2014 AHA/ACC Guideline for the Management of Patients …/media/Non-Clinical/Files-PDFs...Prosthetic...
Transcript of 2014 AHA/ACC Guideline for the Management of Patients …/media/Non-Clinical/Files-PDFs...Prosthetic...
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2017 AHA/ACC Guideline for the
Management of Patients With
Valvular Heart Disease
Developed in Collaboration with the American Association for Thoracic Surgery,
American Society of Echocardiography, Society for Cardiovascular Angiography
and Interventions, Society of Cardiovascular Anesthesiologists, and
Society of Thoracic Surgeons
© American College of Cardiology Foundation and American Heart Association
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General Concepts
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Table 1. Applying Class
of Recommendation and
Level of Evidence to
Clinical Strategies,
Interventions,
Treatments, or
Diagnostic Testing
in Patient Care* (Updated August 2015)
(Used in the 2017
VHD Focused Update)
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Anticoagulation for Atrial Fibrillation in
Patients With VHD (New Section)
Recommendations COR LOE
New: Anticoagulation with a VKA is indicated for
patients with rheumatic mitral stenosis and AF I B-NR
New: Anticoagulation is indicated in patients with
AF and a CHA2DS2-VASc score of 2 or greater
with native aortic valve disease, tricuspid valve
disease, or MR
I C-LD
New:
IIa C-LD
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Aortic Stenosis: Choice of Intervention (cont.)
Recommendations COR LOE
Modified: for
patients with (Stage
D) and a
who have a predicted post-TAVR
I A
New: is a reasonable alternative to
surgical AVR for patients with
(Stage D) and an
, depending on patient-specific
procedural risks, values, and preferences
IIa B-R
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Choice of TAVR Versus Surgical AVR in the
Patient With Severe Symptomatic AS (Modified)
Surgical AVR
(Class I)
Severe AS
Symptomatic
(stage D)
Intermediate surgical
risk
Surgical AVR
(Class I)
TAVR
(Class IIa)
Surgical AVR or TAVR
(Class I)
TAVR
(Class I)
Low surgical
risk
High surgical
risk
Prohibitive surgical
risk
Class I
Class IIa
Class IIb
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So, what is the evidence??
New:
IIa C-LD
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CP1293058-11
Meta-analysis
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European Definition of NVAF
AF that occurs in the absence of
heart valves
and in the absence of
(MS, usually of
rheumatic origin)
Updated EHRA practical guide Europace (2015) 17, 1467
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US Definition of NVAF
AF in the absence of
2014 AHA/ACC/HRS Guideline Circulation. 2014;130:e199
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So, what is the evidence??
New: is a reasonable alternative to
surgical AVR for patients with
(Stage D) and an
, depending on patient-specific
procedural risks, values, and preferences
IIa B-R
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So, what is the evidence??
PARTNER 2
New: is a reasonable alternative to
surgical AVR for patients with
(Stage D) and an
, depending on patient-specific
procedural risks, values, and preferences
IIa B-R
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Antithrombotic Therapy for Prosthetic Valves (cont.)
Recommendations COR LOENew: A lower target INR of 1.5 to 2.0 may be
reasonable in patients with mechanical On-X AVR and
no thromboembolic risk factors IIb B-R
New:
IIb B-NR
Clopidogrel 75 mg daily may be reasonable for the
first 6 months after TAVR in addition to life-long aspirin
75 mg to 100 mg dailyIIb C
Anticoagulant therapy with oral direct thrombin
inhibitors or anti-Xa agents should not be used in
patients with mechanical valve prostheses
III:
HarmB
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Prosthetic Valve Stenosis: Intervention
Recommendations COR LOERepeat valve replacement is indicated for severe
symptomatic prosthetic valve stenosis I C
New:
IIa C-LD
New: For severely symptomatic patients with
bioprosthetic aortic valve stenosis judged by the
heart team to be at high or prohibitive risk of
reoperation, and in whom improvement in
hemodynamics is anticipated, a transcatheter
valve-in-valve procedure is reasonable
IIa B-NR
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• Congenital tricuspid dysplasia, severe TR
• S/P tricuspid bioprosthesis & mitral annuloplasty
2010
• Endocarditis MSSA 2010 post-surgery
• S/P re-do tricuspid & mitral bioprotheses 2010
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2017
2012
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2012
2017
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2012
2017
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• Congenital tricuspid dysplasia, severe TR
• S/P tricuspid bioprosthesis & mitral annuloplasty
2010
• Endocarditis MSSA 2010 post-surgery
• S/P re-do tricuspid & mitral bioprotheses 2010
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2017
2012
Thrombosis
Degeneration
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2012
2017Thrombosis
Degeneration
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Bioprosthetic Valve Thrombosis
Does It Exist?
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Patient A Patient B
Gradient 40 mmHg(baseline 12 mmHg)
Gradient 42 mmHg(baseline 15 mmHg)
3 mo 2 years
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Patient A Patient B
Normal LV sizeEF 70%
Normal LV sizeEF 70-75%
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• Early prosthetic valve degeneration
• Pannus ingrowth
• Pressure recovery
• Unrecognized regurgitation
• Patient-prosthesis mismatch
• High cardiac output
• Prosthetic valve thrombosis
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Patient A Patient B
Normal LV sizeEF 70%
Normal LV sizeEF 70-75%
Bioprosthetic Valve
Thrombosis
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Patient A Patient B
Gradients on VKA
1 mo: 32 mmHg
3 mo: 24 mmHg
1 year: 14 mmHg
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BPVT: Mayo Surgical
Experience• All bioprosthetic re-operations 1994-2014
• 46 BPVT (11.6% of all reoperations)
Egbe, Pislaru et al. JACC 2015.
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Egbe et al. JACC 2015.
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Misconceptions in BPVTBPVT is not easy diagnosis
• TTE
– Abnormal findings described in all patients
– BPVT not suspected in ~95% of patients
• TEE
– Original report suggests BPVT in ~ 10% pts
– Retrospective (blinded) look: thrombus seen
in majority of mitral / tricuspid bioprostheses
– Challenging imaging for aortic BPV
The eyes will not see what the
mind does not know
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Proposed Echo Criteria
1. Increased gradient > 50% over baseline
within first 5 years post-implant
2. Thickened, non-calcified leaflets
3. Restricted leaflet mobility
All 3 parameters: 72% sensitivity,
90% specificity for BPVT
Egbe, Pislaru et al. JACC 2015.
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BPVT Degeneration
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Bioprosthetic Valve Thrombosis
Treatment Options
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• ACC/ AHA, ESC guidelines
– no specific therapy for BPVT
– recommendations for “prosthetic thrombosis”
• ACC/AHA 2014
– Left-sided, hemodynamic instability: favor
surgery
– Right-sided, small thrombi (<0.8 cm2): favor
lytics
• ESC 2012
– “optimal AC” if small thrombus
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This is all retrospective…..
• January 2014: Shared BPVT results with
Cardiology and Cardiac Surgery
• Prospective registry of suspected BPVT
– Direct communication with physician with
expertise in BPVT diagnosis / management
– TEE / CT recommended, but at discretion of
primary cardiologist
– Trial of warfarin unless hemodynamically
unstable
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Prospective Registry
• January 2014 – May 2016
• 55 cases suspected BPVT
– 43 responders (gradient decrease >50%)
– 9 non-responders
– 3 lost to f/u
• Echo: 48 (92%) with adequate data
– 3 criteria: response to VKA 38/39
– 2 echo criteria: response to VKA 4/9
Egbe, Pislaru et al. JACC Interventions 2017.
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Prospective Registry
• BPVT is more common than previously
reported
• Echo criteria: excellent prediction of
response to VKA
• Suggest yearly echo within first 3 years
post-implantationEgbe, Pislaru et al. JACC Interventions 2017.
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Prosthetic Valve Stenosis: Intervention
Recommendations COR LOERepeat valve replacement is indicated for severe
symptomatic prosthetic valve stenosis I C
New:
IIa C-LD
New: For severely symptomatic patients with
bioprosthetic aortic valve stenosis judged by the
heart team to be at high or prohibitive risk of
reoperation, and in whom improvement in
hemodynamics is anticipated, a transcatheter
valve-in-valve procedure is reasonable
IIa B-NR
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2017 AHA/ACC Guideline for the
Management of Patients With
Valvular Heart Disease
Developed in Collaboration with the American Association for Thoracic Surgery,
American Society of Echocardiography, Society for Cardiovascular Angiography
and Interventions, Society of Cardiovascular Anesthesiologists, and
Society of Thoracic Surgeons
© American College of Cardiology Foundation and American Heart Association