2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016...
Transcript of 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016...
2016 International Conference of the Korean Society for Molecular and Cellular BiologyK
SM
CB
wwwksmcborkr
SeminarConference Room (3F-4F)
Exhibition amp Poster PresentationHall D1 (3F)
2016 International Conference of the Korean Society for Molecular and Cellular Biology
October 12 (Wed) ndash 14 (Fri) 2016
COEX Seoul Korea
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
2016International Conference of the Korean Society for Molecular and Cellular BiologyOctober 12 (Wed) - 14 (Fri) 2016
COEX Seoul Korea
Organization
Co-Organizations
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
한국분자세포생물학회
2016년 정기학술대회 개최를 축하합니다
회원 여러분의 열정적인 연구로
꺼져가는 생명의 촛불이 살아납니다
한국분자세포생물학회 회원 여러분의
헌신에 경의를 표합니다
강원도 원주시 성지병원 고을용
전라남도 목포시 홍인연합의원 최창준
광주광역시 삼성정맥류클리닉 박경덕
광주광역시 에덴병원 김병룡
전남대학교 의과대학 최석용
Sponsors
This Work was supported by the Korean Federation of Science and Technology Societies (KOFST) grant funded by the Korean Government
2016 International Conference of the Korean Society for Molecular and Cellular Biology 1
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Contents
Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards
Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43
Luncheon Symposia
Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop
(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
983790 Molecules and Cells (Mol Cells)
Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)
Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)
Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)
- Korearsquos leading online open-access journal in the life science
- Indexed in Science Citation Index (SCI)
- International readership
- Spans the breath of molecular and
cellular biology
- Monthly publication
- Rapid review
- URL httpwwwmolcellsorg
- eISSN 0219-1032
Impact factor 267
983790 President Joonho Choe (KAIST Korea)
983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)
983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)
983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees
Scientific Program Committee Dae-Sik Lim (KAIST Korea)
Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)
Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)
Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)
983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)
Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)
Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSCMB Organizing Committee
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Invitation
Invitation
Dear Colleagues
On behalf of the Organizing Committee I am delighted to welcome all the participants
to the International Conference of the Korean Society for Molecular and Cellular Biology
(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The
conference will give you a platform to broaden your knowledge and exchange ideas on
diverse topics in cellular and molecular biology It will also provide the opportunities for
networking among participants In addition many companies and industries in the field of
bioscience will be present for exhibition of research materials biotools and equipment
The conference will be held at the COEX Convention Center which is located in the heart
of Gangnam Seouls business entertainment shopping and culture district
The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the
latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-
search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)
Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering
Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-
turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-
tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies
in the symposia
There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life
Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the
AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical
Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international
participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women
in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science
With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange
the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-
ence for all participants
I look forward to meeting you in Seoul this October
Best regards
Joonho Choe PhD
President KSMCB
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
2016International Conference of the Korean Society for Molecular and Cellular BiologyOctober 12 (Wed) - 14 (Fri) 2016
COEX Seoul Korea
Organization
Co-Organizations
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
한국분자세포생물학회
2016년 정기학술대회 개최를 축하합니다
회원 여러분의 열정적인 연구로
꺼져가는 생명의 촛불이 살아납니다
한국분자세포생물학회 회원 여러분의
헌신에 경의를 표합니다
강원도 원주시 성지병원 고을용
전라남도 목포시 홍인연합의원 최창준
광주광역시 삼성정맥류클리닉 박경덕
광주광역시 에덴병원 김병룡
전남대학교 의과대학 최석용
Sponsors
This Work was supported by the Korean Federation of Science and Technology Societies (KOFST) grant funded by the Korean Government
2016 International Conference of the Korean Society for Molecular and Cellular Biology 1
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Contents
Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards
Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43
Luncheon Symposia
Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop
(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
983790 Molecules and Cells (Mol Cells)
Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)
Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)
Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)
- Korearsquos leading online open-access journal in the life science
- Indexed in Science Citation Index (SCI)
- International readership
- Spans the breath of molecular and
cellular biology
- Monthly publication
- Rapid review
- URL httpwwwmolcellsorg
- eISSN 0219-1032
Impact factor 267
983790 President Joonho Choe (KAIST Korea)
983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)
983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)
983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees
Scientific Program Committee Dae-Sik Lim (KAIST Korea)
Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)
Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)
Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)
983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)
Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)
Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSCMB Organizing Committee
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Invitation
Invitation
Dear Colleagues
On behalf of the Organizing Committee I am delighted to welcome all the participants
to the International Conference of the Korean Society for Molecular and Cellular Biology
(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The
conference will give you a platform to broaden your knowledge and exchange ideas on
diverse topics in cellular and molecular biology It will also provide the opportunities for
networking among participants In addition many companies and industries in the field of
bioscience will be present for exhibition of research materials biotools and equipment
The conference will be held at the COEX Convention Center which is located in the heart
of Gangnam Seouls business entertainment shopping and culture district
The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the
latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-
search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)
Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering
Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-
turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-
tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies
in the symposia
There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life
Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the
AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical
Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international
participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women
in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science
With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange
the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-
ence for all participants
I look forward to meeting you in Seoul this October
Best regards
Joonho Choe PhD
President KSMCB
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
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KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
한국분자세포생물학회
2016년 정기학술대회 개최를 축하합니다
회원 여러분의 열정적인 연구로
꺼져가는 생명의 촛불이 살아납니다
한국분자세포생물학회 회원 여러분의
헌신에 경의를 표합니다
강원도 원주시 성지병원 고을용
전라남도 목포시 홍인연합의원 최창준
광주광역시 삼성정맥류클리닉 박경덕
광주광역시 에덴병원 김병룡
전남대학교 의과대학 최석용
Sponsors
This Work was supported by the Korean Federation of Science and Technology Societies (KOFST) grant funded by the Korean Government
2016 International Conference of the Korean Society for Molecular and Cellular Biology 1
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Contents
Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards
Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43
Luncheon Symposia
Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop
(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
983790 Molecules and Cells (Mol Cells)
Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)
Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)
Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)
- Korearsquos leading online open-access journal in the life science
- Indexed in Science Citation Index (SCI)
- International readership
- Spans the breath of molecular and
cellular biology
- Monthly publication
- Rapid review
- URL httpwwwmolcellsorg
- eISSN 0219-1032
Impact factor 267
983790 President Joonho Choe (KAIST Korea)
983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)
983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)
983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees
Scientific Program Committee Dae-Sik Lim (KAIST Korea)
Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)
Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)
Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)
983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)
Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)
Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSCMB Organizing Committee
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Invitation
Invitation
Dear Colleagues
On behalf of the Organizing Committee I am delighted to welcome all the participants
to the International Conference of the Korean Society for Molecular and Cellular Biology
(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The
conference will give you a platform to broaden your knowledge and exchange ideas on
diverse topics in cellular and molecular biology It will also provide the opportunities for
networking among participants In addition many companies and industries in the field of
bioscience will be present for exhibition of research materials biotools and equipment
The conference will be held at the COEX Convention Center which is located in the heart
of Gangnam Seouls business entertainment shopping and culture district
The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the
latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-
search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)
Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering
Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-
turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-
tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies
in the symposia
There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life
Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the
AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical
Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international
participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women
in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science
With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange
the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-
ence for all participants
I look forward to meeting you in Seoul this October
Best regards
Joonho Choe PhD
President KSMCB
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
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KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 1
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Contents
Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards
Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43
Luncheon Symposia
Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop
(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
983790 Molecules and Cells (Mol Cells)
Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)
Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)
Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)
- Korearsquos leading online open-access journal in the life science
- Indexed in Science Citation Index (SCI)
- International readership
- Spans the breath of molecular and
cellular biology
- Monthly publication
- Rapid review
- URL httpwwwmolcellsorg
- eISSN 0219-1032
Impact factor 267
983790 President Joonho Choe (KAIST Korea)
983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)
983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)
983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees
Scientific Program Committee Dae-Sik Lim (KAIST Korea)
Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)
Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)
Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)
983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)
Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)
Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSCMB Organizing Committee
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Invitation
Invitation
Dear Colleagues
On behalf of the Organizing Committee I am delighted to welcome all the participants
to the International Conference of the Korean Society for Molecular and Cellular Biology
(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The
conference will give you a platform to broaden your knowledge and exchange ideas on
diverse topics in cellular and molecular biology It will also provide the opportunities for
networking among participants In addition many companies and industries in the field of
bioscience will be present for exhibition of research materials biotools and equipment
The conference will be held at the COEX Convention Center which is located in the heart
of Gangnam Seouls business entertainment shopping and culture district
The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the
latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-
search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)
Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering
Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-
turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-
tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies
in the symposia
There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life
Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the
AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical
Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international
participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women
in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science
With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange
the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-
ence for all participants
I look forward to meeting you in Seoul this October
Best regards
Joonho Choe PhD
President KSMCB
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
983790 Molecules and Cells (Mol Cells)
Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)
Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)
Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)
- Korearsquos leading online open-access journal in the life science
- Indexed in Science Citation Index (SCI)
- International readership
- Spans the breath of molecular and
cellular biology
- Monthly publication
- Rapid review
- URL httpwwwmolcellsorg
- eISSN 0219-1032
Impact factor 267
983790 President Joonho Choe (KAIST Korea)
983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)
983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)
983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees
Scientific Program Committee Dae-Sik Lim (KAIST Korea)
Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)
Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)
Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)
983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)
Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)
Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)
2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSCMB Organizing Committee
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Invitation
Invitation
Dear Colleagues
On behalf of the Organizing Committee I am delighted to welcome all the participants
to the International Conference of the Korean Society for Molecular and Cellular Biology
(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The
conference will give you a platform to broaden your knowledge and exchange ideas on
diverse topics in cellular and molecular biology It will also provide the opportunities for
networking among participants In addition many companies and industries in the field of
bioscience will be present for exhibition of research materials biotools and equipment
The conference will be held at the COEX Convention Center which is located in the heart
of Gangnam Seouls business entertainment shopping and culture district
The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the
latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-
search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)
Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering
Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-
turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-
tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies
in the symposia
There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life
Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the
AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical
Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international
participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women
in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science
With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange
the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-
ence for all participants
I look forward to meeting you in Seoul this October
Best regards
Joonho Choe PhD
President KSMCB
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 3
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Invitation
Invitation
Dear Colleagues
On behalf of the Organizing Committee I am delighted to welcome all the participants
to the International Conference of the Korean Society for Molecular and Cellular Biology
(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The
conference will give you a platform to broaden your knowledge and exchange ideas on
diverse topics in cellular and molecular biology It will also provide the opportunities for
networking among participants In addition many companies and industries in the field of
bioscience will be present for exhibition of research materials biotools and equipment
The conference will be held at the COEX Convention Center which is located in the heart
of Gangnam Seouls business entertainment shopping and culture district
The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the
latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-
search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)
Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering
Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-
turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-
tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies
in the symposia
There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life
Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the
AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical
Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international
participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women
in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science
With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange
the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-
ence for all participants
I look forward to meeting you in Seoul this October
Best regards
Joonho Choe PhD
President KSMCB
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Schedule Wednesday October 12 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402
0900-1030 Registration
1030-1200Young Investigators
Session IYoung Investigators
Session IIYoung Investigators
Session III
AMOREPACIFIC Great Global Next Generation
Research Award Lectures
Global Network Session
1200-1300 Break
1300-1440
Sym01Evolutionary Dynamics
of Transposable Elements
Sym02Insulin Resistance and Metabolic Disorders
Sym03Unconventional
Intercellular Protein Trafficking
Sym04Control of Neural Circuits for Animal
Behavior
Sym05Cell Division Control during Development
1440-1510 Break
1510-1530 Opening Ceremony (Rm 401)
1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)
1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)
Thursday October 13 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym06Cilia as Dynamic Organelles in
Development and Disease
Sym07Cell Cycle Control in
Disease
Sym08Epigenetic Roles in Cellular Processes
Sym09Memory Engram
Sym10Pathway and Network Analysis of Disease
Genomics Data
Poster Posting I0920-1800
Poster Presentation I1300-1430
1100-1120 Break
1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)
1210-1300
Koram Biotech ndash Cell Signaling Technology
Workshop
Logos Biosystems
WorkshopKSMCB
Council Meeting
1300-1430 Break amp Poster Viewing (Hall D1)
1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)
1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)
1600-1620 Break
1620-1800
Sym 11 Cell Fate Determination
Sym 12 Phospholipids as
Bioactive Cell Signaling Molecules
Sym 13 Autophagy in Cellular
Homeostasis and Human Diseases
Sym 14 Role of Oncogene in
Altered Tumor Metabolism and CSC
Generation
Sym 15 Mechanistic Regulation
of Organ Fibrosis
1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)
Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)
Luncheon Symposium
Friday October 14 2016
TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)
PosterExhibition
0800-0920 Registration
0920-1100
Sym 16 Metabolic Syndrome and
Cancer
Sym 17 Aging and Metabolic
Homeostasis
Sym 18 Big Data System Biology and Global
Health
Sym 19 Tumor Microenvironment
and Heterogeneity Emerging Targets for Cancer Treatment and
Prevention
Sym 20 Hippo Signaling in Development and
Disease
Poster Posting II0920-1700
Poster Presentation II1310-1500
1100-1130 Break
1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)
1220-1310
1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017
(미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Research Ethics Sym
(Korean) KSMCB General Assembly
1420-1440 Samsung Science and Technology
Foundation Workshop(삼성미래기술육성재단 워크샵)
1310-1500 Break amp Poster Viewing (Hall D1)
1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)
1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)
1620-1640 Break
1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)
1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards
Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)
Luncheon Symposium
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
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KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 5
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Schedu
le
4F
3F Conference Room (Lectures)
Hall D1 (Exhibition Poster Presentation)
Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)
Wednesday October 12 2016 Session Time Place
1 Young Investigators Session I
1030-1200
Rm 300
2 Young Investigators Session II Rm 307
3 Young Investigators Session III Rm 308
4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401
5 Global Network Session Rm 402
6 Sym 01 Evolutionary Dynamics of Transposable Elements
1300-1440
Rm 300
7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307
8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308
9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401
10 Sym 05 Cell Division Control during Development Rm 402
11 Opening Ceremony 1510-1530 Rm 401
12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401
13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401
Thursday October 13 2016 Session Time Place
1 Sym 06 Cilia as Dynamic Organelles in Development and Disease
0920-1100
Rm 300
2 Sym 07 Cell Cycle Control in Disease Rm 307
3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308
4 Sym 09 Memory Engram Rm 401
5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402
6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401
7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300
Rm 300
8 Logos Biosystems Workshop Rm 308
9 KSMCB Council Meeting Rm 402
10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401
11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401
12 Sym 11 Cell Fate Determination
1620-1800
Rm 300
13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307
14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308
15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401
16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402
17Welcome Reception for Principal Investigators
([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows
(Rm 401 Lobby) 1800-1900
Friday October 14 2016 Session Time Place
1 Sym 16 Metabolic Syndrome and Cancer0920-1100
Rm 300
2 Sym 17 Aging and Metabolic Homeostasis Rm 307
3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308
4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100
Rm 401
5 Sym 20 Hippo Signaling in Development and Disease Rm 402
6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401
7
Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
1220-1310
Rm 300
Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307
9 KSMCB General Assembly Rm 401
10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401
11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401
12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401
13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401
PIs ONLY
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Information for Poster Presentation
Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)
Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date
Date amp Time (Mount) Before 0920 on your presentation date
Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date
Place Hall D1(3F)
Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)
Poster Category A Aging and Age-Related Diseases A1-A43
D Cell and Tissue Architecture D1-D8
F Cell Death and Autophagy F1-F57
H Developmental Neuroscience and Neural Circuit H1-H41
M Microbiology Virology and Pathogens M1-M39
O Molecular Cancer Biology O1-O87
P Molecular Medicine P1-P39
Q Plant Development Physiology and Metabolism Q1-Q15
R Plant Interactions with Environmental Stresses R1-R15
S RNA S1-S24
T Signal Transduction T1-T69
U Stem Cells U1-U33
V Systems Biology V1-V14
W Tumor Microenvironment W1-W19
COM Commercial Tutorials COM1-COM5
Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)
Poster Category B Biochemistry Structural Biology and Biophysics B1-B54
C Bioimaging and Biotechnology C1-C18
E Cell Cycle and Genome Stability E1-E41
G Development Differentiation and Regeneration G1-G60
I Epigenetics and Transcription I1-I39
J Immunology J1-J64
K Lipids Membranes and Trafficking K1-K17
L Metabolism L1-L72
N Molecular and Cellular Neuroscience N1-N77
X Vascular Biology X1-X26
Y Others Y1-Y14
Z High School and Undergraduate Students Posters Z1-Z22
COM Commercial Tutorials COM1-COM5
Password for abstract search 2016ICKSMCB
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 7
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Presidential Lecture
Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)
Presidential Lecture
October 14 (Fri) 1500-1550 Rm 401
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL
Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea
Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-
phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process
Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013
Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006
Abstract p51
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
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KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 12 (Wed) 1600-1650 Rm 401
Normal and Neoplastic Stem CellsPL Ⅰ
Sponsored by the GIST BIO IMAGING RESEARCH CENTER
Irving L Weissman MDStanford University School of Medicine USA
Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9
His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has
purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases
Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 9
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)
Plenary Lecture
October 13 (Thu) 1120-1210 Rm 401
The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ
Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)
Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden
Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for
Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University
E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors
Abstract p51
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)
Plenary Lecture
October 13 (Thu) 1510-1600 Rm 401
Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ
Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)
Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA
Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role
for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer
Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications
Abstract p51
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
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KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 11
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Plen
ary Lectu
re
Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)
Plenary Lecture
October 14 (Fri) 1130-1220 Rm 401
The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ
Sponsored by the Intelligent Synthetic Biology Center
Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA
Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts
Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases
A native Californian Klionsky received an AB in Biology from the University of California Los
Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute
Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015
Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy
Abstract p51
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Representative papers
- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961
- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186
- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555
- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507
- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37
Academic Research AwardsKSMCB Life Science Award Lecture
October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Hippo Signaling and Adult Stem Cell
Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules
(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 13
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Awards Year KSMCB Life Science Award MampC Award
Academic Research Awards
2015 Han-Woong Lee (Yonsei University)
Gynheung An (Kyung Hee University)
2014 Ji Hoon Ahn(Korea University)
Kwanghee Back(Kyung Hee University)
2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)
Jong‐Joo Cheong(Seoul National University)
2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)
Kwenseop Kim (Chonnam National University)
2011 Jin Won Cho(Yonsei Univeristy)
Dong‐Kug Choi(Konkuk University)
2010 Jongkyeong Chung(Seoul National University)
Pyeung‐Hyeun Kim (Kangwon National University)
2009 Won‐jae Lee(Ehwa Womans University)
Minkyun Kim (Seoul National University)
2008 Bong‐Kiun Kaang (Seoul National University)
Seongman Kang (Korea University)
2007 Byung‐Ha Oh(Pohang University of Science and Technology)
Sang Sun Kang(Chungbuk National University)
2006 Young‐Joon Kim(Yonsei University)
Chung Sun An(Seoul National University)
2005 Hong Gil Nam (Pohang University of Science and Technology)
Jae Young Seong (Korea University)
2004 Sang Yeol Lee (Gyeongsang National University)
Pann‐Ghill Suh(Pohang University of Science and Technology)
2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)
Hae Mook Kang(Cheongju University)
2002 Sung Ho Ryu (Pohang University of Science and Technology)
Jaehoon Yu (Seoul National University)
Awards Year First Degree Award Second Degree Award
Mogam Awards
2000 Joonho Choe(Korea Advanced Institute of Science and Technology)
Young Sang Kim(Chungnam National University)
1999 Hun‐Taeg Chung(Wonkwang University)
Seong‐Ryong Kim(Sogang Univeristy)
1998 Bin Goo Kang(Yonsei University)
Bok Luel Lee(Pusan National University)
1997 Kyungjin Kim(Seoul National University)
Byeong Jae Lee(Seoul National University)
1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)
Kyu‐Won Kim(Pusan National University)
1995 Yu Sam Kim(Yonsei University)
Changwon Kang(Korea Advanced Institute of Science and Technology)
1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)
Young‐Chul Sung(Pohang University of Science and Technology)
Past Laureates
Aw
ards
Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-
lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee
Molecules and Cells (MampC) Award
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80
Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea
Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-
pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Founder of the KSMCB
PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and
globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea
KSMCB Award for Women in Life Science Lecture
October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)
Biogenesis and Regulation of MicroRNA
V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation
Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of
Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)
Representative papers
- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9
To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
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KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 15
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Year Laureate Year Laureate
2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim
(Korea University)
2014 Jaewhan Song(Yonsei University) 2008
Giltsu Choi(Korea Advanced Institute of Science
and Technology)
2013Ildoo Hwang
(Pohang University of Science and Technology)
2007 Dae-Won Kim(Yonsei University)
2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee
(Ewha Womans University)
2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek
(Seoul National University)
2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim
(Seoul National University)
Aw
ards
Representative papers
- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057
- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503
- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255
- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467
- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136
To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee
Macrogen Scientist Award Lecture
October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)
The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics
Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author
Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK
via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity
Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans
Past Laureates
Abstract p52
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical
School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002
Ilchun Memorial Lecture
October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)
Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System
Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea
Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and
amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999
Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala
J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975
Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology
Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate
2015Hoon Ryu
(Boston University USA and Korea Institute of Science and Technology Korea)
2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo
(University of Tennessee USA) 1998Chil-Yong Kang
(Univ of Western Ontario Canada)
2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi
(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh
(Cornell University USA)
2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh
(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon
(University of Tennessee USA)
2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung
(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung
(NCI NIH USA)
2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee
(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim
(Whitehead Institute MIT USA)
Abstract p52
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 17
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Aw
ards
Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015
Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt
Name Affiliation
Daesik Kim Department of Chemistry Seoul National University
Jinho Seo Department of Biochemistry Yonsei University
Hi-Jai R Shin School of Biological Sciences Seoul National University
Sangho Lim Department of Life Science Hanyang University
Jae-Won Choi Department of Biochemistry Chungbuk National University
Sponsor AMOREPACIFIC Co
Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and
regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015
Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltTaKaRa Excellence Thesis Awardeesgt
Field Name Affiliation
Natural Sciences Su-Yeon Lee Gachon University Life Science Institute
Medical SciencePharmacology
Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine
AgricultureFishery Science
Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University
Sponsor TaKaRa Korea Biomedical Inc
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who
wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015
Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)
ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt
Name Graduated School
Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)
Byeong-Won Kim Department of Life Sciences Korea University
Sangjun Park Department of Medical Science Yonsei University
Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)
Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)
Sponsor SeouLin Bioscience Co Ltd
Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides
Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates
Awards October 14 (Fri) 1710-1800 Rm 401
Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-
senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea
Sponsor Sigma-Aldrich Korea Co Springer Nature
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 19
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)
Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field
Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers
Symposia
October 12 (Wed) 1300-1440 Rm 300
Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)
Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal
and Cancerous Tissues
Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure
Variations (TASVs) in the Korean Genome
Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using
High-Throughput Sequencing
Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained
Transcripts
Abstract p53
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)
Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)
Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and
modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation
October 12 (Wed) 1300-1440 Rm 307
Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death
Korea Mouse Phenotyping Center (KMPC)
Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Peripheral Serotonin in Energy Homeostasis
Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea
Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes
Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea
FGF1 as a New Therapeutic to Treat Type 2 Diabetes
Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan
Role of Akt in Skeletal Muscle in Anti-Aging
Abstract p53-54
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 21
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)
Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)
Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring
cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms
October 12 (Wed) 1300-1445 Rm 308
Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center
Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France
Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases
Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea
Tunneling Nanotubes Regulate Hepatic Gluconeogenesis
Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes
Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate
Trafficking
Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in
the Nervous System
Abstract p54-55
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors
including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior
October 12 (Wed) 1300-1440 Rm 401
Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)
Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France
Neuronal Circuits and Mechanisms of Fear Behaviour
Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social
Avoidance
Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode
Long-Term Memory for Habitual Behavior
Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea
Functional Circuit Mapping of the Anxious State
Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee
Laboratory of Integrative Brain Function The Rockefeller University USA
Quantitative Predictions in a Drosophila Visuomotor Network
Abstract p55-56
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 23
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)
Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have
been known about the importance of cell division for diverse differ-entiation process
October 12 (Wed) 1300-1440 Rm 402
Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity
Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole
Assembly
Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using
Super-Resolution Imaging and Functional Proteomics
Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for
Cdk1 Activation
Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by
Chromatin Modifiers in Mouse ES Cells
Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the
YAP Binding Partners TEAD4 and RUNX3
Abstract p56-57
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology
(KAIST) Korea)
Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis
Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research
October 13 (Thu) 0920-1100 Rm 300
Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)
Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein
Trafficking in Drosophila
Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal
Tubulin Modulates Angiogenesis
Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty
Degeneration of Skeletal Muscle
Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear
Development
Abstract p57
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 25
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)
The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two
decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle
October 13 (Thu) 0920-1100 Rm 307
Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)
Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly
Checkpoint Signaling
Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan
Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer
Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea
Chromatin Remodeling Factor and DNA Damage in the Nervous System
Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan
Cellular Senescence as an Anti-Cancer Barrier
Abstract p57-58
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular
Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)
EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA
damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases
October 13 (Thu) 0920-1100 Rm 308
Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network
Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation
Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA
BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance
Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea
Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation
Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in
Hematologic Differentiation and Transformation
Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea
Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation
Abstract p58-59
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 27
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)
Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical
changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells
October 13 (Thu) 0920-1100 Rm 401
Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory
Center for Cognition and Sociality IBS
Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA
Molecular Cellular and Circuit Mechanisms That Link Memories across Time
Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories
Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated
Memory
Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the
Mouse Hippocampus
Abstract p59
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)
Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-
erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine
October 13 (Thu) 0920-1055 Rm 402
Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research
Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of
Disease-Associated Mutations
Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark
Gene Association Networks Large-Scale Integration of Data and Text
Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data
Patterns Perturbations and Regulations
Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction
of Therapeutic Response to Anti-Cancer Drugs
Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea
The Effect of Genome Duplication on Human Disease-Related Genes
Abstract p60
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 29
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)
In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-
istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented
October 13 (Thu) 1620-1800 Rm 300
Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center
Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem
Cells and Its Microenvironmental Control
Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy
Role of Hedgehog Signaling
Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in
the Arabidopsis Root
Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases
on Auxin Signaling during Vasculature Development
Abstract p60-61
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology
(DGIST) Korea)
Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-
cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease
October 13 (Thu) 1620-1800 Rm 307
Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences
Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy
Asian Individuals
Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea
Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation
Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting
Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids
Abstract p61-62
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 31
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)
Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and
therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases
October 13 (Thu) 1620-1800 Rm 308
Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia
Institute for Basic Science Center for Vascular Research
Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy
(Pexophagy) Regulators
Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China
The Regulation of Energy Deprivation Induced Autophagy
Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders
Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2
Activation and Ang2 Inhibition Enhances Drug Delivery
Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a
Potential Host-Directed Therapy of Tuberculosis
Abstract p62-63
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)
Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-
nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression
October 13 (Thu) 1620-1800 Rm 401
Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14
Sponsored by the Center for Cell to Cell Communication in Cancers
Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea
Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism
Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA
Oncogene-Driven Metabolic Regulation in Liver Cancer
Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3
as a Therapeutic Target for Cancer and the TumorMicroenvironment
Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea
Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression
Abstract p63-64
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 33
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)
Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts
Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial
October 13 (Thu) 1620-1800 Rm 402
Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation
Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer
Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis
after Ischemic Reperfusion Injury
Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China
The Immunological Checkpoint in Liver Fibrosis
Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis
Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea
Exosome-Mediated TLR3 Activation in Liver Fibrosis
Abstract p64-65
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science
College of Medicine Chungnam National University Korea)
Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In
this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution
October 14 (Fri) 0920-1055 Rm 300
Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center
Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea
mTOR Function in Pancreatic β-Cells
Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats
Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic
Regulation
Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia
The Role of TRP Channels in Thermoregulation and Energy Metabolism
Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea
Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90
Abstract p65-66
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 35
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)
In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and
stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines
October 14 (Fri) 0920-1100 Rm 307
Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research
Center for Metabolic Function Regulation
Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging
Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea
Metabolic Role of FoxO1 in Dopaminergic Neuron
Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea
Hematopoietic Stem Cell Aging and Rejuvenation
Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging
Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee
Department of Cell Biology Harvard Medical School USA
Regulation of Proteasome Activity for Protein Homeostasis
Abstract p66-67
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)
Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota
shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota
October 14 (Fri) 0920-1120 Rm 308
Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea
Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host
Physiological Homeostasis
Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator
Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France
Pain Control by Mycobacterium Ulcerans Secreted Mycolactone
Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore
Gut Microbiome of Ageing-Host Friend or Foe
Abstract p67-68
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 37
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)
Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)
The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial
regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target
October 14 (Fri) 0920-1100 Rm 401
Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19
Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University
Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation
Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea
Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu
Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)
A Potent Tumor Microenvironment Regulator
Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast
Cells Undergoing H-ras-Induced EMT
Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment
as a Potential Anticancer Target
Abstract p68
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)
The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the
Hippo pathway and new players are being added by recent re-search progress
October 14 (Fri) 0920-1100 Rm 402
Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation
Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea
Hippo Function in Human Liver Cancer
Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers
YAPTAZ and TEAD
Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of
Cellular Polarity in C elegans Intestine
Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea
Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage
Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway
Abstract p68-69
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 39
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)
October 12 (Wed) 1030-1158 Rm 300
Young Investigators Session IYI I
YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration
Enhancer Elements
YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea
trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans
YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal
Cholinergic Interneurons Regulates Cocaine Addiction Behavior
YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee
Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance
YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection
in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use
YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation
by Controlling Dendritic Spine Morphology
YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee
Department of Biomedical Sciences Ajou University School of Medicine Korea
Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation
YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons
Promote Object Exploration Behavior and Type 2 Theta Rhythm
Abstract p69-71
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)
October 12 (Wed) 1030-1158 Rm 307
Young Investigators Session ⅡYIⅡ
YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA
Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response
YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides
YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of
RAP80 to Sites of DNA Damage
YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the
Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus
YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea
Roles of NAD+ Metabolism in Cancer Progression
YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee
Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea
The Role of Lats12-YapTaz in Embryo and Adult Liver
YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea
Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer
YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee
Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea
Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species
Abstract p71-72
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 41
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)
October 12 (Wed) 1030-1158 Rm 308
Young Investigators Session ⅢYIⅢ
YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea
Guanylation by TUT3 and TUT5 Shields mRNA from Degradation
YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea
Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway
YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by
Deacetylation of RIG-I
YI 3-4 1103-1114Sangjun Park SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea
Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation
YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13
Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation
YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea
The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex
YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome
Show Enhanced Ubiquitin-Conjugate Degradation
YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience
Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea
Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level
Abstract p72-73
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)
October 12 (Wed) 1030-1155 Rm 401
AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA
Awards Ceremony 1030-1040
APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of
Cpf1 Endonucleases in Human Cells
APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-
and Lysosome-Dependent Degradation of RIPK3
APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in
Epigenetic and Transcriptional Regulation of Autophagy
APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2
Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells
APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative
Analysis of Protein Biomarker
Abstract p74-75
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 43
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)
Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic
regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting
October 12 (Wed) 1030-1200 Rm 402
Global Network SessionGN
GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand
recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)
Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer
GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines
recommended by the Philippine Society for Cell Biology (PSCB)
Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum
GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore
recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)
MicroRNA-638 Regulates Iron Storage in Prostate Cancer
GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia
recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)
Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection
GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India
recommended by the Society of Biological Chemistry India (SBC(I))
Genomic Packaging and Epigenetic Regulation of Development
Abstract p75
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)
Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)
Luncheon Symposia
October 14 (Fri) 1220-1310 Rm 307
Research Ethics Symposium
Genome Editing Using CRISPR Nucleases
Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea
Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases
the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it
CRISPR-Cas9 Technology and Bioethical Considerations
Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea
The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications
Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the
modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated
It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities
[Korean]
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 45
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
October 13 (Thu) 1210-1300 Rm 300
Koram Biotech - Cell Signaling Technology Workshop
Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)
Edward Li PhD
Scientific Manager Cell Signaling Technology China amp Asia-Pacific
The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response
Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer
Fluorescent multiplex immunohistochemistry
(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
October 13 (Thu) 1210-1300 Rm 308
Logos Biosystems Workshop
Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging
Woong Sun PhD
Department of Anatomy Korea University College of Medicine Korea
Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will
present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing
Advanced Tissue Clearing System for High-Resolution 3D Imaging
Ho-Jae Lee PhD
Logos Biosystems Inc Anyang Gyunggi-Do Korea
Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property
of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
2016 International Conference of the Korean Society for Molecular and Cellular Biology 47
2016 International Conference of the Korean Society for Molecular and Cellular Biology
Sym
posia
Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300
Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)
Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim
Director Ministry of Science ICT and Future Planning Korea
Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD
Director Division of Life Sciences National Research Foundation of Korea Korea
October 14 (Fri) 1420-1440 Rm 300
Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)
Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem
Program Director Samsung Science and Technology Foundation (SSTF) Korea
Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea
In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013
SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-
lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded
SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world
A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members
The funding policy and interest of SSTF will be dis-cussed in this session
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation
48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr
KSMCB October 12-14 2016 COEX Seoul Korea
Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science
2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science
3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc
4 KOS Inc 41 AMICOGEN 91 MGMED Inc
5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD
6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC
7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources
8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc
9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD
10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI
11 Macrogen 56 SFC Co Ltd 98 DGIST
12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA
13Korea Research Institute of Bioscience amp Biotechnology
58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD
14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT
15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD
16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd
17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience
18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC
19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO
20 THREE SHINE 69 70 SolGent 109 MBIOTECH
21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea
22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO
23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD
24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics
26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center
28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc
30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL
31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd
32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc
33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience
34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc
36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung
Exhibition
Poster Presentation