2014 - Educational ResourcesResources Center (ERC), which has played a role in scientific...

Incorporating Technology into Veterinary Medical Education38th Annual Report

Veterinary Medical Experiment StationCollege of Veterinary Medicine

The University of GeorgiaAthens, Georgia 30602

2014

Director: Dr. Harry W. DickersonManaging Editor: Dr. James MooreAssociate Editor: Holly SnellingDesigner: Brad GillelandMedical Illustrators: Tasha Obrin, Will McAbee, Joe Samson, Neil McMillan and Brad GillelandPhotographer/Videographer: Christopher HerronAugmented Reality: Rafael Machado de Lima Silva

Copyright © 2014 Veterinary Experiment Station, College of Veterinary Medicine, The University of Georgia. No part of this publication may be reproduced without the permission of the publisher.

Overview, Mission, & Objectives................................................................................................1

From the Director.......................................................................................................................2

VMES Financial Tables...............................................................................................................3 Incorporating Technology into Veterinary Medical Education.....................................................4

VMES Projects............................................................................................................................8

Clinical Research-New Faculty Funds..........................................................................................8

Highlighted Research Activities.................................................................................................12

Extramural Contracts & Grants................................................................................................14

Selected Publications.................................................................................................................16

2014 Fiscal Year CVM Graduates..............................................................................................24

Incorporating Technology into Veterinary Medical Education.Cover Illustration by Tasha Obrin, Will McAbee and Brad Gilleland

VMES 2014 www.vet.uga.edu/research/vmes/

Contents

The key to improved animal well-being is animal health.The key to improved animal health is veterinary research.

38th Annual Report July 1, 2013 to June 30, 2014

Science in Service to Animals

Objectives

• Improve the health and productivity of domestic livestock, poultry, fish, and other income-producing animals and wildlife through research

• Assist in preventing disease epidemics by providing laboratory resources and highly skilled scientific personnel

• Assist in protecting human health through the control of animal diseases transmissible to man

• Improve the health of companion animals, which serve to enrich the lives of humankind

• Train new scientists in animal health research in order to provide continuity and growth in this vital area of veterinary medicine

V

VMES 2014 1

The Veterinary Medical Experiment Station (VMES) was established as a budgetary entity by the state legislature

in July 1976 following approval by the University of Georgia Board of Regents in 1973.

Mission

The VMES mission is to coordinate research on animal disease problems of present and potential concern to Georgia’s livestock and poultry industries.

The Veterinary Medical Experiment Station is committed to enhancing animal production, profitability, and well-being by improving animal health.

All programs and activities of the Veterinary Medical Experiment Station are conducted without regard to race, color, national origin, age, sex, or handicap.

2014

From the Director

2 www.vet.uga.edu/research/vmes/

For an interactive experience, download the VMES App located at: http://t.uga.edu/18v

Communication is an essential element of the scientific method. In fact, it is just as important to science as the imagination and creativity required to formulate important questions and generate elegant experiments. For science to advance, one must effectively present results to colleagues and peers for critical review.

Dissemination of scientific knowledge and creation of an educated and science-literate society is equally valuable to the scientific enterprise. Scientific

discovery and communication, as well as science education are important functions of the University of Georgia College of Veterinary Medicine. In this year’s VMES Annual Review, Drs. James Moore and Scott Brown provide an overview of the College’s Educational Resources Center (ERC), which has played a role in scientific communication through visual presentation of data for more than 35 years. As you will read, the ERC provides cutting-edge technologies for visualization of new information as well as for elucidation of complex concepts in science education.

As in our previous publications, this 38th VMES Annual Report gives a synopsis of peer-reviewed, competitive projects and new faculty start-up projects conducted during fiscal year 2014 (July 1, 2013 – June 30, 2014). Projects supported by VMES funding, which is provided by the State of Georgia, and projects funded with USDA 1433 Formula Funds are reviewed by veterinary scientists for quality of science and focus on relevant health issues or disease problems. The research must be both innovative and translatable to the improvement of animal health. Further information on these projects is available by contacting the VMES office staff by phone, e-mail or website, or directly from the investigators themselves. A list of publications is provided. These peer-reviewed papers represent a selection of VMES-supported work and other scholarly research by the faculty of the College of Veterinary Medicine.

It will become apparent from reading this year’s Annual Report that research in the College of Veterinary Medicine is diverse, but clearly targeted to addressing issues related to animal and human health. As I often emphasize, this diversity is both the strength and challenge of the veterinary profession. Diversity in investigations ranging from the molecular to the whole organism and populations ensures the relevancy of the work to the rapidly changing biomedical and veterinary research environment. The challenge lies in maintaining the focus required for establishing excellence in specific areas. We are succeeding based on a number of metrics, including our continuing growth in competitive, extramural research funding.

We list the names of 23 individuals who received graduate degrees in 2014 after completing a comprehensive training program that includes original research conducted under the mentorship of a College researcher. These students are attracted to our programs for the excellent research experiences and mentoring that they find here. The training of future researchers is of utmost importance to fulfilment of the mission of the Veterinary Medical Experiment Station and to meeting the future animal and public health needs of our state, nation and world.

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Financial TablesResearch Dollars Leveraged

A summary of the College’s research funding is provided above. Over the past year approximately six research dollars were leveraged for each VMES dollar invested. Expenditures are from all sources including State Appropriations, Extramural Research Funding, and Donations – Includes all expenditures and personnel costs.

Budget Category

Personnel-Researchers/Techs/Research Staff

Research Materials & Equipment

Personnel-Research Administration & Accounting

Travel

$1,745,427

$462,623

$348,150

$13,641

67.92%

18.00%

13.55%

0.53%

Amount % of Budget

Research Expenditures

Extramural Funding for FY14 does not reflect current endowments

*


Recall concepts in science courses in high school or college that drove you crazy? We all experienced them, though yours might have been different from ours. A common culprit was the combination of glycolysis, Krebs’ cycle and oxidative phosphorylation. How many ATPs came out of which part? Did this step take place in the cytosol or mitochondria? Where did the carbon atoms go? Or, perhaps it was photosynthesis. Which steps took place in the light and which in the dark? Who was Calvin and what was his cycle all about? Do plants have a support groups called Thylakoids Anonymous? Or, maybe immunology drove you crazy with all of its abbreviations. Fab, Fc, IFN, IgM, HLA, LPS, PHA . . . doesn’t anyone know how to spell anymore? Or, our favorites – just about anything in physics.

Why are these concepts, and others like them, so difficult for students to master? There are several possible reasons, not the least of which is the approach many of us took when we studied. Very few of us actually focused on understanding a concept or, heaven forbid, being able to apply it. As a result, most of us viewed the material as something to be wedged into our short-term memory for an upcoming test. Our approach was ‘memorize it for the test on Tuesday and hope that it doesn’t show up again on the final exam’. When a teacher in a subsequent class asked if we’d previously ‘learned’ this material, we’d raise our hands with trepidation, as if to say: “Define learned”.

What do these concepts, and many like them, have in common that cause students to relegate them to short-term

Incorporating Technology into Veterinary Medical Education

Dr. Scott Brown and Dr. James Moore ofEducational Resources Center

memory? For starters, many of these concepts appear to be complex, particularly those that involve biochemical pathways. However, the most common characteristic is that they are very difficult, if not impossible, to envision. As a novice, how do you envision what is happening inside part of a cell or in a leaf or on the surface of an immune cell? Furthermore, and perhaps more importantly, how do you develop a mental model that accounts for the dynamic nature of these concepts, and how do you do this in the limited time available between the introduction of the material and the test? The easy answer is that you need help, and we’re happy to highlight in this issue that help exists in our College’s Educational Resources Center.

Educational Resources is a uniquely skilled unit in the College that has existed for more than 35 years. Originally, Educational Resources was staffed by a handful of photographers and an artist or two, whose responsibilities were to create teaching materials using photographs and line drawings. In the 1970’s, Educational Resources added its first medical illustrator and the game changed immediately. To understand the impact of this change, you need to appreciate the unique background and capabilities of medical illustrators.

Some very forward thinkers in the late 1940s at the then Medical College of Georgia established a Masters of Science level training program for medical illustrators, which later was the first program in the nation to be accredited by the Association of Medical Illustrators. Today that medical illustration training program is one

VMES 2014 5

of only four accredited programs in North America. Not only are students entering these programs highly accomplished as artists, but they also have a proven interest in science in general and medicine in particular. During the training program, the students take gross anatomy and cell biology with medical students, and spend time in the operating room, while receiving advanced training in the latest methods used to create illustrations. As a result, they graduate with a strong understanding of anatomy, physiology and medical practice, and the unique ability to conceptualize complex concepts visually.

Today, Educational Resources has two nationally-recognized medical illustrators, Kip Carter and Brad Gilleland, on its staff, and offers a recently established one-year certificate in Comparative Medical Illustration to newly graduated medical illustrators through the University of Georgia’s Graduate School. Both Kip and Brad serve as adjunct faculty in the medical illustration program at Georgia Regents University in Augusta, and for the past two years have worked with medical illustration students on the master’s projects they need to complete in the their training program. One of our current certificate students, Tasha Obrin, worked with Dr. Bridget Garner in the Department of Pathology to create an interactive iBook about liver enzymes in veterinary practice. The resulting iBook won the Award of Excellence in Interactive Media and Best in Show in New Media at the most recent annual meeting of the Association of Medical Illustrators held at the Mayo Clinic. At the same meeting, our other certificate student, Will McAbee, won an Award of Merit in

Interactive Textbooks for an iBook he created about the anatomy and radiography of the equine tarsus with Dr. Kurt Selberg. Medical illustrations created to help clarify specific points made in the abstracts are included throughout this report.

Making sense of complex concepts isn’t accomplished only with medical illustrations. Understanding many of these concepts is facilitated by other equally important methods. These include the use of photography and/or videography to help students make sense of structures that can be seen, such as bones and joints, to help make learning anatomy easier or to identify changes that occur with certain disease processes. Chris Herron, the medical photographer/videographer in Educational Resources, does an incredible job of capturing informative images such as these for faculty to incorporate into their teaching materials. Some of these photographs have been incorporated into the abstracts on pages 6-13 of this report.

For the past decade, Educational Resources has had the ability to create 3-dimensional models and animations of structures and processes that can’t be seen, such as cell surface receptors, intracellular organelles and interactions among proteins within the cells. The two people in Educational Resources with expertise in 3-D graphics are Thel Melton and Brad Gilleland. They have utilized their skills in this area to create exceptional teaching materials that depict the anatomy of the equine distal limb, the equine gastrointestinal tract, the canine thorax and abdomen, and most recently the equine thorax. Working with Chris Herron, they

have also combined 3-D models with videos of horses to highlight for students the position of bones and joints beneath the skin. As you will learn later in this story, these videos can ‘come alive’ even on the printed page.

Clearly, information doesn’t always have to be presented using 3-dimensional models. In fact, in many instances a combination of text, graphs and images works extremely well. This is true for the presentation of data shared with others in seminars or publications, and in poster sessions at scientific meetings. As you will see soon, graphs and charts don’t need to be static figures. Educational Resources also has the capability of addressing these needs, with Harsh Jain taking the lead on these endeavors. In this regard, Harsh is responsible for printing a large number of posters that graduate students, post-doctoral associates and faculty members to use at national and international meetings, and works with others in the unit to create brochures that highlight specific programs on or off campus.

The most recent addition to Educational Resources’ growing list of capabilities is augmented reality. Augmented reality combines 3-D models and animations with photography, videography and computer programming, and has been made possible through collaborations involving two computer science graduate assistants, Rafael Silva and Arya Basu, working under the tutelage of Dr. Kyle Johnsen in the College of Engineering. To see


augmented reality in action, first go to the following website where you can watch a short movie showing it work:

http://t.uga.edu/18v

After you’ve watched the movie, click on the Download the free app link and load the augmented reality player on your iPhone, iPad or Android device. When you open the app, it will activate the camera on your device. Use the camera to view the images on pages 2-13 of this report, and you’ll see things spring to life, hovering above the page. This use of augmented reality demonstrates how modern technology can be employed to engage students in science, facilitating their understanding of complex concepts.

The novel teaching resources produced by Educational Resources offer new ways to engage students in complex material, and improve their ability to understand, recall, and apply important details of scientific concepts. Our goal is to test the effectiveness of these approaches, comparing the students’ attitudes and understanding of the material to the same measures obtained from students taught using more conventional teaching materials. Ultimately, we hope to help shape the classroom of the future, in which the focus will move from short-term retention of details to deep understanding that enables our students to apply their knowledge to address real-life challenges.

VMES 2014 7


Sepsis – a life-threatening complication of bacterial infections – is a leading cause of death in people worldwide. For example, sepsis strikes approximately 1 in 1,000 adults in developed countries, with mortality rates ranging from 30% to 80%. The situation is equally dire in infants and children, as neonatal

sepsis is the third leading cause of neonatal death worldwide, behind only premature delivery and birth-related complications. Sepsis is also an important disease in animals, and widely affects dogs, cats and horses.

Sepsis occurs when the immune response to a bacterial infection is not appropriate. In some cases, the infection becomes very widespread with bacteria travelling free in the bloodstream (sometimes called “blood poisoning”). The immune system fights the infection by releasing products (inflammatory cytokines) that call other immune cells to the site(s) of infection and activate them to kill the bacteria. This inflammatory response is beneficial when it is controlled and confined to a small area, but when it is widespread and over-zealous, the inflammatory response itself can cause a lot of damage and cause septic shock.

In septic shock, the inflammatory response can be so damaging that it causes organ failure and even death. The inflammatory response in sepsis is typically regulated by a variety of chemicals in the blood called hormones, most importantly by the stress hormone cortisol. Cortisol helps counteract the effects of severe infection on the body and helps rein in the inflammatory response. Unfortunately, in up to 50% of septic patients, insufficient cortisol is released and the inflammatory response goes haywire, a syndrome called Critical Illness-Related Corticosteroid Insufficiency (CIRCI). Septic people, horses and foals with CIRCI have dramatically increased mortality compared to septic patients with adequate cortisol. However, tight regulation of cortisol levels in sepsis is key, because excessive cortisol levels can actually suppress the immune system and worsen the infection.

My laboratory’s overarching research objective is to decipher the complex interactions between the immune and endocrine (hormonal) systems during sepsis in neonatal foals and horses, with the fundamental aim of utilizing this knowledge to decrease sepsis- and CIRCI-related mortality in animals and humans. At present, we do not understand exactly how CIRCI develops and how best to treat it. In some studies, replacement of missing cortisol with low doses of hydrocortisone (synthetic cortisol) appears to effectively treat septic shock and improve survival in septic patients with CIRCI. However, we do not fully understand the effects of this low-dose hydrocortisone therapy on the inflammatory response in people or animals.

In this study, we hypothesized that low-dose hydrocortisone therapy would prevent excessive inflammatory responses without impairing the ability of immune cells to eliminate bacteria in adult horses. Low-dose hydrocortisone therapy and placebo were administered to healthy horses, and immune cells were isolated from blood samples to compare inflammatory responses and immune cell function before, during, and after treatment compared to placebo treatment. Cells were exposed to bacteria in the lab to simulate sepsis. The ability of immune cells to eliminate bacteria was maintained or enhanced by low-dose hydrocortisone therapy, and production of potentially damaging inflammatory cytokines was decreased. Low-dose hydrocortisone therapy had anti-inflammatory effects without impairing immune cell function, and might be helpful in treating sepsis and septic shock in adult horses. Further study is needed to determine its efficacy in septic horses with CIRCI, and to investigate these effects in people and other animals.

Principal Investigator: Dr. Kelsey Hart

Immunologic Effects of Low-Dose Hydrocortisone in Adult Horses

VMES Funded ProjectsDr

. Kels

ey H

art

TREATING SEPSIS IN HORSES

Although the liver is involved in many conditions affecting reptiles, there are no studies in the scientific literature that correlate diagnostic imaging, hematology and plasma chemistry findings with liver abnormalities. As a result, veterinary clinicians often rely on information extrapolated

from birds to diagnose liver disease in reptiles, even though studies in birds correlating liver damage with clinicopathologic findings are also scarce or misleading. This project is part of a larger study designed to identify reliable and clinically useful ante-mortem indicators of liver disease in Green Iguanas. We correlated the findings of diagnostic imaging (MRI and ultrasonography), cytology (ultrasound-guided fine needle aspirates), serum biochemistry, endoscopic biopsies and histopathology in 8 purpose-bred animals.

The primary goal of this pilot study was to identify a non-invasive method for detecting liver disease in the target species. Ultrasonography and MRI were used due to their superior contrast resolution compared with radiography and CT. Additionally, ultrasound is widely available in private practice and academic institutions and is commonly used to guide collection of samples for cytology.

Eight iguanas underwent MRI and ultrasound examinations under sedation and with the assistance of physical restraint (i.e. eyes covered and arms and legs wrapped together with body). Each iguana had 2 imaging examinations performed, separated by one week. The initial exam was performed to obtain baseline images and the second examination was performed after intraperitoneal administration of CCl4 in a vehicle.

All images were reviewed by a boarded veterinary radiologist with experience in the identification of changes associated with CCl4-induced hepatotoxicity via MRI. Quantitative measures of these changes included contrast-to-noise ratios of liver on the T2-weighted images, liver volume on T1-MPRAGE and T1 relaxation of the liver. MRI uses a magnetic field to exploit the behavior of hydrogen atoms in water molecules in tissues in the body. By adjusting certain parameters of the MRI machine, different physical properties of the tissues can evaluated. For example, T2 weighted MRI images are useful for assessing pathologic changes due to the alterations in water dynamics in diseased tissues. T1 weighted images are useful for assessing overall structure and architecture of the organ or body region.

All ultrasound examinations were performed by a boarded veterinary radiologist. Quantitative and qualitative measures of liver size, echogenicity, and presence or absence of abnormal architecture (presence or absence of nodules, irregular margins) and the presence or absence of coelomic fluid were recorded.

The preliminary results indicate that ultrasonography and ultrasound-guided cytology (fine needle aspirates) are insensitive for the antemortem diagnosis of CCl4-induced liver disease in Green Iguanas. MRI data are currently being evaluated.

Principal Investigator: Dr. Ajay Sharma Co-Investigator: Dr. Shannon Holmes

Comparison of MRI and Ultrasonography in the Detection of Drug-induced Liver Disease in

Green Iguanas: A Pilot Study

LIVER DISEASE IN IGUANAS

Dr. A

jay Sh

arm

a

VMES 2014 9


Contrast-Enhanced Ultrasonographic Evaluation of Small Intestinal Viability in Dogs with Obstructive Foreign Material

Contrast media has been successfully used during ultrasonography in the evaluation of normal jejunum in dogs and to diagnose intestinal ischemic injury in people. We hypothesize that contrast-enhanced ultrasonography is a sensitive and specific method of identifying areas of small intestinal

ischemic injury in dogs. In our Teaching Hospital, abdominal radiographs and ultrasound frequently are used to identify small intestinal mechanical ileus due to foreign body ingestion and obstruction in canine patients. In these cases, surgical correction is the treatment of choice, and resection and anastomosis of the affected intestine may be necessary, pending evaluation of the affected site during surgery. In this study, we intend to identify 30 canine patients with small intestinal obstruction requiring surgical treatment. Pre-operative videos will be obtained during contrast-enhanced ultrasonographic evaluation of the small intestine at the site of the obstruction. This will be done to assess intestinal perfusion, as evidenced by the degree of contrast uptake. These findings will be compared against those for adjacent, unaffected small intestine. The radiologist’s subjective evaluation of intestinal perfusion will be scored. The stored video clips will be objectively evaluated by placing regions of interest over the affected and unaffected intestinal segments and comparing contrast perfusion parameters. When areas of perfusion deficiency are identified, the segment length will be measured using electronic calipers. Blood concentrations of L-lactate will be measured immediately prior to surgery, as correlations between lactate levels and the presence of intestinal ischemia have been evaluated in laboratory animals and people. Similar clinical studies have not previously been performed in dogs. At surgery, the surgeon will evaluate the small intestine for viability using routine intra-operative methods, and will assign a subjective score; resection and anastomosis will be performed when deemed necessary. In these instances, the resected segment of intestine will be identified with sutures placed at the orad and aborad margins of the perceived non-viable intestine. The resected segment will be examined histopathologically, using established methods for assessing viability/necrosis and the length of the affected area relative to the sutures placed during surgery.

Small intestinal ischemia is a life threatening condition, as affected patients may suffer from necrotic intestine, perforation, and subsequent septic peritonitis. The ultimate aim of the present study is to evaluate contrast-enhanced ultrasonography as a means to more rapidly identify the presence of ischemic small intestine than is currently possible. If the results of this study are positive, they may lead to improvements in the diagnosis and treatment of this condition in dogs.

Principal Investigator: Dr. David Jiménez Co-Investigators: Drs. Ajay Sharma, Mary Ann Radlinsky and Elizabeth Howerth

Clinical Research - New Faculty FundsEVALUATING INTESTINAL VIABILITY

Dr. D

avid

Jimén

ez

VMES 2014 11

Rhodococcus equi, a facultative intracellular bacterial pathogen, is the most common cause of severe pneumonia in foals and exerts a major financial impact on the equine industry. The disease is endemic at many horse-breeding farms with up to 60% of the foals being infected

with R. equi. Costs associated with diagnosis, veterinary care, long-term therapy, and mortality is exorbitant, and foals that recover from the disease are less likely to race as adults.

Although several antimicrobial agents are active against R. equi in vitro, many are ineffective in vivo, likely due to poor cellular uptake and low intracellular concentrations. The combination of a macrolide (erythromycin, clarithromycin or azithromycin) with rifampin has been the mainstay of therapy for affected foals for nearly 30 years with, until recently, only one report of resistance in the literature. During the last decade, control of R. equi infections at farms endemic for R. equi has relied on early detection of disease using thoracic ultrasonography and treatment with a macrolide antimicrobial agent (± rifampin) before onset of clinical signs. While this approach appears to have decreased mortality due to R. equi pneumonia, it has increased in the number of foals being treated with these drugs. Concurrently, the cumulative incidence of macrolide and rifampin resistance in R. equi isolates has increased, presumably as a result of antimicrobial treatment of subclinically affected foals. We recently found resistant isolates of R. equi in up to 40% of the foals at a farm that has used macrolides and rifampin for years. Unfortunately, foals infected with these resistant isolates of R. equi are significantly more likely to die than foals infected with susceptible isolates.

Resistance to macrolide antimicrobial agents is mediated by one of three mechanisms: (i) rRNA methylation which prevents binding of the macrolide to the bacterial ribosome; (ii) active efflux which pumps the macrolide outside of the bacterial cell; and (iii) enzymatic inactivation of the drug. rRNA methylation and active efflux are the mechanisms responsible for resistance in the majority of bacterial isolates. Most of the genes that confer macrolide resistance are associated with mobile elements and can spread between bacterial strains, species, and ecosystems. Currently, the molecular mechanisms of macrolide resistance in R. equi are unknown. Identification of the mechanism(s) of resistance is the first important step in understanding the ecology and epidemiology of macrolide-resistance on horse farms and in ultimately developing strategies to prevent antimicrobial resistance.

The objectives of the proposed research are: 1) to characterize the mechanisms by which R. equi becomes resistant to macrolides; 2) to determine whether macrolide resistance is transferable from resistant to susceptible R. equi and to other bacterial species; and, 3) to determine whether macrolide resistance is associated with greater virulence (i.e. ability to cause disease). Thus far, we have sequenced the genomes of macrolide-resistant and macrolide-susceptible R. equi isolates, and have identified a novel rRNA methylase gene conferring macrolide resistance that appears to be unique to R. equi. It is now possible to develop molecular tests for the rapid detection and identification of macrolide-resistant isolates from samples collected from diseased foals and from the environment. Early identification of macrolide resistant R. equi in infected foals allows immediate selection of the proper antimicrobial agent instead of wasting precious time treating with antimicrobial agents to which the isolate is resistant. These molecular tools can also be used to monitor emergence or disappearance of macrolide resistance in the environment of horse farms in response to various interventions.

Funding agency: Morris Animal FoundationPrincipal Investigator: Dr. Steeve Giguѐre, University of GeorgiaCo-Investigators: Dr. Jose Vazquez-Boland, University of Edinburgh, Dr. Noah Cohen, Texas A&M University, Dr. Mary Hondalus, University of Georgia, Dr. Marilyn Roberts, University of Washington

Macrolide Resistance in Rhodococcus equi Isolates from Foals: Mechanisms and Association with Virulence

Highlighted Research ActivitiesANTIBIOTIC RESISTANCE IN FOALS

Dr. S

teev

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Diabetes mellitus is the leading cause of kidney disease in humans in the US, and more than 26 million American adults are affected by chronic kidney disease. Although the effects of diabetes on the kidneys are poorly understood in companion animals, chronic kidney disease and diabetes are similarly common in veterinary

medicine. Consequently, there is a critical need to better understand, treat, and ultimately prevent these devastating diseases. Unfortunately, many of today’s most promising college students do not pursue careers in human or veterinary medicine because their undergraduate science courses fail to fully engage them. As a result, the number of students pursuing careers in basic and applied science is dwindling. Fortunately, the National Institute of Diabetes and Digestive and Kidney Diseases recognizes the need to improve educational experiences and is supporting the development of novel approaches.

In this project, we are developing integrative curricular materials using visually-compelling interactive virtual environments. Specifically, we are using industry-leading graphics and virtual 3-D environment software to create materials that share many facets of today’s popular videogames. To maximize the impact of these curricular materials, we are focusing on two related areas: 1) renal and systemic hemodynamics and 2) glucose homeostasis. These topics not only provide excellent opportunities for students to explore the fundamental aspects of kidney function in health and diabetes, but they also reflect global health concerns in human and veterinary medicine of obesity and type II diabetes. Our novel educational materials will allow students to fully understand the important aspects of cardiovascular and renal structure and function and glucose homeostasis. This approach will provide immersive experiences for students to explore the physiology, pathophysiology, and research approaches to understanding chronic kidney disease, cardiovascular disease, and type II diabetes.

The integrative curricular materials being created in this project have at their core the visual and interactive elements that today’s students enjoy and in which they readily immerse themselves. These new materials will be critically evaluated in the undergraduate physiology course taught in the College’s Department of Physiology & Pharmacology

Funding agency: National Institutes of Health Principal Investigator: Dr. Scott Brown, College of Veterinary Medicine Co-Investigators: Dr. James Moore, College of Veterinary Medicine, Dr. Kyle Johnsen, College of Engineering, Dr. Alan Cohen, College of Education

DIABETIC KIDNEY DISEASE

Engaging Students in Diabetic Kidney Disease: An Interactive Inquiry Approach

Dr. S

cott

Brow

n

Highlighted Research Activities

VMES 2014 13

IMPROVING LABORATORY INVESTIGATIONS

The Tifton Veterinary Diagnostic and Investigational Laboratory recently obtained a five-year grant from the Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network program for infrastructure support. This

support will enhance sample analysis and the laboratory’s ability to meet surge capacity issues in the event of animal food or drug-related emergencies. The funding is being used to maintaining trained personnel, and support important quality control procedures, such as participation in proficiency testing schemes. In keeping with the goals of the Veterinary Laboratory Investigation and Response Network program, the laboratory will be able to incorporate and support additional diagnostic tests, which will add further insight into investigations performed to detect compounds in foods, organs, urine and feces. These new capabilities of the laboratory also will enhance its ability to strengthen cooperative agreements and collaborations with other diagnostic laboratories in the Veterinary Laboratory Investigation and Response Network program, and thereby provide seamless interactions during emergency-related testing of specimens. With the support from this program, the Tifton Veterinary Diagnostic and Investigational Laboratory is working to develop new diagnostic testing methods, and improve outbreak preparedness and risk assessment related to food-borne pathogens. To that end, the laboratory participated in a nationwide study on the evaluation of Salmonella in symptomatic and asymptomatic pets. Due to the availability of this funding, the laboratory is significantly better prepared to detect food-borne pathogens.

Principal Investigator: Dr. Sreekumari RajeevCo-Investigator: Dr. Murray Hines

Infrastructure Improvements at the Tifton Veterinary Diagnostic Laboratory: The Veterinary Laboratory Investigation and

Response Network

Dr. S

reek

umar

i Raje

ev


Extramural Contracts & GrantsBrown, Cathy. Characterization of Proteinuric Renal Disease in Miniature Schnauzers. Gray Lady Foundation. $5,150.00 Brown, Corrie. Acquisition of Goods and Services. USDA. $11,867.00 Brown, Corrie. Acquisition of Goods and Services. USDA. $16,077.00 Brown, Corrie. Animal Health Technical Assistance. USDA. $46,750Brown, Corrie. Epidemiological and Ecological Factors Influencing Viral Transmission from Backyard Poultry to Wild Resident Birds. Georgia Ornithological Society. $4,760.00 Brown, Corrie. Interactions of Vaccine and Virulent Newcastle Disease Virus Isolates Focusing on Pathogenesis and Epidemiology. USDA. $12,091.00 Brown, Scott. Engaging Students in Diabetic Kidney Disease: An Interactive Inquiry Approach. NIH. $107,944Budsberg, Steven. Analgesic Efficacy of S-006-8 in Dogs with Chemically Induced Synovitis. Piedmont Pharmaceuticals LLC. $221,415.00 Carmichael, Paige. Promoting Cultural Diversity in the Veterinary Workforce. USDA-NIFA. $4,962.00 Chen, Shiyou. Dedicator of Cytokinesis 2 in Smooth Muscle Phenotypic Modulation. NIH. $445,725.00 Chen, Shiyou. Novel Mechanism of Smooth Muscle Phenotypic Modulation and Vascular Remodeling. NIH. $372,500.00 Chen, Shiyou. Response to gene to complement 32 in atherosclerosis. American Heart Assoc. - National Center. $48,340.00 Chen, Shiyou. SMAD2 and Smooth Muscle Differentiation from Neural Crest Cells. NIH. $18,984.00 Chen, Shiyou. Smooth Muscle Differentiation and Maturation. NIH. $383,130.00Creevy, Kate E. The Domestic Dog as a Model System for Aging Research. NIH. $2,360.00 Dickerson, Harry. B and T lymphocyte Repertoires in Channel Catfish-Memory Cells and Vaccines. USDA. $499,999Dickerson, Harry. Emerging and Re-Emerging Infectious Disease Residency/PHD Program. Industry Sponsored. $90,000Dickerson, Harry. The University of Georgia Veterinary Scholars Program: A Research Training Experience for Veterinary Medical Students. Industry Sponsored. $20,000.00 Divers, Stephen. Intravenous Lidocaine and Fentanyl Effects. Various-Corp Grants. $8,980.00Fischer, John. Comprehensive Evaluation of Health Status of Resident White-Tailed Deer within Parks of the National Capital Region. CESU-Piedmont. $10,800Fischer, John. Diagnostic, Field and Training Assistance for Avian Health and Disease Monitoring. U.S. Department of Fish and Wildlife Services. $40,000.00Fischer, John. Relationships Involving Wildlife, Livestock, and Poultry; Exotic Arthropod Surveillance; and National Feral Swine Mapping system. USDA. $605,300.00 Fischer, John. Southeastern Cooperative Wildlife disease Study. Fish & Wildlife Agencies. $131,500.00Fischer, John. Southeastern Cooperative Wildlife Disease Study. Various Other States. $357,260Fischer, John. Wildlife Disease Related Assistance Provided by SCWDS to Federal/State Wildlife Agencies: Southeastern U.S. and the Conservation Community at Large. U.S. Department of Interior. $65,750Franklin, Samuel. Characterization of Canine Plasma using Commercially Available Platelet Rich Plasma Concentrating Systems. Industry Sponsored. $19,861.00 Franklin, Samuel. Comparison of Ultrasound, MRI, and Arthroscopy for Detecting Meniscal Damage. Industry Sponsored. $26,079.00 Giguere, Steeve. Comparative Pharmacokinetics of Danofloxacin and Enrofloxacin in Adult Horses. Industry Sponsored. $28,482.00 Giguere, Steeve. Macrolide Resistance in Rhodococcus equi Isolates from Foals: Mechanisms and Association with Virulence. Morris Animal Foundation. $94,815.00 Giguere, Steeve. Pulmonary Pharmacokinetics of Intramuscular and Nebulized Ceftiofur Sodium in Foals. Veterinary Comparative Respiratory Society. $5,000Gogal, Robert. Influence of Maternal Lead on F1 Pigeon Hatchlings. Department of Defense. $44,932.00Guo, Tai. Novel Bivalent Multifunctional Ligands towards Alzheimer’s disease. NIH via sub-award under Virginia Commonwealth University. $6,935.00 Harris, R. Keith. National Animal Health Laboratory Network. USDA. $166,000.00He, Biao. A Novel Approach to Mycobacterium Tuberculosis Vaccine Development. NIH. $222,750.00 He, Biao. Developing a Novel RSV Vaccine Based on Mumps Virus. NIH. $371,250.00 He, Biao. Mechanism of a Parmyxovirus Replication. Univ. of Alabama. National Heart Foundation. $178,628.00 He, Biao. Mucosal Protection against HIV Generated by PIV5 Priming and VLP. NIH. $186,250.00 Hines, Murray E. 2014 NAHLN Member Laboratory Agreement. USDA. $55,000.00 Hines, Murray E. 2014 Swine Surveillance Cooperative Agreement. USDA. $13,794.00 Jackwood, Mark. Acquisition of Goods and Services. USDA. $4,716.00 Jordan, Brian. Evaluation of Protection against GA08 IBV Challenged Leghorn Chickens Vaccinated with MA5 and 4/91. Industry Sponsored. $114,504.00Jordan, Brian. Protectotype Experiment: Evaluating Protection from Ciliostasis in MA5 and DE072 Vaccinated Broiler Chickens Challenged with the GA 11 Variant Type of IBV. Industry Sponsored. $227,998Jordan, Brian. Testing of Replikins Synthetic Vaccines in a Study Using H7 Low Pathogenic Avian Influenza. Industry Sponsored. $59,907.00 Kaplan, Ray. Mathematical Modeling of Heartworm Transmission, Drug Resistance and Intervention. Industry Sponsored. $41,541.00 Lafontaine, Eric. Development of an Auto transporter-based Vaccine to Protect against Melioidosis and Glanders. U.S. DOD. $441,589.00

VMES 2014 15

Lafontaine, Eric. Why an Effective Melioidosis/Glanders Vaccine May Not be Possible. DTRA via sub-award under University of Exeter. $214,633.00 Lee, Margie. Detection of NPC Lactobacillus Counts from Feed Samples. Nutrition Physiology Co, LLC. $64,968.00 Mead, Daniel. Vector-Borne Disease Surveillance and Mosquito Diagnostic Support. Chatham County. $64,796Mead, Daniel. Vector-Borne Disease Surveillance and Mosquito Diagnostic Support. Dekalb County Board of Health. $6,900Mead, Daniel. Vector-Borne Disease Surveillance and Mosquito Diagnostic Support. SC Dept. of Health & Env. Control. $55,700Moore, James. Interactive Educational Materials for Veterinary Education and Practice. Zoetis. $120,000.00 Moore, Julie. Immunopathogenesis of Severe Malaria during Pregnancy. NIH. $591,933.00Moore, Julie. Post-Baccalaureate Training in Infectious Disease Research. NIH. $286,858.00 Moorhead, Andrew. Animal Models of Infectious Diseases. NIH. $1,028,593.00 Moorhead, Andrew. Furnish Brugia Malayi Adult Worms and/or B. Malayi Infective Larvae. NIH. $250,000.00 Moorhead, Andrew. Production and Distribution of Acanthocheilonema Viteae Reagents. NIH. $225,672.00 Nagy, Tamas. A Novel Method to Treat Chronic Pain. NIH via sub-award under Univ. of Minnesota. $14,965.00 Peroni, John. Examination of the Mechanisms by which S-nitrosothiols Relax Airway Smooth Muscle. Case Western Reserve University. $19,334.00 Peroni, John. In vivo use of Mesenchymal Stem Cells (MSC) for Bone Regeneration in Maxillo-Facial Surgery. Azienda Ospedaliera Universitaria Integrata. $87,370 Peroni, John. Morris Animal Foundation Veterinary Scholars Program. Morris Animal Foundation. $4,000.00 Peroni, John. Sanuwave Health Inc. Blood Sterilization Pilot Study. Sanuwave Health, Inc. $11,351.00Platt, Simon. Canine Urine Cells to Neural Progenitor Cells: A Novel Approach in Stem Cell Biology (Student Scholar Support-Goedeke). Morris Animal Foundation. $4,000Platt, Simon. Evaluation of GammaCore VET for the treatment of seizure activity in canine epilepsy. Electrocore LLC. $22,023.00 Platt, Simon. Pharmacokinetic Evaluation of Generic Levetiracetam Extended Release (XR) in Comparison to Keppra XR (XR) and Standard Release Keppra ®. Industry Sponsored. $33,480Quinn, Fred. Iraq Science Fellowship Program of the U.S. Department of State. U.S. State Dept. $7,450.00 Rajeev, Sreekumari. TVDIL Infrastructure for CVM VET-LRN Veterinary Diagnostic Laboratory Program. Food and Drug Administration. $16,500.00 Rapoport, Gregg. Correlation between In-Hospital and At-Home Heart Rate in Healthy Cats Administered Atenolol at Multiple Oral Doses. American College of Veterinary Internal Medicine Foundation. $8,257.00 Ritchie, Branson. Research Associate in Exotic/Zoo Infectious Disease and Pathology Postgraduate Program. Riverbank Zoo. $23,000.00 Saba, Corey. B-Cell Lymphoma Vaccine, DNA, CD20. Industry Sponsored. $10,206.00 Sakamoto, Kaori. Role of the Respiratory Syncytial Virus Fusion Protein in Airway Mucus Induction. NIH via sub-award under Emory. $17,582.00 Saliki, Jeremiah T. Diagnostic Pathogen Testing. U.S. Navy. $30,000.00 Saliki, Jeremiah T. SIV (Swine Influenza Virus) Surveillance. USDA. $33,175.00Sanchez, Susan. Georgia Veterinary Scholars Summer Research Program. NIH. $22,565.00Sanchez, Susan. One Health; Epidemiology of Natural and Deliberate Contaminants (Infectious and Toxicities) in Pets and Pet Food. DHHS Food and Drug Administration. $16,500Schank, Jesse. The Role of the Neurokinin-1 Receptor and NF kappa B in Alcohol-Induced Behavior. NIH. $248,252.00 Seabaugh, Kathryn. The Effects of Shock Wave Treatment on Platelet Rich Plasma. Neo Vet. $12,438.00 Sellers, Holly. Development of Avian Reovirus Vaccines from Variant Field Isolates Associated with Clinical Tenosynovitis. Merck Company Foundation. $254,400.00 Stallknecht, David. Epizootic Hemorrhagic Disease: Epidemiology and Development of Vaccine for White-Tailed Deer. Kansas State University. $26,128.00 Tripp, Ralph. KPT-335 to Reduce Influenza Infection in Balb/c Mice. Industry Sponsor. $129,543 Tripp, Ralph. NIAID Centers of Excellence for Influenza Research and Surveillance. NIH via sub-award under Emory. $698,194Tripp, Ralph. Manipulating Natural Host Immunoregulation via IDO during Viral Infection. NIH/NIAID via sub-award under GHSU. $388,593.00 Tripp, Ralph. Phase II: Improved Vaccine Production Technology for Rotavirus Vaccines - Accelerated Proposal. Industry Sponsored. $1,327,570.00 Tripp, Ralph. RSV Nanocapsule Vaccine Engineered with a G Protein Peptide Payload. NIH/NIAID. $563,843.00 Uhl, Elizabeth. Codon Usage in Morbilliviruses: Evidence for Evolutionary Conservation and Importance for Adaptation to New Hosts. U.S. DOD. $222,670.00 Ward, Cynthia. Efficacy of Prozinc Insulin in Naïve and Insulin-Established Cats. Industry Sponsored. $44,808Watford, Wendy. MAP3K8-mediated Regulation of Adaptive Immune Responses and Autoimmunity. NIH. $377,190Wolstenholme, Adrian. Anthelmintics: From Discovery of New Drugs to Modes of Action and Resistance. NIH. $5,000Wolstenholme, Adrian. Modulation of Levamisole Receptors: Pharmacological Diversity of Clade III NACHRS. NIH via sub-award under Iowa State University. $24,000.00 Ye, Xiaoqin. Molecular Mechanism of LPA3-Mediated Uterine Receptivity. NIH/NICHD. $299,470.00

Diagnostic Laboratories

Bagshaw C, Isdell AE, Thiruvaiyaru DS, Brisbin IL, and S. Sanchez. Molecular Detection of Canine Parvovirus in Flies (Diptera) at Open and Closed Canine Facilities in the Eastern United States. Preventive Veterinary Medicine.114: 276-284. PMID: 24679715, 2014.Camus A, Soto E, Berliner A, Claus T, and S. Sanchez. Epitheliocystis hyper infection in Captive Spotted Eagle Rays Aetobatus narinari Associated with a Novel Chlamydiales 16S rDNA Signature Sequence. Diseases of Aquatic Organisms. 104(1): 13–21., 2013.Casey CL, Hernandez SM, Yabsley MJ, Smith KF, and S. Sanchez. The Influence of the Conditions of The Pet Trade on the Commensal Gastrointestinal Flora of Wild-Caught Tokay Geckos (Gekko gecko). Journal of Herpetological Medicine and Surgery., 2014.Cazzini P, Krimer PM, Williams-Fritze MJ et al. Spontaneous Chronic T-cell Leukemia in a Male Rhesus Macaque (Macaca Mulatta). J. Vet. Diag. Invest., 2014.Charles RA, Kjos S, Ellis AE, Barnes JC, and MJ Yabsley. Southern Plains Woodrats (Neotoma micropus) from Southern Texas are Important Reservoirs of Two Genotypes of Trypanosoma cruzi and Host of a Putative Novel Trypanosoma Species. Vector Borne and Zoonotic Diseases. 13:22-30., 2013.Creevy KE, Scuderi M, and AE Ellis. Generalized Peripheral Oedema Associated with Amlodipine Therapy in Two Dogs. J. Small Animal Practice. 54:601-4., 2013.Dill JA and DR Rissi. Suppurative Rhombencephalitis and Meningitis in a Goat. Veterinary Pathology. Published online doi: 10.1177/0300985813485095., 2013.Hines, M. E. Evaluation of Novel Oral Vaccine Candidates and Validation of a Caprine Model of Johne’s disease. Frontiers in Cellular and Infection Microbiology., 4, 1-14., 2014.Hines, M. E. Jejunal Hemorrhage Syndrome in Cattle. Diagnostic Veterinary Matters., (1st ed., vol. 7, pp. 4-5), 2014.Ilha, M. R. and C. Wisell. Cholesterol Granuloma Associated with Otitis Media in a Cat. J. of Vet. Diag. Invest., 25(4)., 2013.McConachie E1, Hart KA, Whelchel DD1, Schroeder EL, Schott II HC, and S. Sanchez. Pulmonary Disease Potentially Associated with Nicolatella semolina in 3 Young Horses. Journal of Veterinary Internal Medicine. 28 (3): 930-943. PMID: 24689696., 2014.Minicozzi J, Sanchez S, Lee MD, Holt PS, Hofacre CL, and JJ Maurer. Development of Recombinant Flagellar Antigens for Serological Detection of Salmonella enterica Serotypes Enteritidis, Hadar, Heidelberg, and Typhimurium in Poultry. Agriculture. 3 (3): 381-397., 2013.Nemeth NM, Blas-Machado U, Cazzini P, Oguni J, Camus MS, Dockery KK, and AM Butler. Well-differentiated Hepatocellular Carcinoma in a Ring-tailed Lemur (lemur catta). J. Comp. Pathol., 148:283-287., 2013.Nemeth NM, Blas-Machado U, Hopkins BA, Phillips A, Butler AM, and S. Sanchez. Granulomatous Typhlocolitis, Lymphangitis, and Lymphadenitis in a Horse Infected with Listeria monocytogenes, Salmonella Typhimurium, and Cyathostomes. Vet. Pathol. 50:252-255., 2013.Rissi DR and CSL Barros. Necrotizing Meningoencephalitis in a Cow. Veterinary Pathology. 50:926-929, 2013.Rissi DR and E. Howerth. Cerebral Cuterebriasis in a Cat. Journal of the American Veterinary Medical Association. 243:493-495, 2013.Rissi DR and L. Susta. Leukoencephalomalacia in a Horse. Journal of the American Veterinary Medical Association. 243:57-59, 2013.Ritter JM, Sanchez S, Jones TL et al. Neurologic Melioidiosis in an Imported Pigtail Macaque (Macaca nemestrina). Veterinary Pathology. 50 (6): 1139-1144., 2013.Rosa FB and DR Rissi. Multicentric B-cell Lymphoma with Cerebral Involvement in an Alpaca. Journal of the American Veterinary Medical Association. 243:645-647, 2013.Sa e Silva M, Rissi DR, Pantin-Jackwood M, and DE Swaine. Highly Pathogenic Avian Influenza Virus in the Reproductive Tract of Chickens. Veterinary Pathology. 50:956-960, 2013.Salyards GW, Blas-Machado U, Mishra S et al. Spontaneous Osteoblastic Osteosarcoma in a Mongolian Gerbil (Meriones Unguiculatus). Comp. Med. 63:62-66., 2013.Sierra E, Sanchez S, Saili JT, Blas-Machado U, Arbelo M, Zuca D, and A. Fernandez. Etiologic Agents Associated with Non-Suppurative Meningoencephalitis in Stranded Cetaceans: A Retrospective Study in the Canary Islands. Journal of Clinical Microbiology., 2014.Silva M, Ellis A, Karaca K, Minke J, Nordgren R, Shixuan W, and DE Swayne. Domestic Goose as a Model for West Nile Virus Vaccine Efficacy. Vaccine. 31:1045-50., 2013.White CL, Schuler KL, Thomas NJ, Webb JL, Saliki JT, Ip HS, Dubey JP, and ER Frame. Pathogen Exposure and Blood Chemistry in the Washington, USA Population of Northern Sea Otters (Enhydra lutris kenyoni). J. Wildlife Dis. 49(4):887-899., 2013.Woldemeskel M, Saliki JT, Blas-Machado U, and L. Whittington. Mast Cells in Canine Parvovirus-Associated Enteritis with Crypt Abscess. Vet. Pathol. 50:989-993., 2013.Woolums AR, Berghaus RD, Berghaus LJ et al. Effect of Calf Age and Administration Route of Initial Multivalent Modified-Live Virus Vaccine on Subsequent Humoral and Cell-Mediated Immune Responses of Calves Following Administration of a Booster Vaccination at Weaning. Am. J. Vet. Res. 74(2): 343-354., 2013.

Infectious Diseases

Barichievy S and A A Bakre. Host-encoded miRNAs Involved in Host-Pathogen Interactions. Bentham Science., 2013.Berger PK, Laing EE, Hausman D, Tripp RA and RD Lewis. Inflammation and Bone In Early Pubertal Black and White Children. J. of Bone and Mineral Res., 2013.Bissinger BW, Knox CT, Mitchell SM, and RM Kaplan. Activity of Plant-Based Compounds on Anthelmintic-Resistant Caenorhabditis Elegans. Bio Pesticides: State of the Art and Future Opportunities., A. D. Gross (Ed.), ACS Books., 2014.Boyoglu-Barnum S, Gaston, KA, Todd SO et al. A Respiratory Syncytial Virus (RSV) Anti-G Protein F (ab’) 2 Monoclonal Antibody Suppresses Mucous Production and Breathing Effort in RSV rA2-line19F-Infected BALB/c Mice. J. Virol., 87(20), 10955-67., 2013.Breithaupt M, Hall RJ, and A Davis. A Preliminary Survey of Birds Killed by Window Collisions in Georgia Based on Museum Specimens. The Oriole., 77(1-2), 9-12., 2013.Buskirk SW and ER Lafontaine. Moraxella Catarrhalis Expresses a Cardiolipin Synthase That Impacts Adherence to Epithelial Cells. J. Bacteriol, 196, 107-120., 2014.Cauchard S, Giguère S, Venner M, Muscatello G, Cauchard J, Cohen ND, Haas A, Hines SA, Hondalus MK, Horohov DW, Meijer WG, Prescott JF, and J Vázquez-Boland. Rhodococcus equi Research 2008-2012: Report of the Fifth International Havemeyer Workshop. (5th ed., vol. 45, pp. 523-6). Equine Vet. J., 2013.Chaughry U, Yazwinski T, Miller MM, Kaplan RM, and J Gilleard. Molecular Genotyping Reveals the Early Emergence of Benzimidazole Resistance Mutations in H. Placei in U.S. Cattle. Vet. Parasitol., 2014.Chen Z, Zhou M, Gao X et al. A Novel Rabies Vaccine Based on a Recombinant Par Influenza Virus 5 Expressing Rabies Virus Glycoprotein. J. Virol., 87(6), 2986-93., 2014.


Selected Publications

Ezenwa VO, Godsey MS, King RJ et al. Ecology of Potential Vectors of West Nile Virus in Southeastern Louisiana: Enzootic Transmission in the Relative Absence of Culex Quinquefasciatus. The American Journal of Tropical Medicine and Hygiene., 88, 986-996., 2013.Ezenwa VO, Fratto, ME, and AK Davis. Infection with Mycoplasma Gallisepticum buffers the Effects of Acute Stress on Innate Immunity in House Finches. Physiological and Biochemical Zoology., 87, 257-264., 2014.Ezenwa VO, Nunn CL, Brezine C, and AE Jolles. Interactions between Micro- and Macro-parasites Predict Micro parasite Species Richness across Primates. American Naturalist., 183, 494-505., 2014.Ezenwa VO and AE Williams. Microbes and Animal Olfactory Communication: Where Do We Go from Here? BioEssays., 2014.Ezenwa VO, Beechler BR, Bengis R et al. Rift Valley Fever in Kruger National Park: Do Buffalo Play a Role in the Inter-Epidemic Circulation of Virus?. Trans boundary and Emerging Diseases., 2014.Ezenwa VO, Anderson K, and AE Jolles. Tick Infestation Patterns in Free Ranging African Buffalo (Syncerus Caffer): Effects of Host Innate Immunity and Niche Segregation among Tick Species. Intl. J. for Parasitol.: Parasites and Wildlife. (2), 1-9., 2013.Ethell V, Lowrance R, Jenkins M, Adams P, Rajeev S, and EK Lipp. Landscape and Seasonal Factors Influence Salmonella and Campylobacter Prevalence in a Rural Mixed Use Watershed. Water Research., 47(16), 6075-6085., 2013.Evans C, Moorhead, AR, Storey, BE, Wolstenholme, AJ, and RM Kaplan. Development of an In Vitro Bioassay for Measuring Susceptibility to Macro cyclic Lactone Anthelmintics in Dirofilaria Immitis. Intl. J. for Parasitol. Drugs & Drug Resistance., 3, 102-108., 2013.Feng Y, Williams B, Koumanov F et al. FGT-1 is the Major Glucose Transporter in C. Elegans and is Central to Aging Pathways. Biochem. J., 456, 219-229., 2013.Fouchier, RA, Kawaoka Y, Cardona C et al. Gain-of-Function Experiments on H7N9. Science., Volume 341, pg. 612-3, 2013.Fox JM, Sage LK, Huang L, Barber JP, Klonowski KD, Mellor AL, Tompkins SM, and RA Tripp. Inhibition of Indoleamine 2, 3-dioxygenase Enhances the T-cell Response to Influenza Virus Infection. J. Gen. Virol., 94(Pt 7), 1451-61., 2013.Fox JM, Sage LK, Poore S, Johnson S, Tompkins SM, and RA Tripp. Drug Analog Inhibition of Indoleamine 2, 3-dioxygenase (IDO) Activity Modifies Pattern Recognition Receptor Expression and Proinflammatory Cytokine Responses Early during Influenza Virus Infection. J. of Leukocyte Biology., 2014.Gabbard JD, Dlugolenski D, Van Riel D et al. Novel H7N9 Influenza Virus Shows Low Infectious Dose, High Growth Rate, and Efficient Contact Transmission in the Guinea Pig Model. J. Virol., 88(3), 1502-12., 2014.Gnanadurai CW, Zhou M, He W, Leyson CM, Huang CT, Salyards G, Harvey SB, Chen Z, He B, Yang Y, Hooper DC, Dietzchold B, and ZF Fu et al. Presence of Virus Neutralizing Antibodies in Cerebral Spinal Fluid Correlates with Non-lethal Rabies in Dogs. PLOS Neglected Tropical Diseases., 7(9), e2375., 2013. Grenfell RF, Coelho PM, Taboada D, de Mattos AC, Davis R, and DA Harn. Newly Established Monoclonal Antibody Diagnostic Assays for Schist soma Mansoni Direct Detection in Areas of Low Endemicity. PloS ONE., 9(1), e87777., 2014.Gupta, T, Coulson, K, Karls RK, Gauthier D, and FD Quinn. Internalization of Mycobacterium Shottsii and Mycobacterium Pseudoshottsii by Acanthamoeba Polyphaga. Canadian J. of Microbiol., 59(8), 570-576., 2013.Hall, RJ, Bartel R, and SM Altizer. Greater Migratory Propensity in Hosts Lowers Pathogen Transmission and Impacts. Journal of Animal Ecology., 2013.Jaso-Friedmann L, Leary JH, Camus A, and DL Evans. The teleost acute-phase inflammatory response and Caspase Activation by a Novel Alarmin-like ligand. J. of Leukocyte Biol., 86(1), 133-141., 2014.Jorquera Astudillo PA, Choy Y, Powell T et al. Nanoparticle Vaccines Comprising the Respiratory Syncytial Virus (RSV) G Protein CX3C Chemokine Motif Induce Robust Immunity Protecting from Challenge and Disease. PLoS ONE., 8(9), e74905., 2013.Jorquera Astudillo PA, Oakley K, and RA Tripp. The Advances in and Potential of Vaccines for RSV. Expert Review of Respiratory Medicine., 7(4), 411-27., 2013.Kaplan, RM. Recommendations for Control of Gastrointestinal Nematode Parasites in Small Ruminants: These Ain’t Your Father’s Parasites. Bovine Practitioner., 47(2), 97-109., 2013.Kaplan, RM, Peregrine AS, Molento MB, and MK Nielsen. Anthelmintic Resistance in Important Parasites of Horses: Does It Really Matter? Vet. Parasitol., 201, 1-8., 2014.Kaplan, RM, Storey BE, Vidyashankar AN et al. Antiparasitic Efficacy of a Novel Plant-based Functional Food Using an Ascaris Suum Model in Pigs. Acta Tropica., 2014.Kaplan, R. M., West, E. M., Norat-Collazo, L. M., and J. Vargas. A combination Treatment Strategy Using Pyrantel Pamoate and Oxibendazole Demonstrates Additive Effects and Offers an Efficacious Alternative for Controlling Equine Cyathostomins. Equine Veterinary Education., 2014.Kaplan RM, Whitley NC, Oh S-H et al. Impact of Integrated Gastrointestinal Parasite Management Training for U.S. Goat and Sheep Producers. Vet. Parasitol., 200, 271-275., 2014.Lafontaine ER, Balder R, Michel F, and RJ Hogan. Characterization of an Auto transporter Adhesion Protein Shared by Burkholderia Mallei and Burkholderia Pseudomallei. BMC Microbiol., 14, 92, 2014.Lafontaine ER, Zimmerman SM, Shaffer TL, Michel F, Gao X, and RJ Hogan. Use of a Safe, Reproducible and Rapid Aerosol Delivery Method to Study Infection by Burkholderia Pseudomallei and Burkholderia Mallei in Mice. PLoS ONE., 8, e76804., 2013.Laing R, Kikuchi T, Martinelli A et al. Genome and Transcriptome of Haemonchus Contortus, a Key Model for Anthelmintic Drug and Vaccine Discovery. Gen. Biol., 14, R88., 2013.Li YS, McManus DP, Lin DD, Williams GM, Harn DA, Ross AG, Feng Z, and DJ Gray. The Schistosoma Japonicum Self-cure Phenomenon in Water Buffaloes: Potential Impact on the Control and Elimination of Schistosomiasis in China. Intl. J. for Parasitol., 44(3-4), 167-71., 2014.Li Z, Gabbard JD, Mooney A et al. Efficacy of Parainfluenza Virus 5 mutants Expressing Hemagglutinin from H5N1 Influenza Virus in Mice. J Virology., 87(17), 9604-9. 2013.Li Z, Xu J, Chen Z et al. The L Gene of J Paramyxovirus Plays a Critical Role in Viral Pathogenesis. Journ., 87(23), 12990-8., 2013.Marrache S, Tundup S, Harn DA, and S Dhar. Ex vivo Programming of Dendritic Cells by Mitochondria-targeted Nanoparticles to Produce Interferon-gamma for Cancer Immunotherapy. ACS Nano., 7(8), 7392-402., 2013.Mason ME, Voris ND, Geeding AA, Orits HA, and RM Kaplan. Comparison of a Single Dose of Moxidectin and a Five-day Course of Fenbendazole to Reduce and Suppress Cyathostomin Fecal Egg Counts in a Commercial Recipient Mare Herd. JAVMA., 2014.McConachie EL, Hart KA, Whelchel DD et al. Pulmonary Disease Potentially Associated with Nicoletella Semolina in 3 Young Horses. J. Vet. Intern Med., 2014.McCutcheon KM, Gray J, Chen NY, Liu K, Park M, Ellsworth S, Tripp RA, Tompkins SM, Johnson SK, Samet S, Pereira L, and LM Kauvar. Multiplexed Screening of Natural Humoral Immunity Identifies Antibodies at Fine Specificity for Complex and Dynamic Viral Targets. mAbs, 6(2), 460-73., 2014.Minicozzi J, Sanchez S, Lee MD, Holt, PS, Hofacre, CL, and JJ Maurer. Development of Recombinant Flagellar Antigens for Serological Detection of Salmonella Enterica Serotypes Enteritidis, Hadar, Heidelberg, and Typhimurium in Poultry. Agriculture., 3(3), 381–397., 2013.

VMES 2014 17

Mooney A, Li Z, Gabbard JD, He B, and SM Tompkins. Recombinant PIV5 Vaccine Encoding the Influenza Hemagglutinin Protects against H5N1 Highly Pathogenic Avian Influenza Virus Infection following Intranasal or Intramuscular Vaccination of BALB/c Mice. J. Virol., 87(1), 363-71., 2013.Mooney A and SM Tompkins. Experimental Vaccines against Potentially Pandemic and Highly Pathogenic Avian Influenza Viruses. Future Virol., 8(1), 25-41., 2013.Morgan E, Charlier J, Hendrickx G et al. Global Change and Helminth Infections in Grazing Ruminants in Europe: Impacts, Trends and Solutions. Agriculture, 3, 484-502., 2013.Nielsen MK, Reinemeyer CR, Donecker JM et al. Anthelmintic Resistance in Equine Parasites - Current Evidence and Knowledge Gaps. Vet. Parasitol., 2014.Nielsen MK, Reist M, Kaplan RM, Pfister K, von Doorn DCK, and A Becher. Equine Parasite Control Under Prescription-only Conditions in Denmark–Awareness, Knowledge, Perception, and Strategies Applied. Vet. Parasitol., 2014.Nielsen MK, Vidyashankar AN, Hanlon BM, Diao G, Peterson SL, and RM Kaplan. Hierarchical Modeling of Observational Data Increases the Accuracy for Detecting Reduced Anthelmintic Efficacy in Livestock. Vet. Parasitol. (197), 614-622., 2013.Nielsen MK, Vidyashankar AN, Hanlon BM, RM Kaplan et al. Hierarchical Model for Evaluating Pyrantel Efficacy against Strongyle Parasites in Horses. Vet. Parasitol., 2013.Olveda DU, Li Y, Olveda RM, Lam AK, McManus DP, Chau TN, Harn DA et al. Bilharzia in the Philippines: Past, Present, and Future. IJID., 18, 52-6., 2014.Park AW. Sex in an Uncertain World: Environmental Stochasticity Helps Restore Competitive Balance to Sexually and Asexually Reproducing Populations. J Evolutionary Biology., 2014.Pathak RK, Marrache S, Harn DA, and S Dhar. Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate. ACS Chemical Biology., 9(5), 1178-87., 2014.Perwitasari O, Bakre A, Tompkins SM, and RA Tripp. siRNA Genome Screening Approaches to Therapeutic Drug Repositioning. Pharmaceuticals., 6(2), 124-160., 2014.Perwitasari O, Torrecilhas AC, Yan, X et al. Targeting Cell Division Cycle 25 Homolog B to Regulate Influenza Virus Replication. J. Virol., 87(24), 13775-84., 2013.Peterson DS, Talundzic E, Maganga M, Masanja IM, Udhayakumar V, and NW Lucchi. Field Evaluation of the Photo-induced Electron Transfer Fluor genic Primers (PET) Real-time PCR for the Detection of Plasmodium Falciparum in Tanzania. Malaria Journal. (13), 31., 2014.Phan S, Chen Z, Xu P, Li Z, Gao X, Foster S et al. A Respiratory Syncytial Virus (RSV) Vaccine Based on Parainfluenza Virus 5 (PIV5). Vaccine., 32(25), 3050-7., 2014.Pickar A, Xu P, Elson A, Li Z et al. The Roles of Serine and Threonine Residues of Mumps Virus P Protein in Viral Transcription and Replication. J. Virol., 88(8), 4414-22., 2014.Proenca LM, Mayer J, Schnellbacher R et al. Ante mortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure (Aratinga solstitialis). JAVMA., 2014.Reyes L, Eiler-McManis E, Rodrigues PH, Chadda AS, Wallet SM, Belanger M, Barret AG, Alvarez S, Akin D, Dunn WAJ, and A Progulske-Fox. Deletion of Lipoprotein PG0717 in Porphyromonas Gingivalis 1-W83 Reduces Gingipain Activity and Alters Trafficking in and 2- Response by Host Cells. PLoS ONE., 2013.Rivera-Betancourt O, Karls RK, Grosse-Siestrup B et al. Identification of Mycobacteria Based on Spectroscopic Analyses of Mycolic Acid Profiles. Analyst., 138(22)., 2013.Ross AG, Olveda RM, Acosta L, Harn DA et al. Road to the Elimination of Schistosomiasis from Asia: The Journey is far from Over. Microbes and Infection., 15(13), 858-65., 2013.Rowley SM, Kuriakose T, Wei L, and W Watford. Tumor Progression Locus 2 (Tpl2) Kinase Promotes Chemokine Receptor Expression and Macrophage Migration During Acute Inflammation. J. Biol. Chem. (288), 1788-15797., 2014.Sage LK, Fox JM, Mellor AL, Tompkins SM, and RA Tripp. Indoleamine 2, 3-Dioxygenase (IDO) Activity during the Primary Immune Response to Influenza Infection Modifies the Memory T Cell Response to Influenza Challenge. Viral Immunol., 27(3), 112-23., 2014.Sage LK, Fox JM, Tompkins SM, and RA Tripp. Subsisting H1N1 Influenza Memory Responses are Insufficient to Protect from Pandemic H1N1 Influenza Challenge in C57BL/6 Mice. J. Gen. Virol., 94(Pt 8), 1701-11., 2013.Sassi A, Geary J, Leroux LP, Moorhead AR et al. Identification of Dirofilaria Immitis Proteins Recognized by Antibodies from Infected Dogs. J. Parasitol., 2014.Shollenberger LM, Bui CT, Paterson Y, Nyhoff L, and DA Harn. HIV-1 Vaccine-Specific Responses Induced by Listeria Vector Vaccines are Maintained in Mice Subsequently Infected with a Model Helminth Parasite, Schistosoma Mansoni. Vaccine., 31(48), 5651-8., 2013.Sturgill TL, Giguère S, Berghaus LJ, Hurley DJ, and MK. Hondalus. Comparison of Antibody and Cell-mediated Immune Responses of Foals and Adult Horses after Vaccination with Live Mycobacterium Bovis BCG. Vaccine., 32(12), 1362-7., 2014.Tompkins SM. Experimental Infection of European Starlings (Sturnus vulgaris) and House Sparrows (Passer domesticus) with Pandemic 2009 H1N1, and Swine H1N1 and H3N2 Triple Reassortant Influenza Viruses. J. Wildl., Diseases., 49(2), 437-40., 2013.Tripp RA. A Respiratory Syncytial Virus (RSV) Anti-G Protein F (ab’) 2 Monoclonal Antibody Suppresses Mucous Production and Breathing Effort in RSV rA2-line19F-Infected BALB/c Mice. J. Virol., 2013.Tripp RA. Advances in and the Potential of Vaccines for Respiratory Syncytial Virus. Expert Review of Respiratory Medicine., 2013.Tripp RA. Decrease in Formalin-Inactivated Respiratory Syncytial Virus Enhanced Disease with RSV G Glycoprotein Peptide Immunization in BALB/c Mice. PLoS ONE., 2013.Tripp RA. Host Gene Expression and Respiratory Syncytial Virus Infection. Microbiol. and Immunol., 2013.Tripp RA. Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs. PLoS ONE., 2013.Tripp RA and O Ramillo. Barney Graham and Larry Anderson, Springer-Verlag Berlin Heidelberg (Ed.), Challenges and Opportunities for Respiratory Syncytial Virus Vaccines., 2013.Turner TM, Jones LP, Tompkins SM, and RA Tripp. A Novel Influenza Virus Hemagglutinin-Respiratory Syncytial Virus (RSV) Fusion Protein Subunit Vaccine against Influenza and RSV. J. Virol., 87(19), 10792-804., 2013.Turner T, Jones L, Tompkins SM, and RA Tripp. A Novel HA-F Protein Subunit Vaccine against Influenza and Respiratory Syncytial Virus. J. Virol., 87(19), 10792-804., 2013.Vatta AF, Dzimianski MT, Storey BE, Camus MS, Moorhead AR, Kaplan RM, and AJ Wolstenholme. Ivermectin-dependent Attachment of Neutrophils and Peripheral Blood Mononuclear Cells to Dirofilaria Immitis Microfilariae in Vitro. Vet. Parasitol., 2014.Xu P, Chen Z, Phan S, Pickar A, and B He. Immunogenicity of Novel Mumps Vaccine Candidates Generated by Genetic Modification. J. Virol., 88(5), 2600-10., 2014.

Large Animal Medicine

Afonso T, Giguere S, Rapoport GS et al. Pharmacodynamic Evaluation of 4 Angiotensin Converting Enzyme Inhibitors in Adult Horses. J Vet Intern Med, 27(5), 1185-1192, 2013.Ahn S, Johnsen K, Robertson T et al. Virtual Pets to Promote Exercising Behavior in Children: An Application of the Youth Physical Activity Promotion Model. J Health Comm., 2013.


Barletta M, Almondia DY, Williams J, Crochik S et al. Radiographic Evaluation of Positional Atelectasis in Sedated Dogs Breathing Room Air vs 100% Oxygen. Can. Vet. J., 2013.Barton MH. Anti-inflammatory Drugs. Equine Clin. Immunol., J. Flaminio (Ed.).,2014.Barton MH, Paske E, Norton N, King D et al. Efficacy of Cyclooxygenase Inhibition by Two Commercially Available Firocoxib Products in Horses. Equine Vet. J., 46(1), 72-75., 2013.Barton MH. Endotoxemia Equine Emergency and Critical Care Medicine., L. Southwood and P. Wilkens (Ed.), Manson Publishing., 2013.Berghaus LJ, Giguère S, and K Guldbech. Mutant Prevention Concentration and Mutant Selection Window for 10 Antimicrobial Agents against Rhodococcus Equi. Vet. Microbiol. 166(3-4), 670-5., 2013.Blong AE, Epstein K, and BM Brainard. In Vitro Effects of Three Formulations of Hydroxyethyl Starch Solutions on Coagulation and Platelet Function in Horses. Am J Vet Res, 2013.Boone LH, Epstein K, Cremer J, Rogers A, Foutz T, Quandt JE, Howerth EW, and POE. Mueller. Comparison of Tensile Strength and Early Healing of Acute Repeat Celiotomy through a Ventral Midline or a Right Ventral Paramedian Approach. Vet. Surg., 2014.Burton AJ, Giguère S, Warner L et al. Effect of Age on the Pharmacokinetics of a Single Daily Dose of Gentamicin Sulfate in Healthy Foals. Equine Vet Journal, 45(4), 507-11., 2013.Cauchard S, Giguère S, Venner M, Muscatello G et al. Rhodococcus Equi Research 2008-2012: Fifth International Havemeyer Workshop. Equine Vet Journal, 45,523-6. 2013.Credille BC, Tennent-Brown B, Jimenez D, and POE Mueller. What’s Your Diagnosis? Arytenoid Chondritis in an Alpaca. JAVMA., 2014.Epstein K, Bergren A, Giguere S et al. Cardiovascular, Colloid Osmotic Pressure, and Hemostatic Effects of Hydroxyethyl Starch in Horses. J Vet Intern Med., 28(1), 223-33., 2014.Fletcher DJ, Brainard BM, Epstein K et al. Therapeutic Plasma Concentrations of Epsilon Aminocaproic Acid and Tranexamic Acid in Horses. J. Vet. Int. Med., 27(6), 1589-95., 2013.Fultz L, Giguère S, Berghaus LJ, and JL Davis. Plasma and Pulmonary Pharmacokinetics of Desfuroylceftiofur Acetamide after Weekly Administration of Ceftiofur Crystalline Free Acid to Adult Horses. Equine Veterinary Journal., 46(2), 252-5., 2014.Grundman INM, Drist WT, Zekas LJ, Belknap JK, Garabed RB, Weisbrode SE, Parks AH, Knopp MV, and J Maierl. Quantitative Assessment of the Equine Foot Using Digital Radiography and Magnetic Resonance Imaging. Equine Vet Journal., 2014.Hart KA and K Epstein. Common Problems and Techniques in Equine Critical Care. Equine Medicine, Surgery and Reproduction, Mair et al (Ed.)., Saunders/Elsevier., 2013.Hart KA, Sherlock WC, Davern JA et al. Effect of N-butylscopolammonium bromide on Equine Ileal Smooth Muscle Activity in an Ex Vivo Model. Equine Vet., J., 2014.Hurcombe SD, Welch BR, Williams JM, Cooper ES, Russell D, and MC Mudge. Dark-field Microscopy in the Assessment of Large Colon Micro Perfusion and Mucosal Injury in Naturally Occurring Surgical Disease of the Equine Large Colon. Equine Veterinary Journal., 2013.J, F. H., W. L., Eggleston, R. B., and M. Q. Lowder. Partial Rupture of the Gastrocnemius Tendon in a 13 year old Tennessee Walking Horse Mare. Equine Veterinary Education., 2014.Johnsen KJ, Ahn SJ, Robertson TP, Moore J et al. Mixed Reality Virtual Pets to Reduce Childhood Obesity. IEEE Transactions on Visualization and Computer Graphics., 20(4)., 2013.Lindsey C, Aschenbroich H, Credille BC, Barton MH, and EW Howerth. Pathology in Practice: Ependymoma in a Horse. J. Amer. Vet. Med. Assoc., 2013.Mathews L, Barletta M, Graham L, and J Quandt. Evaluation of Serial Venous and Arterial Lactate Concentrations in Healthy Anesthetized Sheep Undergoing Ovariectomy. Vet. Anaesth. Analg., 2014.McConachie EL, Hart K A, Whelchel DD, Schroeder EL et al. Pulmonary Disease Potentially Associated with Nicoletella Semolina in 3 Young Horses. J Vet Intern Med., 2014.Mobley JL, Howerth EW, Beccar-Varela A, Mueller POE, and RA Fayrer-Hosken. Pathology in Practice. J. Am. Vet. Med. Assoc., 244(10), 1159-1161., 2014.Monk CS, Cohen EB, Hart KA, Kent M, Jimenez D, and BC Credille. What is Your Diagnosis: Cervical Malformation in a Goat? JAVMA., 2014.Mueller POE, Peroni JF, and JN Moore. Gastrointestinal Emergencies and Other Causes of Colic. JA Orsini and TJ Divers (Ed.), 2014.Schlusselhuber M, Guldbech K, Sevin C, Leippe M, Petry S, Grotzinger J, Giguere S, and J Cauchard. In Vitro Effectiveness of the Antimicrobial Peptide eCATH1 Against Antibiotic-Resistant Bacterial Pathogens of Horses. FEMS Microbiology Letters., 350(2), 216-222., 2013.Schraf A, Holmes SP, JF Peroni. Super paramagnetic Iron Oxide Nanoparticles as a Means to Track Mesenchymal Stem Cells in Model of Tendon Injury. Mol. Imaging Biol., 2014.Scott VH, Williams JM, Mudge MC, and SD Hurcombe. Effect of Body Position on Intra-abdominal Pressures and Abdominal Perfusion Pressures Measured at Three Sites in Horses Anesthetized with Short-term Total Intravenous Anesthesia. Am. J. Vet. Res., 75(3), 301-8., 2014.Seabaugh KA and J Schumacher. Urogenital Surgery Performed with the Mare Standing. Veterinary Clinics of North America. Equine Practice., (1st ed., vol. 30, pp. 191-209)., 2014.Shepard MK, Divers SJ, Braun C, and E Hofmeister. Pharmacodynamics of Alfaxalone after Single-Dose Intramuscular Administration in Red-Eared Sliders (Trachemys scripta elegans): A Comparison of Two Different Doses at Two Different Ambient Temperatures. Vet. Anesthesia and Analgesia., 40(6), 590-8., 2013.Sherlock CE and RB Eggleston. Clinical Signs, Treatment, and Prognosis for Horses with Impaction of the Cranial Aspect of the Base of the Cecum: 7 Cases (2000-2010). J. the American Vet. Med. Assoc., 243(11), 1596-1601., 2013.Sturgill TL, Giguère S, Berghaus LJ, Hurley DJ, and MK Hondalus. Comparison of Antibody and Cell-Mediated Immune Responses of Foals and Adult Horses after Vaccination with Live Mycobacterium Bovis BCG. Vaccine., 32(12), 1362-7., 2014.Trim CM, Hofmeister E, Peroni JF et al M. Evaluation of an Oscillometric Blood Pressure Monitor for Use in Anesthetized Sheep. Veterinary Anesthesia Analgesia., 40(6), 31-9., 2013.Vázquez-Boland JA, Giguère S, Hapeshi A, MacArthur I et al. Rhodococcus Equi: The Many Facets of a Pathogenic Actinomycete. Vet. Microbiol., 167(1-2), 9-33., 2013.Venner M, Credner N, Lämmer M, and S Giguère. Comparison of Tulathromycin, Azithromycin and Azithromycin-Rifampin for the Treatment of Mild Pneumonia Associated with Rhodococcus Equi. The Veterinary Record., 173(16), 397., 2013.Williams JM. Comparison of Two Common Equine Trans fixation Pin Casts and the Effects of Pin Removal. Veterinary Surgery., 2014.Williams JM, Elce YA, Litsky AS. Comparison of 2 Equine Trans fixation Pin Casts and the Effects of Pin Removal. Veterinary Surgery., 2014.Williams JM, Niehaus AJ, and R Cober. Emergency and Critical Care Nursing: Equine. Textbook for Veterinary Technicians., JM Bassert and JM Thomas (Ed.), Elsevier. (ed.), 2014.Woolums AR. Biosecurity and Infection Control. K. Hinchcliff, P. Constable, C. Gay (Ed.), 2014.Woolums AR, Berghaus RD, Smith DR et al. A Survey of Veterinarians in 6 U.S. States Regarding Their Experience with Nursing Beef Calf Respiratory Disease. Boy. Pract., 2014.Woolums AR, Berghaus RD, Smith DR et al. A Producer Survey of Herd-level Risk Factors for Nursing Beef Calf Respiratory Disease. J. Am. Vet. Med. Assoc., 243, 538-547., 2013.

VMES 2014 19

Pathology

Boone LH, Epstein K, Cremer J, Rogers A, Foutz T, Quandt JE, Howerth EW, and POE. Mueller. Comparison of Tensile Strength and Early Healing of Acute Repeat Celiotomy through a Ventral Midline or a Right Ventral Paramedian Approach. Vet. Surg., 2014.Cazzini P, Camus MS, and B Garner. Pathology in Practice: Disseminated Cryptococcosis in a Dog., 2013.Chen Z, Zhou M, Gao X, Zhang G, Ren G et al. A Novel Rabies Vaccine Based on a Recombinant Parainfluenza Virus 5 Expressing Rabies Virus Glycoprotein. J. Virol., 2013.Collicutt N, Cazzini P, Harris RK, Camus MS, and J Scherk. Pathology in Practice: Intestinal Metastasis of Skeletal Osteosarcoma. J. Am. Vet. Med. Assoc., 2013.Collicutt N, Garner B, Brown CA, and MS Camus. What’s Your Diagnosis? Renal Mass in a Dog. Vet. Clin. Pathol., 2013.Duberstein KJ, Platt SR, Holmes SP, Dove CR, Howerth EW, Kent M et al. Gait Analysis in a Pre- and Post-ischemic Stroke Biomedical Pig Model. Physiol. Behav., 125, 8-16., 2014.Gabbard JD, Dlugolenski D, Van Riel D, Marshall N, Galloway SE, Howerth EW et al. Novel H7N9 Influenza Virus Shows Low Infectious Dose, High Growth Rate, and Efficient Contact Transmission in the Guinea Pig Model. J. of Virol., 88(3), 1502-12., 2014.Lindsey C, Aschenbroich H, Credille BC, Barton MH, and EW Howerth. Pathology in Practice: Ependymoma in a Horse. J. Amer. Vet. Med. Assoc., 2013.Mercurio AD, Hernandez SM, Maerz JC, Yabsley MJ, Ellis AE, Coleman AL, Shelnutt LM, Fischer JR, and SB Wilde. Experimental Feeding of Hydrilla Verticillata Colonized by Stigonematales Cyanobacteria Induces Vacuolar Myelinopathy in Painted Turtles (Chrysemys picta). PloS ONE., 9(4), e93295., 2014.Mobley JL, Howerth EW, Beccar-Varela A, Mueller POE, and RA Fayrer-Hosken. Pathology in Practice. J. Am. Vet. Med. Assoc., 244(10), 1159-1161., 2014.Nemeth N, Blas-Machado U, Cazzini P, Oguni J, Camus MS et al. Well-differentiated Hepatocellular Carcinoma in a Ring-tailed Lemur (Lemur catta). J. Comp. Pathol., 2013.Platt SR, Holmes SP, Howerth EW et al. Development and Characterization of a Pig Permanent Middle Cerebral Artery Occlusion Stroke Model. Exp. Transl. Stroke Med., 6, 1., 2014.Proenca LM, Mayer J, Schnellbacher R, Sanchez S, Huang J et al. Ante mortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure. JAVMA., 2014.Santamaria A, Calzada JE, Saldaña A, Yabsley MJ, and NL Gottdenker. Molecular Diagnosis and Species Identification of Ehrlichia and Anaplasma Infections in Dogs from Panama, Central America. Vector Borne and Zoonotic Diseases., 14(5), 368-70., 2014.Vatta AF, Dzimianski MT, Storey BE, Camus MS, Moorhead AR, Kaplan RM, and AJ Wolstenholme. Ivermectin-dependent Attachment of Neutrophils and Peripheral Blood Mononuclear Cells to Dirofilaria Immitis Microfilariae in Vitro. Vet. Parasitol., 2014.Ye J, Zhu B, Fu Z, Chen H, and S Cao. Immune Evasion Strategies of Flaviviruses. Vaccine., 2013.

Physiology & Pharmacology

Ahn S, Johnsen K, Robertson T et al. Virtual Pets to Promote Exercising Behavior in Children: An Application of the Youth Physical Activity Promotion Model. J Health Comm., 2013.Chelko SP, Schmiedt CW, Lewis TH et al. Vasopressin-induced Constriction of the Isolated Rat Occipital Artery is Segment Dependent. J. Vasc. Res., 50(6), 478-485., 2013.Chen S and R Tang. Smooth Muscle-Specific Drug Targets for Next Generation Drug-Eluting Stent. Expert Review of Cardiovascular Therapy., 12(1), 21-23., 2014.Chen Q, Zhang Y, Elad D, Jaffa AJ, Cao Y, and X Ye. Navigating the Site for Embryo Implantation: Biomechanical and Molecular Regulation of Intrauterine Embryo Distribution. Mol. Aspects Med., 34, 1024-1042., 2013.Creevy KE, Gagnepain JF, Platt SR, Edwards GL, and M Kent. Comparison of Concentrations of γ-amino butyric Acid and Glutamate in Cerebrospinal Fluid of Dogs with Idiopathic Epilepsy with and without Seizure-Related Magnetic Resonance Imaging Hyper Intense Areas in the Limbic System. Am. J. of Vet. Res., 74(8), 1118-25., 2013.Diao H, Xiao S, Howerth EW et al. Broad Gap Junction Blocker Carbenoxolone Disrupts Uterine Preparation for Embryo Implantation in Mice. Biol. Reprod., 89(3), 31., 2013.Fei J and S Chen. Splice Site Mutation-Induced Alteration of Selective Regional Activity Correlates with the Role of a Gene in Cardiomyopathy. Journal of Clinical & Experimental Cardiology., S12, 004., 2013.Gao A-M, Ke Z-P, Wang J-N, Yang J-Y, Chen S, and H Chen. Apigenin Sensitizes Doxorubicin-Resistant Hepatocellular Carcinoma BEL-7402/ADM Cells to Doxorubicin via Inhibiting PI3K/Akt/Nrf2 Pathway. Carcinogenesis., 34(8), 1806-1814., 2013.Guo X, Stice SL, Boyd NL, and S Chen. A Novel in Vitro Model System for Smooth Muscle Differentiation Form Human Embryonic Mesenchymal Stem Cells. American Journal of Physiology-Cell Physiology., 304(4), C289-298., 2013.Hart KA, Sherlock WC, Davern J, Robertson TP et al. Effect of N-butylscopolammonium Bromide on Equine Ileal Smooth Muscle Activity in an Ex Vivo Model. Equine Vet. J., 2014.Holmes SP, Brown SA, Zhang JL, and CW Schmiedt. Dynamic Contrast-Enhanced MR Renography (MR excretory urography) Using a Simplified Multicompartment Model for Determination of Glomerular Filtration Rate in Normal Dogs. Vet. Radiol. Ultrasound., 2014.Johnsen KJ, Ahn SJ, Robertson TP et al. Mixed Reality Virtual Pets to Reduce Childhood Obesity. IEEE Transactions on Visualization and Computer Graphics., 20(4)., 2013.Li R, Zhao F, Diao H, Xiao S, and X Ye. Post Weaning Dietary Genistein Exposure Advances Puberty without Significantly Affecting Early Pregnancy in C57BL/6J Female Mice. Reprod. Toxicol., 44, 85-92., 2014.Platt SR, Coates JR, Eifler DM, Edwards GL, Kent M, and KR Bulsara. Effect of Treatment with Simvastatin and Cyclosporine on Neurotransmitter Concentrations in Cerebrospinal Fluid after Subarachnoid Hemorrhage in Dogs. American Journal of Veterinary Research., 74(8), 1111-7., 2013.Saba CF, Schmiedt CW, Freeman KG et al. Indirect Assessment of Dihydropyrimidine Dehydrogenase Activity in Cats. Veterinary and Comparative Oncology., 11(4), 265-71., 2013.Shi N and S Chen. Cell Division Cycle 7 Mediates Transforming Growth Factor-B-induced Smooth Muscle Maturation. JBC., 288(48), 34336-34342., 2013.Shi N and S Chen. Mechanisms Simultaneously Regulate Smooth Muscle Proliferation and Differentiation. Journal of Biomedical Research., 28(1), 40-46., 2014.Tang R, Cui X-B, Wang J-N, and S Chen. CTP Synthase, a Smooth Muscle-Sensitive Therapeutic Target for Effective Vascular Repair. ATVB., 33(10), 2336-2244., 2013.Xie W, Li Z, Shi N, Guo X et al. Smad2 and MRTFB Cooperatively Regulate Vascular Smooth Muscle Differentiation Form Neural Crest Cells. Circ Research., 113(8), e76-86., 2013.Yoshinaga K, Prabhudas M, Davies C, White K, Caron K, Golos T, Fazleabas A, Paria B, Mor G, Paul S, Ye X, Dey SK, Spencer T, and RM Roberts et al. Interdisciplinary Collaborative Team for Blastocyst Implantation Research: Inception and Perspectives. Am. J. Reprod. Immunol., 71(1), 1-11., 2014.Zhao F, Li R, Xiao S, Diao H, Viveiros MM, Song X, and X Ye. Post Weaning Exposure to Dietary Zearalenone (ZEA), a Mycotoxin, Promotes Premature


VMES 2014 21

Puberty Onset and Disrupts Earyl Pregnancy Events in Female Mice. Toxicol. Sciences., 132 (2), 431-342., 2013.Zhang L, Wei S, Tang J-M, Guo L-Y, Zheng F, Kong X, Yang J-Y, Huang Y-Z, Chen S, and JN Wang. PEP-1CAT Protects Hypoxia/Reoxyenation-Induced Cardiomyocyte Apoptosis Through Multiple Signaling Pathways. Journal of Translational Medicine., 11, 113., 2013.

Population Health

Astudillo VG, Hernandez SM, Kistler WM, Boone SL, Lipp EK, Shrestha S, and MJ Yabsley. Spatial, Temporal, Molecular, and Intraspecific Differences of Haemoparasite Infection and Relevant Selected Physiological Parameters of Wild Birds in Georgia, USA. International Journal for Parasitology. Parasites and Wildlife., 2, 178-89., 2013.Banat GR, Tkalcic S, Dzielawa JA, Jackwood MW, Saggese MD, Yates L, Kopulos R, Briles WE, and EW Collisson. Association of the Chicken MHC B Haplotypes with Resistance to Avian Coronaviruses. Developmental and Comparative Immunology., 39, 430-437., 2013.Behnke EL, Hofacre CL, Berghaus RD. Estimation of the Prevalence of Salmonella Species on the Slatted Area Compared to the Scratch Area of Broiler Breeder Chicken Houses. Avian Dis., 57(3), 634-639., 2013.Berghaus RD. Public Health Significance of Poultry Diseases. Diseases of Poultry., Wile-Blackwell. (13th ed.)., 2013.Chamorro MF, Walz PH, Haines DM, Passler T, Earleywine T, and RA Palomares. Comparison of Levels and Duration of Detection of BVDV 1, BVDV 2, BHV-1, BRSV, and PI3V Antibodies in Calves Fed Maternal Colostrum or a Colostrum Replacement Product. Can. J. Vet. Res., 78(2), 81-8., 2014.Colbath A, Patipa L, Berghaus R et al. Influence of Suture Pattern on the Incidence of Incisional Drainage following Exploratory Laparotomy. Equine Vet Journal., 46(2), 156-60., 2014.Credille BC, Tennent-Brown B, Jimenez D, and POE Mueller. What’s Your Diagnosis? Arytenoid Chondritis in an Alpaca. JAVMA., 2014.Cui Y, Alali WQ, Harrison MA, and CL Hofacre. Salmonella Levels in Turkey Neck Skin, Bone Marrow and Spleens. International Poultry Scientific Forum. pp. M46, 2014.Davis A, Benz A, Ruyle L, and MJ Yabsley. Searching Before It’s Too Late: A Survey of Blood Parasites in Ctenosaura Melanosterna, a Critically Endangered Reptile of Honduras. ISRN Parasitology., 2013, 6., 2013.Diezhang W, Alali WQ, Harrison MA, and CL Hofacre. Salmonella in Broiler Carcass Bone Marrow and Neck Skin: Potential Sources for Ground Chicken Contamination. International Association for Food Protection., (pp. T1-04, pg. 26), 2013.Ferguson-Noel NM, Williams SM, and VA Laibinis. The Efficacy of Mycoplasma Gallisepticum K-Strain Live Vaccine in Broiler and Layer Chickens. Avian Pathology., 2013.Franca MS. Clinical Signs, Pathology and Pathogenesis of Infectious Bronchitis. Avian Infectious Bronchitis, Grupo Asis. (vol. 1). Zaragoza., 2014.Franca MS. Co-infection of Mallards with Low-Virulence Newcastle Disease Virus and Low-Pathogenic Avian Influenza Virus. Avian Pathology., 43(1), 8., 2014.Franca MS. Influenza Pathobiology and Pathogenesis in Avian Species. Influenza Pathogenesis and Control, R. W. Compans and M. B. A. Oldstone (Ed.), Current Topics in Microbiology and Immunology/Springer-Verlag. (vol. 1, pp. 22)., 2014.Franca MS. Tribasic Copper Chloride Toxicosis in Commercial Broiler Chicks. Avian Diseases., 20., 2014.Franca MS. Ulcerative Enteritis-like Disease Associated with Clostridium Sordellii in Quail. Avian Diseases., 57(3), 4., 2013.Fritzen C, Mosites E, Applegate R, Telford S, Huang J, Yabsley MJ et al. Environmental Investigation Following the First Human Case of Babesiosis in Tennessee. J. Parasitol., 2013.Hafner S, Reese RL, and SM Williams. Other Tumors. Disease of Poultry., David E Swayne (Ed.), John Wiley and Sons, Inc. (13th ed., pp. 604-673)., 2013.Heins BD, Nydam DV, Woolums AR, Berghaus RD, and M Overton. Comparative Efficacy of Enrofloxacin and Tulathromycin for Treatment of Preweaning Respiratory Disease in Dairy Heifers. J. Dairy Sci., 97(1), 372-382., 2014.Hernandez SM, Mattsson BJ, Peters V, Cooper RJ, and CR Carroll. Coffee Agro Forests Remain Beneficial for Neotropical Bird Community Conservation across Seasons. PLoS ONE., 8(9), e65101., 2013.Jackwood MW and YM Saif. Bordetellosis (Turkey Coryza). Diseases of Poultry., John Wiley & Sons, Inc. (13th ed.)., 2013.Jackwood MW and JJ de Wit. Infectious Bronchitis. Diseases of Poultry., John Wiley & Sons, Inc. (13th ed.)., 2013.Keeler SP, Yabsley MJ, Adams HC, and SM Hernandez. A Novel Isospora Species (apicomplexa: eimeriidae) from Warblers (passeriformes: parulidae) of Costa Rica. The Journal of Parasitology., 100(3), 302-4., 2014.Kistler WM, Hernandez SM, Gibbs S, Ballard JR, Arnold SL, Johnson T, and MJ Yabsley. Evaluation of a Restriction Fragment Length Enzyme Assay for Differentiation of Haemoproteus and Plasmodium across a Standard Region of the Mitochondrial Genome. J. Parasitol., 99(6), 1133–1136., 2013.Kjos SA, Marcet PL, Yabsley MJ, Kitron U, Snowden KF, Logan KS, Barnes JC, and EM Dotson. Identification of Bloodmeal Sources and Trypanosoma cruzi Infection in Triatomine Bugs (Hemiptera: Reduviidae) from Residential Settings in Texas, the United States. J. Med. Entomol., 50(5), 1126–1139., 2013.Lindsey C, Aschenbroich H, Credille BC, Barton MH, and EW Howerth. Pathology in Practice: Ependymoma in a Horse. J. Amer. Vet. Med. Assoc., 2013.Loyd KA, Hernandez SM, Abernathy KJ., Shock BC, and GJ Marshall. Risk Behaviors Exhibited by Free-roaming Cats in a Suburban US Town. Vet. Rec., 173(12), 295., 2013.Magenwirth J, Nemeth NM, Yabsley MJ et al. Infestation of Two Brown-Headed Cowbirds (Molothrus ater) with Harpirhynchus Quasimodo. Avian Diseases., 57(4), 818-21., 2013.Mascarelli PE, Keel MK, Yabsley MJ, Last LA, Breitschwerdt EB et al. Hemotropic Mycoplasmas in Little Brown Bats (Myotis lucifugus). Parasites & Vectors., 7, 117., 2014.McGuire JL, Miller EA, Norton TM et al. Intestinal Parasites of the Gopher Tortoise (G. Polyphemus) from Eight Populations in Georgia. Parasitol. Res., 112(12), 4205–4210., 2013.Mehrkens LR, Shender LA, Yabsley MJ, Shock BC, Chinchilla FA, Suarez J, and KV Gilardi. White-nosed Coatis (Nasua narica) are a Potential Reservoir of Trypanosoma Cruzi and other Potentially Zoonotic Pathogens in Monteverde, Costa Rica. Journal of Wildlife Diseases., 49(4), 1014-8., 2013.Mercurio AD, Hernandez SM, Maerz JC, Yabsley MJ, Ellis AE, Coleman AL, Shelnutt LM, Fischer JR, and SB Wilde. Experimental Feeding of Hydrilla Verticillata Colonized by Stigonematales Cyanobacteria Induces Vacuolar Myelinopathy in Painted Turtles (Chrysemys picta). PloS ONE., 9(4), e93295., 2014.Minicozzi J, Sanchez S, Lee MD, Holt PS, Hofacre CL, and JJ Maurer. Development of Recombinant Flagellar Antigens for Serological Detection of Salmonella Enterica Serotypes Enteritidis, Hadar, Heidelberg, and Typhimurium in Poultry. Agriculture., 3(3), 381–397., 2013.Monk CS, Hart KA, Berghaus RD et al. Detection of Endogenous Cortisol in Equine Tears and Blood at Rest and after Simulated Stress. Vet. Ophthal. (1463-5224)., 2013.Murray HL, Yabsley MJ, Keel MK, Manning EJ, Wilmers TJ, and JL Corn. Persistence of Mycobacterium Avium Subspecies Paratuberculosis in Endangered Florida Key Deer and Key Deer Habitat. J Wildlife Diseases., 50(2), 349-53., 2014.Myers EA, Williams SM, Zavala G, Smith J, and RD Berghaus. Mucosal Lesions and Mortality Associated with The Use of a Ferric Sulfate Poultry Litter Amendment Product. J. of Vet. Diag. Investigation., 26(3), 457 - 461., 2014.Nisanian M, Karpuzoglu E, Kerr RP et al. Exposure of Leghorn Chickens to Lead Acetate Enhances Antibiotic Resistance in Enteric Floura. Poultry Science., 93, 891-897., 2014.Palomares RA. Analysis of mRNA Expression for Genes Associated with Regulatory T Lymphocytes (CD25, FoxP3, CTLA4, and IDO) after Experimental Infection with Bovine Viral Diarrhea Virus of Low or High Virulence in Beef Calves. Comparative Immunology, Microbiology & Infectious Diseases., 2013.


Palomares RA. Comparison of 4-day vs 5-day Controlled Internal Drug Release (CIDR) + Timed Artificial Insemination Protocols in Dairy Heifers. American Association of Bovine Practitioner., 2014.Palomares RA, Brock KV, and PH Walz. Differential Expression of Pro-inflammatory and Anti-inflammatory Cytokines during Experimental Infection with Low or High Virulence Bovine Viral Diarrhea Virus in Beef Calves. Vet. Immunol. and Immunopathol., 157, 149– 154., 2014.Palomares RA. Evaluation of a Monday-Friday 4-day CIDR + Timed Artificial Insemination Protocol in Dairy Heifers. A Pilot Study. Clin. Therio., 2014.Palomares RA, Hurley DJ, Woolums A, and J Parrish. Expression of Toll-like Receptors and Co-stimulatory Molecules in Lymphoid Tissue during Experimental Infection of Beef Calves with Bovine Viral Diarrhea Virus of Low and High Virulence. Vet. Research Comm., 2014.Pedroso AA, Hurley-Bacon AL, Zedek AS, Kwan TW, Jordan AO, Avellaneda G, Hofacre CL, Oakley BB, Collett SR, Maurer JJ, and MD Lee. Can Probiotics Improve the Environmental Microbiome and Resistome of Commercial Poultry Production? International Journal of Environmental Research and Public Health., 10(10), 25., 2013.Ramey AM, Fleskes JP, Schmutz JA, and MJ Yabsley. Evaluation of Blood and Muscle Tissues for Molecular Detection and Characterization of Hematozoa Infections in Northern Pintails (Anas acuta) Wintering in California. Intl. J. for Parasitol. Parasites and Wildlife., 2, 102-9., 2013.Roellig DM, Savage MY, Fujita AW, Barnabe C et al. Genetic Variation and Exchange in Trypanosoma Cruzi Isolates from the United States. PLoS ONE., 8(2), e56198., 2013.Rossow JA, Hernandez SM, Sumner SM, Altman BR, Crider CG, Gammage MB, Segal KM, and MJ Yabsley. Haemogregarine Infections of Three Species of Aquatic Freshwater Turtles from Two Sites in Costa Rica. Intl. J. for Parasitol. Parasites and Wildlife., 2, 131-5., 2013.Roulo RM, Fishburn JD, Alworth LC, Hoberman AM, and MA Smith. Producing Timed-Pregnant Mongolian Gerbils for Developmental Studies. Lab Animal., 42(10), 380-3., 2013.Santamaria A, Calzada JE, Saldaña A, Yabsley MJ, and NL Gottdenker. Molecular Diagnosis and Species Identification of Ehrlichia and Anaplasma Infections in Dogs from Panama. Vector Borne and Zoonotic Diseases., 14(5), 368-70., 2014.Segers J, Hancock DW, Jones AL, Tankersley TB, Lacy RC et al. Poor Quality Forages Pose Life-Threatening Risk to Georgia Cow Herds. UGA Extension. (vol. TP102, pp. 3), 2014.Shock BC, Moncayo A, Cohen S, Mitchell EA, Williamson PC, Lopez G, Garrison LE, and MJ Yabsley. Diversity of Piroplasms Detected in Blood-fed and Questing Ticks from Several States in the United States. Ticks and Tick-Borne Diseases., 5(4), 373-80., 2014.Stallknecht DE and AW Park. Apparent Increase of Reported and Confirmed Hemorrhagic Disease in the Midwest and Northeastern United States., 213.Sturgill TL, Giguère S, Berghaus LJ, Hurley DJ, and MK Hondalus. Comparison of Antibody and Cell-Mediated Immune Responses of Foals and Adult Horses after Vaccination with Live Mycobacterium Bovis BCG. Vaccine., 32(12), 1362-7., 2014.Woolums AR, Berghaus RD, Smith DR et al. A Survey of Veterinarians in 6 U.S. States Regarding their Experience with Nursing Beef Calf Respiratory Disease. Boy Pract., 2014.Woolums AR, Berghaus RD, Smith DR, White BJ et al. Producer Survey of Herd-Level Risk Factors for Nursing Beef Calf Respiratory Disease. JAVMA., 243(4), 538-47., 2013.Wu D, Alali WQ, Harrison MA, and CL Hofacre. Salmonella in Broiler Carcass Bone Marrow and Neck Skin: Potential Sources for Ground Chicken Contamination? International Poultry Scientific Forum. (pp. M47), 2014.Yabsley MJ and J McGuire. Altered Behavior in Gopher Tortoises with URTD. Athens, GA: SCWDS BRIEFS., (2nd ed., vol. 29, pp. 1-2) 2013.Yabsley MJ and BC Shock. Natural History of Zoonotic Babesia: Role of Wildlife Reservoirs. International Journal for Parasitology. Parasites and Wildlife., (vol. 2, pp. 18-31) 2013.Yabsley MJ. Update on Raccoon Roundworm in Florida and North Carolina. Athens, GA: SCWDS BRIEFS., (4th ed., vol. 28, pp. 1-2) 2013.

Small Animal Medicine

Afonso T, Giguère S, Rapoport GS, Berghaus LJ, Barton MH, and AE Coleman. Pharmacodynamic Evaluation of 4 Angiotensin Converting Enzyme Inhibitors in Healthy Adult Horses. J Vet Intern Med., 27(5), 1185-1192., 2013.Baker K, Foutz TL, Johnsen KJ, and SC Budsberg. In Vitro Effects of Tibial Plateau Angle and Spacer Thickness on Canine Total Knee Replacement. Am. J. of Vet. Res., 2014.Chelko SP, Schmiedt CW, Lewis TH et al. Vasopressin-Induced Constriction of the Isolated Rat Occipital Artery is Segment Dependent. J. Vasc. Res., 50(6), 478-485., 2013.Creevy KE, Gagnepain JF, Platt SR, Edwards GL, and M Kent. Comparison of Concentrations of γ-aminobutyric Acid and Glutamate in Cerebrospinal Fluid of Dogs with Idiopathic Epilepsy with and Without Seizure-related Magnetic Resonance Imaging Hyper intense Areas in the Limbic System. Am. J. of Vet. Res., 74(8), 1118-25., 2013.Duberstein KJ, Platt SR, Holmes SP, Dove CR, Howerth EW, Kent M et al. Gait Analysis in a Pre- and Post-ischemic Stroke Biomedical Pig Model. Physiol. Behav., 125, 8-16., 2014.Ebell MH, Budsberg SC, Cervero RM, Shinholser J, and M Call. What are the Clinical Questions of Practicing Veterinarians? J. of Vet. Med. Ed., 40(3), 310-316., 2013.Epstein K, Bergren A, Giguère S et al. Cardiovascular, Colloid Osmotic Pressure, and Hemostatic Effects of Hydroxyethyl Starch in Horses. J Vet Intern Med., 28(1), 223-33., 2014.Feldhaeusser BB, Turek MM, Lawrence J, Cornell KK, and RM. Gogal. Influence of Different Cell Storage/Culture Conditions on Spontaneous Proliferation and Level of Tyrosine Kinase Receptor Inhibition in Two Feline Injection-Site Sarcoma Cell Lines. Journal of Immunoassay and Immunochemistry., 34(3), 266-282., 2013.Fletcher D, Brainard B, Epstein K et al. Therapeutic Plasma Concentrations of Epsilon Aminocaproic Acid and Tranexamic Acid in Horses. J. Vet. Intern. Med., 27(6), 1589-95., 2013.Holmes SP, Brown SA, Zhang JL, and CW Schmiedt. Dynamic Contrast-enhanced MR Renography (MR excretory urography) using a Simplified Multicompartment Model for Determination of Glomerular Filtration Rate in Normal Dogs. Vet. Radiol. Ultrasound., 2014.Holmes SP, Myrna KE, and PA Moore. Technique for Contrast MR Dacrorhinocystoscopy in Canine Patients. Vet. Radiol. Ultrasound., 2014.Karpuzoglu Belgin E, Schmiedt CW, Pardo J, Hansen M, Guo T, Holladay SD, and RM Gogal. Serine Protease Inhibition attenuates rIL-12-induced GZMA Activity and Proinflammatory Events by Modulating the Th2 Profile from Estrogen-Treated Mice. Endocrinology., 2014.Mejia-Fava J, Divers SJ, Jimenez D, Ambrose DL, Rech R et al. Diagnosis and Treatment of Proventricular Nematodiasis in an Umbrella Cockatoo. JAVMA., 242, 1122-1126., 2013.Monk CS, Cohen EB, Hart KA, Kent M, Jimenez D, and BC Credille. What is Your Diagnosis? Cervical Malformation in a Goat. JAVMA., 2014.Munhofen JL, Jimenez D, Peterson DL, Camus AC, and SJ Divers. Comparing Ultrasonography and Endoscopy for Early Gender Identification of Juvenile Siberian Sturgeon. North Am. J. of Aq., 76, 14-23., 2014.Platt SR, Holmes SP, Howerth EW, Duberstein KJ et al. Development and Characterization of a Middle Cerebral Artery Occlusion Stroke Model. Exp. Transl. Stroke Med., 6, 1., 2014.Platt SR, Coates JR, Eifler DM, Edwards GL, Kent M, Bulsara KR. Effect of Treatment with Simvastatin and Cyclosporine on Neurotransmitter Concentrations in Cerebrospinal Fluid after Subarachnoid Hemorrhage in Dogs. Am. J. of Vet. Res., 74(8), 1111-7., 2013.

VMES 2014 23

Proenca LM, Mayer J, Schnellbacher R, Sanchez S et al. Ante mortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure. JAVMA., 2014.Proenca LM, Camus MN, Sharma A et al. Evaluation of Percutaneous Hepatic Fine-Needle Aspirates and Laparoscopic Biopsies in Rabbits. J. Zoo and Wildlife Med., 2014.Regan R, Northrup NC, Sharma A, and A Ellis. What’s your Diagnosis? Intrathoracic Lipoma in a Labrador Retriever. JAVMA., 2014.Saba CF, Schmiedt CW, Freeman KG et al. Indirect Assessment of Dihydropyrimidine Dehydrogenase Activity in Cats. Veterinary and Comparative Oncology., 11(4), 265-71., 2013.Shepard MK, Divers SJ, Braun C, and E Hofmeister. Pharmacodynamics of Alfaxalone after Single-Dose Intramuscular Administration in Red-Eared Sliders (Trachemys scripta elegans): A Comparison of Two Different Doses at Two Different Ambient Temperatures. Vet. Anesth. and Anal., 40(6), 590-8., 2013.Smith JR, Vrono Z, Rapoport GS, Turek MM, and KE Creevy. A Survey of Southeastern United States Veterinarians’ Preferences for Managing Cats with Diabetes Mellitus. J. Feline Med. Surg., 14(10), 716-722., 2013.Stelmach D, Sharma A, Rosselli D, and C Schmiedt. Circumferential Cervical Rubber Band Foreign Body Diagnosis in a Dog Using Computed Tomography. Can Vet Journal., 2013.Trim C, Hofmeister E, Peroni J, and M Thoresen. Evaluation of an Oscillometric Blood Pressure Monitor for use in Anesthetized Sheep. Vet. Anesth. Analgesia., 40(6), e31-9., 2013.Turek MM, Gogal RM, Saba CF, Vandenplas ML, Hill J, Feldhausser B, and J Lawrence. Masitinib Mesylate Does Not Enhance Sensitivity to Radiation in Three Feline Injection-Site Sarcoma Cell Lines Under Normal Growth Conditions. Res Vet Sci., 96(2), 304-307., 2014.Weissman A, Jimenez D, Torres B, Cornell KK, and S Holmes. Canine Vaginal Leiomyoma Diagnosed by Computed Tomography Vaginourethrography. JAAHA., 49, 394-397., 2013.Young BD, Fosgate GT, Holmes SP, Wolff CA, Chen-Allen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, and JM Levine. Evaluation of Standard Magnetic Resonance Characteristics Used to Differentiate Neoplastic, Inflammatory and Vascular Brain Lesions. Vet. Radiol. Ultrasound., EPub., 2014.

Veterinary Biosciences & Diagnostic Imaging

Bigio MA, Gieger TL, Jimenez D, and LA Granger. Detection of Comorbidities and Synchronous Primary Tumours via Thoracic Radiography and Abdominal Ultrasonography and their Influence on Treatment Outcomes in Dogs with Soft Tissue Sarcomas, Primary Brain Tumours, and Intranasal Tumors. Vet. Comp. Oncology., 2013.Cohen EB, Jimenez D, Shaver SL, Nemeth N, Sakamoto K. Colocolic Intussusception in a Dog Secondary to Colonic Lymphosarcoma. Aus. Vet. J., 2014.Credille BC, Tennent-Brown B, Jimenez D, and POE Mueller. What’s Your Diagnosis? Arytenoid Chondritis in an Alpaca. JAVMA., 2014.Daniel AJ, Leise BS and K Selburg. Distension of the Digital Flexor Tendon Sheath for Ultrasonographic and MRI Evaluation of Structures within the Sheath Compared to Tenoscopic Findings in Normal Horses. Vet. Surg. 2013.Duberstein KJ, Platt SR, Holmes SP, Dove CR, Howerth EW et al. Gait Analysis in a Pre- and Post-Ischemic Stroke Biomedical Pig Model. Physiol. Behav., 125, 8-16., 2014.Feldhaeusser BB, Turek MM, Lawrence J, Cornell KK, Gogal RM. Influence of Different Cell Storage/Culture Conditions on Spontaneous Proliferation and Level of Tyrosine Kinase Receptor Inhibition in Two Feline Injection-Site Sarcoma Cell Lines. Journal of Immunoassay and Immunochemistry., 34(3), 266-282., 2013.Finger JW and RM Gogal. Endocrine-Disrupting Chemical Exposure and the American Alligator: A Review of the Potential Role of Environmental Estrogens on the Immune System of a Top Trophic Carnivore. Archives Environmental Contamination and Toxicology., 65(4), 704-714., 2013.Guo TL, Germolec D, Zhang L et al. Contact Sensitizing Potential of Hair Dye Components and 5-Amino-o-Cresol in Female BALB/c Mice. Toxicology., 314(2-3), 202-208., 2013.Guo TL, Germolec DR, Zheng JF, Kooistra L et al. Genistein Protects Female Nonobese Diabetic Mice from Type 1 Diabetes When Fed Soy and Alfalfa-Free Diet. Tox Path., 2014.Gutierrez JC, Prater MR, Navarrete P, Holladay SD. Fetal Myocardial Reduction in Hyperglycemic Pregnancy is Associated with Decreased Expression of the Anti-Apoptotic Gene Bcl-2 in the Developing Heart. Annual Review & Research in Biology., 4, 306-311., 2014.Gutierrez JC, Prater MR, Holladay SD. Quercetin Reduces Maternal Hyperglycemia in a Type 2 Diabetes Mellitus Mouse Model. Ann Review & Research in Biology., 4, 71-78., 2014.Holmes SP, Brown SA, Zhang JL, and CW Schmiedt. Dynamic Contrast-Enhanced MR Renography (MR excretory urography) using a Simplified Multi Compartment Model for Determination of Glomerular Filtration Rate in Normal Dogs. Vet. Radiol. Ultrasound., 2014.Holmes SP, Myrna KE, and PA Moore. Technique for Contrast MR Dacrorhinocystoscopy in Canine Patients. Vet. Radiol. Ultrasound., 2014.Hutcheson KD, Holmes SP, Coleman KD. What’s Your Diagnosis? Hypertrophic Osteopathy and Radiographic Interpretation Errors. J. Am. Vet. Med. Assoc., 2014.Junping H, Qing Z, Min X, Guo T et al. Transplantation of Mesenchymal Stem Cells into the Renal Medulla Attenuated Salt-Sensitive Hypertension in Dahl Rats. J. of Mol. Med., 2014.Karpuzoglu Belgin E, Holladay SD, and RM. Gogal. Parabens: Potential Impact of Low Affinity Estrogen Receptor Binding Chemicals on Human Health. J Toxicol Environmental Health, Part B,, 16(5), 321-335., 2013.Karpuzoglu Belgin E, Schmiedt CW, Pardo J, Hansen M, Guo TL, Holladay SD, and RM Gogal. Serine Protease Inhibition Attenuates rIL-12-induced GZMA Activity and Proinflammatory Events by Modulating the Th2 Profile from Estrogen-Treated Mice. Endocrinology., 2014.Kerr, R. P., Krunkosky, T. M., Hurley, D. J., Cummings, B. S., Holladay, S. D., and R. M. Gogal. Lead at 2.5 and 5.0 μM Induced Aberrant MH-II Surface Expression through Increased MII Exocytosis and Increased Autophagosome Formation in Raw 267.4 Cells. Toxicology In Vitro., 27(3), 1018-1024., 2013.Kishi EN, Holmes SP, Abbott J, and NJ Bacon. Functional Metastatic Parathyroid Adenocarcinoma in a Dog. Can. Vet. J., 55, 383-8., 2014.Lafontaine E, Balder R, Michel F et al. Characterization of an Autotransporter Adhesion Protein Shared by Burkholderia Mallei and Pseudomallei. BMC Microbiology., 14, 92., 2014.Lafontaine E, Zimmerman S, Shaffer T et al. Safe, Reproducible and Rapid Aerosol Method to Study Infection by Burkholderia Pseudomallei and Mallei in Mice. PLoS ONE, 8, 2013.Levine GA, Selberg KT, Sweeney JC, Stone LR, Campbell M et al. Gastric Foreign Bodies in Small Odontocetes, A Clinical Approach. IAAAM Proc., 2014.Liu K, Guo TL, Hait NC, Allegood J, Parikh HI, Xu W, Kellogg GE, Grant S, Spiegel S, and S Zhang. Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-Thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent. PLoS ONE., 8(2), e56471., 2013.Madison AM, Sharma A, Haidekker MA. Noninvasive Intracranial Pressure Assessment in Canines via Biomechanical Response Behavior, Medical Imaging, and Finite Element Analysis: A Pilot Study. Am. J. of Vet. Res., 2014.Mejia-Fava J, Divers SJ, Jimenez D, Ambrose, DL, Rech R et al. Diagnosis and Treatment of Proventricular Nematodiasis in an Umbrella Cockatoo. JAVMA, 242, 1122-1126., 2013.Monk CS, Cohen EB, Hart KA, Kent M, Jimenez D, and BC Credille. What is Your Diagnosis?: Cervical Malformation in a Goat. JAVMA., 2014.


Munhofen JL, Jimenez D, Peterson DL, Camus AC, Divers SJ. Comparing Ultrasonography and Endoscopy for Early Gender Identification of Juvenile Siberian Sturgeon. North American Journal of Aquaculture., 76, 14-23., 2014.Nagata K, Walton R, M Goldschmidt. Usefulness of Immunohistochemistry to Differentiate between Nasal Carcinoma and Lymphoma in Cats. Vet. Comp. Oncol., 12(1), 52-57., 2014.Nisarian Mandana, Holladay SD, Karpuzoglu E, Kerr RP, Williams SM, Stabler L, Tuckfield RC, McArthur JV, and RM Gogal. Exposure of Juvenile Leghorn Chickens to Lead Acetate Enhances Antibiotic Resistance in Enteric Bacterial Flora. Poultry Science., 93(4), 891-897., 2014.Platt SR, Holmes SP, Howerth EW et al. Development and Characterization of a Pig Middle Cerebral Artery Occlusion Stroke Model. Exp. Transl. Stroke Med., 6, 1., 2014.Porter EG, Holmes SP, Brokken MT. Diagnosis and Treatment of Carpometacarpal Desmitis in a Horse. Equine Vet. Educ., 2014.Proenca LM, Mayer J, Schnellbacher R, Sanchez S, Jimenez D et al. Antemortem Diagnosis and Successful Treatment of Pulmonary Candidiasis in a Sun Conure. JAVMA., 2014.Proenca LM, Camus MN, Sharma A, Stelmach D, Mayer J, and SJ Divers. Evaluation of Percutaneous Hepatic Fine-Needle Aspirates and Laparoscopic Biopsies in Rabbits (Oryctolagus Cuniculus). Journal of Zoo and Wildlife Medicine., 2014.Qian G, Tang L, Guo X, Wang F, Massey ME, Su J, Guo T, Williams JH, Phillips TD, and JS Wang. Aflatoxin B (1) Modulates the Expression of Phenotypic Markers and Cytokines by Splenic Lymphocytes of Male F344 Rats. J. Appl. Toxicol., 34(3), 241-9., 2014.Regan, R., Northrup, N. C., Sharma, A., and A. Ellis. What’s your Diagnosis? Intrathoracic Lipoma in a Labrador Retriever. JAVMA., 2014.Sathya S, Gilbert P, and A Sharma. Effect of Tibial Plateau Leveling Osteotomy on Patellar Tendon Angle: A Prospective Clinical Study. Vet. Comp. Orthop. Traumatol., 2014.Secrest SA, Essman SC, Nagy JK, and L Schultz. Effects of Furosemide on Ureteral Diameter and Attenuation Using Computed Tomographic Excretory Urography in Normal Healthy Dogs. Vet. Radiol. Ultrasound., 54, 17-24., 2013.Secrest SA and K Sakamoto. Halo and Reverse Halo Signs in Canine Pulmonary Computed Tomography. Vet. Radiol. Ultrasound., 55(3), 272-277., 2014.Secrest SA, Nagy JK, and SK Kneller. Radiographic Distortion Artifact of Circular External Fixators. J. Am. Anim. Hosp. Assoc., 2014.Schraf A, Holmes SP, JF Peroni. Super paramagnetic Iron Oxide Nanoparticles as a Means to Track Mesenchymal Stem Cells in Model of Tendon Injury. Mol. Imaging Biol., 2014.Shaikh L, Sharma A, and SA Secrest. Imaging Diagnosis: Duodenobiliary Reflux of Barium Sulfate during Esophagogastrography in a Dog. Vet. Radiol. Ultrasound., 2014.Shaffer TL, Balder R, Buskirk SW, Hogan RJ, and E. R. Lafontaine. Use of the Chinchilla Model to Evaluate the Vaccinogenic Potential of the Moraxella Catarrhalis Filamentous Hernagglutinin-like Proteins MhaB1 and MhaB2. PLoS ONE., 8, e676881., 2013.Sharma A, Holladay SD, and RM Gogal. Short Communication: First Report of a Mid-Gastric Intussusception in the Dog. Journal of Veterinary Advances., 2014.Stelmach D, Sharma A, Rosselli D, and C Schmiedt. Circumferential Cervical Rubber Band Foreign Body Diagnosis in a Dog Using Computed Tomography. Can Vet Journal., 2013.Tatarniuk D, Bracamonte J, Wilson D, Sharma A, and A Perry. Laminar Epidermal Hyperplasia and Hyperkeratosis in an Equine Hoof. Can Vet Journal., 54(9), 849-53., 2013.Turek MM, Gogal RM, Saba CF, Vandenplas ML, Hill J, Feldhausser B, and J Lawrence. Masitinib Mesylate Does Not Enhance Sensitivity to Radiation in Three Feline Injection-Site Sarcoma Cell Lines Under Normal Growth Conditions. Res Vet Sci., 96(2), 304-307., 2014.Wang Y, Xu S, Liu J, Zhang Y, and TL Guo. Regulation of Lead Toxicity by Heat Shock Protein 90 (daf-21) is affected by Temperature in Caenorhabditis Elegans. Ecotoxicol. Environ. Saf., 104, 317-22., 2014.Weissman A, Jimenez D, Torres B, Cornell KK, and S Holmes. Canine Vaginal Leiomyoma Diagnosed by Computed Tomography Vaginourethrography. JAAHA., 49, 394-397., 2013.Young BD, Fosgate GT, Holmes SP, Wolff CA, Chen-Allen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, and JM Levine. Evaluation of Standard Magnetic Resonance Characteristics Used to Differentiate Neoplastic, Inflammatory and Vascular Brain Lesions. Vet. Radiol. Ultrasound., EPub., 2014.

2014 Fiscal Year CVM GraduatesBarnabei, Jamie. Doctor of Veterinary Medicine/Master of Public Health (DVM-MPH), Spring 2014Buskirk, Sean. Doctor of Philosophy – Infectious Diseases, Spring 2014Cazzini, Paola. Master of Science – Veterinary & Biomedical Sciences, Spring 2014Collicutt, Nancy. Master of Science – Veterinary & Biomedical Sciences, Spring 2014Copeland, Jennifer. Master of Science – Veterinary & Biomedical Sciences, Spring 2014Coulson, Kari. Doctor of Veterinary Medicine/Doctor of Philosophy (DVM-PhD), Spring 2014Edwards, Thomas. Master of Science – Veterinary & Biomedical Sciences, Spring 2014Fox, Julie. Doctor of Philosophy – Infectious Diseases, Fall 2013 Gresham, Cory. Doctor of Veterinary Medicine/Doctor of Philosophy (DVM-PhD) – Forestry & Natural Recourses (Toxicology), Fall 2013Hammond, Sherri. Doctor of Philosophy – Neuroscience, Spring 2014Hartley, Ashley. Doctor of Veterinary Medicine/Doctor of Philosophy (DVM-PhD), Spring 2014Jeffers, Anna. Doctor of Veterinary Medicine/Master of Public Health (DVM-MPH), Spring 2014Keralapurath, Madhusudhanan. Doctor of Philosophy – Toxicology, Spring 2014Lin, Zhoumeng. Doctor of Philosophy – Toxicology, Fall 2013Malinak, Chad. Master of Avian Medicine, Fall 2013Mason, Caleb. Master of Science – Veterinary & Biomedical Sciences, Fall 2013Myers, Elise. Master of Avian Medicine, Fall 2013Rogers, Ashley. Master of Science – Veterinary & Biomedical Sciences, Summer 2013Sage, Leo. DVM-PhD Dual Degree Candidate, Doctor of Philosophy – Infectious Diseases, Fall 2013Tillman, Glenn. Doctor of Philosophy – Infectious Diseases, Fall 2013 Talundzic, Eldin. Doctor of Philosophy – Infectious Diseases, Summer 2013 Turner, Tiffany. Doctor of Philosophy – Infectious Diseases, Fall 2013Wang, Yun-Ting. Master of Avian Medicine, Fall 2013

Director: Dr. Harry W. DickersonManaging Editor: Dr. James MooreAssociate Editor: Holly SnellingDesigner: Brad GillelandMedical Illustrators: Tasha Obrin, Will McAbee, Joe Samson, Neil McMillan and Brad GillelandPhotographer/Videographer: Christopher HerronAugmented Reality: Rafael Machado de Lima Silva

Copyright © 2014 Veterinary Experiment Station, College of Veterinary Medicine, The University of Georgia. No part of this publication may be reproduced without the permission of the publisher.

Overview, Mission, & Objectives................................................................................................1

From the Director.......................................................................................................................2

VMES Financial Tables...............................................................................................................3 Incorporating Technology into Veterinary Medical Education.....................................................4

VMES Projects............................................................................................................................8

Clinical Research-New Faculty Funds..........................................................................................8

Highlighted Research Activities.................................................................................................12

Extramural Contracts & Grants................................................................................................14

Selected Publications.................................................................................................................16

2014 Fiscal Year CVM Graduates..............................................................................................24

Incorporating Technology into Veterinary Medical Education.Cover Illustration by Tasha Obrin, Will McAbee and Brad Gilleland

VMES 2014 www.vet.uga.edu/research/vmes/

Contents

The key to improved animal well-being is animal health.The key to improved animal health is veterinary research.

2014 - Educational ResourcesResources Center (ERC), which has played a role in scientific...

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Transcript of 2014 - Educational ResourcesResources Center (ERC), which has played a role in scientific...