Health Valley meets Health~Holland

10 September 2015

Personalized health(care) the Radboud approach

Alain van Gool Professor Personalized Healthcare Coordinator Radboudumc Technology Centers E: alain.vangool@radboudumc.nl

Radboud university medical center

• Nijmegen, The Netherlands

• Mission: “To have a significant impact on healthcare”

• Strategic focus on Personalized Healthcare through “the patient as partner”

• Core activities:

• Patient care

• Research

• Education

• 11.000 colleagues

• 52 departments

• 3.300 students

• 1.000 beds

• First academic centre outside US to fully implement EPIC

Strategy Radboudumc – our focus areas

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www.radboudumc.nl

Patient

Radboud Personalized Healthcare

A significant impact

on healthcare

Molecule

Population

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Personalized Healthcare @ Radboudumc

People are different Stratification by multilevel diagnosis

+ Patient’s preference of treatment

Exchange experiences in care communities Select personalized therapy

Population

Man

Molecule

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Example: Personalized healthcare in sepsis

• Sepsis (systemic inflammatory response to infection) • Major cause of death in hospitals in EU and US, with mortality up to 20-40% • No specific treatment is available • Focus on immune-based mechanisms as solution towards therapy

Molecule • Molecular function of inflammatory mediators (cytokines) • Role in host defense and organ damage

Man • Diagnose capacity blood cells to produce cytokines • Individualized sepsis therapy optimally targeting patient’s immune system

Population • Cross-patient analysis of cytokine production and severity of sepsis • Design/evaluate personalized immunotherapies

prof Mihai Netea

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Example: Personalized healthcare in Parkinson’s

Patient

Caregiver

Insurer

Self-monitoring

Patient

Caregiver

Insurer

Participatory

research

prof Bas Bloem dr Marten Munneke

Research themes and institutes

www.radboudumc.nl/Research/Themes/Pages/default.aspx

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Orientation across the spectrum from molecule to man to population

Ori

enta

tio

n a

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ss

the

spec

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m o

f d

isea

ses

PI

Research theme

Te

chn

olo

gy

C

ente

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Research support by Technology Centers

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www.radboudumc.nl/research/technologycenters

Genomics

Bioinformatics

Animal studies

Stem cells

Translational neuroscience

Image-guided treatment

Imaging

Microscopy

Biobank

Health economics

Mass Spectrometry

Radboudumc Technology

Centers Investigational

products

Clinical studies

EHR-based research

Statistics

Human performance

Data stewardship

Molecule

Flow cytometry

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About 250 dedicated people working in 18 Technology Centers, ~1600 users (internal, external), ~140 consortia www.radboudumc.nl/research/technologycenters/

• Proteins • Metabolites • Drugs • PK-PD

• Preclinical • Clinical

• Behavioural • Preclinical

• Animal facility • Systematic review

• Cell analysis • Sorting

• Pediatric • Adult • Phase 1, 2, 3, 4

• Vaccines • Pharmaceutics • Radio-isotopes • Malaria parasites

• Management • Analysis • Sharing • Cloud computing

• DNA • RNA

• Internal • External

• Early HTA • Evidence-based

surgery • Field lab

• Statistics • Biological • Structural

• Preclinical • Clinical • Economic

viability • Decision

analysis

• Experimental design • Biostatistical advice

• Electronic Health Records • Big Data • Best practice

• In vivo • Functional

diagnostics

• iPSC • Organoids

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Working together on the Radboud campus

(Spin-out) companies

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Radboud Research Facilities Shared facilities network across Radboud campus, also made part of Gelderland facilities Funding: 6.2M Eur provincie Gelderland + 6.2M Eur Radboud University/Radboudumc)

www.ru.nl/radboudresearchfacilities/ 13

Working with other Technology Networks Region, nation, Europe, world

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Working through multi-partner projects

Standardisation, harmonisation, knowledge sharing needed in:

1. Assay development

2. Clinical validation

Example: Biomarker Development Center

Roadmap Molecular Diagnostics (2012) Grant 4.3M Eur (2014)

Move towards EU funding (2016)

Prof Alain van Gool Prof Ron Wevers Prof Cees Tack

Working through spin-off companies (LS&H portefeuille Radboud Holding BV)

Pansynt B.V.

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Working through spin-off companies Example: MITeC

www.mitec.nl

Field lab environment for innovations in image-guided surgery. Joined enterprise of several departments of Radboudumc. Applied scientific collaboration with companies for joined product evaluation and development.

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A self-sustaining technology platform to manufacture radiopharmaceuticals for translational imaging. Cyclotron, laboratories and GMP-compliant production facility, also accessible for external users. 14M Eur investment, including 8M Eur European Fund for Regional Development (EFRO) subsidy.

www.radboudtranslationalmedicine.nl/

Example: Radboud Translational Medicine

Working through spin-off companies

Contract Manufacture: A reliable supplier of radiopharmaceuticals for nuclear diagnostic patient care at Radboudumc and other hospitals

Research: Develop new radiotracers for molecular imaging in preclinical and clinical research Part of Radboudumc Technology Centers

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Working through global innovators

Exponential technologies

Digital medicine

Integrated care

Artifical intelligence

Robotics Patients included

Lifestyle

Self quantification

Global health

Watson Artifical intelligence

Regenerative medicine

23andme

Robotics

Example: Singularity University’s Faculty

Lucien Engelen, REshape Innovation Center 19

Takehome message

• Strategic focus on implementing Personalized Healthcare

• Strong technological and methodological infrastructure

• Continuous exploration of functional networks

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