2016 05-20 Hacking Health Holland, Nijmegen, Aain van Gool
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Transcript of 2016 05-20 Hacking Health Holland, Nijmegen, Aain van Gool
Biomarkers in Personalized Health(care): Lost in translation
Alain van Gool Professor Personalized Healthcare
Hacking Health Nijmegen – Inspiration talks 20 May 2016
2
My path 1989-now
Molecular lab world • Mass spectrometry analysis of glycoproteins in human plasma • 0,05 microliter analysis: detection of 100.000 signals in one scan (1,4 Gb) • ~40.000 peptides of which >80% contain sugar modification • Diagnose patients and identify new biomarkers
500
1000
1500
2000
m/z
5 10 15 20 25 30 35 40 Time [min]
Proof of principle study:
{Source: Translational Metabolic Laboratory, Radboudumc} 3
Biomarkers !?
Society world
5
• Heart beat • Steps • Glasses water/coffee • Lifestyle
Where is the molecular data?
Genetic risk lung cancer → don’t smoke !
What does my DNA tell me?
No expected adverse reaction to Warfarin
7
3 key aspects of personalized health(care)
‘I want to stay healthy. If not, how do I get healthy?’
1. What to measure?
2. How much can it change?
3. What should be the follow-up for me?
8
Translation is key in Personalized Healthcare !
“I’m afraid you’re
suffering from an
increased IL-1β and
an aberrant miR843
expression”
Adapted from:
?
9
The challenge: design a data-driven GPS for health
• Monitor on background
• Alert when you are at risk
• Advice what to do
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