2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016...

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KSMCB www.ksmcb.or.kr Seminar Conference Room (3F-4F) Exhibition & Poster Presentation Hall D1 (3F) 2016 International Conference of the Korean Society for Molecular and Cellular Biology October 12 (Wed) – 14 (Fri), 2016 COEX, Seoul, Korea

Transcript of 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016...

Page 1: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular BiologyK

SM

CB

wwwksmcborkr

SeminarConference Room (3F-4F)

Exhibition amp Poster PresentationHall D1 (3F)

2016 International Conference of the Korean Society for Molecular and Cellular Biology

October 12 (Wed) ndash 14 (Fri) 2016

COEX Seoul Korea

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

2016International Conference of the Korean Society for Molecular and Cellular BiologyOctober 12 (Wed) - 14 (Fri) 2016

COEX Seoul Korea

Organization

Co-Organizations

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

한국분자세포생물학회

2016년 정기학술대회 개최를 축하합니다

회원 여러분의 열정적인 연구로

꺼져가는 생명의 촛불이 살아납니다

한국분자세포생물학회 회원 여러분의

헌신에 경의를 표합니다

강원도 원주시 성지병원 고을용

전라남도 목포시 홍인연합의원 최창준

광주광역시 삼성정맥류클리닉 박경덕

광주광역시 에덴병원 김병룡

전남대학교 의과대학 최석용

Sponsors

This Work was supported by the Korean Federation of Science and Technology Societies (KOFST) grant funded by the Korean Government

2016 International Conference of the Korean Society for Molecular and Cellular Biology 1

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Contents

Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards

Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43

Luncheon Symposia

Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop

(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

983790 Molecules and Cells (Mol Cells)

Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)

Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)

Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)

- Korearsquos leading online open-access journal in the life science

- Indexed in Science Citation Index (SCI)

- International readership

- Spans the breath of molecular and

cellular biology

- Monthly publication

- Rapid review

- URL httpwwwmolcellsorg

- eISSN 0219-1032

Impact factor 267

983790 President Joonho Choe (KAIST Korea)

983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)

983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)

983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees

Scientific Program Committee Dae-Sik Lim (KAIST Korea)

Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)

Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)

Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)

983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)

Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)

Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSCMB Organizing Committee

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Invitation

Invitation

Dear Colleagues

On behalf of the Organizing Committee I am delighted to welcome all the participants

to the International Conference of the Korean Society for Molecular and Cellular Biology

(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The

conference will give you a platform to broaden your knowledge and exchange ideas on

diverse topics in cellular and molecular biology It will also provide the opportunities for

networking among participants In addition many companies and industries in the field of

bioscience will be present for exhibition of research materials biotools and equipment

The conference will be held at the COEX Convention Center which is located in the heart

of Gangnam Seouls business entertainment shopping and culture district

The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the

latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-

search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)

Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering

Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-

turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-

tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies

in the symposia

There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life

Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the

AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical

Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international

participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women

in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science

With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange

the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-

ence for all participants

I look forward to meeting you in Seoul this October

Best regards

Joonho Choe PhD

President KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 2: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

2016International Conference of the Korean Society for Molecular and Cellular BiologyOctober 12 (Wed) - 14 (Fri) 2016

COEX Seoul Korea

Organization

Co-Organizations

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

한국분자세포생물학회

2016년 정기학술대회 개최를 축하합니다

회원 여러분의 열정적인 연구로

꺼져가는 생명의 촛불이 살아납니다

한국분자세포생물학회 회원 여러분의

헌신에 경의를 표합니다

강원도 원주시 성지병원 고을용

전라남도 목포시 홍인연합의원 최창준

광주광역시 삼성정맥류클리닉 박경덕

광주광역시 에덴병원 김병룡

전남대학교 의과대학 최석용

Sponsors

This Work was supported by the Korean Federation of Science and Technology Societies (KOFST) grant funded by the Korean Government

2016 International Conference of the Korean Society for Molecular and Cellular Biology 1

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Contents

Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards

Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43

Luncheon Symposia

Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop

(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

983790 Molecules and Cells (Mol Cells)

Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)

Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)

Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)

- Korearsquos leading online open-access journal in the life science

- Indexed in Science Citation Index (SCI)

- International readership

- Spans the breath of molecular and

cellular biology

- Monthly publication

- Rapid review

- URL httpwwwmolcellsorg

- eISSN 0219-1032

Impact factor 267

983790 President Joonho Choe (KAIST Korea)

983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)

983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)

983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees

Scientific Program Committee Dae-Sik Lim (KAIST Korea)

Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)

Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)

Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)

983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)

Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)

Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSCMB Organizing Committee

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Invitation

Invitation

Dear Colleagues

On behalf of the Organizing Committee I am delighted to welcome all the participants

to the International Conference of the Korean Society for Molecular and Cellular Biology

(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The

conference will give you a platform to broaden your knowledge and exchange ideas on

diverse topics in cellular and molecular biology It will also provide the opportunities for

networking among participants In addition many companies and industries in the field of

bioscience will be present for exhibition of research materials biotools and equipment

The conference will be held at the COEX Convention Center which is located in the heart

of Gangnam Seouls business entertainment shopping and culture district

The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the

latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-

search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)

Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering

Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-

turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-

tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies

in the symposia

There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life

Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the

AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical

Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international

participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women

in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science

With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange

the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-

ence for all participants

I look forward to meeting you in Seoul this October

Best regards

Joonho Choe PhD

President KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 3: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

한국분자세포생물학회

2016년 정기학술대회 개최를 축하합니다

회원 여러분의 열정적인 연구로

꺼져가는 생명의 촛불이 살아납니다

한국분자세포생물학회 회원 여러분의

헌신에 경의를 표합니다

강원도 원주시 성지병원 고을용

전라남도 목포시 홍인연합의원 최창준

광주광역시 삼성정맥류클리닉 박경덕

광주광역시 에덴병원 김병룡

전남대학교 의과대학 최석용

Sponsors

This Work was supported by the Korean Federation of Science and Technology Societies (KOFST) grant funded by the Korean Government

2016 International Conference of the Korean Society for Molecular and Cellular Biology 1

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Contents

Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards

Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43

Luncheon Symposia

Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop

(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

983790 Molecules and Cells (Mol Cells)

Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)

Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)

Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)

- Korearsquos leading online open-access journal in the life science

- Indexed in Science Citation Index (SCI)

- International readership

- Spans the breath of molecular and

cellular biology

- Monthly publication

- Rapid review

- URL httpwwwmolcellsorg

- eISSN 0219-1032

Impact factor 267

983790 President Joonho Choe (KAIST Korea)

983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)

983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)

983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees

Scientific Program Committee Dae-Sik Lim (KAIST Korea)

Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)

Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)

Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)

983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)

Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)

Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSCMB Organizing Committee

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Invitation

Invitation

Dear Colleagues

On behalf of the Organizing Committee I am delighted to welcome all the participants

to the International Conference of the Korean Society for Molecular and Cellular Biology

(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The

conference will give you a platform to broaden your knowledge and exchange ideas on

diverse topics in cellular and molecular biology It will also provide the opportunities for

networking among participants In addition many companies and industries in the field of

bioscience will be present for exhibition of research materials biotools and equipment

The conference will be held at the COEX Convention Center which is located in the heart

of Gangnam Seouls business entertainment shopping and culture district

The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the

latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-

search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)

Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering

Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-

turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-

tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies

in the symposia

There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life

Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the

AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical

Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international

participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women

in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science

With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange

the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-

ence for all participants

I look forward to meeting you in Seoul this October

Best regards

Joonho Choe PhD

President KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

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KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 4: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 1

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Contents

Invitation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot3Schedule middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot4Information for Poster Presentation middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot6Academic Programs amp Awards

Presidential Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 7Plenary Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot8KSMCB Life Science Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 12Molecules and Cells (MampC) Award middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 13KSMCB Award for Women in Life Science Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 14Macrogen Scientist Award Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 15Ilchun Memorial Lecture middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 16Awards for Young Scientists middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 17Symposia middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 19Young Investigators Sessions middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot39AMOREPACIFIC Great Global Next Generation Research Award Lectures middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 42Global Network Session middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot43

Luncheon Symposia

Research Ethics Symposium middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot44Koram Biotech ndash Cell Signaling Technology Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot45Logos Biosystems Workshop middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot46Open Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 47Samsung Science and Technology Foundation (SSTF) Workshop

(삼성미래기술육성재단 워크샵) middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot47Exhibition middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot48Lecture Abstracts middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot49Poster Session List middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 79Author Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 139Keyword Index middotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddotmiddot 155

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

983790 Molecules and Cells (Mol Cells)

Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)

Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)

Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)

- Korearsquos leading online open-access journal in the life science

- Indexed in Science Citation Index (SCI)

- International readership

- Spans the breath of molecular and

cellular biology

- Monthly publication

- Rapid review

- URL httpwwwmolcellsorg

- eISSN 0219-1032

Impact factor 267

983790 President Joonho Choe (KAIST Korea)

983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)

983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)

983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees

Scientific Program Committee Dae-Sik Lim (KAIST Korea)

Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)

Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)

Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)

983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)

Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)

Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSCMB Organizing Committee

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Invitation

Invitation

Dear Colleagues

On behalf of the Organizing Committee I am delighted to welcome all the participants

to the International Conference of the Korean Society for Molecular and Cellular Biology

(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The

conference will give you a platform to broaden your knowledge and exchange ideas on

diverse topics in cellular and molecular biology It will also provide the opportunities for

networking among participants In addition many companies and industries in the field of

bioscience will be present for exhibition of research materials biotools and equipment

The conference will be held at the COEX Convention Center which is located in the heart

of Gangnam Seouls business entertainment shopping and culture district

The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the

latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-

search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)

Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering

Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-

turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-

tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies

in the symposia

There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life

Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the

AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical

Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international

participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women

in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science

With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange

the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-

ence for all participants

I look forward to meeting you in Seoul this October

Best regards

Joonho Choe PhD

President KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 5: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

983790 Molecules and Cells (Mol Cells)

Editor-in-ChiefRho Hyun Seong (Seoul Natl Univ Korea)

Associate EditorsJa-Hyun Baik (Korea Univ Korea)Yunje Cho (POSTECH Korea)Jongkyeong Chung (Seoul Natl Univ Korea)Sunjoo Jeong (Dankook Univ Korea)Jaesang Kim (Ewha Womans Univ Korea)

Hyunsook Lee (Seoul Natl Univ Korea)Wang-Shick Ryu (Yonsei Univ Korea)Minho Shong (Chungnam Natl Univ Korea)Dae-Jin Yun (Gyeongsang Natl Univ Korea)

- Korearsquos leading online open-access journal in the life science

- Indexed in Science Citation Index (SCI)

- International readership

- Spans the breath of molecular and

cellular biology

- Monthly publication

- Rapid review

- URL httpwwwmolcellsorg

- eISSN 0219-1032

Impact factor 267

983790 President Joonho Choe (KAIST Korea)

983790 President-elect In Kyung Lim (Ajou Univ School of Medicine Korea)

983790 Vice Presidents Myung-Shik Lee (Yonsei Univ College of Medicine Korea)Kyuyoung Song (Univ of Ulsan College of Medicine Korea)Myungchull Rhee (Chungnam Natrsquol Univ Korea)

983790 Secretary General Seungbok Lee (Seoul Natrsquol Univ Korea)983790 Chair of Committees

Scientific Program Committee Dae-Sik Lim (KAIST Korea)

Finance Committee Junho Lee (Seoul Natrsquol Univ Korea)Planning Committee Goo Taeg Oh (Ewha Womans Univ Korea)

Mol amp Cell Biol News Committee Jae-Hong Kim (Korea Univ Korea)Publication Committee Eun Hee Kim (Chungnam Natrsquol Univ Korea)International Affairs Committee Onyou Hwang (Univ of Ulsan College of Medicine Korea)Edu-Indust-Inst Cooperation Yeon-Soo Seo (KAIST Korea)Election Management Committee Jaesang Kim (Ewha Womans Univ Korea)

Academic Research Awards Committee Sunjoo Jeong (Dankook Univ Korea)Network Affairs Committee You Mie Lee (Kyungpook Natrsquol Univ Korea)Ethic Committee Myeong Jin Nam (Gachon Univ Korea)Ilchun Committee Jong-Il Kim (Seoul Natrsquol Univ College of Medicine Korea)Welfare Committee Kang-Yell Choi (Yonsei Univ Korea)Fusion Science Committee Woo Jin Park (GIST Korea)Winter Conference Program Committee Doil Choi (Seoul Natrsquol Univ Korea)Education Committee Ja-Hyun Baik (Korea Univ Korea)Chapter Committee Jae Bum Kim (Seoul Natrsquol Univ Korea)Publicity Committee Jene Choi (Univ of Ulsan College of Medicine Korea)

983790 Manager of CommitteesScientific Program Affairs Seung-Jae Lee (POSTECH Korea)Treasurer Woong Sun (Korea Univ Korea)Financial Affairs Sang-Kyu Ye (Seoul Natl Univ College of Medicine Korea)Planning Affairs Kisung Ko (Chung-Ang Univ College of Medicine Korea)Mol amp Cell Biol News Affairs You-Sun Kim (Ajou Univ School of Medicine Korea)Publication Affairs Seon-Young Kim (KRIBB Korea)International Affairs Seok-Yong Choi (Chonnam Natl Univ Medical School Korea)Edu-Indust-Inst Cooperation Affairs Hyun-Shik Lee (Kyungpook Natl Univ Korea)Election Management Affairs Hae Yong Yoo (Sungkyunkwan Univ Korea)Academic Research Awards Affairs Taegun Seo (Dongguk Univ Korea)Network Affairs Daehee Hwang (DGIST Korea)Ethic Affairs Jong-Il Park (Chungnam Natl Univ School of Medicine Korea)Ilchun Affairs Jongsun Park (Chungnam Natl Univ College of Medicine Korea)Welfare Affairs Hwa Kyoung Shin (Pusan Natl Univ School of Korean Medicine Korea)Fusion Science Affairs Kye Won Park (Sungkyunkwan Univ Korea)Winter Conference Program Affairs Jung-Shin Lee (Kangwon Natl Univ Korea)

Jaewon Ko (Yonsei Univ Korea)Education Affairs Mi-Ryoung Song (GIST Korea)Chapter Affairs Hail Kim (KAIST Korea)

Membership Affairs Keunwook Lee (Hallym Univ Korea)Publicity Affairs Nayoung Suh (Soonchunhyang Univ Korea)

2 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSCMB Organizing Committee

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Invitation

Invitation

Dear Colleagues

On behalf of the Organizing Committee I am delighted to welcome all the participants

to the International Conference of the Korean Society for Molecular and Cellular Biology

(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The

conference will give you a platform to broaden your knowledge and exchange ideas on

diverse topics in cellular and molecular biology It will also provide the opportunities for

networking among participants In addition many companies and industries in the field of

bioscience will be present for exhibition of research materials biotools and equipment

The conference will be held at the COEX Convention Center which is located in the heart

of Gangnam Seouls business entertainment shopping and culture district

The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the

latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-

search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)

Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering

Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-

turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-

tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies

in the symposia

There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life

Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the

AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical

Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international

participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women

in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science

With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange

the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-

ence for all participants

I look forward to meeting you in Seoul this October

Best regards

Joonho Choe PhD

President KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 6: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 3

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Invitation

Invitation

Dear Colleagues

On behalf of the Organizing Committee I am delighted to welcome all the participants

to the International Conference of the Korean Society for Molecular and Cellular Biology

(KSMCB) This year our annual event will take place in Seoul from October 12 to 14 The

conference will give you a platform to broaden your knowledge and exchange ideas on

diverse topics in cellular and molecular biology It will also provide the opportunities for

networking among participants In addition many companies and industries in the field of

bioscience will be present for exhibition of research materials biotools and equipment

The conference will be held at the COEX Convention Center which is located in the heart

of Gangnam Seouls business entertainment shopping and culture district

The scientific program includes four Plenary Lectures a Presidential Lecture and 20 symposia focusing on the

latest research breakthroughs In addition over 1000 posters will be presented by young scientists to show their re-

search progresses This year we are pleased to have Dr Emmanuelle Charpentier (Max Planck Institute Germany)

Dr Daniel J Klionsky (University of Michigan USA) Dr Alexander Y Rudensky (Memorial Sloan-Kettering

Cancer Center USA) and Dr Irving L Weissman (Stanford University School of Medicine USA) as plenary lec-

turers and Dr Sue Goo Rhee (Yonsei University School of Medicine Korea) as the Presidential Lecturer In addi-

tion more than 120 world-class scientists from domestic and foreign institutions will present cutting-edge studies

in the symposia

There also will be a series of ceremonies for the presentation of various awards including the KSMCB Life

Science Award the Molecules amp Cells Award the Macrogen Scientist Award the Ilchun Memorial Lecture the

AMOREPACIFIC Global Next Generation Research Awards the Excellence Thesis Awards by TaKaRa Biomedical

Inc the Thesis Awards by the SeouLin Bioscience Co Ltd and Presentation Awards for young international

participants This year will see the inaugural presentation of the newly established the KSMCB Award for Women

in Life Science A woman scientist will be recognized for her excellent scientific accomplishment in life science

With the cutting edge information on the latest scientific advancements and valuable opportunities to exchange

the ideas and launch future collaborations we are confident that this conference will be the most satisfying experi-

ence for all participants

I look forward to meeting you in Seoul this October

Best regards

Joonho Choe PhD

President KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 7: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

4 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Schedule Wednesday October 12 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402

0900-1030 Registration

1030-1200Young Investigators

Session IYoung Investigators

Session IIYoung Investigators

Session III

AMOREPACIFIC Great Global Next Generation

Research Award Lectures

Global Network Session

1200-1300 Break

1300-1440

Sym01Evolutionary Dynamics

of Transposable Elements

Sym02Insulin Resistance and Metabolic Disorders

Sym03Unconventional

Intercellular Protein Trafficking

Sym04Control of Neural Circuits for Animal

Behavior

Sym05Cell Division Control during Development

1440-1510 Break

1510-1530 Opening Ceremony (Rm 401)

1530-1600 KSMCB Award for Women in Life Science Lecture V Narry Kim PhD (Rm 401)

1600-1650 Plenary Lecture I Irving L Weissman MD (Rm 401)

Thursday October 13 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym06Cilia as Dynamic Organelles in

Development and Disease

Sym07Cell Cycle Control in

Disease

Sym08Epigenetic Roles in Cellular Processes

Sym09Memory Engram

Sym10Pathway and Network Analysis of Disease

Genomics Data

Poster Posting I0920-1800

Poster Presentation I1300-1430

1100-1120 Break

1120-1210 Plenary Lecture II Emmanuelle Charpentier PhD (Rm 401)

1210-1300

Koram Biotech ndash Cell Signaling Technology

Workshop

Logos Biosystems

WorkshopKSMCB

Council Meeting

1300-1430 Break amp Poster Viewing (Hall D1)

1430-1510 KSMCB Life Science Award Lecture Dae-Sik Lim PhD (Rm 401)

1510-1600 Plenary Lecture III Alexander Y Rudensky PhD (Rm 401)

1600-1620 Break

1620-1800

Sym 11 Cell Fate Determination

Sym 12 Phospholipids as

Bioactive Cell Signaling Molecules

Sym 13 Autophagy in Cellular

Homeostasis and Human Diseases

Sym 14 Role of Oncogene in

Altered Tumor Metabolism and CSC

Generation

Sym 15 Mechanistic Regulation

of Organ Fibrosis

1800-1900 Welcome Reception for Principal Investigators ([Lu] COEX 1F)

Welcome Reception for StudentsPostdoctoral Fellows (Rm 401 Lobby)

 

Luncheon Symposium

Friday October 14 2016

TimePlace Rm 300 Rm 307 Rm 308 Rm 401 Rm 402Hall D1(3F)

PosterExhibition

0800-0920 Registration

0920-1100

Sym 16 Metabolic Syndrome and

Cancer

Sym 17 Aging and Metabolic

Homeostasis

Sym 18 Big Data System Biology and Global

Health

Sym 19 Tumor Microenvironment

and Heterogeneity Emerging Targets for Cancer Treatment and

Prevention

Sym 20 Hippo Signaling in Development and

Disease

Poster Posting II0920-1700

Poster Presentation II1310-1500

1100-1130 Break

1130-1220 Plenary Lecture IV Daniel J Klionsky PhD (Rm 401)

1220-1310

1220-1420 PIs ONLYOpen Forum for Development of Basic Science Support Programs in 2017

(미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Research Ethics Sym

(Korean) KSMCB General Assembly

1420-1440 Samsung Science and Technology

Foundation Workshop(삼성미래기술육성재단 워크샵)

1310-1500 Break amp Poster Viewing (Hall D1)

1500-1550 Presidential Lecture Sue Goo Rhee PhD (Rm 401)

1550-1620 Ilchun Memorial Lecture Kyungjin Kim PhD (Rm 401)

1620-1640 Break

1640-1710 Macrogen Scientist Award Lecture Seung-Jae V Lee PhD (Rm 401)

1710-1800MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis Awards

Best Presentation AwardsPresentation AwardsTravel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401)  

Luncheon Symposium

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 8: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 5

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Schedu

le

4F

3F Conference Room (Lectures)

Hall D1 (Exhibition Poster Presentation)

Conference Room (Presidential Lecture Plenary Lectures Awards Lectures Symposia Reception)

Wednesday October 12 2016  Session Time Place

1 Young Investigators Session I

1030-1200

Rm 300

2 Young Investigators Session II Rm 307

3 Young Investigators Session III Rm 308

4 AMOREPACIFIC Great Global Next Generation Research Award Lectures Rm 401

5 Global Network Session Rm 402

6 Sym 01 Evolutionary Dynamics of Transposable Elements

1300-1440

Rm 300

7 Sym 02 Insulin Resistance and Metabolic Disorders Rm 307

8 Sym 03 Unconventional Intercellular Protein Trafficking Rm 308

9 Sym 04 Control of Neural Circuits for Animal Behavior Rm 401

10 Sym 05 Cell Division Control during Development Rm 402

11 Opening Ceremony 1510-1530 Rm 401

12 KSMCB Award for Women in Life Science Lecture V Narry Kim Ph D 1530-1600 Rm 401

13 Plenary Lecture I Irving L Weissman MD 1600-1650 Rm 401

Thursday October 13 2016  Session Time Place

1 Sym 06 Cilia as Dynamic Organelles in Development and Disease

0920-1100

Rm 300

2 Sym 07 Cell Cycle Control in Disease Rm 307

3 Sym 08 Epigenetic Roles in Cellular Processes Rm 308

4 Sym 09 Memory Engram Rm 401

5 Sym 10 Pathway and Network Analysis of Disease Genomics Data Rm 402

6 Plenary Lecture II Emmanuelle Charpentier PhD 1120-1210 Rm 401

7 Koram Biotech ndash Cell Signaling Technology Workshop1210-1300

Rm 300

8 Logos Biosystems Workshop Rm 308

9 KSMCB Council Meeting Rm 402

10 KSMCB Life Science Award Lecture Dae-Sik Lim Ph D 1430-1510 Rm 401

11 Plenary Lecture III Alexander Y Rudensky PhD 1510-1600 Rm 401

12 Sym 11 Cell Fate Determination

1620-1800

Rm 300

13 Sym 12 Phospholipids as Bioactive Cell Signaling Molecules Rm 307

14 Sym 13 Autophagy in Cellular Homeostasis and Human Diseases Rm 308

15 Sym 14 Role of Oncogene in Altered Tumor Metabolism and CSC Generation Rm 401

16 Sym 15 Mechanistic Regulation of Organ Fibrosis Rm 402

17Welcome Reception for Principal Investigators

([Lu] COEX 1F)Welcome Reception for StudentsPostdoctoral Fellows

(Rm 401 Lobby) 1800-1900

Friday October 14 2016  Session Time Place

1 Sym 16 Metabolic Syndrome and Cancer0920-1100

Rm 300

2 Sym 17 Aging and Metabolic Homeostasis Rm 307

3 Sym 18 Big Data System Biology and Global Health 0920-1120 Rm 308

4 Sym 19 Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and Prevention0920-1100

Rm 401

5 Sym 20 Hippo Signaling in Development and Disease Rm 402

6 Plenary Lecture IV Daniel J Klionsky PhD 1130-1220 Rm 401

7

Open Forum for Development of Basic Science Support Programs in 2017 (1220-1420) (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

1220-1310

Rm 300

Samsung Science and Technology Foundation Workshop (1420-1440) (삼성미래기술육성재단 워크샵)8 Research Ethics Symposium (Korean) Rm 307

9 KSMCB General Assembly Rm 401

10 Presidential Lecture Sue Goo Rhee Ph D 1500-1550 Rm 401

11 Ilchun Memorial Lecture Kyungjin Kim Ph D 1550-1620 Rm 401

12 Macrogen Scientist Award Lecture Seung-Jae V Lee Ph D 1640-1710 Rm 401

13MampC AwardTaKaRa Excellence Thesis AwardsSeouLin Bioscience Outstanding PhD Thesis AwardsBest Presentation AwardsPresentation Awards Travel Grant AwardsExcellent Poster Awards amp Closing Remarks (Rm 401) 1710-1800 Rm 401

PIs ONLY

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 9: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

6 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Information for Poster Presentation

Posting TimePoster Presentation I 0920-1800 Oct 13 (Thu)Poster Presentation II 0920-1700 Oct 14 (Fri)

Presentation Time (QampA)1300-1430 [Oct 13 (Thu)]1310-1500 [Oct 14 (Fri)]on your presentation date

Date amp Time (Mount) Before 0920 on your presentation date

Date amp Time (Removal)After 1800 [Oct 13 (Thu)]After 1700 [Oct 14 (Fri)]on your presentation date

Place Hall D1(3F)

Poster Presentation Ⅰ October 13 (Thu) 0920-1800 Hall D1(3F)

Poster Category A Aging and Age-Related Diseases A1-A43

D Cell and Tissue Architecture D1-D8

F Cell Death and Autophagy F1-F57

H Developmental Neuroscience and Neural Circuit H1-H41

M Microbiology Virology and Pathogens M1-M39

O Molecular Cancer Biology O1-O87

P Molecular Medicine P1-P39

Q Plant Development Physiology and Metabolism Q1-Q15

R Plant Interactions with Environmental Stresses R1-R15

S RNA S1-S24

T Signal Transduction T1-T69

U Stem Cells U1-U33

V Systems Biology V1-V14

W Tumor Microenvironment W1-W19

COM Commercial Tutorials COM1-COM5

Poster Presentation Ⅱ October 14 (Fri) 0920-1700 Hall D1(3F)

Poster Category B Biochemistry Structural Biology and Biophysics B1-B54

C Bioimaging and Biotechnology C1-C18

E Cell Cycle and Genome Stability E1-E41

G Development Differentiation and Regeneration G1-G60

I Epigenetics and Transcription I1-I39

J Immunology J1-J64

K Lipids Membranes and Trafficking K1-K17

L Metabolism L1-L72

N Molecular and Cellular Neuroscience N1-N77

X Vascular Biology X1-X26

Y Others Y1-Y14

Z High School and Undergraduate Students Posters Z1-Z22

COM Commercial Tutorials COM1-COM5

Password for abstract search 2016ICKSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 10: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 7

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Presidential Lecture

Organizer amp Chair Joonho Choe PhD (Korea Advanced Institute of Science and Technology (KAIST) Korea)

Presidential Lecture

October 14 (Fri) 1500-1550 Rm 401

Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation by PeroxiredoxinPRL

Sue Goo Rhee PhDNewilhan Distinguished Professor of Severance Biomedical Science Institute Yonsei University College of Medicine Korea

Dr Sue-Goo Rhee has been studying mecha-nisms of cell signaling and pioneered in two areas of research Dr Rheersquos group is responsible for the dis-covery and characterization of the first three proto-typical members of the phospholipase C family and has contributed greatly to our understanding of the mechanisms by which various cell surface receptors cause activation of these enzymes to generate two intracellular messengers diacylglycerol and in-ositol 145-trisphosphate Another contribution made by Dr Rheersquos group is the discovery of perox-iredoxin family members and elucidation of their role in redox signaling Peroxiredoxin enzymes not only protect against oxidative damage but also me-diate cell signaling by modulating intracellular H2O2levels Their studies revealed that peroxir-edoxin enzymes are extensively regulated via phos-

phorylation as well as reversible hyperoxidation of the active site cysteine to cysteine sulfinic acid Reversibilty of sulfinic acid formation opened the door to a rapidly expanding area of research on re-dox-based cell signaling process

Before joining the current position in 2013 Dr Rhee was in the National Heart Lung and Blood Institute National Institutes of Health in Bethesda from 1973 to 2005 and in Ewha Womans University from 2005 to 2013

Dr Rhee received Ho Am Award in Science in 1995 the Discovery Award from The society of Free Radical Biology and Medicine in 2005 the Health Science prize from the Oxygen Society of California in 2014 and was appointed as the first National Honor Scientist by the Korean government in 2006

Abstract p51

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 11: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

8 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair G-One Ahn PhD (Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 12 (Wed) 1600-1650 Rm 401

Normal and Neoplastic Stem CellsPL Ⅰ

Sponsored by the GIST BIO IMAGING RESEARCH CENTER

Irving L Weissman MDStanford University School of Medicine USA

Irving L Weissman MD is the Director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and Director of the Stanford Ludwig Center for Cancer Stem Cell Research Dr Weissman was a member of the founding Scientific Advisory Boards of Amgen (1981-1989) DNAX (1981-1992) and T-Cell Sciences (1988-1992) He co-founded was a Director and chaired the Scientific Advisory Board at SyStemix 1988-1996 StemCells in 1996-present and Cellerant in 2001-9

His research encompasses the biology and evolu-tion of stem cells and progenitor cells mainly blood-forming and brain-forming He is also en-gaged in isolating and characterizing the rare cancer and leukemia stem cells as the only dangerous cells in these malignancies especially with human cancers He discovered that all cancer stem cells ex-press CD47 the lsquodonrsquot eat mersquo signal to overcome prophagocytic signals that arise during cancer devel-opment and has shown that blocking antibodies to CD47 have therapeutic potential for all tested human cancers Finally he has a long-term research interest in the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems His laboratory was first to identify and iso-late the blood-forming stem cell from mice and has

purified each progenitor in the stages of development between the stem cells and mature progeny (granulocytes macro-phages etc) At SyStemix he co-discovered the human hematopoetic stem cell and at StemCells he co-discovered a human central nervous system stem cell In addition the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo ei-ther as a normal function or as events involved in ma-lignant leukemic metastases

Professor Weissman is a member of the National Academy of Sciences the Institute of Medicine at the National Academy and the American Association of Arts and Sciences He has received many awards in-cluding the Kaiser Award for Excellence in Preclinical Teaching the Pasarow Award in Cancer Research the California Scientist of the Year the De Villiers International Achievement Award of the Leukemia Society of America the Robert Koch Award the Rosenstiel Award The max Delbruck Medaland the Jessie Stevenson Kovalenko Award of the National Academy of Sciences He is also the 2004 New York Academy of Medicine Award for dis-tinguished contributions to biomedical research and has several honorary doctorates

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 12: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 9

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Jin-Soo Kim PhD (Center for Genome Engineering Institute for Basic Science (IBS) Korea)

Plenary Lecture

October 13 (Thu) 1120-1210 Rm 401

The Transformative Genome Engineering CRISPR-Cas9 Technology Lessons Learned from BacteriaPL Ⅱ

Co-organized by the Center for Genome Engineering at Institute for Basic Science (IBS)

Emmanuelle Charpentier PhDMax Planck Institute for Infection Biology Humboldt University Germany amp The Laboratory for Molecular Infection Medicine Sweden Umearing University Sweden

Emmanuelle Charpentier studied biochemistry microbiology and genetics at the University Pierre and Marie Curie Paris France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute She then continued her work in the United States at The Rockefeller University New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York NY) and at St Jude Childrens Research Hospital (in Memphis TN) E Charpentier returned to Europe to establish her own research group as Assistant and Associate Professor at the Max F Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology She was then appointed Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umearing University in Sweden where she habilitated in the field of Medical Microbiology and is still active as a Visiting Professor Between 2013 and 2015 E Charpentier was Head of the Department of Regulation in Infection Biology at the Helmholtz Centre for

Infection Research Braunschweig and Professor at the Medical School of Hannover in Germany In 2013 she was awarded an Alexander von Humboldt Professorship which she has held since 2014 In 2015 E Charpentier was appointed Scientific Member of the Max Planck Society and Director at the Max Planck Institute for Infection Biology in Berlin Germany Since 2016 E Charpentier is Honorary Professor at Humboldt University

E Charpentier is recognized as a world-leading expert in regulatory mechanisms underlying proc-esses of infection and immunity in bacterial pathogens With her recent groundbreaking find-ings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system E Charpentier has laid the foundation for the development of a novel high-ly versatile and specific genome engineering tech-nology that is revolutionizing life sciences research and could open up whole new opportunities in bio-medical gene therapies For this research E Charpentier has been awarded a number of presti-gious honors

Abstract p51

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 13: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

10 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Sin-Hyeog Im PhD (Institute for Basic Science (IBS) amp Pohang University of Science and Technology (POSTECH) Korea)

Plenary Lecture

October 13 (Thu) 1510-1600 Rm 401

Mechanisms of Differentiation and Function of RegulatoryT CellsPL Ⅲ

Co-organized by the Academy of Immunology and Microbiology (AIM) at Institute for Basic Science (IBS)

Alexander Y Rudensky PhDMemorial Sloan-Kettering Cancer Center amp Howard Hughes Medical Institute USA

Alexander Rudensky PhD is Chairman of the Immunology Program and Director of the Ludwig Center for Cancer Immunotherapy at Memorial Sloan-Kettering Cancer Center (MSKCC) an Investigator with the Howard Hughes Medical Institute and a Tri‐Institutional Professor at MSKCC the Rockefeller University and Cornell University and Professor at Gerstner School of Graduate Studies and at Weill‐Cornell Medical School Prior to his joining MSKCC he was Professor of Immunology at the University of Washington School of Medicine Seattle Dr Rudensky received his PhD degree from the Gabrichevsky Research Institute of Epidemiology and Microbiology Moscow and postdoctoral train-ing at Yale University Medical School with the late Dr Charles A Janeway Jr Currently Dr Rudenskylsquos research is focused on the differentiation of regu-latory T lymphocytes and their role in the immune responses His laboratory demonstrated a role for the transcription factor Foxp3 as a Treg cell lineage spec-ification factor his studies revealed an essential role

for these cells as life-long ldquoguardiansrdquo of immune ho-meostasis and key mechanisms of their differ-entiation and function Dr Rudenskyrsquos work pro-vided important insights into the fundamental role for regulatory T cells in immunological tolerance and in a variety of processes and pathologies including au-toimmunity allergy transplantation immunity to in-fections pregnancy tissue repair and cancer

Dr Rudensky is an elected Member of the National Academy of Sciences and National Academy of Medicine and a Fellow of the American Academy of Arts and Sciences He has been named a Thomson-Reuters Citation Laureate He has been a member of numerous advisory and editorial boards including Cancer Research Institute Damon Cancer Research Foundation Cell and Immunity He serves also as an Editor of the Journal of Experimental Medicine Dr Rudensky has authored over 180 publications

Abstract p51

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

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KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 14: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 11

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Plen

ary Lectu

re

Organizer amp Chair Hyun Kyu Song PhD (Department of Life Sciences Korea University Korea)

Plenary Lecture

October 14 (Fri) 1130-1220 Rm 401

The Mechanism and Regulation of Macroautophagy in YeastPL Ⅳ

Sponsored by the Intelligent Synthetic Biology Center

Daniel J Klionsky PhDLife Sciences Institute University of Michigan USA

Cell biologist Daniel J Klionsky PhD is the Alexander G Ruthven Professor of Life Sciences at the University of Michigan Klionsky holds joint ap-pointments as a faculty member at the Life Sciences Institute where his lab is located and in the Department of Molecular Cell amp Developmental Biology in the College of Literature Science and the Arts

Working primarily with bakerrsquos yeast (Saccharomyces cerevisiae) Klionskyrsquos research focuses on the cel-lular process known as autophagy which literally means ldquoself-eatingrdquo Autophagy is the process by which cells break down cellular components to sur-vive stress conditions such as starvation The failure of autophagy plays a role in cancer neurodegenerative conditions such as Parkinson and Alzheimer dis-eases and other areas of human health Using bio-chemistry Klionskyrsquos lab has been asking questions about the individual molecules involved in the trans-port of proteins and cellular signaling related to autophagy Answering these questions could help guide new therapeutic applications to treat or pre-vent certain diseases

A native Californian Klionsky received an AB in Biology from the University of California Los

Angeles in 1980 He received his PhD from Stanford University in 1986 which was followed by Helen Hay Whitney and American Cancer Society Senior Postdoctoral Fellowships at the California Institute of Technology In 1990 Klionsky joined the faculty of the University of California Davis He moved to U-M in 2000 and in 2003 because one of the founding faculty members of the U-M Life Sciences Institute

Klionskyrsquos passion extends to the classroom as well as the lab He received the National Science Foundation Directorrsquos Award for Distinguished Teaching Scholars in 2003 In 2006 the National Academy of Sciences named him an Education Mentor for developing ldquoactive learningrdquo approaches to under-graduate biology courses He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 He was elected a Fellow of the American Association for the Advancement of Science in 2009 was named a Thompson Reuters Citation Laureate in 2013 and received the van Deenen Medal in 2015

Since the journalrsquos founding in 2005 Klionsky has also served as the editor-in-chief of Autophagy

Abstract p51

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 15: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

12 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Representative papers

- Lats-YapTaz controls lineage specification by regulating Tgfβ signaling and Hnf4α expression during liver development (2016) Nature Communications 101038ncomms11961

- A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness (2015) Nature Communications 101038NCOMMS10186

- cAMPPKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes (2013) The EMBO Journal 32 1543 ndash 1555

- ER71 acts downstream of BMP Notch and Wnt signaling in blood and vessel progenitor specification (2008) Cell Stem Cell 2(5)497-507

- The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex (2004) Nature Cell Biology 6(2)129-37

Academic Research AwardsKSMCB Life Science Award Lecture

October 13 (Thu) 1430-1510 Rm 401Chair Han-Woong Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Hippo Signaling and Adult Stem Cell

Dae-Sik Lim PhDNational Creative Research Initiatives Center Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

Dr Dae-Sik Lim is a professor in the Department of Biological Sciences at KAIST He received his bachelors degree and masters degree in Seoul National University and a PhD degree in the Genes and Developmental Program at UT amp M D Anderson Cancer Center in 1996 During his gradu-ate studies in the laboratory of Dr Paul Hasty he in-vestigated the function of two proteins Rad51 and Ku80 in the repair of DNA damage in mice During his postdoctoral training under the guidance of Dr Michael Kastan at Johns Hopkins and St Jude Childrenrsquos Research Hospital he characterized functions of the ATM kinase and identified many substrates for ATM kinases in DNA damage re-sponse pathway He joined Korea University as an assistant Professor in 2000 and moved to KAIST in 2002 Since then he has been interested in under-standing the regulatory mechanisms underlying control of cell proliferation and tumor suppression His initial studies characterized the roles of the tu-mor suppressor protein RASSF1A and identified its associated proteins which were key molecules

(MST12 SAV1WW45 LATS12 and YAP) of the ldquoHippo signaling pathwayrdquo Thereafter he has fo-cused on understanding the roles and mechanism of action of Hippo signaling pathway which is a key player both in the control of cell proliferation and organ development as well as tumor suppression He was one of the pioneers to reveal the functions of mammalian hippo signaling pathway by generating various tissue-specific knockout mice (Mst12 Sav1 Lats12 etc) and analyzing their phenotypes His group demonstrated that Hippo signaling path-way controls stemprogenitor cell proliferation cell fate determination and differentiation by inhibiting YAPTAZ activity in epithelial organs His group al-so revealed that the actin cytoskeletal changes regu-late the Hippo-YAP pathway via cAMPPKA and SRF-IL6 functions as a critical mediator of YAP-in-duced stem cell properties in mammary epithelial cells His current studies are attempting to shed light on the roles of the Hippo signaling pathway in the regulation of adult stemprogenitor cell properties organ development and tissue regeneration

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 16: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 13

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Awards Year KSMCB Life Science Award MampC Award

Academic Research Awards

2015 Han-Woong Lee (Yonsei University)

Gynheung An (Kyung Hee University)

2014 Ji Hoon Ahn(Korea University)

Kwanghee Back(Kyung Hee University)

2013 Jang‐Soo Chun(Gwangju Institute of Sciences and Technology)

Jong‐Joo Cheong(Seoul National University)

2012 Eunjoon Kim(Korea Advanced Institute of Science and Technology)

Kwenseop Kim (Chonnam National University)

2011 Jin Won Cho(Yonsei Univeristy)

Dong‐Kug Choi(Konkuk University)

2010 Jongkyeong Chung(Seoul National University)

Pyeung‐Hyeun Kim (Kangwon National University)

2009 Won‐jae Lee(Ehwa Womans University)

Minkyun Kim (Seoul National University)

2008 Bong‐Kiun Kaang (Seoul National University)

Seongman Kang (Korea University)

2007 Byung‐Ha Oh(Pohang University of Science and Technology)

Sang Sun Kang(Chungbuk National University)

2006 Young‐Joon Kim(Yonsei University)

Chung Sun An(Seoul National University)

2005 Hong Gil Nam (Pohang University of Science and Technology)

Jae Young Seong (Korea University)

2004 Sang Yeol Lee (Gyeongsang National University)

Pann‐Ghill Suh(Pohang University of Science and Technology)

2003 Yeon‐Soo Seo(Korea Advanced Institute of Science and Technology)

Hae Mook Kang(Cheongju University)

2002 Sung Ho Ryu (Pohang University of Science and Technology)

Jaehoon Yu (Seoul National University)

Awards Year First Degree Award Second Degree Award

Mogam Awards

2000 Joonho Choe(Korea Advanced Institute of Science and Technology)

Young Sang Kim(Chungnam National University)

1999 Hun‐Taeg Chung(Wonkwang University)

Seong‐Ryong Kim(Sogang Univeristy)

1998 Bin Goo Kang(Yonsei University)

Bok Luel Lee(Pusan National University)

1997 Kyungjin Kim(Seoul National University)

Byeong Jae Lee(Seoul National University)

1996 Myeong‐Hee Yu(Korea Institute of Science and Technology)

Kyu‐Won Kim(Pusan National University)

1995 Yu Sam Kim(Yonsei University)

Changwon Kang(Korea Advanced Institute of Science and Technology)

1994 Si Myung Byun(Korea Advanced Institute of Science and Technology)

Young‐Chul Sung(Pohang University of Science and Technology)

Past Laureates

Aw

ards

Since 1994 the Foundation of the MOGAM Biological Engineering Research Center had sponsored the MOGAM Awards that recognize members of Korean Society for Molecular and Celluar Biology (KSMCB) who have con-tributed substantially to the advancement of molecular and cellular biology in Korea Later in 2001 these awards were replaced by the Academic Research Awards of the Korean Society for Molecular and Cellular Biology Of these the ldquoKSMCB Life Science Awardrdquo is given to a Korean scientist who has creative research activity in the fields of molecular and cellular biology and exhibited outstanding research performance in Korea for the recent five years The ldquoMolecules and Cells Awardrdquo(MampC Award) is given to a member who has pub-

lished the highly cited paper in Molecules and Cells the main journal of KSMCB during the previous three years The awardees of the KSMCB Life Science Award and the MampC Award receive 20000000 KRW and 3000000 KRW as a cash prize respectively including plaque The awardee of the KSMCB Life Science Award has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of these awards have been recommended by the only members assigned by the member of the Academic Research Awards Committee and the awardees are selected by the strict re-view from the Academic Research Awards Committee

Molecules and Cells (MampC) Award

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation (2015) Mol Cells 38 75-80

Nacksung Kim PhDDepartment of Pharmacology Chonnam National University Medical School Korea

Osteoclasts are unique cells responsible for the re-sorption of bone matrix MicroRNAs (miRNAs) are involved in the regulation of a wide range of physio-logical processes In this study we examined the role of miR-26a in RANKL-induced osteoclastogenesis The expression of miR-26a was up-regulated by RANKL during osteoclastogenesis Ectopic ex-pression of miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation actin-ring for-mation and bone resorption by suppressing the ex-

pression of CTGF which can promote osteoclast for-mation via up-regulation of DC-STAMP On the oth-er hand overexpression of miR-26a inhibitor en-hanced RANKL-induced osteoclast formation and function as well as CTGF expression In addition the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with re-combinant CTGF Collectively our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 17: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

14 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Founder of the KSMCB

PARK Sang-Dai Professor Emeritus at Seoul National University is Founder of Korea Society of Molecular and Cellular Biology (KSMCB) that was established on April 15th 1989 Prof Park has been a pioneer in molecular and cellular biology since 1966 He published many important articles on genomic instability caused by chromosome aberrations cell cycle delays and abnormalities of DNA replication and repair He also discovered DNA-damage response proteins which play a critical role in DNA damage checkpoint by regulating DNA damage inducible genes These findings greatly help the current understanding of DNA double strand breaks-induced recombination repair Prof Park has played a critical role in fostering the development and

globalization of molecular biology in Korea by serving as President of KSMCB President of Korean Federation of Sciences amp Technology Societies and Vice-Chair of the Presidential Advisory Council on Science amp Technology of Korea He received his BS in Biology from Seoul National University and his PhD from St Johnrsquos University in the United States Currently he serves as a member of the National Academy of Sciences (NAS) of Korea a fellow of the Third World Academy of Sciences (TWAS) and Vice President of the Pacific Science Association (PSA) He received numerous prestigious awards including the 1st Korea Science Award the Korean National Academy of Sciences Award and the Chanjo Medal Order of Science amp Technology Merit Korea

KSMCB Award for Women in Life Science Lecture

October 12 (Wed) 1530-1600 Rm 401Chair Sunjoo Jeong PhD (Department of Molecular Biology Dankook University Korea)

Biogenesis and Regulation of MicroRNA

V Narry Kim PhDRNA Research Center Institute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

V Narry Kim has made major contributions to our understanding of RNA biology Her group has been in-vestigating how microRNAs are made and regulated and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells Her research group found and studied several key factors in the microRNA pathway including Drosha DGCR8 Lin28 and TUTases and discovered pluripotent stem cell-specif-ic microRNAs such as human miR-302 cluster miR-369 cluster and miR-371 cluster More recently Kim has made important progresses into under-standing RNA regulation through translation RNA tailing and decay In particular her group developed a technology that allows genome-wide study of RNA tail and revealed important roles of RNA uridylation and adenylation in gene regulation

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of

Biological Sciences at Seoul National University She received her PhD in 1998 from Oxford University UK where she studied the functions of retroviral pro-teins in the construction of gene transfer vectors in the Kingsman lab She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania USA She set up her own research group at Seoul National University in 2001 Narry Kim received LrsquoOreal-UNESCO Women in Science Award (2008) the Ho-Am Prize in Medicine (2009) and the Korea SampT Award (2013) and was elected as Foreign Associate of European Molecular Biology Organization (EMBO 2013) Foreign Associate of National Academy of Science (NAS 2014) and Member of Korean Academy of Science and Technology (KAST 2014)

Representative papers

- Kwon et al (2016) Structure of Human DROSHA Cell 164(1-2)81-90- Cho et al (2015) Multiple repressive mechanisms in the hippocampus during memory formation Science 350(6256)82ndash87- Lim et al (2014) Uridylation by TUT4 and TUT7 marks mRNA for degradation Cell 159(6)1365-1376- Heo et al (2012) Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs Cell 151521-532 - Lee et al (2003) The nuclear RNase III Drosha initiates microRNA processing Nature 425(6956)415-9

To award the women scientists who have accomplished outstanding research achievement and contributions in the fields of life science the KSMCB established KSMCB Award for Women in Life Science in 2016 The awardee of the KSMCB Award for Women in Life Science receives KRW 10000000 as a cash prize including plaque The awardee of the KSMCB Award for Women in Life Science has given a lecture by the keynote speaker at the International Conference of KSMCB Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is supported by the donations of the former KSMCB president Sang-Dai Park who established our society in 1989

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 18: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 15

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Year Laureate Year Laureate

2015 Dae-Jin Yun(Gyeongsang National University) 2009 Yoon Ki Kim

(Korea University)

2014 Jaewhan Song(Yonsei University) 2008

Giltsu Choi(Korea Advanced Institute of Science

and Technology)

2013Ildoo Hwang

(Pohang University of Science and Technology)

2007 Dae-Won Kim(Yonsei University)

2012 Hyun Kyu Song(Korea University) 2006 Won-jae Lee

(Ewha Womans University)

2011 Seung-Hoi Koo(Sungkyunkwan University) 2005 Sung Hee Baek

(Seoul National University)

2010 Ji Hoon Ahn(Korea University) 2004 V Narry Kim

(Seoul National University)

Aw

ards

Representative papers

- Artan et al (2016) Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides Genes Dev 301047-1057

- Lee et al (2015) SREBP and MDT-15 protect C elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat Genes Dev 292490-2503

- Seo et al (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16FOXO transcription factor signaling in C elegans Proc Natl Acad Sci USA 112(31)E4246ndashE4255

- Hwang et al (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in C elegans Proc Natl Acad Sci USA 111(42)E4458-E4467

- Lee et al (2010) Inhibition of respiration extends C elegansrsquo life span via reactive oxygen species that activate HIF-1 Curr Biol 202131-2136

To award the bright young scientists who have accom-plished research achievement and contributions in the field of molecular and cellular biology KSMCB established the Macrogen Scientist Awardin 2003 awarded the 1st scientist in 2004 A junior researcher in a research department chief position (member) in korea or a Korean compatriot living outside Korea is selected by the KSMCB board as the win-ner of the award The winner will be awarded travel ex-penses including 10000000 KRW and will be presented with a plaque by the sponsor of the award Macrogen Co Candidates of the award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee

Macrogen Scientist Award Lecture

October 14 (Fri) 1640-1710 Rm 401Chair Dae-Jin Yun PhD (Department of Biochemistry Gyeongsang National University Korea)

The Quest for Long and Healthy Life Lessons from C elegans Molecular Genetics

Seung-Jae V Lee PhD Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Dr Seung-Jae V Lee obtained his Ph D from Johns Hopkins University School of Medicine in 2003 After fin-ishing his postdoctoral training at University of California San Francisco he joined POSTECH as an assistant pro-fessor in 2009 Dr Lee has become a rising star in his re-search field biology of aging He has published many re-search papers in internationally leading journals includ-ing Genes and Development PNAS and Current Biology as a corresponding author

Dr Leersquos research group has been focusing on how var-ious regulatory genes influence animal aging by using the roundworm C elegans as a model system One important contribution is regarding a paradoxical phenomenon known in the field of aging research mild impairment of mitochondrial respiration increases the lifespan of many organisms including C elegans and mice Dr Leersquos re-search team demonstrated that inhibiting mitochondrial respiration elevates the level of reactive oxygen species (ROS) which in turn promote longevity via up-regulating the transcription factor hypoxia-inducible factor 1 (HIF-1) Further they showed that internal ROS levels are tightly regulated by HIF-1 and the protein kinase AMPK

via feedback mechanisms Their findings are among pio-neering ones answering the enigmatic question regarding how inhibited mitochondria can promote longevity

Most evolutionarily conserved aging-regulatory path-ways including insulinIGF-1 signaling (IIS) and target of rapamycin (TOR) signaling pathways actively monitor external signals to exert internal physiological responses However it remains incompletely understood how these signaling pathways modulate lifespan upon changes in environments Dr Leersquos group found that upon detecting food cues chemosensory neurons shorten lifespan by in-ducing neuroendocrine factors that up-regulate IIS They also demonstrated that under glucose-rich diet conditions SREBP transcription factor protects animals from accel-erated aging via enhancing fat conversion processes In addition they showed that heat shock transcription factor 1 promotes IIS-mediated longevity through integrating sig-nals from TOR and that RNA helicases lengthen lifespan through increasing cellular RNA homeostasis Because all these factors are evolutionarily well conserved similar mechanisms for longevity regulation may operate in mammals including humans

Past Laureates

Abstract p52

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 19: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

16 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

The Late Dr Lee Ki-Young (一泉 李基寧 敎授)IIlchon is the pseudonym of the late Dr and Professor Ki-Young Lee one of the pioneers of biochemistry and mo-lecular biology research in Korea Graduated from Kyung Sung Medical School where the Seoul National University Medical School originated in 1936 he started biochemical research in the Department of Biochemistry at the Kyung Sung Medical School His research continued after restora-tion of independence as a full professor in the Department fo Biochemistry at the Seoul National University Medical

School For 33 years until his retirement he contributed and influenced in great deal to science and education In 1952 he revealed the possibility of classifying micro-organisms based on the genetic information specifically using the information in dif-ference of GC ratio by paper chromatography method during his study at the Pasteur Insitute (Annales de Linstitut Pasteur 1956) He received PhD from the University de Paris in 1956 and returned to continue studies in genomic DNA such ad nucleotide ra-tio and repetitive sequences which initiated molecular biology research in Korea For his work he received numerous awards Prim Minister Award (1968) the Order of Civil Merit (1970) and the Order of Cultural Merit from France (1964) to name few He was a member of the Korea National Academy of Science and honorary professor at the Seoul National University until he took his last breath in January 2002

Ilchun Memorial Lecture

October 14 (Fri) 1550-1620 Rm 401Chair Jong-Il Kim MD PhD (Department of Biomedical Sciences Seoul National University College of Medicine Korea)

Functional Link between Circadian Timing System and Mood Regulation Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopaminergic System

Kyungjin Kim PhDDepartment of Brain amp Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) amp Korea Brain Research Institute (KBRI) Korea

Dr Kyungjin Kim attained BS in zoology magna cum laude at Seoul National University (SNU) South Korea in 1975 and MS in developmental biology at SNU in 1979 and then PhD in physiology at University of Illinois at Urbana-Champaign USA in 1984 Prior to joining SNU he completed post-doctoral research at University of Illinois and Columbia University USA Since 1985 He was Professor of Department of Biological Sciences and Department of Brain and Cognitive Sciences at SNU for nearly 30 years He is cur-rently the President of Korea Brain Research Institute (KBRI) and also Distinguished Professor of Department of Brain amp Cognitive Sciences of Daegu Gyeongbuk Institute of Science and Technology (DGIST) since 2015 He has mainly focused on 1) Molecular and cellular control of circadian clock and its functional relevance in mammalian brain functions 2) Neuroendocrine regulation of the hypothalamic GnRH pulse generator and 3) Neurobiology of prenatal stress particularly concerning synaptic plasticity in the hippocampus and

amygdala throughout his research career He published more than 230 peer-reviewed original articles reviews and invited book chapters He has also served numerous roles in aca-demic government and private sectors He was former direc-tor of the Brain Research Center (BRC) which administered lsquothe 21st Century Frontier Program in Neurosciencersquo sup-ported by Korean government (2003-2013) He was edi-tor-in-chief of lsquoMolecules amp Cellsrsquo (2000-2003) and associate editor of lsquoMolecular Reproduction amp Developmentrsquo (1997-2007) and is currently editorial board member in pres-tigious scientific journals such as lsquoProgress in Neurobiologyrsquo lsquoFrontiers in Neuroendocrinologyrsquo and lsquoNeuroendocrinologyrsquo He received numerous accolades including Alexander von Humbolt foreign fellowship award (1992) Mok-Am bio-science award (1997) and Basic science award from the Korea National Academy of Science (2010) He is also mem-ber of the Korean Academy of Science and Technology since 1999

Representative papers- Chung et al (2014) Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation Cell 157858-868- Choe et al (2013) Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation PNAS 1105677-5682- Lee et al (2013) GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal Nat Neurosci 161436-1444- Lee et al (2011) Impairment of fear memory consolidation in maternally stressed male mouse offspring evidence for nongenomic glucocorticoid action on the amygdala

J Neurosci 317131-7140- Son et al (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production (2008) PNAS 10520970-20975

Introduced in 1994 the Ilchun Memorial Lecture commemorates the late Dr and Professor Ki-Young Lee a pioneer of Korean molecular biology Except 1999 and 2001 when the lecture was given every other year the lecture has benn given ev-ery year by the keynote speaker at the Annual Meeting of the Korean Society for Molecular and Cellular Biology

Past LaureatesYear Laureate Year Laureate Year Laureate Year Laureate

2015Hoon Ryu

(Boston University USA and Korea Institute of Science and Technology Korea)

2010 Ki-Up Lee(Ulsan University Korea) 2005 Tai June Yoo

(University of Tennessee USA) 1998Chil-Yong Kang

(Univ of Western Ontario Canada)

2014 Kyuyoung Song(University of Ulsan College of Medicine Korea) 2009 Augustine MK Choi

(Harvard Medical School USA) 2004 Hee-Sup Shin(Korea Institute of Science and Technology Korea) 1997 Tong Hyub Joh

(Cornell University USA)

2013 Min Goo Lee(Yonsei University Korea) 2008 Jae-Young Koh

(Ulsan University Korea) 2003 Johng S Rhim(Univ of the Health Sciences USA) 1996 Kwang W Jeon

(University of Tennessee USA)

2012 Kwang-Soo Kim(Seoul National University Korea) 2007 Jae U Jung

(Harvard Medical School USA) 2002 Seung U Kim(University of British Columbia Canada) 1995 Yoon Sang Cho-Chung

(NCI NIH USA)

2011 Hyo-Soo Kim(Seoul National University Korea) 2006 Sam W Lee

(Harvard Medical School USA) 2000 Sue Goo Rhee(NHLBI NIH USA) 1994 Peter S Kim

(Whitehead Institute MIT USA)

Abstract p52

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

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KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 20: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 17

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Aw

ards

Great Global Next Generation Research AwardsThe award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the previous years which should be performed in KoreaThe awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recom-mended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by AMOREPACIFIC Co since 2015

Lectures and awards October 12 (Wed) 1030-1200 Rm 401 Awards Lecture P42 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltAMOREPACIFIC Great Global Next Generation Research Awardeesgt

Name Affiliation

Daesik Kim Department of Chemistry Seoul National University

Jinho Seo Department of Biochemistry Yonsei University

Hi-Jai R Shin School of Biological Sciences Seoul National University

Sangho Lim Department of Life Science Hanyang University

Jae-Won Choi Department of Biochemistry Chungbuk National University

Sponsor AMOREPACIFIC Co

Excellence Thesis AwardsThis award is given to research scientists including graduate student postdoctoral research fellow and

regulartemporary doctoral researchers except faculty In order to be awarded qualifications have to meet the criteria that the candidate must publish his research as the first author in the past two years which should be performed in Korea and abroad (1 awardee from each field which is 1) natural sciences 2) medi-cal sciencepharmacology 3) agriculturefishery science) The awardee is given prize money 2000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by TaKaRa Korea Biomedical Inc since 2015

Lectures October 12 (Wed) 1030-1200 Rm 300(YI Ⅰ) Rm 307(YI Ⅱ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltTaKaRa Excellence Thesis Awardeesgt

Field Name Affiliation

Natural Sciences Su-Yeon Lee Gachon University Life Science Institute

Medical SciencePharmacology

Euna LeeDepartment of Biomedical SciencesAjou University School of Medicine

AgricultureFishery Science

Seungill KimDepartment of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University

Sponsor TaKaRa Korea Biomedical Inc

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 21: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

18 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

SeouLin Bioscience Outstanding PhD Thesis AwardsTo encourage student researchers since 1995 the society has given this award to a student member who

wrote the best master or doctoral thesis of given year The awardee is given prize money 1000000 KRW and plaque Candidates of this award have been recommended by the KSMCB regular member and the awardee is selected by the strict review from the Academic Research Awards Committee This award is sponsored by SeouLin Bioscience since 2015

Lectures October 12 (Wed) 1030-1200 Rm Rm 307(YI Ⅱ) Rm 308(YI Ⅲ) Awards October 14 (Fri) 1710-1800 Rm 401 The awardees posters are displayed in the lobby of the Rm 401 (4F) amp Hall D1 (3F)

ltSeouLin Bioscience Outstanding PhD Thesis Awardeesgt

Name Graduated School

Kyung Lock Kim Department of Life Sciences Pohang University of Science and Technology (POSTECH)

Byeong-Won Kim Department of Life Sciences Korea University

Sangjun Park Department of Medical Science Yonsei University

Da-Hye LeeDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST)

Murat ArtanDivision of Information Technology Convergence Engineering (ITCE) Pohang University of Science and Technology (POSTECH)

Sponsor SeouLin Bioscience Co Ltd

Presentation Awards for Young InvestigatorsInternational Conference of the Korean Society for Molecular and Cellular Biology (KSMCB) provides

Presentation Awards for young investigators The Presentation Awards aim to encourage and support the ef-forts of young investigators including graduate students and postdoctoral research fellows who are selected to give talks at the Young Investigators Session of the International Conference of the KSMCB The Academic Research Awards Committee of the KSMCB also selects winners who receive the Best Presentation Awards by considering the significance of the research originality and clarity of their presentations Presentation Award and the Best Presentation Award winners are given prize money 100000 KRW and 300000 KRW respectively with certificates

Awards October 14 (Fri) 1710-1800 Rm 401

Excellent Poster AwardsEach year at the annual meeting since 1997 KSMCB has given poster awards to approximately 70 pre-

senters who delivered excellent poster presentations Extra credits will be given to candidates attended out-side of Seoul area The awardees are selected directly from the venue by poster award evaluation committee Each awardee will be given prize money 150000 KRW and a certificate The awards are spon-sored by the Sigma-Aldrich Korea

Sponsor Sigma-Aldrich Korea Co Springer Nature

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 22: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 19

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Heui-Soo Kim PhD (Biological Sciences Pusan National University Korea)

Since the advent of next-generation sequencing (ie whole ge-nome sequencing) transposable elements have been noticed be-cause of their tremendous copies in various eukaryotic genomes Transposable elements have shown a variety of impacts on their host genomes especially genomic variations Recently many mo-lecular biologists are interested in transposable elements field

Recent research of transposable elements in the eukaryotic ge-nomes provides a glimpse into their diversity and strong influenceon the overall differences in genomic architecture between differ-ent lineages In addition transposable elements are very useful asbiomarkers

Symposia

October 12 (Wed) 1300-1440 Rm 300

Evolutionary Dynamics of Transposable ElementsSym 01Sponsored by the Meta Inflammation Research Institute (MIRI)

Sym 01-1 1300-1325Hee-Jae Cha PhDDepartment of Parasitology and Genetics Kosin University College of Medicine KoreaExpression Profiles of HERV Env Proteins in Normal

and Cancerous Tissues

Sym 01-2 1325-1350Kyudong Han PhDDepartment of Nanobiomedical Science Dankook University KoreaTransposable Element-Associated Structure

Variations (TASVs) in the Korean Genome

Sym 01-3 1350-1420Jinchuan Xing PhDDepartment of Genetics Rutgers The State University of New Jersey USAUnderstanding Mobile Element Biology Using

High-Throughput Sequencing

Sym 01-4 1420-1440Keunsoo Kang PhDDepartment of Microbiology College of Natural Sciences Dankook University KoreaA Genome-Wide Survey of TE-Contained

Transcripts

Abstract p53

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 23: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

20 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Je Kyung Seong DVM PhD (College of Veterinary Medicine Seoul National University Korea)

Chair Sung Ho Ryu PhD (Pohang University of Science and Technology (POSTECH) Korea)

Insulin resistance is the most important phenomenon in various metabolic disorders including type 2 diabetes and obesity Many inflammatory cytokines fatty acids and stress conditions trigger changes of intracellular signaling proteins in metabolic cells and affect the sensitivity of the insulin action on the glucose uptake and

modulation In this symposium current trend of the research area including the roles of intercellular factors and intracellular proteins on the diseases will be covered from fundamental concept to clin-ical relation

October 12 (Wed) 1300-1440 Rm 307

Insulin Resistance and Metabolic DisordersSym 02Sponsored by the National Creative Research Initiative Center for Programmed Cell Death

Korea Mouse Phenotyping Center (KMPC)

Sym 02-1 1300-1325Hail Kim MD PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Peripheral Serotonin in Energy Homeostasis

Sym 02-2 1325-1350Sungsoon Fang PhDCollege of Life Sciences Sejong University Korea

Bile Acid Receptor in the Gut Potent Therapeutic Strategy for the Treatment TypeⅡ Diabetes

Sym 02-3 1350-1415Jae Myoung Suh PhDGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Korea

FGF1 as a New Therapeutic to Treat Type 2 Diabetes

Sym 02-4 1415-1440Kohjiro Ueki MD PhDDepartment of Molecular Diabetic Medicine Diabetes Research Center National Center for Global Health and Medicine Japan

Role of Akt in Skeletal Muscle in Anti-Aging

Abstract p53-54

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 24: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 21

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Co-Organizers amp Chairs Jin Woo Kim PhD (Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea)

Young-Gyu Ko PhD (Division of Life Sciences Korea University Korea)

Intra- and intercellular protein trafficking is recently revisited by many evidences that cannot be explained by classical principles of cell biology Especially various secretion pathways have been identified beyond the conventional ER-Golgi secretion pathway The unconventional trafficking pathways which deliver cytoplas-mic and nuclear proteins as well as membrane proteins to the ex-tracellular space not only aim to drain unnecessary proteins off but also induce proliferation differentiation and death in neighboring

cells In this symposium speakers introduce their latest studies onunconventional protein trafficking by exosomes and tunneling nao-tubes in addition to cell penetrating proteins The studies not only focus to molecular mechanisms but also highlight the physiologicalconsequences of the protein trafficking The audience would have an opportunity to revise their understanding to protein trafficking inmulticellular organisms

October 12 (Wed) 1300-1445 Rm 308

Unconventional Intercellular Protein TraffickingSym 03Sponsored by the Tunneling Nanotube Research Center

Sym 03-1 1300-1325Chiara Zurzolo MD PhDPasteur Institute France

Tunneling Nanotubes Mechanisms of Formation and Role in Spreading Amyloids Proteins in Neurodegenerative Diseases

Sym 03-2 1325-1345Young-Gyu Ko PhDDivision of Life Sciences Korea University Korea

Tunneling Nanotubes Regulate Hepatic Gluconeogenesis

Sym 03-3 1345-1405Yong Song Gho PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaExosomes as Novel Intercellular Communicasomes

Sym 03-4 1405-1425Seung-Jae Lee PhDDepartment of Biomedical Sciences Seoul National University College of Medicine KoreaMechanism of Interneuronal Protein Aggregate

Trafficking

Sym 03-5 1425-1445Jin Woo Kim PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaIntracellular Trafficking of Homeodomain Proteins in

the Nervous System

Abstract p54-55

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 25: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

22 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joung-Hun Kim PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

Understanding how cellular and synaptic mechanisms within neural circuits produce behavior is a fundamental goal of science To ach-ieve that goal we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings Pioneering scientists have established the related fields of behavioral genetics and neural plasticity toward genuine secrets of animal behaviors

including learning and memory and emotion These two ap-proaches have recently been combined unprecedentedly effec-tively fuelled by powerful new technical tools such as optogeneticsAt this symposium leading researchers studying neural circuit andplasticity will present exciting new results and prompt better under-standing for how neural circuits may mediate behavior

October 12 (Wed) 1300-1440 Rm 401

Control of Neural Circuits for Animal BehaviorSym 04Sponsored by the Korea Brain Research Institute (KBRI)

Sym 04-1 1300-1330Cyril Herry PhDUniversity of Bordeaux France

Neuronal Circuits and Mechanisms of Fear Behaviour

Sym 04-2 1330-1350Ja Wook Koo PhDDepartment of Neural Development and Disease Korea Brain Research Institute (KBRI) KoreaCritical Role of Mesolimbic BDNF in Social

Avoidance

Sym 04-3 1350-1410Hyoung Kim PhDDepartment of Biomedical Engineering Sungkyunkwan University KoreaHow Do the Primate Dopamine Neurons Encode

Long-Term Memory for Habitual Behavior

Sym 04-4 1410-1430Sung-Yon Kim PhDDepartment of Biophysics and Chemical Biology amp Institute of Molecular Biology and Genetics Seoul National University Korea

Functional Circuit Mapping of the Anxious State

Sym 04-5 1430-1440 Anmo J Kim PhD Travel Grant Awardee

Laboratory of Integrative Brain Function The Rockefeller University USA

Quantitative Predictions in a Drosophila Visuomotor Network

Abstract p55-56

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 26: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 23

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Kunsoo Rhee PhD (Department of Biological Sciences College of Natural Sciences Seoul National University Korea)

Cell division is often accompanied with cell differentiation It is be-lieved that cell division is necessary for proper gene expression during differentiation In this session we will discuss what have

been known about the importance of cell division for diverse differ-entiation process

October 12 (Wed) 1300-1440 Rm 402

Cell Division Control during DevelopmentSym 05Co-organized by the Institute for Basic Science Center for Genomic Intergrity

Sym 05-1 1300-1315Kunsoo Rhee PhDDepartment of Biological Sciences College of Natural Sciences Seoul National University KoreaPLK4 Phosphorylation of CP110 for Centriole

Assembly

Sym 05-2 1315-1340Laurence Pelletier PhDDepartment of Molecular Genetics University of Toronto CanadaSurveying the Centrosome Landscape Using

Super-Resolution Imaging and Functional Proteomics

Sym 05-3 1340-1400Dongmin Kang PhDDepartment of Life Science Ewha Womans University KoreaThe Role of Local Reactive Oxygen Species for

Cdk1 Activation

Sym 05-4 1400-1420Ho Lee PhDGraduate School of Cancer Science and Policy National Cancer Center KoreaRegulation of Pluripotency and Differentiation by

Chromatin Modifiers in Mouse ES Cells

Sym 05-5 1420-1440Suk-Chul Bae PhDDepartment of Biochemistry College of Medicine Chungbuk National University KoreaRegulation of YAP Activity by Switching between the

YAP Binding Partners TEAD4 and RUNX3

Abstract p56-57

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 27: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

24 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Joon Kim PhD (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology

(KAIST) Korea)

Primary cilia are near-ubiquitous sensory organelles detecting chemical and mechanical stimuli from the environment Moreover primary cilia modulate the activity of several signaling pathways that play key roles in embryonic development and adult homeostasis

Accordingly defects in the formation or function of primary cilia areassociated with a wide range of genetic disorders collectively called the ciliopathies This symposium will address the current status and future directions of cilia research

October 13 (Thu) 0920-1100 Rm 300

Cilia as Dynamic Organelles in Development and DiseaseSym 06Sponsored by the Translational Research Center for Protein Function Control (TRCP)

Sym 06-1 0920-0940Seok Jun Moon DDS PhDDepartment of Oral Biology Yonsei University College of Dentistry KoreaCiliary Phosphoinositide Regulates Ciliary Protein

Trafficking in Drosophila

Sym 06-2 0940-1000 Ji Eun Lee PhDDepartment of Health Sciences and Technology SAIHST Sungkyunkwan University KoreaPosttranslational Modification of Cilia Axonemal

Tubulin Modulates Angiogenesis

Sym 06-3 1000-1040Jeremy Reiter MD PhDBiochemistry Department University of California USACiliary Hedgehog Signaling Controls Fatty

Degeneration of Skeletal Muscle

Sym 06-4 1040-1100Jinwoong Bok PhDDepartment of Anatomy Yonsei University College ofMedicine KoreaTemporal Requirements of Primary Cilia in Inner Ear

Development

Abstract p57

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 28: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 25

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chang-Woo Lee PhD (Sungkyunkwan University School of Medicine Korea)

The regulation of cell cycle is a key mechanism in monitoring the ordered set of events culminating in cell growth and division into two daughter cells and places where errors can lead to cancer In order to design better therapies that effectively treat cancer it is essential to decipher the molecular and biological details of path-ways that control the cell cycle in normal cells and thereafter un-derstand how they become aberrant in cancer However the ex-plosion of our understanding of cell cycle control during the last two

decades has not uncovered models for many different types of disease In this session we will assemble latest studies focusing on the molecular insights into cell cycle-related pathogenesis and therapeutics and aim to understand the molecular grounds for howthe cell cycle control has advantage in preventing the developmentof diseases These efforts would lead us to explore defective cel-lular physiology in pathogenesis and thereby to facilitate develop-ing therapeutic interventions targeting cell cycle

October 13 (Thu) 0920-1100 Rm 307

Cell Cycle Control in DiseaseSym 07Sponsored by the Genomic Instability Research Center (GIRC)

Sym 07-1 0920-0945Hyunsook Lee PhDDepartment of Biological Sciences Seoul National University KoreaBRCA2 Serves as the Platform for Spindle Assembly

Checkpoint Signaling

Sym 07-2 0945-1010Kozo Tanaka MD PhDDepartment of Molecular Oncology Institute of Development Aging and Cancer (IDAC) Tohoku University Japan

Defective Chromosome Dynamics as a Cause of Chromosomal Instability in Cancer

Sym 07-3 1010-1030 Youngsoo Lee PhDGenomic Instability Research Center and Department of Biomedical Sciences School of Medicine Ajou University Korea

Chromatin Remodeling Factor and DNA Damage in the Nervous System

Sym 07-4 1030-1100Makoto Nakanishi MD PhDDivision of Cancer Cell Biology Department of Cancer Biology The Institute of Medical Science The University of Tokyo Japan

Cellular Senescence as an Anti-Cancer Barrier

Abstract p57-58

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 29: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

26 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Hong-Duk Youn PhD (Department of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular

Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul NationalUniversity Korea)

EpigeneticsEpigenomics is defined as a research area to study the dynamic regulation of post-translational modifications of his-tone and DNA on chromatin and their global network with all the chromatin machineries involved in transcription splicing DNA

damage and replication In this session five distinguished speak-ers will discuss the advanced epigenetic researches which appliedfor elucidating the cellular processes in development and human diseases

October 13 (Thu) 0920-1100 Rm 308

Epigenetic Roles in Cellular ProcessesSym 08Sponsored by the National Creative Research Center for Epigenome Reprogramming Network

Sym 08-1 0920-0940Bing Zhu PhDInstitute of Biophysics Chinese Academy of Sciences ChinaDynamic Regulation of DNA Methylation

Sym 08-2 0940-1000Jae-Seok Roe PhDCold Spring Harbor Laboratory USA

BRD4 Connects Enhancer Regulation to Senescence Immune Surveilance

Sym 08-3 1000-1020Kyunghwan Kim PhDDepartment of Biology College of Natural Sciences Laboratory of Epigenetics and Chromatin Biology Chungbuk National University Korea

Targeted Proteolysis of the Histone H3 Tail Facilitates Epigenetic Reprogramming during Differentiation

Sym 08-4 1020-1040Myunggon Ko PhDSchool of Life Sciences Ulsan National Institute of Science and Technology (UNIST) KoreaDNA Methylation and Hydroxymethylation in

Hematologic Differentiation and Transformation

Sym 08-5 1040-1100Hong-Duk Youn PhDDepartment of Biomedical Sciences Seoul National College of Medicine amp Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science Seoul National University Korea

Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation

Abstract p58-59

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 30: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 27

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Bong-Kiun Kaang PhD (Department of Biological Sciences Seoul National University Korea)

Where and how is memory stored in the brain With the advent of modern technology such as molecular and cellular biology elec-trophysiology imaging and optogenetics neuroscience re-searches have now focused on memory traces or engrams in ro-dent models The term engram first coined by Richard Semon is defined as a group of neurons and their connections that are en-gaged in encoding a specific memory Engram cells that encode engrams are thought to undergo enduring physicochemical

changes during learning and their reactivation leads to memory recollection All the speakers invited in this symposium are leadingneuroscientists in the field of learning and memory Dr Silva will cover how the engrams encoding different episodes are asso-ciated temporally Dr Josselyn will describe diverse engram cells and their local circuits in the amygdala Dr Han will discuss how engram cells are recruited by fear conditioning and reactivated by cues Dr Kaang will talk about engram cells

October 13 (Thu) 0920-1100 Rm 401

Memory EngramSym 09Sponsored by the National Honor Scientist Program for Learning amp Memory

Center for Cognition and Sociality IBS

Sym 09-1 0920-0950Alcino J Silva PhDDepartment of Neurobiology Psychiatry and Psychology Integrative Center for Learning and Memory University of California Los Angeles (UCLA) USA

Molecular Cellular and Circuit Mechanisms That Link Memories across Time

Sym 09-2 0950-1020 Sheena A Josselyn PhDDepartment of Psychology Physiology and Institute of Medical Sciences University of Toronto CanadaMaking Breaking and Linking Memories

Sym 09-3 1020-1040Jin-Hee Han PhDDepartment of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) KoreaPersistent Retrieval of Presynaptically Reactivated

Memory

Sym 09-4 1040-1100Bong-Kiun Kaang PhDDepartment of Biological Sciences Seoul National University KoreaStudying Engram Cells and Their Connections in the

Mouse Hippocampus

Abstract p59

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 31: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

28 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Insuk Lee PhD (College of Life Science and Biotechnology Yonsei University Korea)

Unpresented amount of personal genomics data derived from both healthy and disease populations become a promising resource for discovery in human disease research For example GWAS has identified more than 10000 disease-associated genomic loci in hu-man and advanced NGS technology has already revealed numer-ous patient-specific genetic variants However genotype-based prediction of disease states is still challenging due to the high het-

erogeneity in phenotypic effect of the variants Cellular pathways can provide conceptual interface in which heterogeneous ge-nomics data can be integrated filling the gap between genome andphenome This symposium will highlight latest efforts in pathway and network analysis of disease genomics data to understand howpersonal genetic variation impact on diseases and treatments which is critical for precision medicine

October 13 (Thu) 0920-1055 Rm 402

Pathway and Network Analysis of Disease Genomics DataSym 10Sponsored by the Institute for Basic Science Center for RNA Research

Sym 10-1 0920-0940Insuk Lee PhDDepartment of Biotechnology Yonsei University KoreaNetwork-Based Interpretations of

Disease-Associated Mutations

Sym 10-2 0940-1005Lars Juhl Jensen PhDUniversity of Copenhagen Denmark

Gene Association Networks Large-Scale Integration of Data and Text

Sym 10-3 1005-1025Sun Kim PhDDepartment of Computer Science and Engineering Seoul National University KoreaAnalysis of Time-Series Transcriptome Data

Patterns Perturbations and Regulations

Sym 10-4 1025-1040Tae-Min Kim MD PhDDepartment of Medical Informatics College of Medicine The Catholic University KoreaGene Expression-Based Markers for the Prediction

of Therapeutic Response to Anti-Cancer Drugs

Sym 10-5 1040-1055Taejoon Kwon PhDDepartment of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Korea

The Effect of Genome Duplication on Human Disease-Related Genes

Abstract p60

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 32: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 29

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ildoo Hwang PhD (Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea)

In multicellular organisms stem cell exhibits the pluripotency to de-velop into many cell types in different tissues during early life and growth and possesses the ability to maintain its identity as a stem cell In contrast to animals plants go through post-embryonic de-velopment to form new organs replenish the loss of cells or sur-vive from environmental stresses for which meristematic cells (plant stem cells) in apical meristems and vascular cambium are absolutely required throughout the plant life cycle In these mer-

istems robust regulatory networks keep the balance between dif-ferentiation toward descendant cells and proliferationmain-tenance of stem cells but the most of molecular genetic controls ofcell fate are still remained to be explored Various aspect of signal-ing initiated from diverse ligand-membrane receptors which or-chestrate cell fate decision and its comparative aspect in multi-cellular organisms will be presented

October 13 (Thu) 1620-1800 Rm 300

Cell Fate DeterminationSym 11Sponsored by the Systems amp Synthetic Agrobiotech Center

Sym 11-1 1620-1650Shosei Yoshida PhDDivision of Germ Cell Biology National Institute for Basic Biology JapanIn vivo Dynamics of Mouse Spermatogenic Stem

Cells and Its Microenvironmental Control

Sym 11-2 1650-1720Kunyoo Shin PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaBladder Stem Cells in Regeneration and Malignancy

Role of Hedgehog Signaling

Sym 11-3 1720-1740Myeong Min Lee PhDDepartment of Systems Biology Yonsei University KoreaSCRAMBLED 2 Controls Epidermal Cell Patterning in

the Arabidopsis Root

Sym 11-4 1740-1800Ildoo Hwang PhDDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaRegulatory Aspects of Glycogen Synthase Kinases

on Auxin Signaling during Vasculature Development

Abstract p60-61

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 33: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

30 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Byung-Chang Suh PhD (Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology

(DGIST) Korea)

Phosphoinositides are acidic phospholipids of cell membranes with myo-inositol in the head group The parent compound phosphati-dylinositol (PI) can become phosphorylated on the 3 4 and 5 posi-tions of the inositol ring in every combination giving rise to the sev-en low-abundance polyphosphoinositides These lipids found pri-marily in the cytoplasmic leaflet mark the identity of specific sub-

cellular membrane compartments serve as membrane recognitionsites for specific cytoplasmic proteins and act as mem-brane-delimited second messengers modulating the activities of some membrane proteins Here we consider the recent develop-ments in different areas related to the regulation of phosphoinosi-tide metabolism and their role in health and disease

October 13 (Thu) 1620-1800 Rm 307

Phospholipids as Bioactive Cell Signaling MoleculesSym 12Sponsored by the DGIST Department of Brain amp Cognitive Sciences

Sym 12-1 1620-1650 Markus Wenk PhDDepartment Biochemistry National University of Singapore SingaporeNatural Variation of Blood Plasma Lipids in Healthy

Asian Individuals

Sym 12-2 1650-1715Sang Yoon Lee PhDDepartment of Biological Sciences Chronic Inflammatory Disease Research Center Ajou University School of Medicine Korea

Regulation of Focal Adhesion Dynamics through Akt-Mediated PIP5Kγ Phosphorylation

Sym 12-3 1715-1740 Deok-Jin Jang PhDDepartment of Applied Biology Kyungpook National University KoreaPhosphoinositide and Protein Targeting

Sym 12-4 1740-1800Byung-Chang Suh PhDDepartment of Brain and Dognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

Regulation of Voltage-Gated Ion Channels by Anionic Membrane Phospholipids

Abstract p61-62

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 34: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 31

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Eun-Kyeong Jo MD PhD (Chungnam National University School of Medicine Korea)

Autophagy is an intracellular lysosomal pathway that degrades and recycles protein aggregates and damaged organelles to maintain sustain energy homeostasis during various stress situations Recent studies have identified new functions and molecular mech-anisms through which autophagy regulates intracellular homeo-stasis and pathogenesis in diseased conditions Autophagy is re-quired not only for standard functions of degrading intracellular or-ganelles and aggregated proteins but also for prevention and

therapeutics against neurodegenerative inflammatory and in-fectious diseases In this session we will discuss the novel roles and molecular mechanisms of autophagy in regulating physiology and its contribution to disease preventioninhibition Our increasedunderstanding of the roles of autophagy in pathophysiology of dis-eases will bring into light new possibilities for the treatment of diseases

October 13 (Thu) 1620-1800 Rm 308

Autophagy in Cellular Homeostasis and Human DiseasesSym 13Sponsored by the National Research Center for Dementia

Institute for Basic Science Center for Vascular Research

Sym 13-1 1620-1640Dong-Hyung Cho PhDGraduate School of East-West Medical Science Kyung Hee University KoreaIndentification of Novel Peroxosomal Autophagy

(Pexophagy) Regulators

Sym 13-2 1640-1705Li Yu PhDSchool of Life Sciences Tsinghua University China

The Regulation of Energy Deprivation Induced Autophagy

Sym 13-3 1705-1725Hoon Ryu PhDDepartment of Neurology Boston University School of Medicine USAAutophagy and Brain Disorders

Sym 13-4 1725-1745Sangyeul Han PhDCenter for Vascular Research Institute for Basic Science (IBS) KoreaNormalization of Tumor Vasculature by Tie2

Activation and Ang2 Inhibition Enhances Drug Delivery

Sym 13-5 1745-1800Chul-Su Yang PhDDepartment of Molecular and Life Science Hanyang University KoreaAutophagy and Mitochondria Activation as a

Potential Host-Directed Therapy of Tuberculosis

Abstract p62-63

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 35: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

32 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Yun-Han Lee PhD (Keimyung University College of Medicine Korea)

Cancer is an aggressive and severe disease with a poor clinical outcome The tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions such as in-hibition of immune cell functions apoptosis of anti-tumor effector cells alterations in tumor cell metabolism and expansion of cancer stem cells which are accomplished through the activation of one or several molecular mechanisms Cancer cell metabolism is charac-terized by an enhanced uptake and utilization of glucose a phe-

nomenon known as the Warburg effect The persistent activation ofaerobic glycolysis in cancer cells can be linked to activation of on-cogenes or loss of tumor suppressors thereby fundamentally ad-vancing tumor progression In this session we will talk about recentadvances in understanding cellular and molecular pathways oper-ating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression

October 13 (Thu) 1620-1800 Rm 401

Role of Oncogene in Altered Tumor Metabolism and CSC GenerationSym 14

Sponsored by the Center for Cell to Cell Communication in Cancers

Sym 14-1 1620-1645YoungJoo Jeon PhDDepartment of Medical Science and Department of Biochemistry Chungnam National University College of Medicine Korea

Modification by Ubiquitin and Its Cousins in AlteredCancer Cell Metabolism

Sym 14-2 1645-1710Ju-Seog Lee PhDDepartment of Systems Biology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center USA

Oncogene-Driven Metabolic Regulation in Liver Cancer

Sym 14-3 1710-1735Sang-Kyu Ye PhDDepartment of Pharmacology Seoul National University College of Medicine KoreaSignal Transducer and Activator of Transcription 3

as a Therapeutic Target for Cancer and the TumorMicroenvironment

Sym 14-4 1735-1800Jong Bae Park PhDDepartment of System Cancer Science Graduate School of Cancer Science and Policy National Cancer Center Korea

Molecular Switches of Necrosis-Induced Mesenchymal Subtype Change during GlioblastomaProgression

Abstract p63-64

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 36: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 33

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Jung Weon Lee PhD (Department of Pharmacy College of Pharmacy Seoul National University Korea)

Fibrogenesis is highly dynamic processes at molecular cellular and tissue levels characterized by excessive deposition of ex-tracellular matrix resulting from prolonged stress-induced in-flammation and sustained cytokine activation of myofibroblasts

Since fibrosis can lead to further serious diseases like cancer the mechanistic regulation of organ fibrosis would be clinically beneficial

October 13 (Thu) 1620-1800 Rm 402

Mechanistic Regulation of Organ FibrosisSym 15Sponsored by the Center for Molecular Biology of Translation

Sym 15-1 1620-1640Jung Weon Lee PhDDepartment of Pharmacy College of Pharmacy Seoul National University KoreaDriving Force from Liver Fibrosis to Cancer

Sym 15-2 1640-1700Sang-Ho Lee MD PhDDepartment of Nephrology Kyung Hee University KoreaRole of the Mobilized Stem Cells on Renal Fibrosis

after Ischemic Reperfusion Injury

Sym 15-3 1700-1720Zhe-Xiong Lian MD PhDInstitute of Immunology and School of Life Sciences University of Science and Technology of China China

The Immunological Checkpoint in Liver Fibrosis

Sym 15-4 1720-1740Sang-Geon Kim PhDCollege of Pharmacy Seoul National University KoreaNovel Molecules for the Regulation of Liver Fibrosis

Sym 15-5 1740-1800Won-Il Jeong DVM PhDGraduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Korea

Exosome-Mediated TLR3 Activation in Liver Fibrosis

Abstract p64-65

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 37: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

34 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Jongsun Park PhD (Metabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science

College of Medicine Chungnam National University Korea)

Metabolic syndrome and its affiliated diseases are a severe health problem in human and it will get more attention in the future since the incidence of obesity is growing The metabolic syndrome in-cludes abdominal obesity hypertension dyslipidemia and hyper-glycemia and is linked to insulin resistance and the development of diabetes mellitus as well as to nonalcoholic fatty liver disease In

this symposium the members of KSMCB and MNUMS will present and discuss about their research interest (especially focus on themetabolic syndrome and cancer) and provide the opportunity for sharing the idea and developing the collaborative projects in bothinstitution

October 14 (Fri) 0920-1055 Rm 300

Metabolic Syndrome and CancerSym 16Sponsored by the Cell Dynamics Research Center

Sym 16-1 0920-0935Jongsun Park PhDMetabolic Diseases and Cell Signaling Laboratory Department of Pharmacology and Medical Science College of Medicine Chungnam National University Korea

mTOR Function in Pancreatic β-Cells

Sym 16-2 0935-1000Damdindorj Boldbaatar MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Blockade of Endogenouse Ghrelin Improves GLP-1-Induced Insulin Release in Type 2 Diabetic GK Rats

Sym 16-3 1000-1015 In-Chul Park PhDKorea Institute of Radiological and Medical SciencesKoreaOvercoming Tamoxifen Resistance by Metabolic

Regulation

Sym 16-4 1015-1040Battuvshin Lkhagvasuren MD PhDDepartment of Physiology School of Bio-Medicine Mongolian National University of Medical Sciences Mongolia

The Role of TRP Channels in Thermoregulation and Energy Metabolism

Sym 16-5 1040-1055So Hee Kwon PhDCollege of Pharmacy Yonsei University Korea

Selective Inhibition of HDAC6 Regulates Preferential Cytotoxicity in Cancer Cells by Differentially Modulating the Acetylation and Stability of p53 and Hsp90

Abstract p65-66

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 38: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 35

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Ki-Sun Kwon PhD (Aging Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Korea)

In this session we focus on a few recent findings in elucidating the aging process Lifespan extension is now linked to enhancement of processes including detoxification proteostasis autophagy and

stem cell function as well as extracellular matrices Knowledge of ageing will help intervention of a variety of age-related diseases such as metabolic disease immune and cognitive declines

October 14 (Fri) 0920-1100 Rm 307

Aging and Metabolic HomeostasisSym 17Sponsored by the Institute for Basic Science Center for Plant Aging Research

Center for Metabolic Function Regulation

Sym 17-1 0920-0950Thomas Keith Blackwell MD PhDJoslin Diabetes Center amp Harvard Medical School Department of Genetics USARedox Signaling Metabolism and Aging

Sym 17-2 0950-1010 Ki Woo Kim PhDDepartment of Pharmacology and Global Medical Science Wonju College of Medicine Yonsei University Korea

Metabolic Role of FoxO1 in Dopaminergic Neuron

Sym 17-3 1010-1030Haiyoung Jung PhDImmunotherapy Convergence Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) amp University of Science and Technology (UST) Korea

Hematopoietic Stem Cell Aging and Rejuvenation

Sym 17-4 1030-1050Jong-Sun Kang PhDDepartment of Molecular Cell Biology Sungkyunkwan University School of Medicine KoreaMetabolic Regulation of Skeletal Muscle Aging

Sym 17-5 1050-1100 Byung-Hoon Lee PhD Travel Grant Awardee

Department of Cell Biology Harvard Medical School USA

Regulation of Proteasome Activity for Protein Homeostasis

Abstract p66-67

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 39: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

36 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Regis Grailhe PhD (Institut Pasteur Korea Korea)

Big Data analytic tools are invaluable for extracting meaningful in-formation from microbiome data to provide new solution to global health problems This session will highlight how the gut microbiota

shapes intestinal immune responses during health and disease Several example should provide detail on the symbiotic relation-ship between a mammalian host and its microbiota

October 14 (Fri) 0920-1120 Rm 308

Big Data System Biology and Global HealthSym 18Sponsored by the Institut Pasteur Korea

Sym 18-1 0920-0950Shinji Fukuda PhDInstitute for Advanced Biosciences Keio University ampMetaGen Inc JapanGut Microbiota-Derived Metabolites Shape Host

Physiological Homeostasis

Sym 18-2 0950-1020Sin-Hyeog Im PhDInstitute for Basic Science (IBS) amp Pohang Universityof Science and Technology (POSTECH) KoreaProbiotics as an Immune Modulator

Sym 18-3 1020-1050Priscille Brodin PhDInstitut Pasteur de Lille France

Pain Control by Mycobacterium Ulcerans Secreted Mycolactone

Sym 18-4 1050-1120Parag Kundu PhDThe Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore

Gut Microbiome of Ageing-Host Friend or Foe

Abstract p67-68

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 40: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 37

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Co-Chairs Young-Joon Surh PhD (College of Pharmacy Seoul National University Korea)

Hasan Mukhtar PhD (Department of Dermatology University of Wisconsin-Madison USA)

The growth and metastatic potential of cancer cells are influenced by various neighbouring cells that comprise the so-called ldquotumor microenvironmentrdquo Therefore the precise understanding of inter-actions between cancer cells and surrounding environment is very essential for the discovery of novel anticancer targets and devel-opment of efficient therapeutic and preventive strategies The con-cept that the microenvironment of developing tumor is a crucial

regulator of carcinogenesis was originally proposed by Paget in his famous lsquoseed-and-soilrsquo hypothesis Recently much attention has focused on tumor microenvironment as an integral and essential part of cancer treatment and prevention This symposium will high-light the cellular heterogeneity in the tumor microenvironment nich-es as a potential cancer therapeutic and preventive target

October 14 (Fri) 0920-1100 Rm 401

Tumor Microenvironment and Heterogeneity Emerging Targets for Cancer Treatment and PreventionSym 19

Sponsored by the Tumor Microenvironment Global Core Research Center Seoul National University

Overview 0920-0930Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaIntroductory Presentation

Sym 19-1 0930-0950Jong-Wan Park MD PhDSeoul National University College of Medicine Korea

Stromal Cells Help Cancer Cells Cope with Capricious Tumor Milieu

Sym 19-2 0950-1020Hasan Mukhtar PhDDepartment of Dermatology University of Wisconsin-Madison USADietary Flavonoid Fisetin Targets Y Box-1 (YB-1)

A Potent Tumor Microenvironment Regulator

Sym 19-3 1020-1040Aree Moon PhDCollege of Pharmacy Duksung Womens University KoreaA Novel Transcriptional Target of ZEB1 in Breast

Cells Undergoing H-ras-Induced EMT

Sym 19-4 1040-1100Young-Joon Surh PhDCollege of Pharmacy Seoul National University KoreaInflammatory Signaling in Tumor Microenvironment

as a Potential Anticancer Target

Abstract p68

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 41: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

38 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Junho Lee PhD (Department of Biological Sciences Seoul National University Korea)

The Hippo pathway is an evolutionarily conserved signaling path-way involved in many aspects of development New roles of the

Hippo pathway and new players are being added by recent re-search progress

October 14 (Fri) 0920-1100 Rm 402

Hippo Signaling in Development and DiseaseSym 20Sponsored by the National Creative Initiatives Center for Cell Division and Differentiation

Sym 20-1 0920-0940Yun-Young Park PhDAsan Institute for Life Sciences Asan Medical Center Department of Convergence Medicine Ulsan College of Medicine Korea

Hippo Function in Human Liver Cancer

Sym 20-2 0940-1000HyunWoo Park PhDDepartment of Biochemistry Yonsei University KoreaUpstream Regulators of the Hippo Transducers

YAPTAZ and TEAD

Sym 20-3 1000-1020Junho Lee PhDDepartment of Biological Sciences Seoul National University KoreaThe Roles of the Hpo Pathway in the Maintenance of

Cellular Polarity in C elegans Intestine

Sym 20-4 1020-1035Eunjeong Seo PhDAsan Research Medical Center Korea

Hippo Pathway in Determination of Cell Fate in Osteo-Adipo Lineage

Sym 20-5 1035-1100Wanjin Hong PhDInstitute of Molecular and Cell Biology Astar SingaporeTAZYAP and Their Regulators in Hippo Pathway

Abstract p68-69

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 42: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 39

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yonghwan Kim PhD (Division of Biological Sciences Sookmyung Womens University Korea)

October 12 (Wed) 1030-1158 Rm 300

Young Investigators Session IYI I

YI 1-1 1030-1041Junsu KangDepartment of Cell Biology Duke University Medical Center USAModulation of Tissue Repair by Regeneration

Enhancer Elements

YI 1-2 1041-1052Jihye YeonDepartment of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea

trp-1 and trp-2 TRPC Channels Modulate Locomotive Behavior of C elegans

YI 1-3 1052-1103Joo Han LeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) KoreaDopamine D2 Receptor Abundance in Accumbal

Cholinergic Interneurons Regulates Cocaine Addiction Behavior

YI 1-4 1103-1114 Su-Yeon Lee TaKara Excellence Thesis Awardee

Gachon University Life Science Institute KoreaAdipocyte-Specific Deficiency of de novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Systemic Insulin Resistance

YI 1-5 1114-1125Kang-Min LeeSchool of Life Sciences Gwangju Institute of Scienceand Technology (GIST) KoreaBlood Glycemia Modulates Timing of Sperm Ejection

in Drosophila Female A Potential Contribution of Male Ejaculate Sugar in Biasing Sperm Use

YI 1-6 1125-1136Sang-Eun LeeDepartment of Physiology and Biomedical Sciences Seoul National University College of Medicine KoreanArgBP2 Regulates Excitatory Synapse Formation

by Controlling Dendritic Spine Morphology

YI 1-7 1136-1147 Euna Lee TaKara Excellence Thesis Awardee

Department of Biomedical Sciences Ajou University School of Medicine Korea

Pacemaker-Neuron-Dependent Disturbance of theMolecular Clockwork by a Drosophila CLOCK Mutant Homologous to the Mouse Clock Mutation

YI 1-8 1147-1158Gireesh GangadharanCenter for Cognition and SocialityInstitute for Basic Science (IBS) KoreaMedial septal GABAergic Projection Neurons

Promote Object Exploration Behavior and Type 2 Theta Rhythm

Abstract p69-71

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 43: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

40 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Chair TaeSoo Kim PhD (Department of Life Science Ewha Womans University Korea)

October 12 (Wed) 1030-1158 Rm 307

Young Investigators Session ⅡYIⅡ

YI 2-1 1030-1041Hyun-Eui KimHoward Hughes Medical Institute Department of Molecular and Cell Biology University of California at Berkeley USA

Lipid Biosynthesis Coordinates a Mitochondrial to Cytosolic Stress Response

YI 2-2 1041-1052 Murat Artan SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Food Smell and Taste Shorten C elegans Lifespanvia Inducing Distinct Neuroendocrine Insulin-Like Peptides

YI 2-3 1052-1103Nam Soo LeeDepartment of Biological Sciences Sungkyunkwan University KoreaTRAIPRNF206 Is Required for Recruitment of

RAP80 to Sites of DNA Damage

YI 2-4 1103-1114Seongju LeeDepartment of Biological Sciences Konkuk University KoreaFAM21 Directs SNX27-Retromer Cargoes to the

Plasma Membrane by Preventing Their Transport tothe Golgi Apparatus

YI 2-5 1114-1125Sun Mi HongDivision of Integrative Biosciences and Biotechnology Pohang University of Science and Technology (POSTECH) Korea

Roles of NAD+ Metabolism in Cancer Progression

YI 2-6 1125-1136 Da-Hye Lee SeouLin Bioscience Outstanding PhD Thesis Awardee

Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Korea

The Role of Lats12-YapTaz in Embryo and Adult Liver

YI 2-7 1136-1147Pu-Hyeon ChaTranslational Research Center for Protein Function Control Department of Biotechnology College of LifeScience and Biotechnology Yonsei University Korea

Simultaneous Destabilization of β-Catenin and Ras by a Small Molecule Binding of the Axin-RGS Domain Suppresses Colorectal Cancer

YI 2-8 1147-1158 Seungill Kim TaKara Excellence Thesis Awardee

Department of Plant Sciences Plant Genomics and Breeding Institute College of Agriculture and Life Sciences Seoul National University Korea

Genome Sequence of the Hot Pepper Provides Insights into the Evolution of Pungency in Capsicum Species

Abstract p71-72

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 44: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 41

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Chair Yoon Ki Kim PhD (Department of Life Sciences Korea University Korea)

October 12 (Wed) 1030-1158 Rm 308

Young Investigators Session ⅢYIⅢ

YI 3-1 1030-1041Jaechul LimInstitute for Basic Science (IBS) amp School of Biological Sciences Seoul National University Korea

Guanylation by TUT3 and TUT5 Shields mRNA from Degradation

YI 3-2 1041-1052Ji Hyun KimDepartment of Life Science and the Research Center for Cellular Homeostasis Ewha Womans University Korea

Modulation of mRNA Expression Dynamics by the Set2Rpd3S Pathway

YI 3-3 1052-1103Hyun-Cheol LeeCollege of Veterinary Medicine Chungnam National University KoreaHDAC6 Regulates Cellular Viral RNA Sensing by

Deacetylation of RIG-I

YI 3-4 1103-1114Sangjun Park SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Medical Science Yonsei University Korea

Role of Mitochondrial Anti-Viral Signaling Protein and Dynamin-Related Protein 1 for the NLRP3 Inflammasome Activation

YI 3-5 1114-1125Jung-Ah KangSchool of Life Sciences Gwangju Institute of Science and Technology (GIST) KoreaEpigenetic Regulation of Kcna3-Encoding Kv13

Potassium Channel by Cereblon Contributes to Regulation of CD4+ T-Cell Activation

YI 3-6 1125-1136Byeong-Won Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Korea University Korea

The Structural and Biochemical Study of Autophagic Receptor NDP52 and Sugar Receptor Galectin-8 Complex

YI 3-7 1136-1147Won Hoon ChoiDepartment of Biochemistry and Molecular Biology Seoul National University College of Medicine KoreaOpen-Gate Mutants of the Mammalian Proteasome

Show Enhanced Ubiquitin-Conjugate Degradation

YI 3-8 1147-1158Kyung Lock Kim SeouLin Bioscience

Outstanding PhD Thesis AwardeeDepartment of Life Sciences Pohang University of Science and Technology (POSTECH) Korea

Regulatory Mechanism of EGF-Induced EGFR Phosphorylation Patterns at the Single-Molecule Level

Abstract p72-73

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 45: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

42 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Organizer amp Chair Kyung-Hee Chun PhD (Department of Biochemistry and Molecular Biology Yonsei University College of Medicine Korea)

October 12 (Wed) 1030-1155 Rm 401

AMOREPACIFIC Great Global Next Generation Research Award LecturesAPA

Awards Ceremony 1030-1040

APA-1 1040-1055Daesik KimDepartment of Chemistry Seoul National University KoreaGenome-Wide Analysis Reveals Specificities of

Cpf1 Endonucleases in Human Cells

APA-2 1055-1110Jinho SeoDepartment of Biochemistry Yonsei University KoreaCHIP Controls Necroptosis through Ubiquitylation-

and Lysosome-Dependent Degradation of RIPK3

APA-3 1110-1125Hi-Jai R ShinSchool of Biological Sciences Seoul National University KoreaAMPK-SKP2-CARM1 Signaling Cascade in

Epigenetic and Transcriptional Regulation of Autophagy

APA-4 1125-1140Sangho LimDepartment of Life Science Hanyang University KoreaA Novel Blood-Brain Barrier-Permeable Peptide dNP2

Enables ctCTLA-4 to Ameliorate Multiple Sclerosis and Human Skin Graft via Induction of Regulatory T Cells

APA-5 1140-1155Jae-Won ChoiDepartment of Biochemistry Chungbuk National University KoreaDroplet-Based Microfluidics for Quantitative

Analysis of Protein Biomarker

Abstract p74-75

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 46: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 43

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Organizer amp Chair Chunghun Lim PhD (School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Korea)

Five outstanding speakers have been recommended by each bio-logical society in New Zealand Philippines Singapore Malaysia and India The speakers will discuss their recent findings on the di-verse aspects of molecular and cellular biology ranging from the biochemical bases underlying photosynthesis to the epigenetic

regulation during development Given living organisms have evolved with genetic diversity this special session adds a uniqueatmosphere to the 2016 conference of the KSMCB to strengthen ourunderstanding of Nature and enrich our experience at the meeting

October 12 (Wed) 1030-1200 Rm 402

Global Network SessionGN

GN-1 1030-1048Julian Eaton-Rye PhDBiochemistry Department School of Medical Sciences University of Otago New Zealand

recommended by the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB)

Photosystem Ⅱ of Oxygenic Photosynthesis The Role of Bicarbonate and Low-Molecular-Weight Proteins in Assembly and Electron Transfer

GN-2 1048-1106Jose Enrico Lazaro PhDNational Institute of Molecular Biology and Biotechnology College of Science University of the Philippines Philippines

recommended by the Philippine Society for Cell Biology (PSCB)

Imaging Flow Cytometry for Cytotoxicity Testing of Drugs and Natural Products against Plasmodium falciparum

GN-3 1106-1124Yvonne TAY Mei Sian PhDDepartment of Biochemistry National University of Singapore Yong Loo Lin School of Medicine Singapore

recommended by the Singapore Society for Biochemistry and Molecular Biology (SSBMB)

MicroRNA-638 Regulates Iron Storage in Prostate Cancer

GN-4 1124-1142Hasidah Mohd Sidek PhDSchool of Biosciences and Biotechnology Faculty of Science and Technology Universiti Kebangsaan Malaysia Malaysia

recommended by the Malaysian Society for Biochemistry and Molecular BIology (MSBMB)

Elucidating the Role of Glycogen Synthase Kinase-3β in theAnti-Inflammatory Action of Selected Plant-Borne BioactiveCompounds in a Murine Model of Malarial Infection

GN-5 1142-1200Rakesh K Mishra PhDCSIR-Centre for Cellular and Molecular Biology (CCMB)India

recommended by the Society of Biological Chemistry India (SBC(I))

Genomic Packaging and Epigenetic Regulation of Development

Abstract p75

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 47: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

44 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Co-Organizers Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Jong-Il Park MD PhD (School of Medicine Chungnam National University Korea)

Chair Myeong Jin Nam PhD (Department of Biological Sciences Gachon University Korea)

Luncheon Symposia

October 14 (Fri) 1220-1310 Rm 307

Research Ethics Symposium

Genome Editing Using CRISPR Nucleases

Sangsu Bae PhDDepartment of Chemistry Hanyang University Korea

Genome editing with programmable nucleases such as ZFNs TALENs and CRISPRCas9 or CRISPRCpf1- de-rived RNA-guided endonucleases is broadly useful for biomedical research biotechnology and medicine Now CRISPR nucleases become one of the hottest topic in the scientific world due to the ease of use and inex-pensive cost researchers can induce gene editing at dif-ferent DNA sites by simply altering the guide RNAs Notably in April 2015 Chinese group performed hu-man embryo editing using CRISPR-Cas9 nucleases for the first time And recently DNA-free CRISPR nucleases

the delivery of preassembled Cas9 protein-gRNA ribo-nucleoproteins (RNPs) has been introduced in various organisms including plants It could be exempt of regu-lation that applies to genetically modified organisms (GMO) due to the absence of foreign DNA sequences in the transformant cells Furthermore CRISPR would be used for various applications such as disease control making drugs de-extinction vector control better food production improving pets making disease models Here I introduce the brief history of CRISPR and would like to discuss the pros and cons of it

CRISPR-Cas9 Technology and Bioethical Considerations

Myeong Jin Nam PhDDepartment of Biological Sciences Gachon University Korea

The recent development of the clustered regularly in-terspaced short palindromic repeat (CRISPR)associated nuclease system has greatly accelerated genome en-gineering applications When these systems bind to a target DNA sequence in the genome they create a DNA double strand break (DSB) the repair of which leads to specific DNA sequence modifications

Recent results (Introducing precise genetic mod-ifications into human 3PN embryos by CRISPRCas- mediated genome editing) call for immediate attention being paid to the regulation of the genetic modification of human germline cells It is believed that any attempt to generate genetically modified humans through the

modification of early embryos needs to be prohibited For any germline genetic modification the resulting al-lele needs to be precisely predefined The specificity of the technologies needs to be further investigated and im-proved to ensure that no off-target mutations will be introduced For any introduced allele the effect of its in-troduction into a different genetic background needs to be carefully evaluated

It is advocated for preventing any application of ge-nome editing in the human germline until after a rig-orous and thorough evaluation and discussion are un-dertaken by the global research and ethics communities

[Korean]

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 48: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 45

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

October 13 (Thu) 1210-1300 Rm 300

Koram Biotech - Cell Signaling Technology Workshop

Exploring the Tumor Immunology Checkpoints by Fluorescent Multiplex Immunohistochemistry (mIHC)

Edward Li PhD

Scientific Manager Cell Signaling Technology China amp Asia-Pacific

The healthy immune system employs a series of checkpoints in order to maintain self-tolerance or prevent collateral tissue damage during an im-mune response

Immune checkpoint ligands are often up-regu-lated in cancer cells as a means to evade immune detection Activating antitumor immunity through the blockade of immune checkpoint proteins has become a promising therapeutic strategy for the treatment of cancer

Fluorescent multiplex immunohistochemistry

(mIHC) is a method that enables simultaneous de-tection of multiple (2-6 or more) proteins of interest in formalin-fixed paraffin-embedded (FFPE) tissue mIHC allows the simultaneous detection of multi-ple (gt6) targets of interest in a speciesisotype in-dependent manner while providing ample signal amplification Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 49: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

46 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

October 13 (Thu) 1210-1300 Rm 308

Logos Biosystems Workshop

Rapid and Efficient Tissue Clearing toward 3D Molecular Imaging

Woong Sun PhD

Department of Anatomy Korea University College of Medicine Korea

Making tissue transparent has tremendous advan-tages and potentials for 3D imaging of large tissues or even whole organisms In this short talk I will

present polymer-based tissue processing technique which offers fastest reliable and scalable tissue clearing

Advanced Tissue Clearing System for High-Resolution 3D Imaging

Ho-Jae Lee PhD

Logos Biosystems Inc Anyang Gyunggi-Do Korea

Various tissue clearing technologies have been developed for 3D volume imaging which allows visualization of structural organization of organs at the cellular level without tissue sectioning Among them CLARITY technique removes lipid compo-nents a major light scattering source in the bio-logical samples from tissues which are embedded with hydrogel as a structural alternative to lipids CLARITY and related techniques are well recog-nized as a compatible method for immune labeling of various biomolecules due to the porous property

of tissue-hydrogel hybrids However wide applica-tions of CLARITY has been limited by several draw-backs of the original do-it-yourself (DIY) design Recently Logos Biosystems has developed the X-CLARITY Tissue Clearing System which enables rapid and reproducible clearing of various tissues or whole bodies within a day while preserving tissue architecture and signals form endogenous fluo-rescence proteins The speed and consistency of this system will accelerate high-content mapping and analysis of cellular structures of intact organs

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 50: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

2016 International Conference of the Korean Society for Molecular and Cellular Biology 47

2016 International Conference of the Korean Society for Molecular and Cellular Biology

Sym

posia

Principal Investigators ONLY October 14 (Fri) 1220-1420 Rm 300

Open Forum for Development of Basic Science Support Programs in 2017 (미래창조과학부 및 한국연구재단 기초연구사업 설명회)

Future Development of Basic Research in Science amp EngineeringSeong-Kyu Kim

Director Ministry of Science ICT and Future Planning Korea

Open Forum for the 2017 Basic Research in Science amp EngineeringChul-Seung Park PhD

Director Division of Life Sciences National Research Foundation of Korea Korea

October 14 (Fri) 1420-1440 Rm 300

Samsung Science and Technology Foundation (SSTF) Workshop(삼성미래기술육성재단 워크샵)

Funding Policy of Samsung Science and Technology Foundation (SSTF)Seongmu Rheem

Program Director Samsung Science and Technology Foundation (SSTF) Korea

Samsung Electronics launched a 15 billion USD 10-year grant program to support creative and in-novative RampDs in areas of lsquobasic sciencersquo rsquonovel mate-rialsrsquo and rsquoinformation and communication technology (ICT) based convergencersquo in Korea beginning in 2013 These programs aim to contribute to catalyzing creative and challenging RampDs and building a foundation for technological innovation for the benefit of the broader society and economy through supporting RampDs in uni-versities public research institutes and RampD centers of small business in Korea

In order to nurture basic science Samsung decided to contribute 05 billion USD over the next 10 years and established a non-profit foundation SSTF in 2013

SSTF believes it can make a significant and positive impact in the science community in Korea SSTF tackles important issues where it can achieve significant and measurable impacts It takes risks and makes long-term and relatively large commitments It undertakes chal-

lenges that are not accessible to many other organ-izations It looks for and funds grant proposals that challenge ldquoundefinedrdquo ldquounsolvedrdquo or ldquodefined but not-knowing how-to-solverdquo problems Projects tackling problems in mathematics physics chemistry life sci-ence and their convergent fields are funded

SSTF fosters path-breaking discovery in science and offers funding after an in-depth reviewing process A research proposal which is regarded challengeable should be based on proposerrsquos own original and in-genious idea and eventually lead to scientific advance and have broader impacts on the world

A proposer applies for a research grant and funding that is within the reasonable bounds according to hisher research plan-theme methodology term mile-stone and members

The funding policy and interest of SSTF will be dis-cussed in this session

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation

Page 51: 2016 International Conference of the Korean Society for Molecular … · 2016-10-08 · 2016 International Conference of the Korean Society for Molecular and Cellular Biology KSMCB

48 October 12-14 2016 Coex Seoul Korea wwwksmcborkr

KSMCB October 12-14 2016 COEX Seoul Korea

Booth No Company Name Booth No Company Name Booth No Company Name1 Vivagen Co Ltd 38 SCINCO CO LTD 88 EmaGene Science

2 Trabis BioScience Co Ltd 39 RIGONG INTERNATIONAL INC 89 Sungwoo life science

3 Agilent Technologies Inc 40 Sigma-Aldrich 90 Technomart Inc

4 KOS Inc 41 AMICOGEN 91 MGMED Inc

5 DNA Link 42 43 VIEWORKS 92 KANGSTEM BIOTECH CO LTD

6 YoungWha Scientific Co LTD 44 45 50 51 Nikon Instruments Korea 93 WOOJUNGBSC

7 LK LAB KOREA 46 47 Takara Korea Biomedical Inc 94Nakdonggang National Institute of Biological Resources

8 Genenmed Inc 48 49 Bio-Medical Science Co Ltd 95 Central LabAnimal Inc

9 ProPharmTech 52 53 54 eppendorf Korea Ltd 96 HANSHIN MEDICAL CO LTD

10 Peptron Inc 55 ICLS (International Chemical Life Science) 97 KBSI

11 Macrogen 56 SFC Co Ltd 98 DGIST

12 Boo Kyung SM Co Ltd 57 Ferramed Inc 99 ATTO KOREA

13Korea Research Institute of Bioscience amp Biotechnology

58 59 Tucsenkorea 100 WOOSUNG CRYOTECH COLTD

14 Pohang Technopark 60 61 Logos Biosystems Inc 101 Korea Chemical Bank of KRICT

15 InnogeneTech Inc 62 63 QIAGEN Korea Ltd 102 Cosmo Genetech Co LTD

16 SJENG 64 TecscoAbberior 103 Donginbiotech Co Ltd

17 NAMOTEC 65 Osong Medical Innovation Foundation 104 105 SeouLin Bioscience

18 BIOEDIT LTD 66 67 Seegene 106 107 DYNEBIO INC

19 NAROO DITECH INC 68 Koram Biotech Corp 108 B2BIO

20 THREE SHINE 69 70 SolGent 109 MBIOTECH

21 NanoEnTek 71 KOMA BIOTECH 110 111 Roche Diagnostics Korea

22 DOOYEOLBIOTECH 72 73 HYUNDAI MICRO 112 YOUNGBIO

23 DONG YOUNG INSTRUMENTS CO LTD 74 75 METTLER TOLEDO 113 114 OLYMPUS KOREA CO LTD

24 25 Thermo Fisher Scientific 76 77 78 KAISCO 115 Korea Cryogenics

26 27 SPL Lifesciences 79 80 BIONEER 116 Korea National Research Resource Center

28 29 ZEISS Korea (Carl Zeiss Korea) 81 WuXi AppTec Korea 117 GHBIO Inc

30 Enzynomics Inc 82 iCELL 118 SAMCHUN PURE CHEMICAL

31 BN Korea Co LTD 83 BIOFACT 119 120 Kyongshin Scientific Co Ltd

32 Daemyung Science Co Ltd 84 AbClon Inc 121 Advanced Technology Inc

33 ATGen 85 TESCAN KOREA 122 Taeshin Bioscience

34 35 BioTek Instruments Korea 86 Centers for Disease Control amp Prevention 123 SimTech Systems Inc

36 37 GreenMate Biotech Corp 87 LPS Solution Publisher 01 HongReung

Exhibition

Poster Presentation