

ss u

sage

of s

ervi

ces

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

19

Page 20: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

•E

mpi

rical

evi

denc

e fr

om a

larg

e em

ploy

er

•R

ich

data

set w

hich

incl

udes

fou

r bi

omet

ric in

dica

tors

: sy

stol

ic, d

iast

olic

, gl

ucos

e, a

nd c

hole

ster

ol

•E

xam

ine

four

diff

eren

t hea

lth p

rogr

am p

rom

otio

ns

–W

elln

ess

cour

se

–H

eart

hea

lth c

ours

e

–D

iabe

tes

prev

entio

n co

urse

–R

egis

tere

d D

ietit

ian

cons

ulat

ion

CO

NT

RIB

UT

ION

: H

ow is

thi

s di

ffere

nt t

han

rela

ted

rese

arch

?A

pp

roac

h

•W

hat a

ppro

ach

was

take

n?–

Was

not

invo

lved

in th

e de

sign

pha

se

–To

ok in

to c

onsi

dera

tion

of s

elec

tion

into

of

fere

d he

alth

pro

mot

ion

prog

ram

sto

def

ine

trea

tmen

t and

con

trol

gro

ups

–U

se q

uasi

-exp

erim

enta

l app

roac

h to

iden

tify

trea

tmen

t effe

ct o

f the

hea

lth p

rogr

am

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

Ap

pro

ach

•O

verv

iew

of r

esul

ts•

Ove

rall,

hea

lth p

rogr

ams

offe

red

have

a

posi

tive

impa

ct o

n th

e st

udie

d he

alth

ou

tcom

es o

f the

em

ploy

ees

•A

lthou

gh ty

pica

lly u

nder

10%

, the

mag

nitu

de

of p

rogr

am e

ffect

s ra

nge

from

2%

to 2

7% in

te

rms

of im

prov

emen

t in

hea

lth o

utco

mes

OV

ER

VIE

W O

F R

ES

ULT

S:

Ap

pro

ach

•O

ffer

and

prom

ote

heal

th p

rogr

ams

at th

e w

orkp

lace

•Im

prov

es h

ealth

and

qua

lity

of li

fe o

f em

ploy

ees

•Im

prov

es p

rodu

ctiv

ity o

f em

ploy

ees

•Lo

wer

ove

rall

cost

s (m

anag

emen

t and

he

alth

)

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

20

Page 21: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

CH

OT

Res

earc

h Im

pac

t &

Insi

gh

t:Im

pro

ve P

atie

nt

Car

e T

hro

ug

h

Clin

ical

Pro

cess

Op

tim

izat

ion

Pro

ject

Lea

ders

: Ev

a K

Lee

, PhD

.

Clin

ical

Lea

ders

: A

mel

ia A

. Lan

gsto

n, M

D, S

agar

Lon

ial,

MD

, Ed

mun

d K

. Wal

ler,

MD

, PhD

, FAC

P.

Eng

aged

IAB

Mem

bers

: Em

ory

Uni

vers

ity S

choo

l of

Med

icin

e, C

hild

ren’

s H

ealth

care

of A

tlant

a

Eng

aged

CH

OT

Uni

vers

ity

Site

s:

Geo

rgia

Inst

itute

of T

echn

olog

y

Stud

ent

Nam

e(s)

: T

ess E

. Bee

ler,

Bin

gy B

ao, R

ache

l B. D

efili

pp, R

ober

ts

Rod

rigu

ez, J

onat

han

C. Y

. Pan

g, A

bhin

av B

hard

waj

, Yifa

n W

ang

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Ob

ject

ive:

•Im

prov

e pa

tient

exp

erie

nce,

sch

edul

ing,

utili

zatio

n, c

linic

al p

roce

sses

, and

prov

ider

s’ m

oral

e.

Par

tner

s / R

elev

ance

:

•O

verc

ome

the

inef

ficie

ncy

in r

esou

rces

and

staf

f util

izat

ion

to im

prov

e pa

tient

expe

rienc

e.

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

crip

tion

of P

roje

ct

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Wh

at p

rob

lem

is t

his

pro

ject

see

kin

g t

o

add

ress

?•

The

over

all

auto

logo

ushe

mat

opoi

etic

stem

cell

tran

spla

ntat

ion

proc

ess

can

bech

alle

ngin

gan

dst

renu

ous

for

man

ypa

tient

sto

goth

roug

h

•P

roce

dure

ssu

chas

hem

aphe

resi

s(s

tem

cell

colle

ctio

n)ca

ncr

eate

bottl

enec

kdu

eto

patie

ntva

riabi

lity

•V

aria

bilit

yca

nca

use

inef

ficie

ncy

inre

sour

cean

dst

affu

tiliz

atio

n

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Res

earc

h P

ersp

ecti

ve

•P

atie

nts:

Red

uce

back

logs

, wai

ting

time.

•P

rovi

ders

: Im

prov

e ef

ficie

ncy

for

iden

tifie

dob

ject

ives

.

•H

ealth

sys

tem

s: Im

prov

e ov

eral

l res

ourc

eut

iliza

tion

and

allo

catio

n.

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

21

Page 22: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

A fr

amew

ork

for

the

heal

thca

re t

oef

ficie

ntly

allo

cate

re

sour

ces

and

staf

f bas

ed o

n th

e va

riabi

lity

of p

atie

nts.

CO

NT

RIB

UT

ION

: How

is th

is d

iffer

ent

than

rel

ated

res

earc

h?A

pp

roac

h

•O

ur a

ppro

ach:

1.In

terv

iew

rele

vant

stak

ehol

ders

inth

ebo

nem

arro

wtr

ansp

lant

proc

ess.

2.P

erfo

rmtim

e-m

otio

nst

udie

san

dob

serv

atio

nsto

esta

blis

hth

eB

MT

proc

ess

map

s.

3.A

naly

zeob

serv

atio

nal,

time-

mot

ion,

sche

dulin

g,ap

poin

tmen

tan

dse

rvic

edu

ratio

n,an

dpa

tient

data

toes

tabl

ish

patie

ntan

dse

rvic

ech

arac

teris

tics

and

syst

emic

inte

rdep

ende

ncie

s.

4.M

odel

and

optim

ize

sche

dule

san

db

edca

paci

ties

toal

ign

dem

and

and

supp

ly,e

qual

ize

utili

zatio

nan

dre

duce

over

time.

5.Im

plem

enta

ndev

alua

teac

hiev

edre

sults

.

AP

PR

OA

CH

: E

xper

imen

tal A

ppro

ach

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pro

ach

•P

revi

ous

vs O

ptim

ized

Res

ults

•P

revi

ous

obse

rvat

ions

•W

eekl

y ut

iliza

tion

of 5

6% le

aves

muc

h ro

om f

or o

ptim

izat

ion

•O

nly

67.5

% o

f pa

tient

s ar

e ab

le to

fin

ish

colle

ctio

n in

one

day

•S

ched

ulin

g fo

r pa

tient

s w

ho n

eed

mul

tiple

day

s to

col

lect

targ

et s

tem

cel

l qu

antit

ies

is n

ot d

one

in a

dvan

ce

•C

onsi

dera

ble

stan

dard

dev

iatio

n be

twee

n ut

iliza

tion

on w

eekd

ays

resu

lts in

ei

ther

res

ourc

e/st

aff

shor

tage

or

exce

ss

•T

he n

eed

for

Sat

urda

y co

llect

ions

res

ults

in u

nnec

essa

ry s

taff

over

time

•O

ur o

ptim

ized

res

ults

•P

atie

nt S

tem

Cel

l Col

lect

ion

Dat

a ac

quire

d fo

r al

l pat

ient

s be

fore

and

afte

r im

plem

enta

tion

of t

he o

ptim

ized

sch

edul

ing

mod

el

•A

vera

ge u

tiliz

atio

n in

crea

sed

from

56%

to

92%

•N

o ov

ertim

e st

affin

g on

Sat

urda

y

•30

% in

crea

sed

patie

nt t

hrou

ghpu

t pe

rmitt

ed b

y ne

w s

ched

ulin

g m

odel

OV

ER

VIE

W O

F R

ES

ULT

S:

Ap

pro

ach

OV

ER

VIE

W O

F R

ES

ULT

S:

0

0.2

0.4

0.6

0.81

1.2

Mon

Tue

sW

edT

hur

Fri

Sat

Ori

gin

al U

tiliz

atio

n

00.

10.

20.

30.

40.

50.

60.

70.

80.

91

Mon

Tue

sW

edT

hur

Fri

Sat

Th

eore

tica

l Uti

lizat

ion

0

0.2

0.4

0.6

0.81

1.2

Mon

Tue

sW

edT

hur

Fri

Sat

Imp

lem

ente

d U

tiliz

atio

n

Orig

inal

util

izat

ion

vs th

eore

tical

(op

timiz

ed)

vs im

plem

ente

d re

sults

22

Page 23: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Ap

pro

ach

•A

fram

ewor

k th

at b

uild

s pr

oces

s m

aps,

ana

lyze

s da

taan

dop

timiz

es s

ched

ules

to:

–Im

prov

e sc

hedu

ling

capa

city

.

–R

educ

e pa

tient

bac

klog

s an

d w

ait-

time.

–In

crea

se r

esou

rces

util

izat

ion.

–A

void

unn

eces

sary

sch

edul

es.

•B

oth

patie

nts

and

heal

thca

re p

rovi

ders

wou

ld b

enef

it fr

om th

e im

prov

emen

t of

the

serv

ice

deliv

ery

effic

ienc

y.

OV

ER

VIE

W O

F R

ES

ULT

S:

Ben

efits

to In

dust

ry

23

Page 24: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

24

Page 25: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

An

Un

sup

ervi

sed

Mac

hin

e L

earn

ing

M

eth

od

fo

r D

isco

veri

ng

Pat

ien

t C

lust

ers

Bas

ed o

n G

enet

ic S

ign

atu

res

Pro

ject

Lea

ders

: Con

rad

Tuck

er, P

h.D

.

Co-

Lead

ers:

Chr

isto

pher

DeF

litch

, MD

; Gre

g Le

wis

, Ph.

D.

Stud

ent

Nam

e(s)

: Chr

istia

n Lo

pez,

Scot

t Tuc

ker, T

arik

Sal

ameh

Enga

ged

IAB

mem

bers

: Sie

men

s, H

ighm

ark,

Her

shey

Med

ical

Cen

ter,

AT

&T

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Penn

Sta

te U

nive

rsity

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Ob

ject

ive:

•D

evel

op n

ovel

mac

hine

lear

ning

te

chni

ques

for

iden

tifyi

ng a

ctio

nabl

e ge

nom

ic s

imila

ritie

s am

ong

patie

nts

with

chr

onic

imm

une

dise

ases

.

Par

tner

s / R

elev

ance

:

•R

educ

e tr

ial-a

nd-e

rror

trea

tmen

t co

sts

and

impr

ove

patie

nt o

utco

mes

.

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

escr

iptio

n of

Pro

ject

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nW

hat

pro

ble

m i

s th

is p

roje

ct s

eeki

ng

to

ad

dre

ss?

•C

hron

ic im

mun

e di

sord

ers

man

ifest

diff

eren

tly

from

pat

ient

to

patie

nt,

yet

have

a g

enet

ic

etio

logy

.

•E

nhan

ced

unde

rsta

ndin

g of

the

gen

etic

un

derp

inni

ngs

can

impr

ove

dise

ase

trea

tmen

t.

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

un

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nR

esea

rch

Per

spec

tive

•P

atie

nt –

enha

nced

car

e

•P

rovi

der

–in

form

ed tr

eatm

ent d

ecis

ions

•H

ealth

sys

tem

–im

prov

ed p

atie

nt

outc

omes

•P

ayer

–ef

ficie

nt p

atie

nt-b

ased

trea

tmen

t

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

25

Page 26: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

•A

pre

limin

ary

step

to

iden

tifyi

ng g

enet

ical

ly-

dist

inct

pat

ient

coh

orts

with

in t

he p

opul

atio

n su

fferin

g fr

om c

hron

ic im

mun

e di

sord

ers.

CO

NT

RIB

UT

ION

: H

ow is

thi

s di

ffere

nt t

han

rela

ted

rese

arch

?A

pp

roac

h•

Hie

rarc

hica

l uns

uper

vise

d m

achi

ne le

arni

ng is

em

ploy

ed t

o im

mun

ochi

p da

ta c

olle

cted

fro

m a

M

ultip

le S

cler

osis

pat

ient

coh

ort.

•S

igni

fican

t ge

netic

clu

ster

s ar

e de

fined

by

the

algo

rith

m a

nd p

atie

nts

are

assi

gned

to

thes

e cl

uste

rs b

ased

on

thei

r ge

netic

mak

eup.

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

Ap

pro

ach

OV

ER

VIE

W O

F R

ES

ULT

S:

•2

dist

inct

clu

ster

s ar

ise

from

the

pat

ient

coh

ort.

•G

ene

Pat

hway

Ana

lysi

s re

veal

s si

gnifi

cant

di

ffere

nces

bet

wee

n th

e cl

uste

rs in

cel

lula

r ad

hesi

on,

cyto

kine

res

pons

e, a

nd im

mun

e pr

oces

s pa

thw

ays.

Ap

pro

ach

•C

lust

ers

iden

tifie

d in

the

patie

nt

coho

rt c

an b

e as

sess

ed fo

r lin

ks

to c

linic

al o

utco

mes

suc

h as

:–

Age

of

onse

t of

dis

ease

–R

espo

nse

to t

reat

men

t

–S

peci

fic d

isea

se c

ours

e

•A

ccur

ate

pred

ictio

n of

thes

e ou

tcom

es w

ill im

prov

e ov

eral

l di

seas

e ou

tcom

es a

nd id

entif

y ap

prop

riate

trea

tmen

t str

ateg

ies.

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

26

Page 27: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

gra

ms

to R

edu

ce M

edic

atio

n-

Rel

ated

Rea

dm

issi

on

sP

roje

ct L

eade

rs:

Nat

han

Car

roll,

Ph.D

., M

HA

Stud

ent

Nam

e(s)

: R

eena

Jose

ph, M

HA

Nee

raj P

uro,

MH

A

Eng

aged

IAB

mem

bers

: H

ealth

Sout

h

Eng

aged

CH

OT

Uni

vers

ity

Site

s: U

nive

rsity

of A

laba

ma

at B

irm

ingh

am

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Ob

ject

ive:

•To

iden

tify

inte

rven

tions

tha

t ha

ve b

een

succ

essf

ul in

red

ucin

g m

edic

atio

n-re

late

d re

adm

issi

ons

Par

tner

s / R

elev

ance

:

•E

stim

ated

13-

20%

of

read

mis

sion

s ar

e ca

used

by

med

icat

ion-

rela

ted

fact

ors

•R

educ

ing

read

mis

sion

s im

prov

es t

he q

ualit

y of

ca

re a

nd r

educ

es p

rovi

der

pena

lties

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

escr

iptio

n of

Pro

ject

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Wh

at p

rob

lem

is t

his

pro

ject

see

kin

g t

o

add

ress

?•

Fro

m 2

007-

2015

rea

dmis

sion

rat

es d

eclin

ed

from

22%

to 1

8%–

Man

y pr

ovid

ers

are

impl

emen

ting

prac

tices

to

redu

ce r

eadm

issi

ons

–R

eadm

issi

on r

ates

are

stil

l rel

ativ

ely

high

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Res

earc

h P

ersp

ecti

ve

•R

esea

rch

focu

ses

on in

terv

entio

ns

impl

emen

ted

by h

ospi

tals

•P

atie

nt p

ersp

ectiv

e is

impo

rtan

t but

isn’

t ad

dres

sed

in m

ost o

f the

stu

dies

we

foun

d

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

27

Page 28: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

•F

ocus

on

med

icat

ion-

rela

ted

caus

es o

f re

adm

issi

ons

•D

isse

min

ate

wha

t aca

dem

ics

have

lear

ned

abou

t rea

dmis

sion

inte

rven

tions

to m

anag

ers

•Id

entif

y ba

rrie

rs to

usi

ng a

cade

mic

res

earc

h in

pra

ctic

e

CO

NT

RIB

UT

ION

: H

ow is

thi

s di

ffere

nt t

han

rela

ted

rese

arch

?

Ap

pro

ach

•Li

tera

ture

rev

iew

-22

stu

dies

iden

tifie

d–

Pee

r-re

view

ed e

mpi

rical

stu

dies

fro

m a

cade

mic

da

taba

ses

(Sco

pus,

Pub

Med

, C

INA

HL)

pu

blis

hed

sinc

e 20

00

–C

onta

ins

MeS

Hte

rms

rela

ted

to

•“M

edic

atio

n ad

here

nce”

or

“dru

g-re

late

d si

de e

ffect

s”

AN

D “

read

mis

sion

s”

–In

clus

ion

crite

ria•

The

stu

dy d

escr

ibes

an

inte

rven

tion

•Ta

rget

s m

edic

atio

n-re

late

d fa

ctor

s le

adin

g to

re

adm

issi

ons

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

Ap

pro

ach

•7

inte

rven

tions

res

ulte

d in

a s

igni

fican

t re

duct

ion

in r

eadm

issi

ons

•M

any

used

com

bina

tion

of c

ompo

nent

s (d

/c

plan

ning

, ed

ucat

ion,

pos

t d/

c ph

one

calls

, pa

tient

cou

nsel

ling,

med

rec

onci

liatio

n)

•S

ever

al o

nly

used

a c

are

coor

dina

tor

assi

gned

to

impr

ove

coor

dina

tion

and

com

mun

icat

ion

betw

een

prog

ram

co

mpo

nent

s an

d cl

inic

ians

•C

are

coor

dina

tion

seem

s ef

fect

ive

OV

ER

VIE

W O

F R

ES

ULT

S:

Ap

pro

ach

•D

eliv

erab

le:

Writ

ten

repo

rt th

at:

–D

etai

ls e

valu

ated

effo

rts

to r

educ

e m

edic

atio

n-re

late

d re

adm

issi

ons

–S

ynth

esiz

es w

hat

we

know

abo

ut s

ucce

ssfu

l in

terv

entio

ns

•Im

port

ance

: –

Man

y pr

ovid

ers

have

suc

cess

fully

red

uced

re

adm

issi

ons

usin

g a

varie

ty o

f st

rate

gies

–In

cent

ives

to

redu

ce t

hem

fur

ther

rem

ain

larg

e (H

RR

P, b

undl

ed p

aym

ent)

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

28

Page 29: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Med

ical

Imag

ing

Lo

gfi

les:

Big

Dat

a A

nal

ysis

& F

ind

ing

sP

roje

ct L

eade

rs:

Chr

istin

a M

astr

ange

lo

Co-

lead

ers:

Chr

isto

pher

Hal

l –Ph

ilips

Hea

lthca

reR

ebec

ca J.

Mie

losz

yk –

Phili

ps H

ealth

care

Stud

ent

Nam

e:

Lari

ssa

P. G

. Pet

roia

nu

Eng

aged

IAB

mem

bers

: Ph

ilips

Hea

lthca

re

Eng

aged

CH

OT

Uni

vers

ity

Site

s: U

nive

rsity

of W

ashi

ngto

n

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Bac

kgro

un

d a

nd

Rel

evan

ce:

•M

RI

mac

hine

s ar

e im

port

ant

for

dete

ctin

g or

mon

itorin

g sp

ecifi

c he

alth

co

nditi

ons.

•M

RI

is a

hig

h co

st p

roce

dure

: ab

out

$600

/hou

r in

the

US

•W

ides

prea

d ef

fect

: •

39 M

RI m

achi

nes

per

1,00

0,00

0 in

habi

tant

s1~

12,

519

mac

hine

s

•11

7.8

MR

I exa

ms

per

1,00

0,00

0 in

habi

tant

s pe

r ye

ar2

~ 3

7,81

3.8

exam

s/ye

ar

•D

iffer

ent

fact

ors

can

influ

ence

in w

aste

d sc

anne

r tim

e, fo

r ex

ampl

e:–

Poo

r sc

hedu

ling,

faile

d/lo

w v

alue

seq

uenc

es, o

r id

lene

ss

–H

uman

fact

ors

, suc

h a

s tr

ans

por

t, m

ove

me

nt o

f pat

ient

s an

d te

chni

cian

s

•F

ind

a w

ay

to d

ecre

ase

the

exam

tim

e an

d its

var

iabi

lity

will

–re

duce

the

cost

s of

the

exa

m

–im

prov

e th

e pa

tient

’s e

xper

ienc

e

•D

evel

op a

met

hodo

logy

tha

t can

gen

eral

ize

to o

ther

site

s.

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

escr

iptio

n of

Pro

ject

1 ht

tps:

//dat

a.oe

cd.o

rg/h

ealth

eqt/m

agne

tic-r

eson

ance

-imag

ing

-mri-

units

.htm

-03

/26/

2018

2 ht

tps:

//dat

a.oe

cd.o

rg/h

ealth

care

/mag

netic

-res

onan

ce-im

agin

g-m

ri-ex

ams.

htm

-03

/26/

2018

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Wh

at p

rob

lem

is t

his

pro

ject

see

kin

g t

o

add

ress

?•

Hig

h va

riabi

lity

in t

ime

and

quan

tity

of s

eque

nces

for

si

mila

r ex

ams

whi

ch a

ffect

s th

e pa

tient

exp

erie

nce

and

cost

of M

RI p

roce

dure

s.

•O

bje

ctiv

es:

–Id

entif

y an

d m

easu

re “

was

ted”

tim

e in

MR

I exa

ms.

–A

scer

tain

the

root

cau

ses

of th

e no

n-pr

oduc

tive

time.

–Id

entif

y ke

y m

easu

res.

–U

se lo

g fil

es a

s th

e so

urce

of d

ata

to a

naly

ze d

urat

ion

and

varia

bilit

y.

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

hP

roje

ct O

verv

iew

an

d D

escr

ipti

on

Res

earc

h P

ersp

ecti

ve

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

Pat

ient

Re

du

ctio

nin

du

ratio

n o

f th

e

exa

m

Kn

ow

led

ge o

f th

e e

xpe

cte

d

du

ratio

n

Pro

vide

rR

ed

uct

ion

of

cost

Re

du

ctio

n o

f tim

eB

ett

er

sch

ed

ule

p

lan

nin

g

Hea

lth

syst

emL

ess

va

riab

ility

Re

du

ctio

n o

f tim

e

Pay

erR

ed

uct

ion

of

cost

29

Page 30: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

•U

nder

stan

d ho

w t

o an

alyz

e in

form

atio

n ex

istin

g in

MR

log

files

.

•Im

prov

e pa

tient

’s e

xper

ienc

e.

•Id

entif

y ca

uses

of

varia

bilit

y.

•Id

entif

y im

prov

emen

ts t

o re

duce

“w

aste

d” t

ime

and

incr

ease

pro

cess

qua

lity.

•A

pply

to

othe

r ra

diol

ogy

area

s, s

uch

as C

T

CO

NT

RIB

UT

ION

: H

ow is

thi

s di

ffere

nt t

han

rela

ted

rese

arch

?A

pp

roac

hA

PP

RO

AC

H: E

xper

imen

tal A

ppro

ach

Und

erst

and

the

log

files

Und

erst

and

the

proc

ess

Pre

-pr

oces

sing

th

e da

ta

Cor

rela

tion

anal

ysis

Out

lier

dete

ctio

nP

redi

ctio

n m

odel

s

Site

s co

mpa

rison

Iden

tify

ing

Co

rrel

ates

OV

ER

VIE

W O

F R

ES

ULT

S

•V

aria

ble

s re

late

d t

o p

atie

nt’

s ch

arac

teri

stic

s an

d d

ura

tio

ns

•U

nex

pec

ted

lac

k o

f co

rrel

atio

n b

etw

een

pat

ien

t’s

char

acte

rist

ics

and

du

rati

on

•E

xpec

ted

co

rrel

atio

n b

etw

een

rep

eate

d s

can

s an

d c

on

tras

t w

ith

exa

m d

ura

tio

n

Exa

m D

ura

tio

n a

nd

Rat

io o

f R

epea

ted

Seq

uen

ceb

y A

nat

om

y an

d S

ite

Sho

rtes

tLo

nges

t

•L

arg

e va

riab

ility

exi

sts

bet

wee

n s

ites

.•

Sit

e 3

has

bet

ter

met

rics

an

d w

ill b

e an

alyz

ed a

s a

ben

chm

ark.

30

Page 31: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Fra

ctio

n o

f R

epea

ted

Seq

uen

ces

by

An

ato

my

OV

ER

VIE

W O

F R

ES

ULT

S

•‘B

rain

’ an

d ‘

Hea

d’ h

ave

mo

re e

xam

s, h

ow

ever

are

mo

re c

on

sist

ent

wit

h f

ew r

epea

ted

sc

an s

equ

ence

s.•

‘Ab

do

men

’ an

d ‘

Liv

er’ h

ave

hig

h r

atio

of

rep

etit

ion

an

d i

s an

op

po

rtu

nit

y fo

r im

pro

vem

en

t.

Ap

pro

ach

•D

efin

ed 3

key

met

rics

to a

naly

ze w

aste

:–

% o

f rep

eate

d se

quen

ces

(sca

ns)

–E

xam

dur

atio

n

–Id

le ti

me

•P

atie

nt p

hysi

olog

ical

cor

rela

tes

are

cont

rary

to w

hat

was

ex

pect

ed;

they

do

not s

igni

fican

tly a

ffect

dur

atio

ns.

•S

igni

fican

t va

riabi

lity

exis

ts w

ithin

the

sam

e ex

am c

ard

sequ

ence

s be

twee

n th

e di

ffere

nt s

ites.

•D

iffer

ent p

redi

ctiv

e m

odel

s ha

ve b

een

expl

ored

to

anal

yze

the

data

, but

no

sign

ifica

nt r

esul

ts y

et.

•T

he b

igge

st o

ppor

tuni

ty t

o re

duce

exa

m d

urat

ion

is b

y re

duci

ng t

he n

umbe

r of

rep

eate

d sc

ans.

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

31

Page 32: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

32

Page 33: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

RESEARCH PROPOSALS

Research Theme #1:

Population Health

Research Theme #2:

Care Coordination

Research Theme #3:

Analytics and Innovative Technologies

Research Theme #4:

Patient Experience

Research Theme #5:

Access to Care

33

Page 34: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

34

Page 35: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Research Theme #1:

POPULATION HEALTH

Theme Champion: Dr. Conrad Tucker, Pennsylvania State University

Pop 1 Comprehensive Analysis on Impact of Social Determinants to Improve Care Across Populations Pop 2 Participating in a Community Health Improvement Network Pop 3 The Effectiveness of Substance Abuse Treatment Services in Combating Opioid Crisis

35

Page 36: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

36

Page 37: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Comprehensive Analysis on Impact of Social Determinants to Improve Care Across Populations

Pop1 Borkowski, Mastrangelo, Ferris, Kash

Population Health

$150,000 YES 1

Social and environmental determinants, such as economic stability, housing and physical environment, food access, communitysupport, and availability of health care systems impact health outcomes and the satisfaction of patients and care providers. Initiativesare under way to improve our understanding of how these social factors can influence the organization and delivery of care to patientcommunities, targeting the broad population as well as focused efforts on those with certain medical conditions. However, only limitedresearch has focused on the relationship between social determinants and healthcare for specific sub-populations, such as militaryveterans, pediatric populations, and those with histories of readmission or repeated ED visits. Additionally, there is value in morecompletely understanding how these social factors interact with health conditions in regard to patient satisfaction and HCAHPSscores. This collaborative project seeks to address these aims and broaden the knowledge base concerning the effects of socialdeterminants on mental and physical health and the utilization of available healthcare.

This proposed research focuses on identifying the social factors that contribute to the mental and physical health of individuals fromtarget populations (veterans, children, recurrent ED visitors). The understanding of these factors can inform ways of improving theeffectiveness of care and the patient experience. This research will support efforts to extend patient care beyond clinical parameters,to understand the effects of social demographics on patient experience through HCHAPS, and to orient clinical practice for improvedpatient experience and reduction in the cost of care.

We will obtain data from the UAB enterprise data warehouse (EDW) for all patients who were discharged between 2016 - 2017.Notably, these data will include Social Determinants of Health (SDH). Data will also be obtained from patients enrolled in the CentralTexas Veteran's Health Care system that are enrolled in their integrated health program. The compiled database will be analyzed viamixed methods to determine significant direct and interacting social and medical factors impacting healthcare utilization. This analysiswill inform the development of a predictive model that can be evaluated in simulation.

Month 1-2: Obtain IRB approvalMonth 3-6: Distinguish relationships among social determinants and health variables, obtain/merge/develop databases that includeboth mental and physical health flags, process data and produce descriptive analyticsMonth 7-8: Develop predictive model and evaluate in simulation, iteratively refine model.Month 9-12: Write report to include results for each target population

1) Predictive models for readmission, which incorporate socialand medical factors, can be used to inform and guide careplans.2) Access to databases for selected patient groups.

1) Publication of results of the analysis, including the identificationof social determinants affecting care need and readmissions.2) Publication of the developed predictive model to assesslikelihood of repeat ED visits and readmissions.3) Access to developed databases that integrates both mentalhealth and clinical factors for selected patient groups.

37

Page 38: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Com

preh

ensi

ve A

naly

sis

on Im

pact

of

Soc

ial D

eter

min

ants

to Im

prov

e C

are

Acr

oss

Popu

latio

nsP

roje

ct L

eade

r: T

hom

as F

erri

s, P

hD

Co-

lead

ers:

Chr

isti

na M

astr

ange

lo, P

hD, M

SN

ancy

Bor

kow

ski,

DB

AB

ita

Kas

h, P

hD, M

BA

, FA

CH

ESt

uden

t N

ame(

s):

Enga

ged

IAB

mem

bers

: Vet

eran

s Adm

inis

trat

ion

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Cen

tral

Tex

as

Vete

rans

Hea

lthca

re, S

eatt

le C

hild

ren’

s H

ospi

tal,

Mai

n Li

ne H

ealth

Proj

ect O

verv

iew

and

Des

crip

tion

Obj

ectiv

es:

Dev

elop

pre

dict

ive

mod

els

to e

xam

ine

the

rela

tions

hip

betw

een

soci

al fa

ctor

s an

d th

e lik

elih

ood

of e

mer

genc

y ro

om

visi

ts a

nd re

peat

hos

pita

lizat

ions

.

Dev

elop

a d

atab

ase

that

incl

udes

bot

h m

enta

l and

phy

sica

l hea

lth fa

ctor

s fo

r ta

rget

pop

ulat

ions

.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Part

ners

/ R

elev

ance

:Th

e m

odel

s w

ill pr

ovid

e in

sigh

t int

o se

rvic

e ne

eds

that

mig

ht n

ot o

ther

wis

e be

iden

tifie

d fo

r vet

eran

and

ped

iatri

c po

pula

tions

.

The

deve

lope

d da

taba

se w

ill su

ppor

t tra

ckin

g pa

tient

pro

gres

s an

d an

alys

is

of s

ocia

l fac

tors

.

Proj

ect O

verv

iew

and

Des

crip

tion

Wha

t pro

blem

doe

s th

is p

roje

ct a

ddre

ss?

•Fe

w h

ealth

car

e m

odel

s in

corp

orat

e m

edic

al a

nd s

ocia

lfac

tors

in p

redi

ctin

g un

met

pat

ient

car

e ne

eds

•N

eed

to c

onsi

der b

oth

phys

ical

and

men

tal c

are

need

s•

Dev

elop

ed m

odel

s w

ill su

ppor

t ana

lysi

s of

com

plex

rela

tions

hips

am

ong

soci

al d

emog

raph

ics,

phy

sica

l and

men

tal h

ealth

, and

hea

lthca

re u

tiliz

atio

n

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

Hea

lthca

re U

tiliz

atio

n

Proj

ect O

verv

iew

and

Des

crip

tion

Res

earc

h Pe

rspe

ctiv

eTh

e m

odel

s w

ill he

lp c

are

prov

ider

s id

entif

y pa

tient

s w

ho

have

gre

ater

nee

d fo

r car

e se

rvic

es, b

ased

on

soci

al a

nd

med

ical

fact

ors

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

The

pred

ictiv

e m

odel

s w

ill al

so

be u

sed

to e

valu

ate

way

s to

re

duce

cos

ts, p

reve

nt

read

mis

sion

s, a

nd in

crea

se

patie

nt s

atis

fact

ion

38

Page 39: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

n to

Indu

stry

and

Aca

dem

ia•

Con

tribu

te to

und

erst

andi

ng o

f com

plex

re

latio

nshi

p am

ong

inte

ract

ing

soci

al a

nd

med

ical

fact

ors

in h

ealth

care

util

izat

ion

•P

redi

ctiv

e m

odel

s of

hea

lth o

utco

mes

, lik

elih

ood

of re

adm

issi

on c

an b

e us

ed to

in

form

and

gui

de c

are

plan

s

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

App

roac

h•

UA

BH

S E

nter

pris

e D

ata

War

ehou

se (c

linic

al,

soci

al, a

nd e

cono

mic

var

iabl

es) f

or 2

016

and

2017

•M

ixed

ana

lytic

al m

etho

ds to

unc

over

re

latio

nshi

ps a

mon

g so

cial

det

erm

inan

ts a

nd

med

ical

fact

ors

in h

ealth

care

util

izat

ion

•D

evel

op a

nony

miz

ed p

atie

nt-le

vel d

atab

ases

to

supp

ort p

redi

ctiv

e m

odel

ing

•D

evel

op p

redi

ctiv

e m

odel

of r

eadm

issi

on/ E

D

visi

t fre

quen

cy a

nd e

valu

ate

in s

imul

atio

n

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

App

roac

hO

VE

RV

IEW

OF

RE

SU

LTS

: Exp

ecte

d M

ilest

ones

Mon

ths

1-2

Obt

ain

IRB

ap

prov

al

Mon

ths

3-6

Dis

tingu

ish

rela

tions

hips

, de

velo

p da

taba

ses,

pr

oces

s da

ta

Mon

ths

7-8

Dev

elop

and

ev

alua

te

pred

ictiv

e m

odel

Mon

ths

9-12

W

rite

repo

rts

incl

udin

g re

sults

for e

ach

targ

et

popu

latio

n

App

roac

h

•P

ublic

atio

n(s)

and

pre

sent

atio

n(s)

:–

Res

ults

of a

naly

sis,

iden

tific

atio

n of

sig

nific

ant

soci

al fa

ctor

s as

soci

ated

with

car

e ne

ed a

nd

read

mis

sion

beh

avio

r–

Rep

ort o

n de

velo

pmen

t and

eva

luat

ion

of

pred

ictiv

e m

odel

for l

ikel

ihoo

d of

repe

at

hosp

italiz

atio

ns•

Acc

ess

to d

atab

ases

that

inte

grat

e bo

th

men

tal h

ealth

and

clin

ical

fact

ors

for

sele

cted

pat

ient

s

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

39

Page 40: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

40

Page 41: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Participating in a Community Health Improvement Network

Pop2 Judah Thornewill

Population Health

$90,000 NO 1

The project participants will participate in one or more innovative "consumer-directed" community health information sharing networksdesigned to improve ability for people and organizations to more easily share health and well-being data to improve care coordinationand support research across the community. The project will explore implementation and use of several innovations: 1) amulti-stakeholder, community-based governance and oversight structure; 2) consumer-directed health information exchange leveragingHIPAA individual right of access mechanisms; 3) a technology platform supporting safe, secure, encrypted data sharing among people,providers, plans, apps, AI firms, and researchers; 4) a sustainable business model tied to reducing costs and improve quality andoutcomes; and 5) potential to generate millions in new private-sector led investments from sales of equity and a blockchain baseddigital currency.

1. Organizing meeting2. 3-4 documents describing best practices and lessons learned.3. Formal presentation in month 9.

The CHIN project will research a new paradigm of health information sharing that puts the person (patient/consumer) in the center ofinformation sharing about them, and also uses next generation security technologies, including block chain, to protect and enablepersonal health information sharing. The CHIN will engage public and private-sector organizations to advance this emerging form ofsecure "consumer-directed exchange." The project will focus on use cases with potential for high impact and ROI, emphasizingpopulations with type-II diabetes and opiate addiction, but also looking at other chronically ill or under-served populations with carecoordination challenges.

CHOT members will be invited to actively participate in the CHIN, working alongside embedded "action researchers" from UofL.Action-oriented research will focus on developing best practice recommendations for: 1) goverance of the CHIN; 2) organizationalparticipation agreements with the CHIN; 3) engaging "connectors" at providers, plans, social agencies and other offices to helppatients/consumers sign-up with the system; 4) obtaining informed consent to access and re-share data with members of the CHIN; 5)conducting searches of data, starting with type II diabetes; and 6) potential to expand nationwide - in a network of CHINs, potentiallyincluding other CHOT sites.

Month 2: CHOT members invited to participate in CHIN process. Getting organized.Month 6-9: First "connectors" trained and certified. Taught how to use system.Month 6-9: "Dummy" and real patients enrolled; data moved. Experience evaluated.Month 6-9: Encrypted data-search tested with selected sources.Month 6-9: Presentation of results presented to sponsor(s).Month 9-12: Write-up best practice recommendations.

1. Advance knowledge of best practices for consumer-directedexchange (CDEx).2. Advance knowledge of best practices for encrypted searchwith high security3. Models for profitable CDEx-driven sharing in systems,communities, states.

41

Page 42: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Part

icip

atin

g in

a C

omm

unity

H

ealth

Impr

ovem

ent N

etw

ork

Pro

ject

Lea

ders

: Jud

ah T

horn

ewill

, PhD

Co-

lead

ers:

Paul

Win

drum

, PhD

Stud

ent

Nam

e(s)

: Moh

amed

Ahm

ed, M

olly

O’K

eefe

Enga

ged

IAB

mem

bers

: Pas

spor

t Hea

lth P

lan,

Sa

nofi,

Uni

vers

ity o

f Lou

isvi

lle H

ospi

tal

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Uni

vers

ity o

f Lo

uisv

ille,

Uni

vers

ity o

f Not

tingh

am

Proj

ect O

verv

iew

and

Des

crip

tion

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Obj

ectiv

e:D

evel

op a

"co

nsum

er-d

irect

ed"

com

mun

ity h

ealth

info

rmat

ion

shar

ing

netw

ork

desi

gned

to im

prov

e ab

ility

for

peop

le a

nd o

rgan

izat

ions

to m

ore

easi

ly s

hare

hea

lth a

nd w

ellb

eing

dat

a to

impr

ove

care

coo

rdin

atio

n an

d su

ppor

t res

earc

h ac

ross

the

com

mun

ityPa

rtne

rs /

Rel

evan

ce:

Cre

ates

a n

ew p

arad

igm

of h

ealth

in

form

atio

n sh

arin

g th

at p

uts

the

pers

on

(pat

ient

/con

sum

er) i

n th

e ce

nter

of

info

rmat

ion

shar

ing

abou

t the

m, a

nd

also

use

s ne

xt g

ener

atio

n se

curit

y te

chno

logi

es, i

nclu

ding

blo

ckch

ain,

to

prot

ect a

nd e

nabl

e pe

rson

al h

ealth

in

form

atio

n sh

arin

g

and

Des

crip

tion

and

Des

can

dD

esc

Pt

/Rl

Proj

ect O

verv

iew

and

Des

crip

tion

Prob

lem

: Po

or h

ealth

out

com

es a

nd th

e ne

ed fo

r a b

ette

r way

to s

hare

hea

lth

impr

ovem

ent d

ata

for c

are

and

rese

arch

in

clud

ing

cons

umer

s an

d th

eir f

amili

es

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

•C

onsu

mer

s–

Enr

ollm

ent d

elay

s, p

oor c

are

coor

dina

tion,

hig

h co

sts

•Pr

ovid

ers

–hi

gh c

osts

, lac

k of

acc

ess

to q

ualit

y da

ta o

ut o

f ne

twor

k, q

ualit

y/ou

tcom

e sc

ores

•Pl

ans

–hi

gh c

osts

enr

ollin

g an

d en

gagi

ng p

atie

nts;

clin

ical

er

rors

and

cha

lleng

es

•Pu

rcha

sers

–hi

gh c

osts

•D

igita

l hea

lth fi

rms

–ch

alle

nges

acc

ess

data

nee

ded

to

inno

vate

and

mak

e a

diffe

renc

e

•R

esea

rche

rs–

high

cos

ts o

f acc

essi

ng d

ata

for c

linic

al tr

ials

, re

sear

ch, p

op. h

ealth

•D

iabe

tes

initi

al fo

cus

•M

any

new

type

s of

dat

a•

Soc

ial.

Hom

e. S

urve

ys.

App

s.

Gen

omic

s. B

eyon

d E

MR

.

•Fr

ustra

ted

peop

le /

fam

ilies

•E

nrol

lmen

t cha

lleng

es

•C

are

coor

dina

tion

chal

leng

es

•D

uplic

ate

test

s an

d pr

oced

ures

•M

edic

al e

rror

s

•Av

oida

ble

spen

ding

Proj

ect O

verv

iew

and

Des

crip

tion

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

B-C

-B –

New

Par

adig

m

42

Page 43: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

Sour

ces

• • • • • • • •

Acce

ss

Perm

issio

ns

•IR

A /

othe

r•

FHIR

CCDA

HIE

Grap

h

Loca

l En

cryp

tions

• •

PP

P

P P8.

Dat

a us

ers r

ecei

ve

serv

ices

and

pay

with

ca

sh/d

igita

l coi

ns

(Rxc

oin)

Cons

umer

Nav

igat

or

5. C

onsu

mer

s req

uest

ac

cess

to d

ata

Trus

t Aut

horit

ies

• • • • •

P P

X

P

4. U

nifie

d He

alth

Re

cord

s con

nect

to

netw

ork

X

P

RRR

R

PR

XP

AAR

R

A

Why

?

Kent

ucky

Hea

lth Im

prov

emen

t Net

wor

k

Rx

Rx

Rx

7. M

essa

ges a

nd A

lert

sM

M M

2. D

ata

sour

ces a

cces

s res

ourc

es a

nd

conn

ect

P

9. S

ourc

es g

et p

aid

1.Da

ta u

sers

requ

est b

ette

r dat

a &

se

rvic

es

3. C

loud

Se

rvic

es• • • • • • • • •

6. C

onse

nt e

ngin

eT

T

P

App

roac

hA

ctio

n-or

ient

ed re

sear

ch w

ill fo

cus

on

deve

lopi

ng b

est p

ract

ice

reco

mm

enda

tions

for:

1.

CH

IN g

over

nanc

e2.

Org

aniz

atio

nal p

artic

ipat

ion

agre

emen

ts w

ith th

e C

HIN

3.E

ngag

ing

"con

nect

ors"

at p

rovi

ders

, pla

ns, s

ocia

l ag

enci

es a

nd o

ther

offi

ces

to h

elp

patie

nts/

cons

umer

s si

gn-u

p w

ith th

e sy

stem

4.O

btai

ning

info

rmed

con

sent

to a

cces

s an

d re

-sha

re d

ata

with

mem

bers

of t

he C

HIN

5.C

ondu

ctin

g se

arch

es o

f dat

a, s

tarti

ng w

ith ty

pe II

di

abet

es

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

App

roac

hO

VE

RV

IEW

OF

RE

SU

LTS

: Exp

ecte

d M

ilest

ones

Mon

th

2

Mon

ths

6-9

Mon

ths

9-12

•C

HO

T m

embe

rs in

vite

d to

par

ticip

ate

in

CH

IN p

roce

ss•

Get

ting

orga

nize

d

•Fi

rst c

onne

ctor

s tra

ined

and

cer

tifie

d•

Dum

my

and

real

pat

ient

enr

olle

d; d

ata

mov

ed;

expe

rienc

e ev

alua

ted

•E

ncry

pted

dat

a-se

arch

test

ed w

ith s

elec

ted

sour

ces

•P

rese

ntat

ion

of re

sults

pre

sent

ed to

spo

nsor

s

•W

rite

up b

est p

ract

ice

reco

mm

enda

tions

App

roac

hO

VE

RV

IEW

OF

RE

SU

LTS

: Ben

efits

to In

dust

ry

Ben

efits

to In

dust

ry:

1.Ad

vanc

e kn

owle

dge

of b

est

prac

tices

for c

onsu

mer

-di

rect

ed e

xcha

nge

(CD

Ex)

2.A

dvan

ce k

now

ledg

e of

bes

t pr

actic

es fo

r enc

rypt

ed s

earc

h w

ith h

igh

secu

rity

3.M

odel

s fo

r pro

fitab

le C

DE

x-dr

iven

sha

ring

in s

yste

ms,

co

mm

uniti

es, s

tate

s

Expe

cted

Del

iver

able

s:1.

Org

aniz

ing

mee

ting

2.D

ocum

ents

des

crib

ing

best

pr

actic

es a

nd le

sson

s le

arne

d

3.Fo

rmal

pre

sent

atio

n in

mon

th

nine

43

Page 44: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

44

Page 45: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

The Effectiveness of Substance Abuse Treatment Services in Combating Opioid Crisis

Pop3 Hui Zhao

Population Health

$50,000 NO 1

Each day, more than 115 Americans die due to overdosing on opioid. Addiction to opioid (including heroin and fentanyl) becomes aserious national crisis that devastates public health. To combat the opioid crisis, the Substance Abuse Treatment Services (SATS)facilities across the country provide opioid addicts professional counseling and treatments. The objective of this project is to evaluatethe effectiveness of the different opioid addiction treatment programs provided by these SATS facilities, by using sophisticatedeconometric models to analyze the national survey data on SATS facilities, the epidemic data on opioid abusers, and other relateddata.

While the opioid crisis has attracted much research recently, most of the research focuses on the supply side of the problem andinvestigate ways to control the supply and prescription of opioid such that only for legitimate reasons, patients can have access toreasonable amount of opioid. Much less research investigates the demand side of the problem. As we know, opioid abusers, whotypically have developed addictions, often seek illegal access to opioid or other alternatives. Our study takes this angle and looks fromthe demand side of the opioid problem by investigating the effectiveness of the different treatments and services used to recoveropioid addicts. While some medical papers have examined the effectiveness of SATS from individual patient perspective, our studyevaluates SATS from a population perspective, from which we expect to provide policy guidance of managing such programs.

The experimental plan includes the following tasks:1) Acquire and clean data from the National Survey of Substance Abuse Treatment Services from 2006-2016.2) Acquire metrics such as total deaths caused by opioid overdosing from Centers for Disease Control and Prevention (CDC)WONDER Database from 2006-2016.3) Collect demographic information from census data.4) Build an econometric model that evaluates the effectiveness of SATS in reducing opioid overdosing related deaths.5) If possible, collect individual opioid addicts information from a few SATS facilities to validate finding.6) Report and disseminate research findings.

The expected milestones of this project include:1) Collection and compilation of data from National Survey of Substance Abuse Treatment Services.1) Collection and compilation of data on opioid overdosing related deaths from CDC WONDER.3) Integration of different data sources into a master datafile.4) An econometric model that evaluates the effectiveness of SATS.5) A manuscript documenting the research.

1) Evaluate the effectiveness of SATS in curbing opioidoverdosing related deaths from a population level perspective.2) Recommend effective programs (e.g. individual counseling,group counseling) to recover opioid abusers.3) Combat the opioid crisis from the demand-side

1) A master datafile on opioid overdosing related deaths andSATS facility across the country.2) An econometric model that predicts the effectiveness of SATSprogram.3) Policy recommendation for how to manage SATS programs tobest curb opioid overdosing death.

45

Page 46: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

The

Effe

ctiv

enes

s of

Sub

stan

ce

Abu

se T

reat

men

t Ser

vice

s in

C

omba

ting

the

Opi

oid

Cris

isP

roje

ct L

eade

rs:

Hui

Zha

o, S

mea

lCol

lege

of B

usin

ess,

Supp

ly C

hain

Co-

lead

ers:

Chr

isto

pher

DeF

litch

Stud

ent

Nam

e(s)

: TB

D

Enga

ged

IAB

mem

bers

: Sie

men

s, H

ersh

ey M

edic

al C

ente

r, H

ighm

ark,

AT

&T

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Penn

Sta

te

Proj

ect O

verv

iew

and

Des

crip

tion

Obj

ectiv

e:E

valu

ate

the

effe

ctiv

enes

s of

the

diffe

rent

opi

oid

addi

ctio

n pr

ogra

ms

prov

ided

by

Sub

stan

ce A

buse

Tr

eatm

ent S

ervi

ces

(SAT

S).

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Part

ners

/ R

elev

ance

:In

form

hea

lthca

re p

rovi

ders

abo

ut th

e ef

fect

iven

ess

of c

urre

nt tr

eatm

ent

prog

ram

s us

ed in

com

batti

ng th

e op

ioid

cris

is

Are

sub

stan

ce

abus

e tre

atm

ent

serv

ices

ef

fect

ive

in

treat

ing

opio

id

addi

tion?

Wha

t pro

blem

is

this

pro

ject

see

king

to

add

ress

?G

athe

r and

qua

ntify

de

man

d si

de d

ata

usin

g so

phis

ticat

ed

econ

omet

ric m

odel

s to

ana

lyze

the

natio

nal s

urve

y da

ta

on S

ATS

faci

litie

s, th

e ep

idem

ic d

ata

on

opio

id a

buse

rs, a

nd

othe

r rel

ated

dat

a.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

hPr

ojec

t Ove

rvie

w a

nd D

escr

iptio

nR

esea

rch

Pers

pect

ive

The

econ

omic

an

d so

ciet

al

impa

cts

of th

e op

ioid

epi

dem

ic

are

stag

gerin

g.

Hea

lthca

re

prov

ider

s, p

olic

y m

aker

s, a

nd th

e co

mm

unity

nee

d to

und

erst

and

wha

t tre

atm

ents

ar

e m

ost e

ffect

ive.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

46

Page 47: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

ns to

Indu

stry

and

Aca

dem

ia•

Cur

rent

rese

arch

prim

arily

focu

ses

on s

uppl

y si

de p

robl

ems

and

how

to c

ontro

l the

sup

ply

and

pres

crip

tion

of o

pioi

ds. T

his

rese

arch

w

ill in

vest

igat

e th

e de

man

d si

de.

•M

edic

al p

aper

s ex

ist o

n th

e ef

fect

iven

ess

of

SAT

S fr

om th

e pe

rspe

ctiv

e of

indi

vidu

al

patie

nts.

Thi

s re

sear

ch w

ill ev

alua

te S

ATS

fro

m a

pop

ulat

ion

pers

pect

ive.

•R

esul

ting

rese

arch

is e

xpec

ted

to p

rovi

de

polic

y gu

idan

ce fo

r tre

atm

ent p

rogr

am

man

agem

ent.

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

App

roac

hW

hat d

o yo

u pl

an o

n do

ing?

1.A

cqui

re a

nd c

lean

dat

a fro

m th

e N

atio

nal S

urve

y of

Sub

stan

ce A

buse

Tr

eatm

ent S

ervi

ces

from

200

6 -2

016

2.A

cqui

re m

etric

s su

ch a

s to

tal d

eath

s ca

used

by

opio

id o

verd

osin

g fro

m th

e C

DC

WO

ND

ER

Dat

abas

e fro

m 2

006

–20

163.

Col

lect

dem

ogra

phic

info

rmat

ion

from

cen

sus

data

4.Bu

ild a

n ec

onom

etric

mod

el th

at e

valu

ates

SAT

S e

ffect

iven

ess

in re

duci

ng

opio

id d

eath

s5.

Valid

ate

findi

ngs

usin

g da

ta fr

om re

al w

orld

opi

oid

addi

cts

6.R

epor

t and

dis

sem

inat

e fin

ding

s

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

App

roac

hO

VE

RV

IEW

OF

RE

SU

LTS

: Exp

ecte

d M

ilest

ones

Expe

cted

Mile

ston

es1.

Col

lect

ion

and

com

pila

tion

of d

ata

from

Nat

iona

l S

urve

y of

Sub

stan

ce

Abu

se T

reat

men

t Ser

vice

s2.

Col

lect

ion

and

com

pila

tion

of d

ata

on o

pioi

d ov

erdo

sing

rela

ted

deat

hs

from

CD

C W

ON

DE

R3.

Dev

elop

an

econ

omet

ric

mod

el th

at e

valu

ates

the

effe

ctiv

enes

s of

SAT

S4.

Pub

lish

man

uscr

ipts

that

do

cum

ent r

esea

rch

findi

ngs

5.C

reat

e a

heal

thca

re

deci

sion

sup

port

tool

that

vi

sual

izes

the

resu

lts

App

roac

h

Ben

efits

to In

dust

ry:

1.E

valu

ate

the

effe

ctiv

enes

s of

SAT

S in

cur

bing

opi

oid

over

dosi

ng re

late

d de

aths

from

a p

opul

atio

n le

vel p

ersp

ectiv

e2.

Rec

omm

end

effe

ctiv

e pr

ogra

ms

for o

pioi

d ab

user

s3.

Com

bat t

he o

pioi

d cr

isis

from

the

dem

and-

side

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

Expe

cted

D

eliv

erab

les:

1.

A m

aste

r dat

a fil

e on

op

ioid

ove

rdos

ing

rela

ted

deat

hs a

nd

SAT

S fa

cilit

ies

acro

ss

the

US

2.A

n ec

onom

etric

mod

el

that

pre

dict

s ef

fect

iven

ess

of S

ATS

pr

ogra

ms

3.P

olic

y re

com

men

datio

n on

how

to m

anag

e S

ATS

pro

gram

s to

bes

t cu

rb o

pioi

d ov

erdo

sing

de

ath.

47

Page 48: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

48

Page 49: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Research Theme #2:

CARE COORDINATION

Theme Champion: Dr. Christina Mastrangelo, University of Washington

Care 1 Measuring Patient Experience and the Effects of Community Factors on Value-based Reimbursement across the Continuum of Care Care 2 Developing a Risk Prediction Model for Hospital Acquired Clostridium Difficile Infection

49

Page 50: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

50

Page 51: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Care Coordination & Patient Experience across the Continuum of Care: A Value-Based Reimbursement Perspective

Value-based reimbursement (VBR) in health care has resulted in an increased focus on care coordination and patient experience(CAHPS) across the continuum of care, including hospitals, home health, and ambulatory care. This project has three aims: 1) Identifyand pilot test a survey instrument that can be used to assess patient experience across the continuum of care from acute care topost-acute care; 2) incorporate VBR concepts into medical curricula and adapt practices to support patient experience in a VBR-basedsystem; and 3) develop a HIPAA compliant messaging platform to ensure timely delivery of all messages to a care team with a criticalpatient information attached with each message.

Care1 Agarwal, Ferris, and Weech-Maldonado

Care Coordination

$100,000 YES 1

Aim 1: a) Review the literature on patient experience measurement across the continuum of care from acute care to post-acute care;b) Identify and adapt measures that can be used to assess patient experience across the continuum of care; and c) Pilot test thesurvey instrument identified under b.

Aim 2: a) Evaluate current platforms for care coordination; b) Develop a mobile application framework for secured asynchronousmessaging system; c) Implement the framework for centralized monitoring and integration of care services. The current proposal willaddress the phase-3 of the project.

Months 1-2: Obtain IRB approvalMonths 3-4: Literature review and evaluation of current modelsMonths 5-6: Focus groups and stakeholder interviewsMonths 7-8: Develop pilot studyMonths 9-10: Conduct pilot studyMonths 11-12: Analyze results from pilot study and write final report

This research contributes to the areas of measurement, training and development, and technology implementation with the goal ofimproving care coordination and patient experience across the continuum of care. First, there has been a focus on assessing patientexperience on separate components of the continuum of care care, or a silo approach; however, less research has been conductedon assessing patient experience across the continuum of care as patients transition from one setting to another. Second, there is aneed for medical curricula to incorporate principles associated with value-based reimbursement. Finally, while several new mobilehealthcare messaging applications are available, such as HIPPA compliant WhatsApp, they ultimately create more silos.

With the rise of integrated delivery systems, such as theaccountable care organizations, it is important for health careorganizations and payers to have tools that can be used tocoordinate care assess patient experience and across thecontinuum of care.

A final report outlining the findings of the study.

51

Page 52: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Car

e C

oord

inat

ion

and

Patie

nt

Expe

rienc

e ac

ross

the

Con

tinuu

m

of C

are:

A V

alue

-Bas

ed

Rei

mbu

rsem

ent P

ersp

ectiv

eP

roje

ct L

eade

rs:

Ank

urA

garw

al, T

hom

as F

erri

s, an

d R

ober

t Wee

ch-M

aldo

nado

Enga

ged

IAB

mem

bers

: Te

xas A

&M

Uni

vers

ity C

olle

ge o

f Med

icin

e, U

AB

Hea

lth S

yste

m

Enga

ged

CH

OT

Uni

vers

ity S

ites:

UA

B/TA

MU

/FA

U

Proj

ect O

verv

iew

and

Des

crip

tion

Obj

ectiv

es:

•Id

entif

y an

d pi

lot t

est a

sur

vey

inst

rum

ent t

o as

sess

pat

ient

exp

erie

nce

acro

ss th

e co

ntin

uum

of

car

e fro

m a

cute

car

e to

pos

t-acu

te c

are

•In

corp

orat

e va

lue-

base

d re

imbu

rsem

ent (

VB

R)

conc

epts

into

med

ical

cur

ricul

a an

d ad

apt

prac

tices

to s

uppo

rt pa

tient

exp

erie

nce

in a

VB

R-

base

d sy

stem

•D

evel

op a

HIP

AA

com

plia

nt m

essa

ging

pla

tform

to

ensu

re ti

mel

y de

liver

y of

all

mes

sage

s to

a c

are

team

with

a c

ritic

al p

atie

nt in

form

atio

n at

tach

ed

with

eac

h m

essa

ge

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Proj

ect O

verv

iew

and

Des

crip

tion

Prob

lem

:•

Valu

e-ba

sed

reim

burs

emen

t (V

BR

) has

resu

lted

in a

n in

crea

sed

focu

s on

car

e co

ordi

natio

n an

d pa

tient

exp

erie

nce

(CA

HP

S) a

cros

s th

e co

ntin

uum

of c

are

•M

easu

rem

ent

–Fo

cus

has

been

on

asse

ssin

g pa

tient

exp

erie

nce

on s

epar

ate

com

pone

nts

of th

e co

ntin

uum

of c

are,

or a

silo

app

roac

h.

–Le

ss re

sear

ch o

n as

sess

ing

patie

nt e

xper

ienc

e ac

ross

the

cont

inuu

m o

f ca

re

•Tr

aini

ng a

nd D

evel

opm

ent

–N

eed

for m

edic

al c

urric

ula

to in

corp

orat

e pr

inci

ples

ass

ocia

ted

with

va

lue-

base

d re

imbu

rsem

ent.

•Te

chno

logy

–S

ever

al n

ew m

obile

hea

lthca

re m

essa

ging

app

licat

ions

are

ava

ilabl

e;

how

ever

, the

y ar

e ba

sica

lly H

IPA

A co

mpl

iant

text

mes

sagi

ng a

mon

g do

ctor

s -i

.e. H

IPA

A co

mpl

iant

wha

tsap

p, a

nd e

ffect

ivel

y cr

eate

mor

e,

not l

ess,

silo

s.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

hPr

ojec

t Ove

rvie

w a

nd D

escr

iptio

n

Res

earc

h Pe

rspe

ctiv

e•

Pro

vide

rs: H

ospi

tals

, hea

lth s

yste

ms

•P

ayer

s: M

edic

are,

insu

ranc

e co

mpa

nies

•P

atie

nts:

Acu

te to

pos

t-acu

te p

atie

nts

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

52

Page 53: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

n to

Indu

stry

and

Aca

dem

ia•

With

the

rise

of v

alue

-bas

ed

reim

burs

emen

t mod

els,

suc

h as

bun

dled

pa

ymen

ts a

nd a

ccou

ntab

le c

are

orga

niza

tions

, it i

s im

porta

nt fo

r hea

lth

care

org

aniz

atio

ns a

nd in

sure

rs to

hav

e to

ols

that

can

be

used

to c

oord

inat

e ca

re

and

asse

ss p

atie

nt e

xper

ienc

e ac

ross

the

cont

inuu

m o

f car

e.

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

App

roac

h•

Aim

1:

–R

evie

w th

e lit

erat

ure

on p

atie

nt e

xper

ienc

e m

easu

rem

ent a

cros

s th

e co

ntin

uum

of

car

e fro

m a

cute

car

e to

pos

t-acu

te c

are

–Id

entif

y an

d ad

apt m

easu

res

that

can

be

used

to a

sses

s pa

tient

exp

erie

nce

acro

ss th

e co

ntin

uum

of c

are

–P

ilot t

est t

he s

urve

y in

stru

men

t ide

ntifi

ed u

nder

ste

p 2

•A

im 2

: –

Pha

se 1

: Eva

luat

e cu

rren

t pla

tform

s fo

r car

e co

ordi

natio

n–

Pha

se 2

: Dev

elop

a m

obile

app

licat

ion

fram

ewor

k fo

r sec

ured

asy

nchr

onou

s m

essa

ging

sys

tem

–P

hase

3: I

mpl

emen

t the

fram

ewor

k fo

r cen

traliz

ed m

onito

ring

and

inte

grat

ion

of

care

ser

vice

s. (T

he c

urre

nt p

ropo

sal w

ill a

ddre

ss th

e ph

ase-

3 of

the

proj

ect)

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

App

roac

h

•M

onth

s 1-

2:

Obt

ain

IRB

app

rova

l•

Mon

ths

3-4:

L

itera

ture

revi

ew a

nd

eval

uatio

n of

cur

rent

mod

els

•M

onth

s 5-

6:

Foc

us g

roup

s an

d st

akeh

olde

r int

ervi

ews

•M

onth

s 7-

8:

Dev

elop

pilo

t stu

dy•

Mon

ths

9-10

: C

ondu

ct p

ilot s

tudy

•M

onth

s 11

-12:

Ana

lyze

resu

lts fr

om p

ilot

stud

y an

d w

rite

final

repo

rt

OV

ER

VIE

W O

F R

ES

ULT

S: E

xpec

ted

Mile

ston

esA

ppro

ach

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

•D

eliv

erab

les

•S

urve

y in

stru

men

t tha

t can

be

used

to

asse

ss p

atie

nt e

xper

ienc

e ac

ross

the

cont

inuu

m o

f car

e•

Med

ical

cur

ricul

a th

at in

corp

orat

es V

BR

pr

inci

ples

•A

mob

ile/ m

essa

ging

app

licat

ion

to im

prov

e co

mm

unic

atio

n am

ong

prov

ider

s of

a c

are

team

53

Page 54: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

54

Page 55: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Developing a Risk Prediction Model for Hospital Acquired Clostridium Difficile Infection

Care2 Midge Ray, Ferhat Zengul

Care Coordination

$42,000 NO 2

Hospital Acquired Infections (HAI), infections acquired after admission to the hospital, consume about $25 to $31 billion. In 2002, theCenters for Disease Control and Prevention estimated the rate for HAIs to be about 1.7 million, with 99,000 related to deaths duringhospitalization. Hence, HAI affect quality and cost of healthcare. In 2008, Medicare initiated a plan to reduce payments to hospitals forcomplications that occur during the hospital stay, including HAI. One such infection is the Clostridium difficile infection (CDI), which isthe most common cause of infectious diarrhea occurring in the hospital. Treatments costs per patient is approximately $8,911 to$30,049 in the U.S. In Phase I, we identified predictors of hospital acquired CDI. In Phase II, we will conduct a retrospective studyusing UAB i2b2 dataset to develop a risk prediction model for CDI. The main goal of this study is to develop a CDI risk predictionmodel that allows categorizing patients into high, medium, and low risk categories, which will allow for more targeted strategies.

Even though there have been studies exploring the predictors of CDI, there has not been a study that develops a CDI risk predictionmodel that allows categorizing patients into high, medium, and low risk categories. These risk categories would allow the developmentof more targeted testing strategies for CDI infection. Given that CDI testings tend to be expensive and they are not reimbursed by thepayers, it is crucial for hospitals to be able to develop more targeted CDI testing strategies.

Phase I: Literature Review - CompletedPhase II: Initial UAB i2b2 exploration generated 20,325 patients who were tested for CDI. Currently, we don't know how many of thesepatients had positive test results. We will be able to know this information after acquiring the IRB approval. If a patient was tested forCDI, there should be some clinical reason. Having both positive and negative tested patients would allow us to develop models thatwould better differentiate these two categories of patients.Phase III: Testing the findings by using industry partner's data set and writing a grant proposal for the development of a clinicaldecision support system, integrated into electronic health records, that would use findings from machine learning algorithms to provideprobability of risk for each patient for present-on-admission CDI or development of CDI during hospital stay.

A risk prediction model of CDI will be useful in screening patientsat risk for the infection at the time of admission, leading to moretargeted strategies in testing CDI, reducing costs. Identifyingpredictors of CDI would also allow development of potentialinterventions to reduce the rate of CDI by (1) administeringproactive treatment to patients at risk (2) diagnosing patients whohave pre-existing or HAI CDI resulting in quicker treatment, and(3) potentially reducing the length of stay, also reducing costs.

Year 1: Final report on risk prediction model of CDIYear 2: (1) Publish a manuscript based upon the findings and (2)Poster presentation by PhD student at professional meeting.

Month 1-2: Acquiring IRB approvalMonth 3-6: Preprocessing the data and running descriptive statisticsMonth 7-8: Predictive AnalysesMonth 9-12: Write report on the results of risk prediction model of CDI

55

Page 56: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Dev

elop

ing

a R

isk

Pred

ictio

n M

odel

for

Hos

pita

l Acq

uire

d C

lost

ridiu

m D

iffic

ile

Infe

ctio

n

Pro

ject

Lea

ders

: M

idge

N. R

ay;

Fer

hat

D. Z

engu

l

Co-

lead

ers:

Ken

Coc

hran

, Jea

nine

Tho

mas

Stud

ent

Nam

e(s)

:N

eera

j A. P

uro;

Ree

na Jo

seph

, Rac

hel V

irgi

nia W

isni

ewsk

i

Enga

ged

IAB

mem

bers

: O

PELO

USA

S G

ENER

AL

HEA

LTH

SYS

TEM

Enga

ged

CH

OT

Uni

vers

ity S

ites:

The

Uni

vers

ity o

f Ala

bam

a at

Bir

min

gham

Prob

lem

and

Obj

ectiv

e:•

Clo

strid

ium

diff

icile

infe

ctio

ns (C

DIs

) are

one

of t

he m

ost

com

mon

nos

ocom

ial i

nfec

tions

that

incr

ease

pat

ient

s’

mor

bidi

ty &

mor

talit

y, a

nd a

re a

ssoc

iate

d w

ith a

nnua

l co

sts

in e

xces

s of

$4.

8 bi

llion

•P

urpo

se o

f thi

s st

udy

is to

dev

elop

a C

DI r

isk

pred

ictio

n m

odel

that

cat

egor

izes

pat

ient

s in

to h

igh,

med

ium

and

lo

w ri

skPa

rtne

rs /

Rel

evan

ce:

•H

ealth

care

org

aniz

atio

ns w

ould

be

able

to d

evel

op m

ore

targ

eted

test

ing

stra

tegi

es fo

r CD

I•

HC

Os

may

be

able

to re

duce

unn

eces

sary

test

ing

and

asso

ciat

ed c

osts

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Proj

ect O

verv

iew

and

Des

crip

tion

•P

er p

atie

nt c

ost a

ssoc

iate

d w

ith tr

eatin

g C

DIs

rang

e fro

m a

ppro

xim

atel

y $8

,911

to $

30,0

49

•Tr

eatin

g C

DIs

can

resu

lt in

long

er h

ospi

tal s

tays

and

hi

gher

cos

ts to

the

heal

th c

are

orga

niza

tion

•Te

stin

g al

l pat

ient

s fo

r CD

I is

not f

easi

ble

sinc

e te

stin

g is

co

stly

and

hos

pita

ls a

re o

ften

not r

eim

burs

ed fo

r sc

reen

ing

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

Res

earc

h Pe

rspe

ctiv

e

•C

DIs

acq

uire

d du

ring

hosp

ital s

tay

are

pena

lized

by

CM

S u

nder

the

Hos

pita

l-Acq

uire

d C

ondi

tion

Red

uctio

n P

rogr

am (H

AC

RP)

•C

DI r

isk

pred

ictio

n m

odel

is im

porta

nt fo

r pro

vide

rs to

aid

w

ith e

arly

iden

tific

atio

n of

hig

h ris

k pa

tient

s

•P

atie

nts

may

ben

efit

from

bet

ter i

nfor

med

and

co

ordi

nate

d cl

inic

al c

are

thro

ugh

CD

I ris

k pr

edic

tion

mod

el

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

56

Page 57: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Con

trib

utio

n to

Indu

stry

and

Aca

dem

ia

•C

DI r

isk

pred

ictio

n m

odel

can

aid

in p

oten

tial

inte

rven

tions

suc

h as

: –

early

dia

gnos

is o

f pat

ient

s at

risk

for d

evel

opin

g C

DIs

–pr

oact

ive

treat

men

t to

at-r

isk

patie

nts,

ther

eby

min

imiz

ing

likel

ihoo

d of

HA

I pen

alty

for h

ospi

tals

–po

tent

ially

redu

cing

the

leng

th o

f sta

y an

d as

soci

ated

ho

spita

l cos

ts

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

App

roac

h•

Usi

ng th

e pr

edic

tors

of C

DIs

that

wer

e pr

evio

usly

id

entif

ied

in P

hase

I, w

e w

ill co

nduc

t a re

trosp

ectiv

e st

udy

usin

g th

e U

AB

i2b2

dat

aset

to d

evel

op a

risk

pre

dict

ion

mod

el•

This

dat

aset

incl

udes

:

•P

redi

ctio

n m

odel

will

allo

w fo

r dev

elop

men

t of t

arge

ted

test

ing

stra

tegi

es

•W

ill us

e st

anda

rd s

tatis

tics

(i.e.

, lin

ear r

egre

ssio

n) a

nd

mac

hine

lear

ning

app

roac

hes

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

Posi

tive

Neg

ativ

eTo

tal #

of C

DI

Test

s Pe

rfor

med

4,81

336

,677

41,4

90

Prop

osed

Tim

elin

e

•M

onth

1-2

: Acq

uirin

g IR

B a

ppro

val

•M

onth

3-6

: Pre

proc

essi

ng th

e da

ta a

nd ru

nnin

g de

scrip

tive

stat

istic

s•

Mon

th 7

-8: P

redi

ctiv

e A

naly

ses

•M

onth

9-1

2: W

rite

repo

rt on

the

resu

lts o

f ris

k pr

edic

tion

mod

el o

f CD

I

OV

ER

VIE

W O

F R

ES

ULT

S: E

xpec

ted

Mile

ston

esA

ppro

ach

•A

CD

I ris

k pr

edic

tion

mod

el th

at c

an b

e ex

pand

ed a

nd im

prov

ed b

y ut

ilizi

ng la

rger

dat

a so

urce

s an

d ul

timat

ely

inte

grat

e in

to th

e E

HR

of

heal

thca

re p

rovi

ders

, whi

ch w

ould

impr

ove

care

an

d po

tent

ially

redu

ce c

ost

•P

ublis

hed

man

uscr

ipt b

ased

upo

n th

e fin

ding

s

•P

oste

r pre

sent

atio

n at

pro

fess

iona

l mee

ting

and/

or a

cade

mic

con

fere

nce

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

57

Page 58: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

58

Page 59: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Research Theme #3:

ANALYTICS AND INNOVATIVE TECHNOLOGIES

Theme Champion: Dr. Eva Lee, Georgia Institute of Technology

Tech 1 HIE Project for Chronic Disease and Workflow Management Tech 2 Leveraging technology to enhance communication in healthcare Tech 3 Data-driven analytics and machine learning for improving healthcare outcomes

59

Page 60: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

60

Page 61: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

HIE Project for Chronic Disease and Workflow Management

There is a need in the healthcare industry to unify disparate sources of patient data to provide better care at lower costs. Theintegration of administrative, clinical, environmental and personal data sources is an opportunity to reconcile patients across all of theirdata records and the failure to do so can impede interoperability, leading to patient safety risks, revenue loss and decreased providerefficiency. The goal of this project is to explore the opportunities and challenges of integrated patient health data by characterizing thedata, identifying the issues, determining relevant algorithms and models and applying the algorithms and models to healthcaredelivery. The aims of this project are to apply this knowledge to three areas: 1) understanding the effects of integrated patient healthdata on workflows, 2) developing an architecture for a chronic care management system and 3) predicting re-admissions for a chronicdisease.

Tech1 Mastrangelo, Weech-Maldonado, Borkowski, Agarwal

Analytics & Innovative Technologies

$150,000 YES 1

A system architecture, a working prototype, a white paper onintegration, a journal paper on using ML in workflow analysis.

This project is novel for using machine learning methods in new healthcare applications and using the resulting analytics for visual,patient-centered information to support meaningful and actionable decisions regarding chronic condition and potential hospitalre-admission.

Conducting literature and market search.Identify preliminary workflows.Identify and obtain data sources.Develop methods to complete definition (feature engineering) and construction of models.Develop and implement ML algorithms and decision support rules.Evaluate the models and metrics and integrate.

8/31/ 2018 Literature and market research5/31/2018 Conceptual Modeling7/31/2018 Construction of datasets11/31/2018 Implementation of algorithms2/28/2019 Evaluation of the models and metrics4/30/2019 Integration

Looking at healthcare delivery workflows from the perspectiveof integrated data analytics and visualization will result in thedevelopment of procedures to improve patient flow, to providetimely treatment of chronic conditions, to maximize utilization ofavailable resources and reduce re-admissions.

61

Page 62: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

HIE

Pro

ject

for C

hron

ic D

isea

se

and

Wor

kflo

w M

anag

emen

tP

roje

ct L

eade

rs:

Ank

urA

garw

al, C

hris

tina

Mas

tran

gelo

, Be

n O

zayd

in

Co-

lead

ers:

Ferh

atZ

engu

l, Et

a Be

rner

, Joe

Hei

m

Stud

ent

Nam

e(s)

: TBD

Enga

ged

IAB

mem

bers

: Edi

fecs

Enga

ged

CH

OT

Uni

vers

ity S

ites:

FAU

, UA

B, U

W

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

•B

ackg

roun

d•

Hea

lth In

form

atio

n E

xcha

nge

(HIE

) he

lps

mee

t the

nee

d in

the

heal

thca

re in

dust

ry to

uni

fy

disp

arat

e so

urce

s of

pat

ient

dat

a to

pr

ovid

e be

tter c

are

at lo

wer

cos

ts.

•Th

e in

tegr

atio

n of

thes

e da

ta

sour

ces

is a

n op

portu

nity

to

reco

ncile

pat

ient

s ac

ross

all

of th

eir

data

reco

rds.

•R

esul

ts in

incr

ease

d in

tero

pera

bilit

y w

hich

lead

s to

redu

ced

to p

atie

nt

safe

ty ri

sks,

incr

ease

d re

venu

e an

d in

crea

sed

prov

ider

effi

cien

cy.

•O

bjec

tive:

To

expl

ore

new

op

portu

nitie

s an

d ch

alle

nges

as

soci

ated

with

HIE

thro

ugh

3 ai

ms.

Proj

ect O

verv

iew

and

Des

crip

tion

Aim

1:

•E

xpan

d H

IE b

y in

tegr

atin

g da

ta fr

om h

ome

med

ical

dev

ices

use

d by

pa

tient

s w

ith c

hron

ic c

ondi

tions

by

–U

sing

the

initi

al p

hase

to d

esig

n, b

uild

, and

test

an

inte

grat

ed c

hron

ic c

are

man

agem

ent s

yste

m to

cap

ture

, ana

lyze

and

pre

sent

real

-tim

e, c

onsu

mab

le

heal

th in

form

atio

n–

Util

izin

g an

alyt

ics

and

visu

aliz

atio

n to

ols

to p

rese

nt a

ggre

gate

d in

form

atio

n th

at

is m

eani

ngfu

l and

act

iona

ble

for t

he p

rovi

ders

–M

aint

aini

ng in

tero

pera

bilit

y w

ith o

ther

info

rmat

ion

syst

ems

in th

e en

viro

nmen

t an

d co

mpl

ianc

e w

ith p

rivac

y an

d se

curit

y pr

otoc

ols

Rel

evan

ce fo

r Par

tner

s:•

Sys

tem

will

allo

w p

rovi

ders

to m

anag

e pa

tient

s w

ith m

ultip

le c

hron

ic

cond

ition

s re

mot

ely,

redu

cing

cos

t by

avoi

ding

unn

eces

sary

vis

its.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ctPr

ojec

t Ove

rvie

w a

nd D

escr

iptio

n

Aim

2:

•D

evel

op a

n ar

chite

ctur

e fo

r int

egra

ting

unst

ruct

ured

dat

a el

emen

ts

that

can

be

used

for p

redi

ctiv

e m

odel

s in

a s

yste

m c

hara

cter

ized

by

–A

web

-bas

ed p

roto

type

for p

redi

ctin

g ho

spita

l rea

dmis

sion

s fo

r pa

tient

s w

ith C

hron

ic O

bstru

ctiv

e P

ulm

onar

y D

isea

se (C

OP

D)

–P

redi

ctiv

e m

odel

s th

at a

lso

utili

ze lo

cal/e

nviro

nmen

tal f

acto

rs

Rel

evan

ce fo

r Par

tner

s:•

Sys

tem

will

redu

ce th

e ra

te o

f rea

dmis

sion

by

acco

untin

g fo

r fac

tors

th

at v

ary

by lo

catio

n w

hich

will

, in

turn

, im

prov

e ca

re c

oord

inat

ion

and

hom

e he

alth

care

.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

62

Page 63: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Aim

2 C

once

ptua

l Arc

hite

ctur

ePr

ojec

t Ove

rvie

w a

nd D

escr

iptio

n

Aim

3:

•U

nder

stan

d th

e im

plem

enta

tion

of H

IE b

y st

udyi

ng th

e ef

fect

of

inte

grat

ed d

ata

on w

orkf

low

s by

–Id

entif

ying

whe

re d

ata

disp

ariti

es m

ay o

ccur

in a

wor

kflo

w b

y m

odel

ing

the

wor

kflo

w p

roce

sses

–D

evel

opin

g M

L al

gorit

hms

for t

he c

hara

cter

izat

ion

of s

uch

disp

ariti

es, s

uch

as

proc

ess

bottl

enec

ks–

Eva

luat

ing

the

mod

els

and

met

rics

for a

repr

esen

tativ

e he

alth

care

reco

ncili

atio

n so

lutio

n

Rel

evan

ce fo

r Par

tner

s :

•G

iven

the

pres

sure

s to

con

tain

cos

ts, i

t is

criti

cal f

or h

ospi

tals

, hea

lth

care

sys

tem

s, a

nd p

ayer

s to

dev

elop

hig

hly

effic

ient

sys

tem

s w

hich

ca

n re

conc

ile d

ata

disp

ariti

es a

cros

s th

e sy

stem

nod

es q

uick

ly a

nd

accu

rate

ly.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Proj

ect O

verv

iew

and

Des

crip

tion

Res

earc

h Pe

rspe

ctiv

e

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

Pat

ient

Impr

oved

and

ta

ilore

d ca

reR

educ

ed R

isk

Pro

vide

rR

educ

ed c

osts

Incr

ease

d ac

cess

to

patie

nt d

ata

Hea

lth

syst

emIn

crea

sed

effic

ienc

yR

educ

ed re

-ad

mis

sion

s

Pay

erR

educ

es c

ost

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

n to

Indu

stry

and

Aca

dem

ia•

Ana

lytic

s an

d vi

sual

izat

ion

tool

s to

pre

sent

agg

rega

te

info

rmat

ion

that

is m

eani

ngfu

l and

act

iona

ble

•A

n un

ders

tand

ing

of th

e sc

ienc

e be

hind

the

deve

lopm

ent

of d

ecis

ion

supp

ort s

yste

m w

hich

is k

ey in

co

mm

erci

aliz

ing

new

pro

duct

s an

d ap

plic

atio

ns•

An

early

look

at h

ealth

care

del

iver

y w

orkf

low

s fro

m th

e pe

rspe

ctiv

e of

inte

grat

ed a

dmin

istra

tive

and

clin

ical

dat

a re

sulti

ng in

new

pro

cedu

res

to im

prov

e pa

tient

flow

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

63

Page 64: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

App

roac

h•

Con

duct

lite

ratu

re a

nd m

arke

t sea

rch

•Id

entif

y pr

elim

inar

y w

orkf

low

s•

Iden

tify

and

obta

in d

ata

sour

ces

•D

evel

op m

etho

ds to

com

plet

e de

finiti

on (f

eatu

re

engi

neer

ing)

and

con

stru

ctio

n of

mod

els

•D

evel

op a

nd im

plem

ent M

L al

gorit

hms

and

deci

sion

sup

port

rule

s•

Eva

luat

e th

e m

odel

s an

d m

etric

s an

d in

tegr

ate

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

hA

ppro

ach

•O

verv

iew

of r

esul

ts: U

sing

mac

hine

lear

ning

met

hods

in n

ew

heal

thca

re a

pplic

atio

ns a

nd u

sing

the

resu

lting

ana

lytic

s fo

r vis

ual,

patie

nt-c

ente

red

info

rmat

ion

to s

uppo

rt m

eani

ngfu

l and

act

iona

ble

deci

sion

s re

gard

ing

chro

nic

cond

ition

and

pot

entia

l hos

pita

l re-

adm

issi

on•

Lite

ratu

re a

nd m

arke

t res

earc

h8/

31/2

018

•C

once

ptua

l Mod

elin

g5/

31/2

018

•C

onst

ruct

ion

of d

atas

ets

7/31

/201

8•

Impl

emen

tatio

n of

alg

orith

ms

11/3

1/20

18•

Eva

luat

ion

of th

e m

odel

s an

d m

etric

s2/

28/2

019

•In

tegr

atio

n4/

30/2

019

OV

ER

VIE

W O

F R

ES

ULT

S: E

xpec

ted

Mile

ston

es

App

roac

h

•A

syst

em a

rchi

tect

ure

•A

web

-bas

ed p

redi

ctio

n pr

otot

ype

•A

whi

te p

aper

on

inte

grat

ion

•A

jour

nal p

aper

on

usin

g M

L in

wor

kflo

w

anal

ysis

OV

ER

VIE

W O

F R

ES

ULT

S: D

eliv

erab

les

64

Page 65: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Leveraging technology to enhance communication in healthcare

Tech2 Eva K Lee

Analytics & Innovative Technologies

TBD NO 1

With continuous advancements in technology, care providers have access to more tools than ever to combat breakdowns incommunication with referring physicians and to ultimately play a greater role in improved patient care. Often overwhelmed with heavyworkloads, care communication may suffer. For example, radiologists may be hesitant to assume additional responsibilities related toconveying test results and ensuring proper follow-up with patients. Certain symptoms discovered during surgical procedures bysurgeons may be conveyed ineffectively to intensivists and bed-side teams. Yet those activities can play an important role in not onlycarefully interpreting images or making recommendations but also acting as a safe, patient-centered back-up system and ensuringthat actionable results are not overlooked. In a similar manner, non-English speaking patients may require enhanced carecoordination plan to ensure that they understand the discharged and home care process.

This study is the first study which utilizes machine learning, text mining, and deep learning techniques to hospital discharge notes tobuild an accurate automatic translation system which will facilitate discharge and home care process design, particularly fornon-English speaking patients. In addition, it incorporates system design and human-device interaction technologies to offer real-timedecision support providers.

We will first conduct literature review on existing machine translation systems and explore gaps in discharge and home care process.Various sites with lack of medical translation experts will be identified and their needs will be assessed. Machine learning and naturallanguage processing techniques will be applied to build automatic translation systems using discharge notes. We will use the BLEUalgorithm to evaluate the translation quality and further refine the system. In addition, we will design chatbox and virtual messaging toenhance family engagement and facilitate knowledge dissemination across sites.

Aim 1: Improve communication, compliance and quality of carethrough automated machine translation. Initial focus will be thedischarge procedureAim 2: Design chatbox and virtual messaging to enhance familyengagement, knowledge dissemination (e.g., feeding plan,compliance and awareness of hospital acquired infection, childhealth).

1) Systematic literature review of a) existing machine translation algorithms and accuracies, b) indicators of lack of medical translationexperts and where the most needs for them are.2) Develop a machine learning / natural language processing framework using hospital discharge notes that can automatically andaccurately translate clinical documents to foreign languages.3) Evaluation and refinement of the translation system4) Design and implementation of chatbox and virtual messaging systems

-Enhanced care coordination plan-Reduced workforce requirements for translation experts-Improved discharged and home care process-Enhanced family engagement-Improved patient compliance and treatment outcome-Reduced staff time and cost for treatment

65

Page 66: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Leve

ragi

ng te

chno

logy

to

enha

nce

com

mun

icat

ion

in

heal

thca

re

Pro

ject

Lea

ders

: Eva

Lee

Stud

ent

Nam

e(s)

: Cod

y W

ang

Enga

ged

IAB

mem

bers

: Gra

dy, C

hild

ren'

s: H

ealth

care

of A

tlant

a, M

oreh

ouse

Sch

ool o

f M

edic

ine,

Res

tore

Med

ical

Sol

utio

ns

Enga

ged

CH

OT

Uni

vers

ity S

ites:

GIT

Proj

ect O

verv

iew

and

Des

crip

tion

Obj

ectiv

es:

Obj

ectiv

e1:

Impr

ove

com

mun

icat

ion,

com

plia

nce,

and

qual

ityof

care

thro

ugh

auto

mat

edm

achi

netra

nsla

tion.

Initi

alfo

cus

will

beth

edi

scha

rge

proc

edur

e.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Obj

ectiv

e2:

Des

ign

chat

box

and

virtu

alm

essa

ging

toen

hanc

efa

mily

enga

gem

ent,

know

ledg

edi

ssem

inat

ion

(e.g

.,fe

edin

g pl

an,c

ompl

ianc

e an

d aw

aren

ess

ofho

spita

lacq

uire

din

fect

ion,

child

heal

th).

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

Part

ners

/ R

elev

ance

:•

Car

e pr

ovid

ers

will

be

equi

pped

with

tool

s to

com

bat b

reak

dow

ns in

com

mun

icat

ion

with

refe

rrin

g ph

ysic

ians

and

to u

ltim

atel

y pl

ay a

gre

ater

role

in im

prov

ed p

atie

nt c

are

•Im

prov

e pa

tient

exp

erie

nce,

MR

I util

izat

ion,

and

sch

edul

ing

effic

ienc

y

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ct

66

Page 67: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

Wha

t pro

blem

is th

is p

roje

ct s

eeki

ng to

ad

dres

s?•

Util

izes

mac

hine

lear

ning

, tex

t min

ing,

and

dee

p le

arni

ngte

chni

ques

to h

ospi

tal d

isch

arge

not

es to

bui

ld a

nac

cura

te a

utom

atic

tran

slat

ion

syst

em w

hich

will

faci

litat

edi

scha

rge

and

hom

e ca

re p

roce

ss d

esig

n, p

artic

ular

ly fo

rno

n-E

nglis

h sp

eaki

ng p

atie

nts

•P

rovi

de a

saf

e, p

atie

nt-c

ente

red

back

-up

syst

em a

nden

sure

that

act

iona

ble

resu

lts a

re n

ot o

verlo

oked

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

hPr

ojec

t Ove

rvie

w a

nd D

escr

iptio

n

Res

earc

h Pe

rspe

ctiv

e

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

Pat

ient

Bet

ter

inte

rpre

tatio

n of

re

com

men

datio

ns

and

hom

e ca

re

proc

ess

Red

uced

leng

th

of s

tay

Bet

ter t

reat

men

t ou

tcom

e

Pro

vide

rR

educ

tion

of s

taff

time

Impr

oved

hom

e ca

re p

roce

ssIm

prov

ed c

are

coor

dina

tion

Hea

lth

syst

emIm

prov

ed

effic

ienc

yIm

prov

ed

utiliz

atio

n of

te

chno

logy

Pay

erR

educ

tion

of c

ost

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

n to

Indu

stry

and

Aca

dem

ia•

This

stud

y is

the

first

stu

dyw

hich

utili

zes

mac

hine

lear

ning

,tex

tmin

ing,

and

deep

lear

ning

te

chni

ques

toho

spita

l dis

char

ge n

otes

tobu

ild

anac

cura

te a

utom

atic

tran

slat

ion

syst

emw

hich

w

illfa

cilit

ate

disc

harg

ean

dho

me

care

proc

ess

desi

gn,p

artic

ular

ly fo

r non

-Eng

lish

spea

king

pa

tient

s. In

addi

tion,

it in

corp

orat

essy

stem

de

sign

and

hum

an-d

evic

e in

tera

ctio

n te

chno

logi

esto

offe

r rea

l-tim

ede

cisi

onsu

ppor

t to

pro

vide

rs.

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

App

roac

hA

PP

RO

AC

H: E

xper

imen

tal A

ppro

ach

•S

yste

mat

ic li

tera

ture

revi

ewof

a) e

xist

ing

mac

hine

tra

nsla

tion

algo

rithm

san

d ac

cura

cies

, b) i

ndic

ator

sof

la

ck o

f med

ical

tran

slat

ion

expe

rts a

nd w

here

the

mos

t ne

eds

fort

hem

are

•D

evel

op a

mac

hine

lear

ning

/nat

ural

lang

uage

pr

oces

sing

fram

ewor

kus

ing

hosp

itald

isch

arge

not

es

that

can

aut

omat

ical

ly a

nd a

ccur

atel

y tra

nsla

te c

linic

al

docu

men

tsto

fore

ign

lang

uage

s•

Eva

luat

ion

and

refin

emen

t of t

he tr

ansl

atio

n sy

stem

•D

esig

n an

d im

plem

enta

tion

of c

hatb

oxan

dvi

rtual

mes

sagi

ng s

yste

ms

67

Page 68: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

App

roac

hO

VE

RV

IEW

OF

RE

SU

LTS

: Exp

ecte

d M

ilest

ones

•Id

entif

icat

ion

and

sum

mar

y of

gap

s in

hom

e ca

repr

oces

s, in

par

ticul

ar th

e di

scha

rge

proc

ess

•D

evel

op a

sec

ure

onlin

e au

tom

atic

tran

slat

ion

syst

emfo

rhos

pita

l dis

char

ge n

otes

•A

n ev

alua

tion

syst

em b

ased

on

BLE

U to

ass

ess

the

qual

ity o

f tra

nsla

ted

docu

men

ts•

Des

ign

and

impl

emen

tatio

n of

virt

ual m

essa

ging

syst

ems

p

•E

nhan

ced

care

coo

rdin

atio

n pl

an•

Enh

ance

wor

kfor

ce c

apab

ility

in tr

ansl

atio

n•

Impr

oved

dis

char

ged

and

hom

e ca

re p

roce

ss•

Enh

ance

d fa

mily

eng

agem

ent

•Im

prov

ed p

atie

nt c

ompl

ianc

e an

d tre

atm

ent

outc

ome

•R

educ

ed s

taff

time

and

cost

for t

reat

men

t•

Impr

ove

patie

nt-p

rovi

der t

rust

and

rela

tions

hip

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

68

Page 69: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Data-driven analytics and machine learning for improving healthcare outcome

Tech3 Lee (GT), Mastrangelo (UW), Tucker (PSU)

Analytics & Innovative Technologies

$150,000 YES 1

Data-driven healthcare has the potential to revolutionize care delivery and trim costs. A major challenge is that providers must siftthrough and analyze mountains of disparate data to materialize the substantial gain. We continue our healthcare innovation throughsystems and data analytics. Utilizing EMR and various procedural and personal health data, along with social and behavioralinformation, we will address all aims - with specific regard to radiologic exam variability. This also had implications in utilizingpredictive models to use at the point-of-care when treating infectious disease.

1) Develop predictive models for KPI’s (Exam Duration, Idle Time,Ratio of Repeated Scans), using logfile variables; 2) Define bettersequence of scans per exam (exam cards); 3) Design pilot projectimproving exam cards; 4) Develop models that predict machineutilization efficiency; 5) Design evidence-based expert decisionsupport system and optimize personalized treatment plans.

This is the first study where 1) large amounts of patient data are extracted unbiased and globally analyzed, 2) automated encryption ofPHI and data integration through terminology mapping is achieved using natural language processing, 3) time series clustering isdone with consideration of disease progression despite sparse and missing data, 4) discriminatory factors that inform key decisionsare systematically selected using machine learning, 5) individual patient conditions are addressed with the design of personalizedevidence-based treatment methods, and 6) this research will be able to be replicated to other cases and sites to improve theirprocess.

1. Conduct & benchmark literature review2. Data collection, extraction, and encryption of PHI3. Data cleaning and integration across types of records and multiple sites4. Build predictive models using machine learning and derive knowledge for personalized treatment, resource utilization andtreatment procedure optimization for best outcome5. Run pilot projects with optimized procedures and analyze preliminary findings to further refine processes

Objective 1: Use MRI log file data to identify variability and "wasted" time opportunities and to develop predictive models of examduration, idle time, and repeated scansObjective 2: Leverage the size and availability of population health data to model and predict machine utilization efficiencyObjective 3: Apply machine learning techniques to electronic Health Records containing patient demographics, labs, medications,procedures, and clinical notes to establish health trends and uncover definitive factors that can predict treatment outcome and optimalpatient care characteristicsObjective 4: Design evidence-based expert decision support system to facilitate early diagnosis, optimize and personalize treatment,and ensure safety and reduce errors to provide high quality outcome

1) Industry practitioners can make more informed decisionsand achieve care that is personalized, timely, evidence-based,and appropriate; 2) Optimize the usage of hospital resources,treatment process, and outcome; 3) Reduce waste, risk, andcost associated with procedures and operations; 4) Thisresearch can be replicated to other cases and sites to improveprocess.

69

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Dat

a-d

rive

n a

nal

ytic

s an

d

mac

hin

e le

arn

ing

fo

r im

pro

vin

g

hea

lth

care

ou

tco

me

Pro

ject

Lea

ders

: Eva

Lee

Co-

lead

ers:

Con

rad

Tuc

ker,

Chr

isti

na M

astr

ange

lo

Stud

ent

Nam

e(s)

: TB

D

Enga

ged

IAB

mem

bers

: Col

labo

rativ

e

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Col

labo

rativ

e

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nO

bje

ctiv

es:

Obj

ectiv

e 1:

Use

MR

I log

file

dat

a to

iden

tify

varia

bilit

y an

d “w

aste

d” ti

me

oppo

rtun

ities

and

to d

evel

op p

redi

ctiv

e m

odel

s of

exa

m d

urat

ion

, idl

e tim

e, a

nd

repe

ated

sca

ns

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

crip

tion

of P

roje

ct

p

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Obj

ectiv

e 2:

Lev

erag

e th

e si

ze a

nd a

vaila

bilit

y of

pop

ulat

ion

hea

lth d

ata

to m

odel

an

d pr

edic

t mac

hine

util

izat

ion

effic

ienc

y

OB

JEC

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ES

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AR

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ER

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crip

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roje

ctP

roje

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verv

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an

d D

escr

ipti

on

Obj

ectiv

e 3:

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ly m

achi

ne le

arni

ng te

chni

ques

to e

lect

roni

c H

eal

th R

ecor

ds

cont

aini

ng p

atie

nt d

emog

raph

ics,

labs

, med

icat

ions

, pro

cedu

res,

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ical

no

tes

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lish

heal

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ends

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arac

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OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

crip

tion

of P

roje

ct

70

Page 71: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Obj

ectiv

e 4:

Des

ign

evid

ence

-bas

ed e

xper

t dec

isio

n su

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t sys

tem

to fa

cilit

ate

early

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gnos

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rror

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S:

Des

crip

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roje

ctP

roje

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verv

iew

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d D

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Par

tner

s / R

elev

ance

:•

Est

ablis

h po

pula

tion

heal

th m

odel

that

pre

dict

s m

achi

ne u

tiliz

atio

n ef

ficie

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prov

e pa

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exp

erie

nce,

MR

I util

izat

ion,

and

sch

edul

ing

effic

ienc

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crea

se e

ffici

ency

of r

esou

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allo

catio

n an

d re

duce

cos

ts

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JEC

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ES

& P

AR

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S:

Des

crip

tion

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roje

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Pro

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rvie

w a

nd

Des

crip

tio

n

Wh

at p

rob

lem

is t

his

pro

ject

see

kin

g t

o

add

ress

?•

Incr

ease

util

izat

ion

of la

rge

amou

nts

of d

ispa

rate

med

ical

data

incl

udin

g M

RI i

mag

ing

logs

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edur

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ogra

phic

s, a

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ocia

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nfor

mat

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ptim

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usag

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pita

l res

ourc

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trea

tmen

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nd o

utco

me

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ddre

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best

qual

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reat

men

t pr

oced

ures

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ES

& P

AR

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ER

S:

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ign

Thi

nkin

g A

ppro

ach

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ject

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rvie

w a

nd

Des

crip

tio

n

Res

earc

h P

ersp

ecti

ve

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

Pat

ient

Indi

vidu

aliz

ed t

reat

men

t ex

perie

nce

and

trea

tmen

t ou

tcom

e

Red

uctio

n of

hos

pita

l sta

y

Red

uced

ris

k fo

r in

fect

ion

Pro

vide

r

Red

uctio

n of

cos

t

Red

uctio

n of

tim

e

Bet

ter

sche

dule

pla

nnin

g

Hea

lth s

yste

m

Less

var

iabi

lity

Red

uctio

n of

tim

e

Impr

oved

util

izat

ion

of

med

ical

dat

a

Pay

er

Red

uctio

n of

cos

t

71

Page 72: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

•C

are

team

s ca

n m

ake

mor

ein

form

edde

cisi

ons

and

achi

eve

pers

onal

ized

,tim

ely,

evid

ence

-bas

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and

appr

opria

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re•

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ter

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omes

are

achi

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low

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satis

fyin

gth

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eds

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lder

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cher

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n be

bette

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tool

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efit

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atie

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ive

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car

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nalp

aper

san

dco

nfer

ence

pres

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for

broa

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CO

NT

RIB

UT

ION

: How

is th

is d

iffer

ent

than

rel

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res

earc

h?A

pp

roac

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PP

RO

AC

H:

Exp

erim

enta

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roac

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Ben

chm

ark

revi

ew

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a co

llect

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actio

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Dat

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Bui

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pilo

tpro

ject

sw

ithop

timiz

edpr

oced

ures

Ap

pro

ach

OV

ER

VIE

W O

F R

ES

ULT

S:

Exp

ecte

d M

ilest

ones

2018

2019

pppppppppppp

oac

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

2019

Feb

Mar

5/1/

2018

-7/

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Deve

lop

pred

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7/1/

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lot p

rogr

am

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ize ro

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st a

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tility

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plem

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Esta

blish

dise

ase

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ends

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perv

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ning

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ver p

atte

rns o

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arac

teris

tics v

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perv

ised

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Desig

n ev

iden

ce-b

ased

exp

ert d

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on su

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tem

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n an

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timize

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ns

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019

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emin

ate

know

ledg

e

Obj

ectiv

e 4

Ap

pro

ach

•In

dust

ry p

ract

ition

ers

can

mak

e m

ore

info

rmed

dec

isio

ns a

nd a

chie

ve c

are

that

is p

erso

naliz

ed, t

imel

y, e

vide

nce-

base

d,an

d ap

prop

riate

•R

educ

e w

aste

, ris

k, a

nd c

ost a

ssoc

iate

dw

ith p

roce

dure

s an

d op

erat

ions

•T

his

rese

arch

can

be

repl

icat

ed to

oth

erca

ses

and

site

s to

impr

ove

qual

ity a

ndpr

oces

s

OV

ER

VIE

W O

F R

ES

ULT

S:

Ben

efits

to In

dust

ry

72

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Theme Champions:

73

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74

Page 75: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Care Coordination Activities for Individuals with Spinal Cord Injury

Patient1 Tapan Mehta, Allyson Hall

Patient Experience

$50,000 NO 2

This is Phase 2 of a project designed to develop and pilot-test a care coordination program for people newly diagnosed with spinalcord injury (SCI). Phase 1 activities, which are currently underway, focused on developing the care coordination program. This phaseincludes (1) a review of relevant literature and (2) in-depth interviews with patients with SCI, their caregivers, physicians, other healthcare workers who specialize in SCI, and staff at the Lakeshore Foundation. Based on findings from these two activities, a pilotintervention will be developed. Phase 2 will implement the care coordination program developed in Phase 1 and assess the extent towhich it improves the quality of life of participants.

Several studies have documented the effectiveness of care coordination/transitions of care activities. Most of these studies focus onthe general population and do not address the specific and unique needs of individuals newly diagnosed with SCI. The proposedproject aims at addressing the needs of individuals with significant mobility limitations. In additions, the project specifically addresseshow a local disability focused community organization can partner with an academic medical center to improve the quality of life ofindividuals with SCI.

Phase 2 will be a mixed methods study with the following components:(1) Participant self-reported assessments of their quality of life using validated instruments from the PROMS inventory.

- Pre/Post comparisons among individuals receiving care coordination- Comparisons between individuals who did and did not receive care coordination

(2) Compare hospital use between intervention and control groups(3) In-depth interviews with both groups. These interviews will focus on care experiences following their SCI diagnosis.

Implementation of care coordination interventionQuality of life assessments and hospital data acquisitionAnalysis on hospital use and quality of lifeIn-depth interviewsFinal reportPeer review manuscript

Evidence of the effectiveness of a care-coordination programon improving the quality of life of SCI patients

Final report documenting study findingsSubmitted manuscript for publication

75

Page 76: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Car

e C

oo

rdin

atio

n A

ctiv

itie

s fo

r In

div

idu

als

wit

h S

pin

al C

ord

Inju

ry

Pro

ject

Lea

ders

: Tap

an M

ehta

, Ph.

D., A

llyso

n G

. Hal

l, Ph

.D.,

Rob

ert W

eech

-M

aldo

nado

, MBA

, Ph.

D.

Stud

ent

Nam

e(s)

: Ree

na Jo

seph

, MH

A, N

eera

j Pur

o, M

HA

, Gan

ishe

r D

avly

atov

, R

ache

l Wis

niew

ski,

Nat

han

Miy

asak

i

Enga

ged

IAB

mem

bers

: Lak

esho

re F

ound

atio

n, U

AB

Hea

lth S

yste

m

Enga

ged

CH

OT

Uni

vers

ity S

ites:

The

Uni

vers

ity o

f Ala

bam

a at

Bir

min

gham

Ob

ject

ive:

•In

divi

dual

s w

ith tr

aum

atic

spi

nal c

ord

inju

ries

(SC

Is)

face

uni

que

chal

leng

es in

rei

nteg

ratin

g in

to s

ocie

ty a

nd h

ave

a hi

gher

ris

k of

un

plan

ned

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genc

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part

men

t vis

its a

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ospi

tal r

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ons

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are

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dina

tion

and

care

tran

sitio

n m

odel

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velo

ped

for

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e pa

tient

s ha

ve m

ixed

res

ults

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his

proj

ect w

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evel

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car

e co

ordi

natio

n m

odel

for

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vid

uals

ne

wly

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char

ged

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ting.

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tner

s / R

elev

ance

:

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rovi

ding

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gete

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sear

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at is

mea

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able

to

the

heal

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yste

m to

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ress

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need

s of

this

vul

nera

ble

popu

latio

n

•D

emon

stra

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asib

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car

e co

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n pr

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t bet

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n he

alth

sy

stem

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d co

mm

unity

org

aniz

atio

ns fo

r pe

ople

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SC

I

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

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crip

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roje

ct

Pro

ject

Ove

rvie

w a

nd

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crip

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nS

cope

of t

he p

robl

em•

~28

8,00

0 pe

ople

live

with

SC

I

•17

,700

new

cas

es e

ach

year

•~

30%

are

re-

hosp

italiz

ed o

ne o

r m

ore

times

dur

ing

the

year

follo

win

g in

jury

SC

I pat

ient

s ne

ed:

•F

requ

ent,

spec

ializ

ed, i

nter

disc

iplin

ary

heal

thca

re

•C

onne

cts

with

in th

e co

mm

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to

prov

ide

soci

al a

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ther

sup

port

s

OB

JEC

TIV

ES

& P

AR

TN

ER

S: D

esig

n T

hink

ing

App

roac

h

Nat

iona

l Spi

nal C

ord

Inju

ry S

tatis

tical

Cen

ter,

Fac

ts a

nd F

igur

es a

t a G

lanc

e. B

irmin

gham

, AL:

Uni

vers

ity o

f Ala

bam

a at

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irmin

gham

, 201

8.

Pro

ject

Ove

rvie

w a

nd

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crip

tio

nR

esea

rch

Per

spec

tive

•To

impr

ove

the

qual

ity o

f life

and

com

mun

ity in

tegr

atio

n fo

r pa

tient

s fo

llow

ing

disc

harg

e fr

om th

e re

habi

litat

ion

faci

lity

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educ

ing

read

mis

sion

s by

impr

ovin

g ca

re c

oord

inat

ion

Co

ntr

ibu

tio

n t

o In

du

stry

an

d A

cad

emia

•To

dem

onst

rate

the

feas

ibili

ty o

f a c

are

coor

dina

tion

proj

ect

focu

sed

on p

atie

nts

with

SC

Is

•T

he s

peci

fic n

eeds

of t

his

popu

latio

n ha

ve n

ot b

een

adeq

uate

ly r

esea

rche

d

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iabi

lity

of a

par

tner

ship

bet

wee

n lo

cal d

isab

ility

foc

used

co

mm

unity

org

aniz

atio

n an

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adem

ic m

edic

al c

ente

r

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

76

Page 77: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Ap

pro

ach

Ph

ase

I (C

urr

entl

y O

ng

oin

g)

Goa

l: D

evel

op In

terv

entio

n

•Li

tera

ture

Rev

iew

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ualit

ativ

e in

terv

iew

s•

Pat

ient

s w

ith S

CI

•P

rovi

ders

•S

tatis

tical

ana

lyse

s to

det

erm

ine

pred

icto

rs o

f rea

dmis

sion

AP

PR

OA

CH

: E

xper

imen

tal A

ppro

ach

Ap

pro

ach

Pro

po

sed

Ph

ase

II

•P

ilot-

test

car

e co

ordi

natio

n pr

ogra

m f

or p

atie

nts

new

ly

diag

nose

d w

ith S

CI

–A

ssis

tanc

e w

ith o

btai

ning

nee

ded

heal

th c

are,

reh

ab, c

omm

unity

su

ppor

ts a

nd c

omm

unity

eng

agem

ent

–F

ocus

on

care

coo

rdin

atio

n w

ith th

e La

kesh

ore

Fou

ndat

ion

•M

ixed

met

hods

eva

luat

ion

with

the

follo

win

g co

mpo

nent

s:–

Pre

/pos

t com

paris

ons

amon

g in

divi

dual

s re

ceiv

ing

care

co

ordi

natio

n ve

rsus

thos

e no

t rec

eivi

ng c

are

coor

dina

tion

•C

ompa

re h

ospi

tal u

se b

etw

een

inte

rven

tion

and

cont

rol g

roup

s

•P

artic

ipan

t sel

f-re

port

ed a

sses

smen

ts o

f the

ir qu

ality

of l

ife u

sing

val

idat

ed

inst

rum

ents

(P

RO

MIS

)

–In

-dep

th in

terv

iew

s w

ith b

oth

grou

ps•

Car

e ex

perie

nces

follo

win

g th

eir

SC

I dia

gnos

is.

AP

PR

OA

CH

: E

xper

imen

tal A

ppro

ach

Ap

pro

ach

Fin

aliz

e ca

re-c

oord

inat

ion

inte

rven

tion

Obt

ain

IRB

app

rova

l

Enr

oll s

tudy

par

ticip

ants

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terv

entio

n an

d co

ntro

l

Sta

tistic

al a

naly

sis

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ompa

re h

ospi

taliz

atio

ns a

nd q

ualit

y of

life

Con

duct

in-p

erso

n in

terv

iew

with

stu

dy p

artic

ipan

ts•

The

mat

ic a

naly

sis

Fin

al r

epor

ts a

nd p

ublic

atio

ns

OV

ER

VIE

W O

F R

ES

ULT

S:

Exp

ecte

d M

ilest

ones

Ap

pro

ach

Del

iver

able

s•

Fin

al r

epor

t doc

umen

ting

stud

y fin

ding

s

•P

eer-

revi

ewed

man

uscr

ipt

for

publ

icat

ion

in a

n ac

adem

ic

jour

nal

Imp

ort

ance

to

ind

ust

ry

•E

vide

nce

of th

e ef

fect

iven

ess

of a

car

e-co

ordi

natio

n pr

ogra

m o

n im

prov

ing

the

qual

ity o

f life

of

patie

nts

with

S

CIs

•F

easi

bilit

y of

fost

erin

g co

mm

unity

-bas

ed p

artn

ersh

ips

OV

ER

VIE

W O

F R

ES

ULT

S:

Ben

efits

to In

dust

ry

77

Page 78: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

78

Page 79: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Generating Tailored Recommendations Automatically with Explanations via an Interactive Dialog-based System

Patient2 Prasenjit Mitra

Patient Experience

$50,000 NO 1

While certain medical diagnostic and treatment tasks can be automated, others require the decision-making by a medical practitioner.In such cases, a well-designed automated system can be of great value to the practitioner. The current state-of-the-art involvesretrieval systems that largely perform basic information retrieval. In this project, we seek to go further. Based on the level ofinteraction desired by the practitioner, our tool will take in a textual input ranging from a few keywords to all the notes available byinterviewing the patient during intake and existing past notes. Using this textual input, the system will request additional information orprovide recommendations for further investigation or treatment. The practitioner will be provided a clear explanation as to how therecommendations were generated quoting existing guidelines or best-practices in the field. Furthermore, using the latest developmentin chatbot technology, the system will enable the practitioner to refine the information and/or the treatment plan. Based on theseinteractions with the practitioner, the system will learn and adapt to make future interactions with a particular practitioner, similarpractitioners and even all practitioners better.

Currently, there exists no system that extracts relevant information with high accuracy, learns from interactions, provides explanationsabout how the suggestion was generated, and adapts using conversations to retrieve different suggestions. To generate therecommendations, our system will use (but require substantial retooling of) state-of-the-art technology on adaptive summarization thatwe have successfully used in generating Wikipedia articles. Generating explanations of why information was chosen succinctly will bedone using state-of-the-art deep learning techniques. To the best of our knowledge, explaining recommendations using deep-learninghas not been addressed in a medical recommendation system scenario. Adaptive recommendations based on dialogs using deeplearning has not been addressed either. Finally, an integrated system that provides summarized information, a tailoredrecommendation, explanations of recommendations, adapts recommendations based on dialog with high accuracy and usersatisfaction has not been designed or demonstrated. Our system will not be the final answer in one year but it will be one step closer.

1. Retool our abstractive summarizer to generate summarized recommendations based on textual input. Evaluate output usingdomain experts and adapt the information selection and summarization algorithms based on their inputs.2. Generate an explanation of the recommendations. Provide a link to the other alternatives and allow a domain expert to indicatewhether the other alternatives should have been selected instead. Perform user study to rate the quality of the explanation and theaccuracy of the explanations. Find where the explanations were lacking and try to regenerate explanations that are lacking.3. Re-purpose chatbot technology and couple it with our system to interact with medical practitioners. Evaluate if the interactionbetween the practitioner and chatbot helps refine the recommendation & increases the satisfaction of the end-users via user study.4. Evaluate the entire integrated system for improvement in productivity and the quality of care provided by the medical practitioner.Detect the shortcomings of the system for the next round of research to improve interactive medical recommendation systems.

Month 1-3: Generation of summaries, guidelines, and recommendations automatically.Month 4: Evaluation of the generated summaries and adaptation of the algorithms. Generation of explanations for generated content.Month 5: Generation of summaries, guidelines, and recommendations with higher accuracy.Month 6: Evaluation of the explanations and identification of what needs to be improved.Month 7: Improve the explanation generation module.Month 8: Evaluate the explanation generation module and perform experiments to validate its efficacy.Month 9-11: Repurpose chatbot technology to create an interactive module. Use interactions with the end-user to refinerecommendations or explanations.Month 12: Evaluate the interactive dialog-based system. Evaluate overall system. Identify successes and failures for future research.

1. The basic technology that will be developed in this projectwill influence products being developed by the medicalinformatics industry in this area.2. The changes required to make the information output highquality and highly relevant may be useful in making the generaltechnology better. Then, this technology will be useful ingeneral to any user who wants to build an interactiverecommendation system that explains what it is doing.

1. A (very basic) prototypical software that generatesrecommendations and allows end-users to refine them viadialogue based on deep-learning. All code will be releasedopen-source.2. Systematic evaluation of the methods used to generateabstractive summaries, recommendations, and explanations.3. Papers describing the core technology and the improvementsmade to the systems utilized in this project.

While certain medical diagnostic and treatment tasks can be automated, others require the decision-making by a medical practitioner.In such cases, a well-designed automated system can be of great value to the practitioner. The current state-of-the-art involvesretrieval systems that largely perform basic information retrieval. In this project, we seek to go further. Based on the level ofinteraction desired by the practitioner, our tool will take in a textual input ranging from a few keywords to all the notes available byinterviewing the patient during intake and existing past notes. Using this textual input, the system will request additional information orprovide recommendations for further investigation or treatment. The practitioner will be provided a clear explanation as to how therecommendations were generated quoting existing guidelines or best-practices in the field. Furthermore, using the latest developmentin chatbot technology, the system will enable the practitioner to refine the information and/or the treatment plan. Based on theseinteractions with the practitioner, the system will learn and adapt to make future interactions with a particular practitioner, similarpractitioners and even all practitioners better.

Currently, there exists no system that extracts relevant information with high accuracy, learns from interactions, provides explanationsabout how the suggestion was generated, and adapts using conversations to retrieve different suggestions. To generate therecommendations, our system will use (but require substantial retooling of) state-of-the-art technology on adaptive summarization thatwe have successfully used in generating Wikipedia articles. Generating explanations of why information was chosen succinctly will bedone using state-of-the-art deep learning techniques. To the best of our knowledge, explaining recommendations using deep-learninghas not been addressed in a medical recommendation system scenario. Adaptive recommendations based on dialogs using deeplearning has not been addressed either. Finally, an integrated system that provides summarized information, a tailoredrecommendation, explanations of recommendations, adapts recommendations based on dialog with high accuracy and usersatisfaction has not been designed or demonstrated. Our system will not be the final answer in one year but it will be one step closer.

1. Retool our abstractive summarizer to generate summarized recommendations based on textual input. Evaluate output usingdomain experts and adapt the information selection and summarization algorithms based on their inputs.2. Generate an explanation of the recommendations. Provide a link to the other alternatives and allow a domain expert to indicatewhether the other alternatives should have been selected instead. Perform user study to rate the quality of the explanation and theaccuracy of the explanations. Find where the explanations were lacking and try to regenerate explanations that are lacking.3. Re-purpose chatbot technology and couple it with our system to interact with medical practitioners. Evaluate if the interactionbetween the practitioner and chatbot helps refine the recommendation & increases the satisfaction of the end-users via user study.4. Evaluate the entire integrated system for improvement in productivity and the quality of care provided by the medical practitioner.Detect the shortcomings of the system for the next round of research to improve interactive medical recommendation systems.

Month 1-3: Generation of summaries, guidelines, and recommendations automatically.Month 4: Evaluation of the generated summaries and adaptation of the algorithms. Generation of explanations for generated content.Month 5: Generation of summaries, guidelines, and recommendations with higher accuracy.Month 6: Evaluation of the explanations and identification of what needs to be improved.Month 7: Improve the explanation generation module.Month 8: Evaluate the explanation generation module and perform experiments to validate its efficacy.Month 9-11: Repurpose chatbot technology to create an interactive module. Use interactions with the end-user to refinerecommendations or explanations.Month 12: Evaluate the interactive dialog-based system. Evaluate overall system. Identify successes and failures for future research.

1. The basic technology that will be developed in this projectwill influence products being developed by the medicalinformatics industry in this area.2. The changes required to make the information output highquality and highly relevant may be useful in making the generaltechnology better. Then, this technology will be useful ingeneral to any user who wants to build an interactiverecommendation system that explains what it is doing.

79

Page 80: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Gen

erat

ing

Tailo

red

Rec

omm

enda

tions

Aut

omat

ical

ly

with

Exp

lana

tions

via

an

Inte

ract

ive

Dia

log-

base

d Sy

stem

Pro

ject

Lea

ders

: P

rase

njit

Mit

ra, P

enn

Stat

e C

olle

ge o

f Inf

orm

atio

n Sc

ienc

e an

d Te

chno

logy

Co-

lead

ers:

Con

rad

Tuck

er, P

enn

Stat

e C

olle

ge o

f Eng

inee

ring

Stud

ent

Nam

e(s)

: TB

D

Enga

ged

IAB

mem

bers

: AT

&T,

Sie

men

s

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Penn

Sta

te

Proj

ect O

verv

iew

and

Des

crip

tion

Obj

ectiv

e:D

evel

op a

pro

toty

pe a

utom

ated

de

ep le

arni

ng-d

riven

sys

tem

. The

sy

stem

use

s te

xtua

l inp

ut fr

om

patie

nt re

cord

s du

ring

inta

ke a

nd

past

not

es to

gen

erat

e re

com

men

datio

ns, b

ased

on

best

-pr

actic

es in

the

field

.

Part

ners

/ R

elev

ance

:D

evel

op th

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sic

tech

nolo

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bu

ild in

tera

ctiv

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com

men

datio

n sy

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rive

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re m

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info

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prod

ucts

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heal

thca

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rovi

ders

and

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actit

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ES

& P

AR

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RS

: Des

crip

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of P

roje

ct

Text

ual I

nput

from

pa

tient

reco

rds,

test

re

sults

, and

not

es

Adap

tabl

e de

ep

lear

ning

sys

tem

Rec

omm

enda

tions

of

fere

d to

aid

in

deci

sion

-mak

ing

Proj

ect O

verv

iew

and

Des

crip

tion

With

less

tim

e al

loca

ted

per

patie

nt, h

ealth

care

pro

vide

rs

mus

t qui

ckly

cap

ture

and

as

sess

pat

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a, m

ake

deci

sion

s, a

nd c

omm

unic

ate

impo

rtant

info

rmat

ion

to

patie

nts.

Pra

ctiti

oner

s ne

ed to

incr

ease

ef

ficie

ncie

s to

incr

ease

the

time

spen

t on

valu

e -ad

ded

task

s th

at d

irect

ly re

late

to

patie

nt c

are.

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JEC

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ES

& P

AR

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RS

: Des

ign

Thin

king

App

roac

h

Less

tim

e pe

r pa

tient

can

lead

to

med

ical

err

ors

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nt E

xpec

tatio

nsVs

.R

ealit

y

Wha

t pro

blem

is th

is p

roje

ct s

eeki

ng to

add

ress

?Pr

ojec

t Ove

rvie

w a

nd D

escr

iptio

nR

esea

rch

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pect

ive

OB

JEC

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& P

AR

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: Des

ign

Thin

king

App

roac

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prov

ed e

ffici

ency

in u

tiliz

ing

avai

labl

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ta fr

om e

lect

roni

c m

edic

al re

cord

s to

ass

ist

prac

titio

ners

in m

akin

g re

com

men

datio

ns fo

r tre

atm

ent.

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ss ti

me

will

be

spen

t by

prac

titio

ners

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e ad

ded

func

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to a

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e tim

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r pa

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educ

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rmat

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bein

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itted

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cisi

on-m

akin

g pr

oces

s.

80

Page 81: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

Con

trib

utio

n to

Indu

stry

and

A

cade

mia

Cur

rent

sta

teon

ly p

erfo

rms

basi

c in

form

atio

n re

triev

al in

the

med

ical

spa

ce.

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e is

cur

rent

ly n

o sy

stem

that

:•

extra

cts

rele

vant

info

rmat

ion

with

hig

h ac

cura

cy•

lear

ns fr

om in

tera

ctio

ns•

expl

ains

how

sug

gest

ions

are

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•ad

apts

usi

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onve

rsat

ions

to

retri

eve

diffe

rent

sug

gest

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tract

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sum

mar

izer

, D

eep

lear

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and

C

hatb

ox T

echn

olog

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Inte

ract

ive

and

adap

tive

syst

em

that

gen

erat

es h

igh

qual

ity, r

elev

ant

reco

mm

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tionsB

asic

info

rmat

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Ret

rieva

l

App

roac

hA

PP

RO

AC

H: E

xper

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ppro

ach

Ret

ool a

bstra

ctiv

e su

mm

ariz

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ge

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umm

ariz

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mm

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bas

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valu

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perts

Gen

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com

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datio

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atio

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ourc

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have

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ain

expe

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view

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appr

opria

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ss

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box

tech

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r us

e w

ith m

edic

al p

ract

ition

ers

and

eval

uate

if th

e in

tera

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n in

crea

ses

satis

fact

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of e

nd-

user

s vi

a a

user

stu

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Eva

luat

e en

tire

inte

grat

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em fo

r inc

reas

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prod

uctiv

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re b

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Iden

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roac

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VE

RV

IEW

OF

RE

SU

LTS

: Exp

ecte

d M

ilest

ones

Mon

th 1

-3: G

ener

atio

n of

su

mm

arie

s, g

uide

lines

, an

d re

com

men

datio

ns

auto

mat

ical

ly

Mon

th 4

: Eva

luat

ion

of

gene

rate

d su

mm

arie

s an

d ad

aptio

n of

the

algo

rithm

s an

d ge

nera

tion

of

expl

anat

ions

for t

he

gene

rate

d co

nten

t

Mon

th 5

: Gen

erat

ion

of

sum

mar

ies,

gui

delin

es,

and

reco

mm

enda

tions

w

ith h

ighe

r acc

urac

y

Mon

th 6

: Eva

luat

ion

of

expl

anat

ions

and

id

entif

icat

ion

of a

reas

for

impr

ovem

ent

Mon

th 7

: Im

prov

e th

e ex

plan

atio

n ge

nera

tion

mod

ule

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th 8

: Eva

luat

e th

e ex

plan

atio

n ge

nera

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mod

ule

and

perfo

rm

expe

rimen

ts to

val

idat

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ficac

y

Mon

th: 9

-11:

Enh

ance

ch

atbo

xte

chno

logy

to

crea

te in

tera

ctiv

e m

odul

e,

use

end-

user

inte

ract

ions

to

refin

e

Mon

th 1

2: E

valu

ate

com

pone

nts

and

over

all

tech

nolo

gy, u

se fa

ilure

s fo

r fut

ure

rese

arch

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roac

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roto

type

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tem

that

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nera

tes

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tions

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low

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d-us

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to

refin

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a di

alog

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ased

on

deep

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ning

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yste

mat

ic e

valu

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m

etho

ds u

sed

to g

ener

ate

abst

ract

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mar

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re

com

men

datio

ns, a

nd

expl

anat

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aper

s de

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the

core

te

chno

logy

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roto

type

sof

twar

e th

at c

an

be in

tegr

ated

into

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lthca

re

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ER

VIE

W O

F R

ES

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enef

its to

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stry

Appppppppppppppppppppppppppppppppppppp

rrrrrrrrrrrrrrrroooooooooooooaaaaaaaaaaaaaaaaacccccccccccccccc

hhhhhhhhhhhhhhhh

ns on

Pat

ient

dat

a su

mm

ary

com

pile

d.

Wou

ld y

ou li

ke to

vie

w

reco

mm

enda

tions

now

? Ye

s/ N

o

Yes

show

reco

mm

enda

tions

.

Bas

ed o

n th

e pa

tient

s m

edic

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cord

, cl

ick

here

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Del

iver

able

s:

81

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82

Page 83: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Embedding Routine Informal, Family Caregiver Assessment of Delirium Superimposed on Dementia into Acute Care

Patient3 Andrea Sillner

Patient Experience

$100,000 YES 1

The purpose of this pilot study is to assess initial accuracy and feasibility of communication of observed symptoms of delirium in olderadults with complex multiple chronic conditions dementia by family caregivers utilizing app-based delivery of the Family ConfusionAssessment Method (FAM-CAM) in the acute care setting.

Current standards in diagnosing delirium rely on diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5thEdition (DSM-5) and the International Statistical Classification of Disease and Related Health Problems, 10th Revision (ICD-10);however, there are no specific diagnostic criteria for delirium in persons with preexisting dementia. Recommended assessment toolsfor delirium, such as the Confusion Assessment Method (CAM), take into account changes from normal, but often this is unknown toformal healthcare providers. For older adults with complex multiple chronic conditions and cognitive impairment, the person who maybe best able to assess baseline cognitive function is the family caregiver. A modification of CAM, FAM-CAM, allows family caregiversto report their observations of symptoms of delirium in a standardized method. The FAM-CAM shows potential to improve recognition,and therefore, management of delirium in the acute care setting.

Aim 1: to assess the initial agreement of communication of observed symptoms of delirium in older adults with complex multiplechronic conditions by family caregivers utilizing app-based delivery of FAM-CAM compared to trained observers.

Aim 2: to determine feasibility of embedding the app-based FAM-CAM within the electronic medical record.

To meet the aims of the proposed project, the following steps will be undertaken:1) development of application based FAM-CAM for use within the acute care setting,2) assessment of the accuracy and feasibility of using this tool within the acute care setting, and3) determination of how to sync FAM-CAM with the acute care electronic medical record so that the communication of symptomsnoted by informal caregiver at the bedside is routinely and accurately delivered to healthcare providers, so that action can take place.

Understanding how we can allow informal family caregivers atthe bedside to routinely communicate observed signs andsymptoms of common hospital adverse events to medical staffusing app-based technology and standardized screeninginstruments.

Dissemination of findings by publications and presentations tostakeholders at all levels of care, including, but not limited tohealthcare providers, patients, informal caregivers, and industrypartners.

83

Page 84: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Embe

ddin

g R

outin

e In

form

al,

Fam

ily C

areg

iver

Ass

essm

ent o

f D

eliri

um S

uper

impo

sed

on

Dem

entia

into

Acu

te C

are

Pro

ject

Lea

ders

: And

rea

Yevc

hak

Silln

er, P

enn

Stat

e C

olle

ge o

f Nur

sing

Stud

ent

Nam

e(s)

: TB

D

Enga

ged

IAB

mem

bers

: Her

shey

Med

ical

Cen

ter,

Hig

hmar

k

Enga

ged

CH

OT

Uni

vers

ity S

ites:

FAU

/PSU

Proj

ect O

verv

iew

and

Des

crip

tion

Obj

ectiv

e:Ex

plor

e fe

asib

ility

and

accu

racy

of u

sing

dat

a fro

m

fam

ily c

areg

iver

sto

est

ablis

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selin

e co

gniti

ve fu

nctio

n in

th

e ac

ute

care

set

ting

for o

lder

ad

ults

with

com

plex

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tiple

ch

roni

c co

nditi

ons

and

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to in

crea

se th

e lik

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of re

cogn

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mpt

oms

of d

eliri

um.

Part

ners

/ R

elev

ance

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ive

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thca

re p

rovi

ders

m

ore

data

obs

erva

tions

usi

ng

a st

anda

rdiz

ed m

etho

d fro

m

thos

e w

ho b

est k

now

the

patie

nt to

impr

ove

man

agem

ent a

nd o

utco

mes

.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

crip

tion

of P

roje

ctD

elir

ium

is a

stat

e of

wor

se-th

an-u

sual

m

enta

l con

fusio

n, b

roug

ht o

n by

som

e ty

pe

of u

nusu

al st

ress

on

the

body

or

min

d.

Diff

icul

ty fo

cusi

ngM

emor

y Pr

oble

ms

Vivi

d H

allu

cina

tions

Dis

orie

ntat

ion

Lang

uage

Diff

icul

tyR

estle

ssne

ss

Proj

ect O

verv

iew

and

Des

crip

tion

Wha

t pro

blem

is

this

pro

ject

see

king

to

add

ress

?C

urre

nt s

tand

ards

in

diag

nosi

ng d

eliri

um

rely

on

crite

ria th

at d

o no

t tak

e pr

eexi

stin

g de

men

tia in

to

acco

unt,

mak

ing

it di

fficu

lt to

ass

ess

base

line

cogn

itive

fu

nctio

n an

d m

onito

r sy

mpt

oms.

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h Sig

n of

oth

er

illnes

s or

stre

ssC

onfu

sed

pers

on

at h

ighe

r ris

k fo

r fa

lls a

nd in

jurie

sIn

crea

ses

leng

th o

f ho

spita

l sta

ys a

nd

chan

ce o

f dea

th.

Loss

of

inde

pend

ence

Acc

eler

ates

co

gniti

ve d

eclin

e

Del

irium

is a

n im

port

ant p

robl

em to

pr

even

t, de

tect

, and

man

age,

esp

ecia

lly

with

dem

entia

pat

ient

s.

rds

in

irium

th

at d

o st

ing

ng it

ss

tiv

e on

itor

Sig

nilln

esC

onfu

at h

igfa

lls a

Incr

eho

spi

chan

cLo

ssin

dep

Acc

eco

gni

Proj

ect O

verv

iew

and

Des

crip

tion

Res

earc

h Pe

rspe

ctiv

eH

ealth

car

e pr

ovid

ers,

usi

ng

info

rmal

fam

ily

care

give

r dat

a, w

ill be

ab

le to

det

ect

OB

JEC

TIV

ES

& P

AR

TNE

RS

: Des

ign

Thin

king

App

roac

h

eeeeeeeeeeeeeeeeee

delir

ium

sym

ptom

s ea

rlier

to g

uide

car

e de

cisi

ons

if it

can

be e

asily

cap

ture

d in

a

patie

nt’s

ele

ctro

nic

heal

th re

cord

.

84

Page 85: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

n to

Indu

stry

and

A

cade

mia

•A

ddin

g th

e co

nstru

ct o

f the

Fam

ily

Con

fusi

on A

sses

smen

t Met

hod

(FA

M-C

AM

) dat

a w

ill al

low

he

alth

care

pro

vide

rs b

ette

r ins

ight

in

to tr

eatin

g de

liriu

m p

atie

nts

with

pr

eexi

stin

g de

men

tia.

•A

pp-b

ased

tech

nolo

gy, u

tiliz

ing

stan

dard

ized

scr

eeni

ng in

stru

men

ts,

will

enab

le m

ore

obse

rvat

ions

of

sym

ptom

s fro

m th

ose

who

bes

t kn

ow th

e pa

tient

’s b

asel

ine

cogn

itive

st

ate,

fam

ily c

areg

iver

s.

CO

NTR

IBU

TIO

N: H

ow is

this

diff

eren

t tha

n re

late

d re

sear

ch?

App

roac

hW

hat d

o yo

u pl

an o

n do

ing?

•A

IM 1

: Obt

ain

agre

emen

t of

com

mun

icat

ion

of

obse

rved

sym

ptom

s fro

m fa

mily

ca

regi

vers

com

pare

d to

trai

ned

obse

rver

s.•

AIM

2: D

eter

min

e fe

asib

ility

of

embe

ddin

g th

e ap

p-ba

sed

FAM

-CA

M

with

in th

e el

ectro

nic

med

ical

reco

rd.

AP

PR

OA

CH

: Exp

erim

enta

l App

roac

h

App

roac

hTi

mel

ine

and

Ove

rvie

w o

f Ex

pect

ed R

esul

ts•

Dev

elop

app

bas

ed o

n FA

M-

CA

M (m

onth

s 1-

3)

•A

sses

smen

t of a

ccur

acy

and

feas

ibili

ty (m

onth

s 4-

8)

•D

eter

min

atio

n of

how

to s

ync

FAM

-CA

M w

ith a

cute

car

e el

ectro

nic

med

ical

reco

rd fo

r ap

prop

riate

mon

itorin

g(m

onth

s 9-

12)

OV

ER

VIE

W O

F R

ES

ULT

S: E

xpec

ted

Mile

ston

espp of

n FA

M-

acy

and

) to s

ync

care

App

roac

h

Del

iver

able

s:•

Dis

sem

inat

ion

of

findi

ngs

by p

ublic

atio

ns

and

pres

enta

tions

to

stak

ehol

ders

•Fu

nctio

nal m

obile

app

th

at c

aptu

res

FAM

-CA

M

Dat

a

OV

ER

VIE

W O

F R

ES

ULT

S: B

enef

its to

Indu

stry

85

Page 86: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

86

Page 87: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Research Theme #5:

ACCESS TO CARE

Theme Champion : Dr. Christopher Johnson, University of Louisville

Access 1

Telemedicine in Primary Care and in the Management of Chronic Conditions: Exploring Patient & Provider Perspectives Access 2 Ask Me 3®: A Home Health Intervention to Address Health Literacy Barriers, Increase Patient Engagement, and Improve Patient Experi-ence and Outcomes

87

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88

Page 89: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

PI:

Telemedicine in Primary Care & in the Management of Chronic Conditions: Exploring Patient & Provider Perspectives

Access1 Lee, Lerouge, Tucker, Borkowski, Kash, Johnson, Agarwal

Access to Care

$200,000 YES 2

Timely access to quality healthcare service is a real challenge—as outlined in the 2015 IOM report—and misalignment of resourcesand demands result in long delays for care. Telehealth can offer alternative and timely care to rural area patients who lack sufficienthealthcare options. Telehealth can also help to improve health conditions and to promote active patient engagement, which isparticularly important for chronic disease management. This project identifies drivers and barriers of patient engagement by populationgroups and chronic conditions and provides recommendations for implementing appropriate telehealth/telemedicine interventionsthrough multiple care settings given governmental policies, reimbursement payments, and delivery of care.

1) Technology readiness model for telemedicine in primary caresettings2) Conference presentations3) Piloted technology in Primary Care Assessment Survey4) Optimized point-of-access for study sites5) A low-cost personalized prototype remote patient monitoringdevice

The adoption of telemedicine and the level of patient engagement and services provided across healthcare facilities remain unevenand far from optimal. Little evidence, particularly in the form of understanding from the viewpoint and situation of providers, is availableto guide stakeholder organizations as they consider introducing telemedicine into primary care practice. This study examines issuesincluding point-of-access, administrative logistics, timely primary care, monitoring chronic disease and mental health, and providingequal and affordable care to the poor and rural areas. We also investigate and design a personalized remote patient monitoringsystem to connect patients and providers. By exploring successful application in multiple settings such as the rural and primary caresetting, this study will define the terms telehealth and telemedicine.

1) Literature review of existing primary care literature to identify (a) various iterations of the telemedicine service provision in primarycare contexts, (b) possible forces affecting adoption and innovation, and (c) indicators of technology readiness factors and pathwaysfor primary care practices to implement telemedicine services in primary care.2) Secondary data analysis of former CHOT landscape project to identify (a) various iterations of the telemedicine service provision inprimary care contexts and (b) possible forces affecting adoption and innovation.3) Create a low-level prototype showcasing the design of a personalized remote patient monitoring system. This system will integratetelehealth devices using a smartphone application to connect patients and providers.

1) Perform systematic literature review2) Identify gaps in care through gap analysis3) Data and system modeling including optimizing point-of-access4) Develop and administer survey instrument to be completed by providers and carry out pilot study5) Collect feedback from partner sites and conduct further analyses to characterize barriers to the use of telehealth services andassess their level of telemedicine readiness

1) Understanding the adoption and diffusion of telemedicine inprimary care can inform decision making regarding servicedesign, implementation, operations, and provider engagement.2) An assessment tool based on these forces can help assessindividual primary care organizational readiness fortelemedicine innovation to promote organizational success indelivering this mode of service.

89

Page 90: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Tel

emed

icin

ein

Pri

mar

y C

are

and

in

the

Man

agem

ent

of

Ch

ron

icC

on

dit

ion

s: E

xplo

rin

g P

atie

nt

&P

rovi

der

Per

spec

tive

s

Co-

lead

ers:

Eva

Lee

, Geo

rgia

Tec

h; C

ynth

ia L

eRou

ge, U

W,

Con

rad

Tuc

ker,

Pen

n St

ate.

Oth

er In

vest

igat

ors:

N B

orko

wsk

(U

AB

), B

Kas

h (T

AM

U),

C

John

son

(UL)

, A A

garw

al (

FAU

)

Enga

ged

IAB

mem

bers

: C

olla

bora

tive

Enga

ged

CH

OT

Uni

vers

ity S

ites:

Col

labo

rativ

e

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

n•

Exp

lore

and

def

ine

the

itera

tions

of t

elem

edic

ine

serv

ices

and

mod

els

in p

rimar

y ca

re a

nd fo

r th

e ca

re o

f chr

onic

dis

ease

•Id

entif

y dr

iver

s an

d ba

rrie

rs t

o pa

tient

eng

agem

ent i

n te

lem

edic

ine

serv

ice

lines

by

popu

latio

n gr

oups

and

chr

onic

con

ditio

ns t

ypic

ally

m

anag

ed in

prim

ary

care

set

tings

(e.

g., d

iabe

tes,

dep

ress

ion)

•Id

entif

y th

e pr

ovid

er d

river

s an

d ba

rrie

rs t

o in

tegr

atin

g te

lem

edic

ine

in p

rimar

y ca

re fr

om t

he p

ersp

ectiv

e of

pro

vide

rs r

esul

ting

in a

prov

ider

tech

nolo

gy r

eadi

ness

fact

or m

odel

•In

vest

igat

e an

d de

sign

a p

erso

naliz

ed r

emot

e pa

tient

mon

itorin

gsy

stem

to c

onne

ct p

atie

nts

and

prov

ider

s.

•P

rovi

de r

ecom

men

datio

ns fo

r im

plem

entin

g ap

prop

riate

tele

med

icin

e in

terv

entio

ns th

roug

h m

ultip

le c

are

setti

ngs

give

ngo

vern

men

tal p

olic

ies,

rei

mbu

rsem

ent p

aym

ents

and

del

iver

y of

careO

BJE

CT

IVE

S &

PA

RT

NE

RS

: D

escr

iptio

n of

Pro

ject

on

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nO

BJE

CT

IVE

S &

PA

RT

NE

RS

: D

escr

iptio

n of

Pro

ject

Wh

at p

rob

lem

is t

his

pro

ject

see

kin

g t

o a

dd

ress

?

•W

ithou

t cha

nges

to h

ow p

rimar

y ca

re is

del

iver

ed, t

he g

row

th in

prim

ary

care

phy

sici

an s

uppl

y w

ill n

ot b

e ad

equa

te to

mee

t dem

and

in 2

020,

with

a p

roje

cted

sho

rtag

e of

20,

400

phys

icia

ns.

•N

early

150

mill

ion

Am

eric

ans

suffe

r at

leas

t one

chr

onic

con

ditio

n,an

dne

arly

30

mill

ion

are

livin

g w

ith fi

ve c

hron

ic c

ondi

tions

or

mor

e,w

hich

acc

ount

for

abou

t 12

perc

ent o

f the

U.S

. adu

lt po

pula

tion

and

mor

e th

an 4

0 pe

rcen

t of U

.S. h

ealth

spe

ndin

g.

•Te

lem

edic

ine,

in v

ario

us it

erat

ions

, pro

vide

em

ergi

ng m

odel

s of

deliv

erin

g pr

imar

y ca

re a

nd m

anag

ing

chro

nic

dise

ase.

•In

form

hea

lthca

re p

rovi

ders

abo

ut th

e ef

fect

iven

ess

of c

urre

ntte

lem

edic

ine

syst

ems

and

may

sug

gest

way

s to

leve

rage

tele

med

icin

e fo

r pr

imar

y ca

re a

nd c

hron

ic d

isea

se m

anag

emen

t.

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nR

esea

rch

Per

spec

tive

Ph

ase

1 -

Lit

. Rev

iew

Lite

ratu

re r

evie

w to

iden

tify:

•V

ario

us it

erat

ions

of t

he te

lem

edic

ine

serv

ice

prov

isio

n in

pri

mar

yca

re c

onte

xts

•P

ossi

ble

forc

es a

ffect

ing

prov

ider

ado

ptio

n an

d in

nova

tion

and

indi

cato

rs o

f tec

hnol

ogy

read

ines

s fa

ctor

s an

d pa

thw

ays

for

prim

ary

care

pra

ctic

es to

impl

emen

t te

lem

edic

ine

serv

ices

in p

rimar

y ca

re

•P

atie

nt p

opul

atio

ns' e

ngag

emen

t in

succ

essf

ul u

se o

fte

lem

edic

ine/

tele

med

icin

e op

tions

.

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

90

Page 91: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nR

esea

rch

Per

spec

tive

Ph

ase

2 –

Pro

vid

er R

ead

ines

s S

urv

ey•

Sec

onda

ry d

ata

anal

ysis

of f

orm

er C

HO

Tpr

ojec

t to

iden

tify

a) v

ario

us it

erat

ions

of t

hete

lem

edic

ine

serv

ice

prov

isio

n in

prim

ary

care

con

text

s an

d b)

pos

sibl

e fo

rces

affe

ctin

g ad

optio

n an

d in

nova

tion

•B

ased

on

resu

lts o

f lite

ratu

re r

evie

w a

nd

seco

ndar

y da

ta a

naly

sis,

dev

elop

apr

ovid

er s

urve

y in

stru

men

t aim

ed a

tm

easu

ring

the

barr

iers

affe

ctin

g ad

optio

n of

tele

med

icin

e in

prim

ary

care

set

tings

and

leve

ls o

f tec

hnol

ogy

read

ines

s .

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nR

esea

rch

Per

spec

tive

Ph

ase

3–

Pro

toty

pe

Bas

edon

Pha

se1

and

2re

sults

,th

ete

am w

illus

e a

desi

gnsc

ienc

eap

proa

chto

cre

ate

alo

w-le

vel

prot

otyp

esh

owca

sing

the

desi

gnof

ape

rson

aliz

edre

mot

epa

tient

mon

itorin

gsy

stem

. Thi

ssy

stem

will

inte

grat

ete

lehe

alth

devi

ces

usin

ga

smar

tpho

neap

plic

atio

nto

con

nect

patie

nts

and

prov

ider

s.

OB

JEC

TIV

ES

& P

AR

TN

ER

S:

Des

ign

Thi

nkin

g A

ppro

ach

Pro

ject

Ove

rvie

w a

nd

Des

crip

tio

nC

on

trib

uti

on

s to

Ind

ust

ry a

nd

Aca

dem

ia

•T

his

proj

ect

will

hel

p in

dust

ry m

embe

rs u

nder

stan

d th

e st

atus

and

oppo

rtun

ities

of l

ever

agin

g te

lem

edic

ine

to s

uppo

rtpr

imar

y ca

re a

nd m

anag

emen

t of

chr

onic

dis

ease

fro

m b

oth

the

patie

nt a

nd p

rovi

der

pers

pect

ive.

•In

dust

ry m

embe

rs w

ill g

ain

a be

tter

unde

rsta

ndin

g of

bot

h th

epa

tient

and

pro

vide

r co

ncer

ns a

nd in

tere

sts

in u

sing

tele

med

icin

e in

the

cont

ext o

f prim

ary

care

and

the

man

agem

ent

of c

hron

ic d

isea

se.

•It

will

con

cept

ualiz

e a

viab

le r

emot

e pa

tient

mon

itorin

gsy

stem

.

CO

NT

RIB

UT

ION

: How

is th

is d

iffer

ent

than

rel

ated

res

earc

h?A

pp

roac

hW

hat

do

yo

u p

lan

on

do

ing

?

•P

erfo

rm s

yste

mat

ic li

tera

ture

rev

iew

•D

evel

op a

nd a

dmin

iste

r a

tele

med

icin

e pr

imar

y ca

repr

ovid

er s

urve

y ai

med

at m

easu

ring

the

barr

iers

affe

ctin

gad

optio

n of

tele

med

icin

e in

prim

ary

care

set

tings

and

leve

lsof

tech

nolo

gy r

eadi

ness

•Id

entif

y ga

ps in

car

e ev

iden

ced

by th

e lit

erat

ure

revi

ew a

ndsu

rvey

thr

ough

gap

ana

lysi

s

•D

evel

op a

sys

tem

pro

toty

pe t

o ad

dres

s on

e or

mor

e ga

ps in

care

•C

onfe

renc

e su

bmis

sion

AP

PR

OA

CH

: E

xper

imen

tal A

ppro

ach

91

Page 92: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Ap

pro

ach

OV

ER

VIE

W O

F R

ES

ULT

S:

Exp

ecte

d M

ilest

ones

Exp

ecte

d M

ilest

on

esE

xpec

ted

Mile

sto

nes

1)Te

chno

logy

rea

dine

ssm

odel

for

tele

med

icin

e in

pr

imar

y ca

re s

ettin

gs

2)C

onfe

renc

e pr

esen

tatio

ns

3)P

ilote

d te

chno

logy

inP

rimar

y C

are

Ass

essm

ent

Sur

vey

4)O

ptim

ized

poi

nt-o

f-ac

cess

for

stud

y si

tes

5)A

low

-cos

t pe

rson

aliz

edpr

otot

ype

rem

ote

patie

nt

mon

itorin

g de

vice

ach

Ap

pro

ach

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ER

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W O

F R

ES

ULT

S:

Ben

efits

to In

dust

ry

•U

nder

stan

ding

the

forc

es a

ffect

ing

adop

tion

and

diffu

sion

to

tele

med

icin

e in

prim

ary

care

set

tings

can

info

rm d

ecis

ion

mak

ing

rega

rdin

g se

rvic

ede

sign

, im

plem

enta

tion,

ope

ratio

ns,

and

prov

ider

enga

gem

ent.

•A

n as

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t to

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ased

on

unde

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thes

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can

hel

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vidu

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rimar

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ucce

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deliv

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g th

is m

ode

of s

ervi

ce.

92

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PI:

An Intervention to Address Health Literacy Barriers, Increase Patient Engagement, & Improve Patient Experience & Outcomes

Value-based reimbursement in health care has resulted in an increasing focus on patient engagement as a mechanism to improvepost-acute care outcomes, particularly in reducing readmissions. However, health system strategies aimed at increasing patientengagement should account for health literacy and generational differences. Strategies that may work with a high literacy populationmay not be as effective among a population with low literacy.

Access2 Weech-Maldonado, Borkowski, and Lord

Access to Care

$40,000 YES 1

There has been limited research on the effectiveness of health literacy interventions in improving patient engagement and healthoutcomes, particularly in the home health context. This is a two-phase project. During the current first phase, we are conducting aliterature review to identify best practices/strategies in addressing health literacy barriers in a home health environment with theultimate goals of improving patient engagement and reducing hospital readmissions. We are proposing a second phase, which willconsist of a pilot intervention Ask Me 3® in a home health setting. Ask Me 3® is an educational program that encourages patients andfamilies to ask three specific questions of their providers to better understand their health conditions and what they need to do to stayhealthy: (1) what is my main problem?; (2) what do I need to do?; and (3) why is it important for me to do this?

A final report outlining the findings of the pilot project.

A pre-post experimental design: select two comparable health agency sites in the Birmingham metro area. In the experimental site,nurses will receive training on Ask Me 3® and patient data on health literacy. A second site will serve as a control group, with nursesproviding usual care. We will compare the intervention and control sites in terms of pre-post patient outcomes, such as patientengagement, patient experience, and readmissions.

Obtain IRB approval and finalize intervention Months 1-3Collect baseline data Months 4-5Implement intervention Months 6-7Collect post-intervention data Months 8-9Data analysis Months 10-11Final report Month 12

This pilot project will provide the foundation for futureinterventions of health system strategies to address barriersrelated to health literacy, increase patient engagement, andimprove patient outcomes.

93

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Ask

Me

3®: A

Hom

e H

ealth

In

terv

entio

n to

Add

ress

Hea

lth

Lite

racy

Bar

riers

, Inc

reas

e Pa

tient

En

gage

men

t, an

d Im

prov

e Pa

tient

Ex

perie

nce

and

Out

com

es

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ged

IAB

mem

bers

: A

laca

re

Enga

ged

CH

OT

Uni

vers

ity S

ites:

UA

B

Pro

ject

Lea

ders

: R

ober

t Wee

ch-M

aldo

nado

, Nan

cy B

orko

wsk

i; Ju

stin

Lor

d

Co-

lead

ers:

Sa

mik

a W

illia

ms

Stud

ent

Nam

e(s)

: R

eena

Jose

ph; N

eera

j Pur

o

Proj

ect O

verv

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and

Des

crip

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sk M

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94

Page 95: 2018 SPRING INDUSTRY ADVISORY BOARD MEETING - CHOT

Proj

ect O

verv

iew

and

Des

crip

tion

Con

trib

utio

n to

Indu

stry

and

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dem

ia

CO

NTR

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TIO

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ow is

this

diff

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n re

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terv

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enef

its to

Indu

stry

95

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RESEARCH PROJECT UPDATES AND OVERVIEWS

97

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Research Project Updates Overview

Title % Completed $ Remaining

Patient Engagement and Hospital Readmissions: The Role of Health Literacy

25% $45,000

Impact of Direct-to-Consumer Telemedicine on Downstream Health Care Utilization and Costs

15% $50,000

Telehealth and Remote Patient Monitoring Systems to Improve Access and Promote Active Patient Engagement in Rural Communities

35% $100,000

Development of a Middleware Framework for Medical Device Integration for Telemedicine

0% $50,000

Using Care Coordination to Address Cost, Quality, and Access to Care Across Systems and Populations

80% $250,000

Effects of Care Coordination on the Improvement of Quality of Care

40% $65,000

Effects of Care Coordination on Care Transitions 25% $100,000

A Mobile Based Care Coordination System for Critical Care 25% $50,000

Integration of Population Health Data and Digital Assistants to Reduce Readmission Risks 10% $50,000

Gamification and its impact on the Population Health Management of Chronic Conditions 10% $50,000

Improving Employee and Patient Health through Population Data Mining 10% $50,000

Data-Driven Predictive Analytics to Improve Diagnosis, Treatment, Care Coordination, and Resource Utilization 60% $120,000

Machine Learning for Evidence –Based Practice, Resource Allocation, and Risk Prediction 60% $80,000

98

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PROJECT TITLE:

PROJECT ID: PI:

RESEARCH THEME:

PROJECT START DATE:

BUDGET:

I/UCRC EXECUTIVE SUMMARY | PROJECT UPDATE

DESCRIPTION:

PROJECT OBJECTIVES: SCOPE:

HOW THIS IS DIFFERENT THAN RELATED RESEARCH:

MILESTONES TARGETED START DATE TARGETED END DATE

PERCENT COMPLETED OVERALL:

ISSUES AND RISKS:

NEXT STEPS:

BENEFITS TO INDUSTRY: EXPECTED DELIVERABLES:

MULTI-UNIVERSITY PROJECT:

UPDATED: OCTOBER 1, 2017

CHOT CONFIDENTIAL

Patient Engagement and Hospital Readmissions: The Role of Health Literacy

01-05171.UAB-FAU Robert Weech-Maldonado, Nancy Borkowski, & Justin Lord

Access to Care

6/15/2017

$45,000

Value-based reimbursement in healthcare has resulted in an increasing focus on patient engagement as a mechanism to improve post-acute care outcomes, particularly in reducing readmissions. However, interventions to address patient engagement should account for health literacy and generational differences. Strategies that may work with a high literacy population may not be as effective among a population with low literacy. Similarly, strategies used with millennials may not be as effective among baby boomers.

(1) Conduct a systematic literature review of the relationships among health literacy, generational differences, patient engagement, and hospital readmissions, (2) identify best practices to address barriers, and (3) propose a pilot project from findings.

Databases included PubMed, Scopus, and ABI Inform. Search terms include patient engagement, health literacy, and health outcomes/readmissions.

This research is attempting to examine the relationship between patient engagement and hospital readmissions as mediated by health literacy. Patient engagement is comprised of four separate but distinct elements. Personalizations (an element of engagement) has been linked to health literacy. It is from this aspect that the barriers to health literacy will be addressed using the social ecological model. This paper will also highlight the best practices/strategies to addressing health literacy barriers which will in turn improve patient engagement.

Systematic Literature Review 8/1/2017 10/30/2017

Synthesize Findings 11/1/2017 1/31/2018

Propose a Pilot Project 2/1/2018 5/31/2018

Draft of Report 6/1/2018 8/31/2018

25%

There is limited research that examines health literacy as a mediator between patient engagement and health outcomes. Our study is focused on reducing readmissions; however, the limited existing literature exploring patient engagement and health literacy in areas of different diseases and contexts. This may pose a possible limitation but provide a unique opportunity to contribute new findings to this field.

Complete the literature review to identify the relationship between patient engagement and readmissions as mediated by health literacy. Will start on the draft of the report.

This project will provide the foundation for future interventions of health system strategies to address barriers related to health literacy generational differences, increase patient engagement, and improve patient outcomes.

A final report outlining the findings of the literature review and the proposed pilot project.

UAB & FAU

99

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PROJECT TITLE:

PROJECT ID: PI:

RESEARCH THEME:

PROJECT START DATE:

BUDGET:

I/UCRC EXECUTIVE SUMMARY | PROJECT UPDATE

DESCRIPTION:

PROJECT OBJECTIVES: SCOPE:

HOW THIS IS DIFFERENT THAN RELATED RESEARCH:

MILESTONES TARGETED START DATE TARGETED END DATE

PERCENT COMPLETED OVERALL:

ISSUES AND RISKS:

NEXT STEPS:

BENEFITS TO INDUSTRY: EXPECTED DELIVERABLES:

MULTI-UNIVERSITY PROJECT:

UPDATED: OCTOBER 1, 2017

CHOT CONFIDENTIAL

Impact of Direct-to-Consumer Telemedicine on Downstream Health Care Utilization and Costs

02-05171.TAM Cynthia LeRouge

Access to Care

12/15/2017

$50,000

Direct-to-consumer telemedicine (DTCT) provides patient-initiated, on-demand access to care for common non-emergent conditions using real-time interactive technologies. DTCT holds the promise of increased accessibility, improved service fit, and cost containment/savings. However, more research is needed to assess the impact of DTCT on downstream use of health care services and associated costs. We will use a retrospective observational study design to describe, analyze, and report information on service utilization and spending patterns among DTCT users and a control group of non-users across different patient populations and organizational settings.

Compare patterns of service utilization and cost between DTCT users and non-users among self-insured and Medicaid patients. Examine the extent to which DTCT visits replace in-person visits among Medicaid enrollees for leading DTCT conditions.

Health organizations offering DTCT services to self-insured and Medicaid patient populations. Data capture across multiple provider organizations with service areas across the United States (WA, IL, WI, OK).

The project represents a new and timely step in advancing DTCT research among different health organizations, patient populations, and types of non-emergent conditions. This study will be the first to explore downstream utilization and cost using datasets that combine longitudinal claims files with DTCT encounter data from a telemedicine vendor company, allowing for a novel examination of relationships between socio-demographic/encounter variables and downstream utilization and cost following DTCT use. We will also offer first insights into how DTCT effects underserved populations that may benefit most from the accessibility and low cost of DTCT.

Gather and Clean Data 12/15/2017 6/30/2018

Descriptive Analysis 2/1/2018 6/30/2018

Final Modeling 3/1/2018 8/31/2018

Reporting Deliverables 9/1/2018 12/14/2018

15%

Negotiating data use agreements with participating organizations. Potential challenges and delays with secure data capture/transfer. Potential challenges and delays with cleaning and management of claims data (i.e. missing data, file formatting).

Complete data use agreements with participating health organizations Securely transfer data to University of Washington servers Complete data cleaning and management needs Complete data descriptive analysis and statistical modeling Complete expected reporting deliverables

Provide insights regarding DTCT impact on service utilization and cost across different target markets and organizational settings. Share strategies to evaluate return on investment for DTCT.

PPT slide deck of key findings for CHOT members. Submit abstract(s) to conference proceedings.

TAM

100

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PROJECT TITLE:

PROJECT ID: PI:

RESEARCH THEME:

PROJECT START DATE:

BUDGET:

I/UCRC EXECUTIVE SUMMARY | PROJECT UPDATE

DESCRIPTION:

PROJECT OBJECTIVES: SCOPE:

HOW THIS IS DIFFERENT THAN RELATED RESEARCH:

MILESTONES TARGETED START DATE TARGETED END DATE

PERCENT COMPLETED OVERALL:

ISSUES AND RISKS:

NEXT STEPS:

BENEFITS TO INDUSTRY: EXPECTED DELIVERABLES:

MULTI-UNIVERSITY PROJECT:

UPDATED: OCTOBER 1, 2017

CHOT CONFIDENTIAL

Telehealth & Remote Patient Monitoring Systems Improve Access & Promote Patient Engagement in Rural Communities

03-05171.UAB-GIT Shannon Houser, Darrell Burke, & Eva Lee

Access to Care

6/1/2017

$100,000

Timely access to quality healthcare service is a real challenge--as outlined in the 2015 IOM report--and misalignment of resources and demands results in a long delay for care. Telehealth can offer alternative and timely care to rural area patients who lack sufficient healthcare options. Telehealth can also help to improve health conditions and to promote active patient engagement, which is particularly important for chronic disease management. This project identifies drivers and barriers of patient engagement by population groups and chronic conditions and provides recommendations for implementing appropriate telehealth/telemedicine interventions.

(1) Examine patient populations' engagement in successful use of telehealth/telemedicine options and (2) explore the success of telehealth/telemedicine interventions in chronic conditions and design a remote patient monitoring system of practical usage .

(1) Databases: PubMed, Scopus, CINAHL, Embase, and ABI/Inform, (2) Search terms including telehealth, telemedicine, m-health, e-health, obesity, COPD, diabetes, and (3) A prototype remote-patient monitoring system to connect patients and providers.

The adoption of telemedicine and level of patient engagement and services provided across healthcare facilities remain uneven and far from optimal. There has been little research examining various patient populations engagement in the successful use of telehealth/telemedicine options. By exploring successful application in rural care setting, this study will define the terms telehealth and telemedicine. We will also investigate and design a personalized remote patient monitoring system to connect patients and providers.

Systematic Literature Review 8/1/2017 10/30/2017

Gap Analysis 11/1/2017 1/31/2018

Data and System Modeling 7/1/2017 5/31/2017

Draft of Report 6/1/2018 8/31/2018

35%

Availability of studies related to COPD, privacy, and issuance policy remain critical issues.

Complete the literature review to identify barriers to patient engagement and look at the successful interventions of telehealth/telemedicine in chronic conditions. Complete the design of the remote patient monitoring prototypical system.

This project will help industry members understand the benefits of implementation of telehealth/telemedicine practices to improve patients' health. It will establish a viable, low-cost remote patient monitoring system.

1) Systematic literature review 2) Prototype remote patient monitoring device

UAB & GIT

101

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PROJECT TITLE:

PROJECT ID: PI:

RESEARCH THEME:

PROJECT START DATE:

BUDGET:

I/UCRC EXECUTIVE SUMMARY | PROJECT UPDATE

DESCRIPTION:

PROJECT OBJECTIVES: SCOPE:

HOW THIS IS DIFFERENT THAN RELATED RESEARCH:

MILESTONES TARGETED START DATE TARGETED END DATE

PERCENT COMPLETED OVERALL:

ISSUES AND RISKS:

NEXT STEPS:

BENEFITS TO INDUSTRY: EXPECTED DELIVERABLES:

MULTI-UNIVERSITY PROJECT:

UPDATED: OCTOBER 1, 2017

CHOT CONFIDENTIAL

Development of a Middleware Framework for Medical Device Integration for Telemedicine

04-05171.FAU Ankur Agarwal

Access to Care $50,000

An integration of mobile, wireless, and sensor technologies has the potential to greatly advance the ability to enable automated data collection for monitoring patient health status in real time, even from a remote environment. This could dramatically increase the ability to rapidly respond to a critical healthcare need. However, the networking capability of currently available health status monitoring devices is limited in functionality and primarily relies on proprietary communication protocols offered by a multitude of different vendors. Furthermore, current systems are missing critical elements of a truly robust system.

-Design a working prototype based on IEEE11073 protocol -Develop a hardware/software used for interfacing biosensors -Evaluate and Expand existing capabilities of the IEEE 11073 protocol to enable remote patient monitoring

The networking capability of currently available health status monitoring devices is limited in functionality and primarily relies on proprietary communication protocols offered by a multitude of different vendors and current systems are missing critical elements of a truly robust system. The development of a middle-ware layer framework in this project will be able to use the recorded data to continuously mine it in real-time to detect data inconsistencies due to network issues. Then, the intelligent system engine (knowledge base) could automatically detect potential health-related issues in patients and alert the caregivers.

Understand IEEE 11073 Protocol

Middleware Layer Completion

Develop a "MOT"

Testing Various Devices

0%

This project provides better remote patient monitoring while keeping costs down. The current project further provides unique technology to reduce the cost for patient data collection thereby helping the economics of home-healthcare providers, nursing homes.

A prototype which is based on IEEE 11073 protocol for various device integration. The system will be interface with various medical devices which are compatible with WiFi and Bluetooth for physiological data collection. The software will based on LAMP environment and hosted on amazon cloud in a secured manner.

FAU

102

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PROJECT TITLE:

PROJECT ID: PI:

RESEARCH THEME:

PROJECT START DATE:

BUDGET:

I/UCRC EXECUTIVE SUMMARY | PROJECT UPDATE

DESCRIPTION:

PROJECT OBJECTIVES: SCOPE:

HOW THIS IS DIFFERENT THAN RELATED RESEARCH:

MILESTONES TARGETED START DATE TARGETED END DATE

PERCENT COMPLETED OVERALL:

ISSUES AND RISKS:

NEXT STEPS:

BENEFITS TO INDUSTRY: EXPECTED DELIVERABLES:

MULTI-UNIVERSITY PROJECT:

UPDATED: OCTOBER 1, 2017

CHOT CONFIDENTIAL

Data-Driven Predictive Analytics to Improve Diagnosis and Treatment -- Innovation to Cancer Treatment

05-05171.GIT Eva Lee, Cao Yu, Alistair Temple, Rui Yao, & Jame Chu

Analytics & Innovative Technologies

4/1/2017

$120,000

Personalized data-driven predictive analytics is one of the most significant topics in recent years. With the newly improvement of imaging technology, personalized high-quality data collection has become quick and reliable. Machine learning and statistics based high-level representation of these data induce accurate diagnosis. With the help of advanced optimization planning algorithm and equipment frontier, a very precise individualized treatment can be delivered. Care coordination and resource utilization remain an uphill-battle up until now. Data-driven novel analytics combined with innovative planning will definitely reform this field.

Utilizing the PET imaging and data-driven imaging reconstruction,we obtain individualized cancer biology and tumor cell distribution. Capture the nature of the tumor cells by data-driven deep learning further boost diagnosis accuracy and plan quality.

PET enables characterization of tumor cells. The robustness of data-driven approach leads us to find the nature in disease source, which results in an enhancement in treatment planning. Initial focus will be on prostate, head-and-neck and lung cancer.

This project analyzes heterogeneous types of data including imaging, clinical and biological patient data across multiple clinic sites and platforms using large-scale data and predictive analytics. The study involves precision medicine, utilizing individual patient-specific data to advance innovative disease treatment with lab diagnostics and imaging advances. It will contribute to the development of state-of-the-art system data analytics and real-time decision technologies with broad applicability. This study is the first biological image-guided cancer treatment. We have currently completed cancer cases of the prostate, lung, and head-and-neck.

PET Guided Treatment Planning Models 4/1/2017 8/31/2017

Optimization for Individualized Plan Design 9/1/2017 10/31/2017

Machine Learning to Characterize Plan Result 7/1/2017 2/28/2018

Plan Performance Comparison 11/1/2017 3/31/2018

60%

We have thus far obtained outstanding treatment results for prostate, head-and-neck and lung cancer patients, compare to current approaches. One of the remaining challenges is to efficiently reconstruct the imaging using advanced data-driven algorithms. A better dose delivery control measurement is needed to characterize the dose delivered to PET pockets. A clear interpretation of the data-driven machine learning result of large scale patients' data will be useful for generalization to multiple clinical sites.

More patient cases will be tested and further analyzed to explore tumor cells response to radiation with respect to normal cells. We will investigate real-time generation of tumor constraints. Machine learning will be used to analyze which models work best for what tumor and biological characteristics. Highly-integrated simulation and optimization system will be used to optimize care coordination and resource utilization.

Improve quality of care, improve tumor control, improve treatment outcome, improve care coordination, improve resource usage, and advance data analytics for innovative cancer treatment.

Improved treatment plans and a new data-driven model combining cancer biology with cells distribution for advanced personalized treatment. The system results in improved plan quality, improved treatment outcome, and reduce hospital resources (due to shorter treatment time).

GIT

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Machine Learning for Evidence-Based Practice, Risk Prediction, and Optimal Care Coordination and Outcome

06-05171.GIT Eva Lee, Joe Malecki, Chris Kwan, Ellie Cheng, & Cody Wang

Analytics & Innovative Technologies

4/1/2017

$80,000

Fueled by rapid digital media advances, healthcare systems are investing more in advanced sensors and robotics, communication technologies, and sophisticated data centers. This facilitates information and knowledge visibility and delivery standardization and performance efficiency through big data analytics. In this study, 20 years of millions of EMR records are used to perform machine learning and data mining to identify evidence and characteristics of best practice, uncover risk factors of different patient groups, develop effective clinical practice guidelines and disease management strategies, and optimize the service delivery to meet demand.

Apply machine learning, optimization and decision models to EMR to uncover evidence and treatment knowledge. We aim to determine timing, decision and treatment options within clinical patient care process that positively influence the outcome.

We will initially focus on chronic kidney disease (CKD) and prostate cancer. The work will expand to other chronic diseases including cardiovascular patients, diabetes, hypertension, arthritis and sepsis treatment control.

This project involves multi-units, multi-disease and stakeholders. It is the first study of this kind that includes a massive amount of data across heterogeneous hospital and provider sites. The data captures a diverse population across the United States with varying demographics, clinical practices, and outcome measures.

Data Extract from EMR and Deidentification 4/1/2017 8/1/2017

Text Mining and Clinical Concept Mapping 6/1/2017 10/1/2017

Clinical Process Maps and Simulation Models 7/1/2017 12/1/2017

Clustering and Outcome Prediction Model 10/1/2017 3/31/2018

60%

This project is the first study of this kind that combine machine learning with simulation models and process maps to identify major clinical bottle necks and optimize treatment timing, process and decision making using a holistic, evidence-based approach. It includes a massive amount of data across heterogeneous provider sites, and initially we tackle prostate cancer and all stages of CKD patients.

1) Use machine learning to uncover treatment evidence and critical clinical features to predict outcome. 2) Complete disease progression model to understand and optimize the current treatment process. 3) Build simulation models to identify bottlenecks and optimize resources allocation and other clinical processes for best outcome. 4) Design optimized evidence-based treatment plans and dissemination of this knowledge and best practice transfer to multiple sites.

1) Improve quality and efficiency of care across patient population. 2) Identify best practice, offer evidence-based care. 3) Optimize timing and individualized treatment 4) Reduce unnecessary resources/procedures

1) Identification of effective treatment plans and best practice characteristics. 2) Optimization of evidence-based treatment plans. 3) Detailed plans and methods for best practice transfer across hospital sites.

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CHOT CONFIDENTIAL

Using Care Coordination to Address Cost, Quality, and Access to Care Across Systems and Populations

07-05171.TAM Bita Kash & Farzan Sasangohar

Care Coordination

6/1/2017

$250,000

Consumers access healthcare in a multitude of settings, ranging from acute care to home and community based services (HCBS). With a variety of access points, care coordination programs are essential to facilitate care from one system to another, which emphasizes the isolated nature of the US healthcare system. In an effort to bring about broader systemic changes, this project aims to develop a care coordination program that focuses on the utilization of a bio-psycho-social model and leveraging community resources to facilitate care coordination outcomes.

Identify best practices for improving care coordination across systems and populations. Develop a toolkit for providers to evaluate practice and identify gaps in care coordination

Use of PubMed (MEDLINE) database Use of CINAHL database Use of Embase database

Related research focuses on a piece meal approach to improving care coordination, often focusing on single visits and procedures, rather than the whole continuum of care. This project takes a more holistic approach by defining the continuum of care and developing models of collaborative best practices in care coordination that take into account the full system of care.

Systematic Literature Review 9/1/2017 12/20/2017

Team Care: Measurement Tools Needed 9/1/2017 1/31/2018

Evaluation of Selected CC Programs 9/1/2017 4/15/2018

Creation and Dissemination of Toolkit 3/1/2018 5/31/2018

80%

We do not foresee any risks with this project as it is mostly dependent on time and effort from PIs and graduate research assistants. A potential survey on care team effectiveness might produce response rate issues.

Write up final reportComplete list of tools and metrics, evaluation of care coordination programs, create and disseminate toolkit

This project will assist industry members in identifying best practices for improving care coordination across systems and populations.

1) Care coordination model for people with disabilities, theirfamilies, providers, and communities; 2) template for integratinginstitutional care and community care coordination; 3) structuredtoolkit for providers to access their practice and identify gaps incoordination; and 4) manuscript and conference presentations

TAM

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Effects of Care Coordination on the Improvement of Quality of Care

08-05171.UAB Nathan Carroll and Midge Ray

Care Coordination

6/1/2017

$65,000

Transitions in patient care include home/community to acute care to post-acute care back to home/community. During these transitions, gaps in care may occur, which can negatively impact quality as well as increase healthcare costs. Two examples are hospital-acquired infections (HAI) and reconciliation for discharged and/or transferred patients. Both remain high nationwide, meaning providers have an opportunity to improve the quality of care they offer during care transitions. This project summarizes best practices for HAIs and identifies peer-reviewed evaluations of programs for medication management and adherence to reduce readmission rates.

Demonstrate practices to reduce certain hospital-acquired conditions and prevent readmissions from medication adherence. Identify best practices to increase quality of care while reducing avoidable costs.

Various databases have been used to conduct a systematic literature review including CINAHL, PubMed, Scopus, Cochrane, and Embase

The literature contains numerous case studies of HAIs and medication non-adherence, but is limited in nature. HAIs have been studied, but literature is scarce on hospital-acquired clostridium difficile (C. diff) infection. The literature on programs made to improve medication adherence and reconciliation for discharged patients has yet to be considered a cohesive body. A systematic review of published evaluations of readmission reduction programs will allow researchers to identify best practices common to the most effective programs and will identify elements important to the programs' success and intervention characteristics that are less effective.

Develop a Search Strategy 6/15/2017 7/15/2017

Synthesize Findings 7/16/2017 11/15/2017

First Draft for Industry Feedback 12/1/2017 2/1/2017

Final Draft of Report 2/15/2017 4/1/2017

40%

Synthesis of findings may be challenging as numerous variables are involved in all the studies.

(1) Identifying predictors of hospital-acquired C. diff infection (2) Identifying interventions for reducing medication non-adherence related hospital readmissions.

This project will assist industry members in better understanding how to reduce certain hospital-acquired conditions, and to prevent readmissions relating to medication adherence. The "best practices" identified will help industry members to increase quality of care while reducing avoidable costs.

Final reports outlining the findings of literature reviews and recommendations.

UAB

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Effects of Care Coordination on Care Transitions

09-05171.FAU-UAB Ravi Behara, Tapan Mehta, & Robert Weech-Maldonado

Care Coordination

6/15/2017

$100,000

Care coordination programs and care transition programs often center on the intersection of acute care and chronic care (such as the transition from nursing home to hospital), but in reality people access healthcare in a multitude of settings. This project aims to develop a care coordination program that focuses on measuring care coordination program impact, utilize the bio-psycho-social and spiritual model, and create a model that continually improves provider collaboration specifically for older adults and individuals with disabilities. This approach can play a critical role especially when dealing with under-served and underrepresented populations.

Develop metrics to measure care coordination program impact Utilize the bio-psycho-social and spiritual model Build a community-based care coordination model for older adults and people with disabilities that is continually improving

Databases include PubMed, Scopus, CINAHL, and Google Scholar. Search terms include care coordination, care transition, and spinal cord injuries.

Traditional research in care coordination is related to coordination between acute and/or chronic care providers. Yet, delivery of care to older adults and people with disabilities extends beyond traditional institutional-based clinical care to include home-based care, as well as services which are social, financial, legal, and spiritual in nature. This project broadens the perspective of care coordination by developing a system that also includes the non-traditional participants, such as social service and public health agencies, religious organizations, and end-of life services, in addition to traditional participants such as hospitals and skilled nursing homes.

Systematic Literature Review 8/1/2017 10/30/2017

Gap Analysis 11/1/2017 1/31/2018

Data and System Modeling 2/1/2018 5/31/2018

Draft of Report 6/1/2018 8/31/2018

25%

Availability of specific studies related to spinal cord injuries may be limited.

Complete the literature review to identify models of care coordination and care transition for patients transitioning from acute care to post-acute care setting.

This project will help industry members understand the benefits and the effects of care coordination on care transitions outside of traditional healthcare settings. If successful, partnerships between healthcare systems and community partners can be way to improve the quality of life of people with disabilities.

(1) Care coordination model, (2) template for institutional care, (3)structured toolkit for providers to assess their practice, (4) functionally-working cloud-based solution of a learning care coordination system, and (5) manuscripts and conference calls

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A Mobile Based Care Coordination System for Critical Care

10-05171.FAU Ankur Agarwal and Ravi Behara

Care Coordination

8/30/2017

$50,000

Currently, the healthcare industry is going through rapid transformations including readmission penalties, payment bundling, and patient compliance related medical coding. Such changes have given rise to Accountable Care Organizations (ACO) and Managed Care Organizations (MCO). These organizations are directly incentivized to reduce the cost of healthcare as well as improve quality in order to stay profitable. This project aims to develop a mobile-based care coordination system for critical care patients. The created system will provide a secured, asynchronous messaging system, which will ensure an instant communication with the entire care team for a patient.

Design a HIPAA compliant messaging platform to ensure a timely delivery of message to a patient's care team Facilitate tight communication, collaboration, and coordination among care team members.

The project will develop a mobile application for the medical practitioner (physicians, nurses) and a web-based system for backend data.

While communication or the lack of it is the main reason for missed diagnosis, hospital admission, readmission, and duplication of care, it has not yet been successfully addressed in any EHR system. Though several new mobile healthcare messaging applications have been implemented, they are basically HIPAA compliant text messaging among doctors (i.e. WhatsApp) and effectively create more silos. This project proposes to build a mobile EHR agnostic application connecting the patient with their outpatient and inpatient doctors, staff, and others related to care for intelligent communication, which has potential to improve healthcare and provide opportunities.

Compare and Analyze System 8/30/2017 10/30/2017

Develop Prototype System 10/15/2017 4/30/2018

Internal System Testing 5/1/2018 5/30/2018

Prepare Final Product 6/1/2018 7/30/2018

25%

System adaptability is always a challenge for this type of project. There needs to be a mind set for medical professionals to be open to adopting the new technology. Transitions to a new technology pose the challenge in terms of training and efficiency of usage and adaptability. Further, in an ideal scenario, the system should be able to communicate with an EHR system; such interface is available for modern solution via CDA interface. It becomes a training issue for the medical office to learn to make it communicate with their existing EHR systems.

We have completed the system analysis phase of the project by comparing various current systems in the medical space. The gaps among the current solutions have been identified. We have finalized a system design and the technology mapping. The next step in the project is to develop the system prototype and then take it for an internal system testing.

Care coordination is a major issue which has been clearly identified by healthcare companies. The proposed system provides a method and presents an approach to coordinate care among various care givers specifically for sick patients such as critical care where several medical professionals are engaged.

The deliverable for this project is a report comparing various care coordination systems and a working prototype for phase-2 deliverable. The prototype will be a cloud-based mobile application developed on a LAMP environment.

FAU

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Integration of Population Health Data and Digital Assistants to Reduce Readmission Risks

11-05171.PSU-GIT Conrad Tucker, Eva Lee, Alva Ferdinand, & Susan Feldman

Population Health

9/1/2017

$50,000

Frequently, the factors that influence medical readmissions exist outside the borders of a healthcare setting and include patient-level decisions and societal interactions. The objective of this project is to leverage the size and availability of population health data to model and predict readmission risk factors. Data will be acquired on a large scale by mining publicly-available websites. The collected data will then be used to segment, model, and identify patients at risk of medical readmissions. For patient segments at a high risk of readmission, digital assistants (e.g. IBM Watson) will provide interactive feedback in an attempt to mitigate the risks.

Create a model that predicts readmission risk factors from population health data. Evaluate the impact of digital assistants in reducing medical readmission through pilot study.

Acquire large scale publicly available health data my mining. Segment, model, and identify patients at risk. Intervene via digital assistants. Conduct an experiment to evaluate impact. Report results.

Typically, medical readmission research focuses on investigating clinical-level factors (such as age and medical condition) that have the potential of increasing medical readmission. Yet when patients leave the hospital, a wide range of factors may influence their risk profiles, such as their support system and social norms. This project includes population health data that provides a more holistic understanding of what happens to patients once they are discharged from the hospital and utilizes a digital assistant that can provide real time decision support to patients who have been predicted to be at a higher risk of readmission.

Identify Data Features that Predict Risk 9/1/2017 10/15/2017

Evaluation of Value of Digital Assistants 10/1/2017 11/20/2017

Integration into Healthcare System Pilot 1/1/2018 3/1/2018

Dissemination of Work/Publications 3/1/2018 3/31/2018

10%

Risk of not acquiring enough meaningful data from publicly available social media sites due to privacy settings. Recruiting pilot subjects with the criteria needed to evaluate sufficiently.

Create Model of the features in social media data that predict medical readmission Create Digital Assistant (e.g., IBM Watson) that is tailored to providing interventions for patients at risk of medical readmissions.

This project benefits industry in several ways: 1) Discovery of the value of publicly available social media data in modeling patient-specific outcomes 2) Quantify the impact of digital assistants in serving as ubiquitous decision support systems

1) Model of features in social media data that predict medical readmission 2) Digital assistant (e.g., IBM Watson) that is tailored to providing interventions for patients at risk of medical readmissions

PSU & GIT

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CHOT CONFIDENTIAL

Gamification and its Impact on the Population Health Management of Chronic Conditions

12-05171.PSU-GIT Nilam Ram, Eva Lee, Sherry Lin, & Susan Feldman

Population Health

9/1/2017

$50,000

Despite advances is medical technologies and public awareness programs, the rates of chronic conditions such as diabetes and asthma continue to rise. For example, in the United States, more than 29 million individuals have been diagnosed with diabetes, with a new diagnosis occurring every 23 seconds. This data indicates the need to evaluate the clinical effectiveness and economic impact of different approaches to managing diabetes and asthma. Data analysis will measure the impact of gamification methods in changing the behavior of patients, toward better healthcare outcomes.

The objective of this project is to evaluate the efficacy of chronic condition treatment programs.

Evaluate the clinical effectiveness and economic impact of approaches to managing diabetes and asthma; exploring secondary data analysis of program operations and biometric data on participants; investigating impact that gamification methods.

Existing research has focused on predicting factors that influence chronic diseases, but a knowledge gap exists between research on chronic disease management and translating the recommended practices for disease management. This project aims to identify specific practices that best translate into practice, as well as explore the influence of gamification in chronic disease management to determine whether successful implementations in other settings (e.g. education and rehabilitation) can be adapted for management of chronic disease.

Review Existing Lit on Existing Mgt. Programs 9/1/2017 9/30/2017

Study Factors that Facilitate Adoption of tech 9/30/2017 11/30/2018

Quantify Impact of Gamification (experiment) 1/1/2018 3/1/2018

Dissemination of Research/Publication 3/1/2018 3/31/2018

10%

Ineffectiveness or loss of interest in gamification. An increased addiction to mobile games. Reduced participation due to design of game (i.e. adverse to 3-D play)

Create and demonstrate downloadable apps that uses gamification to manage diabetes and asthma in conjunction with an industry partner for possible commercialization.

This project benefits industry in several ways: 1) Understanding the sets of basic research that may contribute to better management of chronic conditions 2) Exploring the role of gamification in changing behavior, towards positive health outcomes

1) Knowledge about the factors that impact chronic diseases such as diabetes and asthma 2) Gamification model that demonstrates short-term and long-term behavior changes in patients with chronic health conditions.

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Improving Employee and Patient Health through Population Data Mining

13-05171.PSU Vasant Honavar

Population Health

9/1/2017

$50,000

The majority of patients' time is spent away from the healthcare facility, where there exists little to no ability of healthcare decision makers to monitor patients' health improvement or outcomes. A recent study by the CDC reported that 54% (for women) and 42% (for men) of the 33+ million injuries occurring between 2004-2007 were inside/outside of home. The emergence of ubiquitous sensing systems such as mobile phones and wearable sensors has enabled the rapid acquisition of health-related data at population scale. This indicates the need to explore the ability to mine ambulatory data in order to improve employee and patient health outcomes.

The objective of this project is to explore methods to effectively manage the health of a population, who typically spend a majority of their time outside the confines of a healthcare facility.

Explore the current barrier that exist to capturing health-related data at home/work; conduct interviews at medical facility to gain understanding of needs; design a mobile app that has the ability to capture patient-specific data to be aggregated for population.

Existing research related to population health is limited by data acquisition tools (e.g. mobile app) currently available. Rather than utilize existing data acquisition tools, this project will design and create a data acquisition tool that is based on patient and employee feedback. Such feedback will guide tool development to ensure it is highly customizable, user friendly, patient access friendly, and valued by the healthcare decision makers and patients.

Understand In-Situ / Health Data Challenges 9/1/2017 10/15/2017

Quantify Attributes Needed for Mobile App 10/15/2017 12/15/2017

Design/Dev. iOS and Android App to Deploy 1/1/2018 3/1/2018

Disseminate Research 3/1/2018 3/30/2018

10%

Lack of access to devices. Fear of loss of privacy.

Work with industry partner to optimize and commercialize iOS and Android applications.

1) Healthcare app that can be deployed to capture patient-specific data 2) Data mining tool that can be used to extract valuable information from patient-centered data

1) Knowledge of the needs of patients and employees 2) Functional iOS and Android app 3) Data mining model that informs provision of patient-centered health care

PSU

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