2015 innovation day_hyperspectral camera_verhaert & lambda-x

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Hyperspectral camera technology & applications Template Innovation Day presentation HYPERSPECTRAL CAMERA: HOW TO GROW IN THE MEDICAL MARKET AS AN OUTSIDER ? Olivier DUPONT Thierry EMERAUD CEO Lambda-X Business Developer Verhaert [email protected] [email protected] MEDICAL: CONVERGENCE IN HEALTH CARE

Transcript of 2015 innovation day_hyperspectral camera_verhaert & lambda-x

Hyperspectral camera technology & applications

Template Innovation Day presentationCONFIDENTIAL

HYPERSPECTRAL CAMERA: HOW TO GROW IN THE MEDICAL MARKET AS AN OUTSIDER ?

Olivier DUPONT Thierry EMERAUDCEO Lambda-X Business Developer [email protected] [email protected]

MEDICAL: CONVERGENCE IN HEALTH CARE

Hyperspectral camera technology & applications

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CONTENT

Medical market for an outsider

Lambda-X context

Hyperspectral at Lambda-X: a 13 years journey from space

Landing onto the medical ecosystem

Towards a Proposition Value

Conclusion

Hyperspectral camera technology & applications

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MEDICAL MARKET: MULTIFACETED & MULTIPLE TRENDS

140 million people with Alzheimer in 2050

Age related macular degeneration

8% of the WW population having diabetes …50% not aware of it!

Infectious diseases (Ebola) H1N1 pandemic

Early cancer detection

Personalized Healthcare

Surgery guidance

Point-Of-Care testing (near patient testing)

Prevention instead of healing

Tele monitoring

Gene therapy

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A GLOBAL TREND FOR CONVERGENCE

imaging

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• Belgian Company founded in 1996

• 100% Private Belgian shareholders

• Established in Nivelles since 2004

• Member of the Verhaert Group since 2014

LAMBDA-X CONTEXT

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LAMBDA-X BUSINESS MODEL

• Concept & Design• Prototyping• Serial Production

• Scientific instruments• Earth observation• Space exploration• Solar pointers

• Metrology tailored to ophthalmic markets

• Spectacles• Contact lenses• Intraocular lenses

AEROSPACE OPTICS SUPPORT TO INDUSTRY OPHTHALMICS

CONCEPT / PROJECTSSERIAL PRODUCTS

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SOME LAMBDA-X CUSTOMERS

Confidential

SPACE DEFENSE

INDUSTRY

OPHTHALMICS

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HYPERSPECTRAL TECHNOLOGY

1. Acquiring the 3D data cube (XY) at once

2. Hyperspectral = high spatial & spectral resolutions simultaneously • detectors are 2D only…

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HYPERSPECTRAL AT LAMBDA-XA 13 YEARS JOURNEY FROM SPACE2002 ESA: explore future biological Lab in Space.

Conclusion: go “confocal” and enable “fluorescence studies”

2005 Miniaturized confocal microscope (AMME project).Excite biological tissues at 1 & measure at 2 & 3

2007 Hyperspectral function for confocal microscope (ACMO)

2009 New ESA project “Intelligent spectroscopic device coupled with high-speed cameras” forchemical analysis of the re-entry of space (ISDE)

2012 HYPE camera HYPEMI project (UCL, de Duve)

2014 Collaboration with GIGA/ULg

2015 Doing business in biology

3µM BODIPY-GlcCer

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FUNDAMENTAL LEARNINGS FROM THE SPACE ODYSSEY

1. Miniaturization(3 steps optics development)

A compact, flexible and robust imaging instrument that can adapt to microscopes for biology applications.

Footprint / 3.5 (m²)/ 8 (m³)

3. Reliability

2. Modularity

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Diagnostics / point-of-care

Patient(Home)

Anatomo-pathologists Hospital

Doctor

Academicresearch

IVD companies

Pharmaceu-ticals

Centers forhuman

genetics

LANDING WITH HYPE IN THE MEDICAL ECOSYSTEM

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HYPERSPECTRAL FOR THE BIOLOGIST RELATES TO FLUORESCENCE

• Fluorescence: absorbing light at exc and re-emitting light at em

• Fluorescent molecules: auto fluorescent proteins (GFP) or

organic probes that are used as biomarkers for• Cell nucleus (DAPI)

• Cell parts (cytoplasmic membrane)

• Antibodies primary and secondary (AlexaFluor 488)

• Proteins

• DNA/chromosomes (FISH), etc…

• Fluorescence is impacted by environmental factors enabling

advanced studies on bio-organisms

• Fluorescence is a reference technique for biologists:

epifluorescence microscopes

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HOW TO TACKLE THE EXPECTATIONS IN THE BIOLOGY MARKET ?

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INTEGRATED PRODUCT INNOVATION

Technology & IP development

Proof of principle

Prototype development

Demonstration

First series

Validating process

Product & business strategy

Directing innovation

Strategic design

Value capturing

Product documentation training

Product launch

Strategic innovation services FEI

Product development services NPD

Pre-launch services NPI

Hybrid collaboration

models

CONSULTANCY

INSOURCING

OUTSOURCING

TRAINING

TECHNICAL TRACK

BUSINESS TRACK

USE

RCE

NTE

RED

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PRODUCT SHARPENING: MANY POTENTIAL DIFFERENTIATORS

HIGHLOWLO

WH

IGHmust haves rivals

indifferent outperformers

DESIRABILITY

High spectral resolution

Ease-of-use

Flexiblecan be mounted on any microscope

Affordable

UTILITY

Fast enoughfor vital imaging

Photoncontrast

Accreditation

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TOWARDS AN INNOVATIVE VALUE PROPOSITION ?

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3affordability

ease-of-use

acrreditationSpectral resolution

photon contrast

Epifluorescence microscope Confocal microscope (laser scan)

HYPE camera (Lambda-X)

Value againstconfocal

Value againstepifluo

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GO TO MARKET STRATEGY

1. Biological market: largest growth for optical microscopy

2. Make the story happen…

• Find the appropriate niche where to anchor (identified)

• Leverage on killer applications (FISH, protein colocalisation,…)

• Work closely with the academic world: UCL, ULg, ULB, UGent, UHasselt,… (on-going)

3. Build our own learning curve

• Fail fast

• Learn fast

• Reduce uncertainties

• Manage the risk

4. Market creation: barriers ?

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DEVELOP ON THE APPLICATION SIDE

Pharma-ceuticals

Ex-Vivo analysis

Surgery tissue imaging

Protein co-localisation

Cancer detection

Cell therapies

Geneticanalysis

Molecularinteractions

FISH

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LANDING SOMEWHERE ELSE WITH HYPE IN THE FUTURE ?

Food sorting

Cropspathogens

Paint Plastic manufacturing

Water treatment

Gas combustion

flame

Recycling (plastic)

UAV (agriculture)

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CONCLUSION

Tech transfer from space

Numerous applications in the biological world

Usage aspects are value drivers beyond technology

Several market spots next to biology

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Develop in a non existing market

Is our vision on user value correct ? (assessment)

Next market spot besides biology ?

Open innovation model of Verhaert + Lambda-X hyperspectral technology = USP ?

What did we learn?

Unknowns and potential pitfalls

Hyperspectral camera technology & applications

KruibekeBelgiumVerhaert New Products & Services Hogenakkerhoekstraat 21B-9150 KruibekeT +32 3 250 19 00E [email protected]

www.verhaert.com

NivellesBelgium

NoordwijkNetherlands

Lambda-XAvenue Robert Schuman 102B-1400 NivellesT +32 67 47 57 10E [email protected]

www.lambda-x.com

Verhaert NetherlandsKapteynstraat 12201 BB NoordwijkT +31 71 760 05 50E [email protected]

connect.verhaert.com

INDUSTRYFMCGCONNECT

MEDICAL TECHXFER

MEDICALAEROSPACE

TECHXFER

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AveiroPortugalLoad InteractiveAv. Dr. Lourenço Peixinho 153800-159 AveiroT +351 234 604 088E [email protected]

www.load-interactive.com

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