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Platinum Sponsor Platinum Sponsor Platinum Sponsor Platinum Sponsor

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Izmir – TurkeySeptember 15 – 18, 2013

11th World Congress of the International Cartilage Repair Society

www.cartilage.org

Diamond Partner Diamond Partner Platinum Sponsor

Preliminary Programme & Call for Abstracts

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Regeneratingcartilagein the knee

TiGenix is a leading European celltherapy company with a commercialproduct and a strong clinical stagepipeline of adult stem cell programs.

info@tigenix.com • www.tigenix.com

_TIGX_ADV_CC_A5ADVERTENTIE__TIGX_ADV_CC_A5ADVERTENTIE 14/11/12 15:43 Pagina 1

Welcome by the President

It is my enormous pleasure to invite you to join us in the great melting pot of culture at the interface of Europe and Asia and the equally great melting pot of cartilage research at the interface of basic science, clinical investigation, industrial development and patient rehabilitation.

Many of you will already know the importance of our World Con-gress, held only once every 18 months, providing a unique chance to meet and learn from the world’s best experts in cartilage research and therapy. For those of you who see ICRS as your natural home, we are keen to welcome you back. For those who have rarely or never attended our congresses, please come along and find out what we are all about. We have taken even more care than before to integrate scientific and clinical aspects of each session so that we can all learn from each other.

For those of you who have visited Turkey before you will know what a delightful country it is. For those who have never been before, please come and discover this jewel of a nation. The people are warm and friendly, the climate enticing and the food delicious. If you can extend your stay before or after the congress then you will be able to move seamlessly between modern cartilage science and ancient antiquities, taking some time out in between to do some hard bargaining in a carpet shop or simply to wander along the seashore, enjoying a relaxing mo-ment. Bring your family if you can; you are all in for a treat.

Our scientific committee has done a fantastic job in putting together the pro-gramme, whilst the local organizing committee is working closely with Stephan Seiler from the ICRS office to make sure the venue in Izmir as well as the culture and entertainment are just right for you.

So please mark up your calendars for the 11th World Congress of ICRS. Make yourself at home in our Society by joining us at this great venue and making many new friends and collaborators. I look forward to meeting you in Izmir in Septem-ber 2013.

Anthony HollanderICRS President

“Advancing science & education in cartilage repair worldwide!”

Regeneratingcartilagein the knee

TiGenix is a leading European celltherapy company with a commercialproduct and a strong clinical stagepipeline of adult stem cell programs.

info@tigenix.com • www.tigenix.com

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Welcome from the Local Committee

It is our privilege to invite you to the 11th World Congress of International Cartilage Repair So-ciety – ICRS 2013 to be held in Izmir, Turkey on 15-18 September 2013.

ICRS 2013 will be the event where you will find answers for many important questions

on cartilage. Although many musculoskeletal system related injuries and ill-nesses have been well-defined and classified, advances in preclinical, clinical and industrial research and studies on novel therapeutic approaches are still on going on cartilage related pathologies. We believe that ICRS members, friends and industry partners will share new and exciting developments in clinical and preclinical applications and insights into stem-cell and cellular therapies and related technologies at ICRS 2013. This meeting will promote interdisciplinary education and relations between the clinical professionals and basic scientists.

As Local Organizing Committee we look forward to welcoming you in Izmir, the healing lands of Asclepius since fifth century B.C. Herodotus described Izmir as “the city under the most sublime blue sky with a remarkable climate”. Located on the crossroads of Europe, Asia and the Middle East, as symbol of tolerance and friendship, Izmir of Modern Turkey founded by Mustafa Kemal Ataturk, will also be a scientific bridge between continents.

City of Izmir, named after the Amazon queen Smyrna, in the west of Asia Minor will help you to taste different pleasures during your stay as it has been doing for many civilizations for 8500 years throughout the history. As a port city with all the colours of turquoise to indigo of the Aegean Sea, Izmir is a whole with its land interlaced with the bays, beaches and thermal springs. Izmir will bring you the taste of a rich culinary culture influenced by many civilizations since ancient times and based on healthy eating.

The cultural heritage and natural beauty of Izmir are getting ready to welcome you for the 11th World Congress of ICRS.

Mehmet Binnet Didem KozaciCongress Chair 2013 Chair of the Local Committee 2013

“Advancing science & education in cartilage repair worldwide!”

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Welcome by the Scientific Programme Committee

We have the great pleasure of inviting you to the 11th Word Congress of the International Cartilage Repair Society in Izmir, Turkey in September 2013. This next meeting of our society will provide anoth-er exciting and comprehensive update on the basic science of cartilage as well as clinical research on cartilage injury and cartilage repair. It provides a

wonderful opportunity for basic scientists, surgeons, rehabilitation specialists, and industry partners to share the rapidly advancing knowledge in cartilage biology and regenerative medicine. Besides providing our members and guests with update on the latest developments, a specific goal of the programme committee is to provide a unique forum for interdisciplinary education and to inspire a creative translational exchange between clinical and preclinical scientists in this exciting field. Accordingly, the scien-tific sessions were designed to combine both basic science and clinical aspects of each individual topic to facilitate translational scientific exchange, education, and collabora-tion.

The basic science (preclinical) perspective includes new stem cell and tissue engineer-ing topics, some new research areas (ECM derived scaffolds, lessons from cartilage de-velopment, molecular regulation of repair) as well as world class speakers which will provide in-depth presentations on the specific topics that promise to become the sourc-es for next generation musculoskeletal tissue regeneration and repair technologies.

From a clinical perspective, the most recent, up-to-date information on current treat-ment approaches will be presented as well as emerging clinical technologies and con-cepts that will provide the basis for the future diagnosis of cartilage injury, cartilage restoration and rehabilitation. Specifically, the role of the subchondral bone in cartilage pathology and restoration, immunological aspects of joint injury and function, and new clinical applications of recent tissue engineering approaches, novel biomaterials, and modern molecular biology and cellular technologies for cartilage restoration will be pre-sented. Practical issues like cartilage rehabilitation, lessons from failed cartilage repair, and management of the broad spectrum of cartilage injury and degeneration will be discussed by international clinical leaders. In addition, comprehensive instructional courses and new “Current Concept Lectures” will offer unique learning opportunities from experienced clinical experts on clinically relevant topics. The 11th World Congress is the first ICRS meeting held in the world’s Eastern hemi-sphere bringing state-of-the-art cartilage science and technology closer to the doorstep of many active members and cartilage scientists from Asia, India, and the Middle East. We look forward to an open and stimulating scientific and cultural exchange that will give all participants the opportunity to learn from each other’s unique experiences and approaches to cartilage science and will further promote the active ongoing interna-tional collaboration in our steadily expanding society.

Wiltrud Richter & Kai MithoeferCo- Chairs of the Scientific Programme Committee

Organization

Congress Chair – ICRS 2013• Prof. Mehmet BinnetAnkara UniversityDept of OrthopaedicsIbni Sina Hospital, Sihhiye06100 Ankara, TurkeyPhone: +90 312 46 85 040Email: msbinnet@medicine.ankara.edu.tr

Chair of the Local Committee – ICRS 2013• MD. PhD Didem KozaciUniversity of Adnan MenderesFaculty of MedicineDept of Medical Biochemistry09010 Aydin, TurkeyPhone: +90 218 20 00 (Ext 1324)Email: dkozaci@adu.edu.tr

Members of the Local Organizing CommitteeAkgun Isik, Esenyurt-IstanbulAtik O. Sahap, Bilkent-AnkaraBeyzadeoglu Tahsin, IstanbulBinnet Mehmet, AnkaraBozkurt Murat, Gölbaci-AnkaraHaklar Ugur, IstanbulKozaci Didem, Aydin

Congress Organizing OfficeCartilage Executive Office GmbHMr. Stephan SeilerExecutive DirectorSpitalstrasse 190 – House 3CH-8623 Wetzikon ZH, SwitzerlandPhone: +41 44 503 73 70Email: sseiler@cartilage.org

Scientific Programme CommitteeChairmen• MD. Kai MithoeferHarvard Vanguard Medical AssociatesHarvard Medical SchoolMA 02467 Chestnut Hill, USAPhone: +1 617 541 6611Email: kmithoefer@partners.org

• Prof. PhD Wiltrud RichterHeidelberg University HospitalResearch Centre for Experimental Orthopaedics69118 Heidelberg, GermanyPhone: + 49 6221 562 92 54wiltrud.richter@med.uni-heidelberg.de

Congress VenueSwissôtel Grand Efes, IzmirGaziosmanpasa Bulvari No:1Alsancak, Izmir 35210, Turkeywww.swissotel.com/izmir

Convention Service ManagerMr. Ali YaziciogluPhone: +90 232 414 50 80Mobile:+90 530 609 13 90Ali.Yazicioglu@swissotel.com

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ICRS Society

ICRS Executive Board

President• Anthony Hollander, Bristol, UK

Vice President• Christoph Erggelet, Zurich, CH

Secretary General• Norimasa Nakamura, Osaka, JP

Treasurer• Ken Zaslav, Richmond, USA

Past President: • Daniël Saris, Utrecht, NL

ICRS General BoardAltman Roy, Los Angeles, USABinnet Mehmet, Ankara, TRCole Brian, Chicago, USAErggelet Christoph, Zurich, CHFarr Jack, Indianapolis, USAGetgood Alan, Cambridge, UKGobbi Alberto, Milano, ITMalda Jos, Utrecht, NLMandelbaum Bert, Santa Monica, USAMithoefer Kai, Chestnut Hill, USAHollander Anthony, Bristol, UKKon Elizaveta, Bologna, ITMalda Jos, Utrecht, NLNakamura Norimasa, Suita, JPRichter Wiltrud, Heidelberg, DESaris Daniël BF, Utrecht, NLZaslav Kenneth, Richmond, USA

• Education & Meeting Committee Chairmen Gobbi Alberto, Milano, IT Nehrer Stefan, Krems, Austria

• Members Trattnig Siegfried, Vienna, AT Polacek Martin, Tromso, NO Shetty Anan, Kent, UK Akgun Isik, Istanbul, TK Arbel Ron, Tel Aviv, Israel Lee Myung Chul, Seoul. KR Hui James, Singapore, SG Ferretti Mario, Sao Paulo, BR

Please note:This is a preliminary programme. The information in this programme is subject to change without prior notice. For updated information, please visit frequently our website: www.cartilage.org

09.00 – 18.00Registration

13.00 – 14.00Plenary Session Cartilage Injury to Osteoarthritis

10.00 – 12.00 Cartilage Restoration in Turkey – A Clinical & Scientific Update (Session in Turkish Language)

14.15 – 15.15 14.15 – 15.15 14.15 – 15.15

Special Special SpecialSession Session Session

Cartilage Biomaterials Minimally and Sports in Cartilage Invasive Repair Cartilage Repair

15.45 – 16.45 15.45 – 16.45 15.45 – 16.45

Special Special SpecialSession Session Session

Cartilage Lessons Intervertebral Rehabilitation Cartilage Disk Development

15.15 – 15.45

Coffee Break / Intermission / Exhibition

17.00 – 17.45

Opening Ceremony & Awards

17.45 – 18.45

Honorary Lectures

19.00 – 20.30

Welcome Cocktail

07.30 – 08.15

Instructional Courses / Current Concept Lectures

10.45 – 11.15

Coffee Break / Intermission / Exhibition

14.15 – 15.45

Free Paper Sessions

16.00 – 18.00

Poster Viewing Cocktail

16.00 – 17.15

Member’s General Assembly

18.30 – 23.00

President’s Dinnerin Ephesus

Sunday, September 15, 2013 Monday, September 16, 2013

Programme Overview

09.45 – 10.45 09.45 – 10.45 09.45 – 10.45

Special Special SpecialSession Session Session

Lessons Immunology Cartilagefrom Failure Cytokines Injury and Regenokine Pain

08.30 – 09.30

Plenary Session Subchondral Bone & Cartilage Repair

11.15 – 12.45

Free Paper Sessions

13.00 – 14.00

Industry Satellite Symposia

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10.45 – 11.15

Coffee Break / Intermission / Exhibition

13.00 – 14.00

Industry Satellite Symposia

14.15 – 15.15

Plenary Session The Cartilage Odyssey

07.30 – 08.15

Instructional Courses/Current Concept Lectures

09.45 – 10.15

Coffee Break / Intermission / Exhibition

11.30 – 13.00

Free Paper Sessions

13.00

End of the Meeting

Tuesday, September 17, 2013 Wednesday, September 18, 2013

07.30 – 08.15

Instructional Courses / Current Concepts Lecture

08.30 – 09.30

Plenary Session Stem Cells

08.30 – 09.45

Plenary Session ICRS Vision and Development

09.45 – 10.45 09.45 – 10.45 09.45 – 10.45

Special Special SpecialSession Session Session

Joint-Specific Systemic MolecularCartilage Effects RegulationInjury & Repair

11.15 – 12.45

Free Paper Sessions

19.30 – 23.30

1001 Turkish Nights (Congress Party)

17.30 – 18.30 17.30 – 18.30 17.30 – 18.30

Special Special SpecialSession Session Session

Meniscus New Horizons CultureUpdate in Tissue Models and Engineering Bioreactors

15.30 – 16.30 15.30 – 16.30 15.30 – 16.30

Special Special SpecialSession Session Session

Cartilage Mesenchymal BiomarkersImaging Stem Cells

10.15 – 11.15 10.15 – 11.15 10.15 – 11.15

Special Special SpecialSession Session Session Lessons Biomechanics- Chondropeniafrom Animal Joint and EarlyModels Distraction Osteoarthritis Arthroplasty

16.30 – 17.30

Intermission

Preliminary Scientific Programme

Sunday, September 15, 2013

10.00–12.00 0.0 Cartilage Restoration in Turkey A Clinical & Scientific Update (Session in Turkish Language)

13.00–14.00 1.0 Plenary Session – Cartilage Injury to Osteoarthritis Spectrum of Disease; Spectrum of Treatment • Basic Science of Cartilage Injury and Degeneration • Clinical Spectrum of Cartilage Injury • Adapting Therapeutic Concepts to Cartilage Injury Severity

14:15 - 15.15 2.0 Special Sessions

2. 1 Cartilage and Sports • Effect of Athletic Activity on Articular Cartilage • Treatment Options for Articular Cartilage Injury in the Athlete • Return to Sport after Cartilage Repair: What Does It Take?

2.2 Biomaterials in Cartilage Repair • ECM-derived Biomaterials in Cartilage Repair • Hydrogels versatile Scaffolds for Cartilage Repair • Biomaterial-based Polarization of the Macrophage Response

2.3 Minimally Invasive Cartilage Repair • Evolution of Minimally Invasive Cartilage Repair • Reducing Invasiveness of Adjuvant Procedures • Arthroscopic transplantation of synovial MSC for Cartilage Regeneration 15:15 - 15:45 Coffee Break/Intermission/Exhibition

15:45 - 16:45 3.0 Special Sessions

3.1 Cartilage Rehabilitation: Current and Developing Concepts • Current Principles and Challenges of Cartilage Rehabilitation • Rehabilitation Equipment: Useful Options for Cartilage Injury and Repair • Promoting Muscle Recovery after Cartilage Repair

3.2 Lessons from Cartilage Development • Evolution of Cartilage Regeneration Capacity • Chondrocyte Proliferation and Differentiation in Cartilage Development • Developmental Engineering of Cartilage from Stem Cells

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3.3 Intervertebral Disk • Comparison of Intervertebral Disc and Articular Cartilage • Clinical Applications of Tissue Engineering Technology in the Intervertebral Disc • Cell and Growth Factor Application in the Spine

17:00 - 17.45 4.0 Opening Ceremony & Awards

17:45 - 18.45 5.0 Honorary Lectures • The Chondrocyte: What is it? Where does it come from? What defines it? • The Joint “Organ”: Comprehensive Concepts for Cartilage Restoration

19:00 – 20.30 Welcome Cocktail in the Gardens of the Swissotel

Free Evening

Monday, September 16, 2013

07:30 - 08:15 6.0 Instructional Courses/Current Concept Lectures • Patellofemoral Cartilage Injury: Workup, Surgery, Rehabilitation • Current Concepts Lecture: Tissue Quality and Outcome • How to write, submit, or review for the Journal ‘Cartilage’

08:30 - 09:30 7.0 Plenary Session - The Subchondral Bone & Cartilage Repair • Basic Science of the Subchondral Bone in healthy, diseased & repaired Cartilage • Clinical Spectrum and Relevance of Subchondral Bone Changes for Cartilage Injury and Repair • Treatment of Subchondral Bone Pathology

09:45 - 10:45 8.0 Special Sessions

8.1 Lessons from Failure: Why is Cartilage Repair Unsuccessful? • Definition and Epidemiology of Failed Cartilage Repair • Why does Cartilage Repair Fail? • Strategies to Improve Failure Rate

8.2 Immunology, Cytokines, Regenokine • Immunological Aspects of Cartilage Science • Value of single Cytokines & Factor Cocktails for Cartilage Repair • Management of Inflammation in Cartilage Regeneration/Repair

09:45 - 10:45 8.3 Understanding & Managing Pain in Cartilage Injury and Repair • Why is Cartilage Injury Painful? • Basic Science of Joint Pain • Treatment Principles and Approaches 10:45 - 11:15 Coffee Break / Intermission / Exhibition

11:15 - 12:45 9.0 Free Paper Sessions • Animal Models • High Level Evidence • Cell-Based Cartilage Repair • Matrix-derived Scaffolds and Biomaterials

13:00 - 14:00 10.0 Industry Satellite Symposia

14:15 - 15:45 11.0 Free Paper Sessions • Rehabilitation • Allograft & Synthetics • Cell based Cartilage Repair • Growth Factors (Basic Science and Clinical)

16:00 - 17:15 12.0 Member’s General Assembly

16:00 - 18:00 13.0 Poster Viewing Cocktail

18.30 – 23.00 President’s Dinner in Ephesus

Tuesday, September, 17, 2013

07:30 - 08:15 14.0 Instructional Courses/Current Concepts Lecture • Management of Cartilage Injury in the Competitive Athlete • Current Concepts of Animal and Culture Models

08:30 - 09:30 15.0 Plenary Session: Stem Cells • Paradigm Shift in Stem Cell Application • Clinical Applications in Cartilage Repair • New Frontiers

09:45 - 10:45 16 Special Sessions

16.1 Joint-Specific Cartilage Injury and Repair • The Shoulder and Elbow • The Hip • The Ankle

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09:45 - 10:45 16.2 Systemic Effect of Cartilage Repair • Overview on Systemic Effects of Cartilage Repair – the Basic Science View. • Melanocortin and Destruction of Articular Cartilage • Effects of Medication on Cartilage

16.3 Molecular Regulation of Cartilage Repair • Small Molecules to promote Cartilage Repair • Growth Factors PRP: Clinical Application • Mathematical Modeling of Growth Factor Networks

10:45-11:15 Coffee Break / Intermission / Exhibition

11:15-12:45 17 Free Paper Sessions • Cartilage Imaging • Chondral & Osteochondral Autograft Techniques • Stem Cells • Culture Models

13:00-14:00 18 Industry Satellite Symposia

14:15-15:15 19 Plenary Session - The Cartilage Odyssey • Landmarks of Cartilage Science Evolution • Quo Vadis Cartilage Repair? Opportunities for Translational Cartilage Science

15:30-16:30 20 Special Sessions

20.1 Cartilage Imaging and Functional Testing • Imaging Options for Cartilage Injury and Repair • Functional Cartilage MRI: Current Status and Future Outlook • Technologies for Qualitative/Biomechanical Cartilage Testing

20.2 Mesenchymal Stem Cells • Better MSC by reprogramming of iPS? • Engineering of Cartilage from Stem Cells • Mesenchymal Stem Cells: Treatment Options in Osteoarthritis and Cartilage Repair

20.3 Biomarkers • Basic Science of Biomarkers in Cartilage Injury and Repair • Clinical Trials and Applications • Synovial fluid Markers in Cartilage Destruction and Repair

16:30-17:30 Intermission (Poster Viewing/Exhibition)

17:30-18:30 21 Special Sessions

21.1 Meniscus Update • Meniscus Function in Cartilage Injury and Repair • Meniscus Repair and Transplantation: Results and Developments • Meniscal Replacement/Substitution: Indications, Outcomes, and Next Steps

21.2 New Horizons in Tissue Engineering • Microtechnologies to construct the Extracellular Microenvironment • High Throughput Tools for Tissue in Engineering • Evolution and Implementation of Clinical Cartilage Tissue Engineering Strategies 21.3 Culture Models and Bioreactors • Lessons from Explant Culture • Co-culture of MSC and Chondrocytes: What Cells teach each other • Novel Developments in Bioreactor based Cell Culture

19:30-23:30 1001 Turkish Nights (Congress Party)

Wednesday, September 18, 2013

07:30 - 08:15 22 Instructional Courses/Current Concepts • Regulatory Aspects of Cartilage Research • Current Concepts of Patient Selection for Cartilage Repair

08:30 - 09:45 23 Plenary Session: ICRS Vision and Development • ICRS Strategic Outline • Young Cartilage Investigator Report: YSOS & Stryker Traveling Fellowship Update • ICRS Meets the Middle East

09:45 - 10:15 Coffee Break / Intermission / Exhibition

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10:15-11:15 24 Special Sessions

24.1 Lessons from Animal Models • Small Animal Models • Large Animal Models • Anti-Angiogenesis in Cartilage Repair Models

24.2 Biomechanics-Joint Distraction Arthroplasty • Progress in Biomechanical Testing • Clinical Aspects of Joint Biomechanics for Articular Cartilage • Distraction Arthroplasty: Scientific Principles and Clinical Experience

24.3 Chondropenia and Early Osteoarthritis • Epidemiology of Early Osteoarthritis • Chondropenia: Concept and Quantification • Treatment Options for Early Osteoarthritis

11:30 - 13:00 25 Free Paper Sessions • Cartilage Repair in the Hip, Shoulder and Ankle • Marrow Stimulation • Growth Factors • New Cartilage Technology

13.00 End of Meeting

ICRS Instructional Courses / Current Concepts SessionsThe “Instructional Courses” and “Current Concept” sessions will be chaired by world renowned leaders and provide a unique possibility to obtain a compact knowledge about a specific topic in a small group. These sessions are geared towards young scientist / clinicians and seasoned specialists. Pre-registration is required to sign-up for these workshops during the online congress registration process. These courses are not included in the congress registration fee and the num-ber of participants is limited to 30 participants for each workshop.

Registration Fees Residents, Students, Junior Members ! 30.00ICRS Members ! 40.00Non – Members ! 50.00Company Representatives ! 60.00

Abstracts – Authors’ Information

Call for AbstractsThe scientific programme committee is pleased to invite all authors wish-ing to present a paper or a poster at ICRS 2013 to submit their abstracts latest until April 5, 2013. No extension of this deadline will be possible. The overall best rated abstract and Post-ers will be awarded by the Society.

• Podium PresentationsFree papers related to all topics in cartilage repair will be presented dur-ing 16 free paper sessions. Each ses-sion will start with a short introductory keynote lecture to set the stage for subsequent podium presentations. Speaking time is 7 minutes plus 3 minutes for discussion. The speaking time must strictly be observed by the presenters.

If an abstract is accepted for an oral presentation, presenters must speak in fluent English and be prepared to answer questions from the audience.All session rooms are equipped with networked computer projection. All presenters are requested to bring their PowerPoint presentation (Win-dows XP or Windows 7) on a CD-ROM or USB stick and to check-in at the Au-diovisual Center 3 hours prior to their presentation. Detailed information will be sent to the presenters on time.

• Electronic PostersOne of the main benefits of an elec-tronic poster exhibit is the post-congress availability of the posters for many years in the ICRS member’s area. Our scientific cartilage knowl-edge database is fully searchable by title, poster ID, authors, full text

and image annotation. Information on how to use the electronic poster submission system will be sent to the authors of the accepted abstracts. An independent jury will judge the elec-tronic posters by online blind grad-ing with regard to scientific content, educational value and visual impres-sion. Awards for the 6 best electronic posters will be given during the ICRS Opening & Awards Ceremony on Sun-day, September 15, 2013 at 17.00

• Traditional PostersIn addition to the electronic posters which must be submitted on a man-datory basis, the authors are also in-vited to produce a traditional poster for the poster walls. If your abstract is accepted as a poster, you will be requested to submit your electronic files to the ICRS online poster submis-sion system and you are requested to bring with you a traditional poster for the poster exhibit by reserving your poster wall in advance through our Office.

Submission of Abstracts - GuidelinesScientific abstracts must be submit-ted in impeccable English within the following structure: Purpose – Mate-rials & Methods – Results – Conclu-sion and must be written according to the few abstract submission instruc-tions to be found in the ICRS abstract online submission system. Abstract length is limited to a maximum of 300 words and may contain up to 2 graphs, pictures or tabs. For experi-mental clinical studies and animal studies, a copy of the approval re-ceived by the local ethical committee must be sent to our Executive Office.

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Abstract submission Deadline Abstracts may be submitted online through April 5, 2013 at noon CET (Cen-tral European Time) by accessing our online submission system on the ICRS website. No abstract submissions by letter, fax or e-mail will be accepted and no extension of the submission dead-line will be granted. ICRS will NOT edit abstracts for language issues, typing, spelling, or grammatical mistakes. There is no fee charged to submit an abstract for ICRS 2013 and you may submit as many abstracts as you wish. However, it is highly recommended to not leave your submissions until the very last day.

Presentation PreferenceSubmitted abstracts will be peer-reviewed and may be accepted for either an oral- or a poster presenta-tion. Submitters may indicate their presentation preference during the submission process but the Scientific Programme Committee reserves the right to define the final presentation type. No podium presentations can be guaranteed to any author.

Financial Disclosure StatementSubmitting authors must complete a Financial Disclosure Statement on be-half of all authors. Disclosures will not be seen or taken into consideration for the abstract grading process nor for the decision of acceptance of an abstract.

We request all submitters to cooper-ate in this by: 1. Declaring any potential conflict of interest by any of the authors when submitting an abstract.2. Declaring any commercial role in the related research of any Co-author on the first slides for podium presentations or on the posters for poster presentations.

Confirmation of AbstractsScientific contributions will be con-firmed in May 2013 by e-mail and only to the presenting author. The present-ing author must inform all co-authors of the notification result. Presenting authors of accepted abstracts will be requested to confirm their presenta-tions and they are expected to regis-ter and must cover their own travel, lodging and registration fees.

Publication – Supplement Journal “Cartilage”Congress abstracts are citable and will be published electronically in the congress supplement of our of-ficial Journal “Cartilage”, published by Sage ISSN 1947-6043 and in the printed congress abstract book.

We furthermore encourage all au-thors to additionally submit their full manuscripts to our peer reviewed journal “Cartilage” which publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and labora-tory research are welcome. Instruc-tions to authors for submissions are available at http://cart.sagepub.com

Awards and Honors ICRS 2013• 1 x Overall best rated abstract• 6 x Best electronic posters 2 x Magna cum Laude 2 x Cum Laude 2 x Certificate of Merit• 1 x Genzyme Award for Excellence in Cartilage REsearch (US$ 5000.00)• 1 x ICRS / Genzyme Lifetime Award• 1 x Young Investigator’s Award (US$ 1000.00)• FIFA Sports and Rehabilitation Award (1x US$ 1000.00)

Important Dates & DeadlinesAbstract Submission Deadline April 5, 2013

Abstract Notification Letters May 2013

Cancellation of Registration (Refund 80%) June 15, 2013

Early Bird Registration Fee June 15, 2013

Confirmation of Registration immediate online

Latest Hotel Reservation Deadline August 12, 2013

Hotel Cancellation Deadline August 12, 2013

Cancellation of Registration (Refund 50%) before August 20, 2013

Late Registration Fee applies as from August 21, 2013

Cancellation of Registration (no refund) after August 21, 2013

Abstracts – Authors’ Information

CME CreditsThe ICRS 2013 Congress intends to be accredited by the European Accredi-tation Council for Continuing Medical Educations – EACCME, an institution of the European Union of Medical Spe-cialists – UEMS, recognized by AMA.

Information on accreditation and the number of CME credits will be avail-able soon at www.cartilage.org

Speaker Service / AV CentrePlease note that only digital material will be allowed for oral presentations. The material must be in English and must be provided on CD-ROM or USB memory stick in (Windows 7 or XP for-mat) to be placed on the central server on-site. Presentations cannot include any promotional commercial messag-es. It will not be possible to use your own laptop or notebook for your pres-entation in the session rooms.

It is mandatory that the data carriers are delivered to the Speaker Ready Room at least 3 hours prior to your

session. Computers are available in each session room for accessing the speakers’ presentations.

The network of our computers in the session rooms and the AV Center are equipped and run with Microsoft Win-dows 7. Macintosh formats are not recommended. If you prefer to use Macintosh formats, please contact the AV Centre well in advance before your presentation. Our technicians will have enough time to verify and adapt your presentation, if needed.

Speaker’s presentations should be delivered as a standard in Microsoft Office format to avoid any techni-cal problems with the presentation system. If you have videos included in your PP presentation, make sure that they run in the most commonly used video formats. If you have any doubt, please contact the ICRS Office at least 15 days before the congress. It is your responsibility to make sure that your video runs on our standard-ized congress IT / AV system. General

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General Information

Congress OrganizerCartilage Executive Office (CEO) GmbH Spitalstrasse 190 – House 38623 Wetzikon ZH, SwitzerlandPhone: +41 44 503 73 70Fax: +41 44 503 73 72office@cartilage.org

Congress VenueSwissôtel Grand Efes, IzmirGaziosmanpasa Bulvari No:1Alsancak, Izmir 35210, Turkeywww.swissotel.com/izmir

Convention Service ManagerMr. Ali YaziciogluPhone: +90 232 414 50 80Mobile:+90 530 609 13 90Ali.Yazicioglu@swissotel.com

Accommodation / Hotel Booking

• Swissotel Grand Efes IzmirReservation Departmentc/o Ms. Zeren OzturkPhone: +90 232 414 00 00, Extension:5071Direct Line: +90 232 414 50 71Email: reservations.izmir@swissotel.com

Toll Free Reservation: International: 800 6379 47 71Online Reservation: www.cartilage.org

• Hilton IzmirC&E DepartmentMs. Derya FiciciPhone: +90 232 49760 60Direct Line: +90 232 497 60 22Email: derya.ficici@hilton.comOnline Reservation: www.cartilage.org

Official Airline Network

SAVE UP TO 20% ON TRAVEL WITH THE STAR ALLIANCE™ NETWORK

The Star Alliance member airlines are pleased to be appointed as the Of-ficial Airline Network for ICRS 2013 Izmir, Turkey.

To obtain the Star Alliance Conventions Plus discounts and for booking office information please visit www.staralli-ance.com/conventionsplus and:Choose “For delegates” - Under “Del-egates login” enter the conventions code TK06S13. Choose one of the participating airlines listed or call the respective reservation contact listed and quote the conventions code TK06S13 when booking the ticket.

Registered participants plus one ac-companying person travelling to the event can qualify for a discount of up to 20%, depending on fare and class of travel booked. Discounts are of-fered on most published business and economy class fares, excluding website/internet fares, senior and youth fares, group fares and Round the World fares. Please note: For travel from Japan and New Zealand special fares or discounts are offered by the participating airlines on their own network.

Convention Code: TK06S13

ICRS is going to Smyrna

As Turkey’s third largest city after Is-tanbul and Ankara, Izmir (old Smyrna) is the capital of the Aegean Region and an important center for manufactur-ing, trade and tourism. The city is one of the oldest settlements in the Medi-terranean basin as recent excavations discovered that the establishment of the city dates back to 6500 BC.

Having witnessed 8,500 years of hu-man history, Izmir had been founded at the side of a gulf, and currently is the third biggest city and second most important seaport of Turkey. Situated at the west of Anatolian Peninsula, at the side of Aegean Sea, the prov-ince has an area of 12,012 km2 with an approximate population of 4 mil-lion people. As one of the oldest port cities of the world, Izmir has always been recognized as an important meeting point for people with differ-ent cultures, languages and religions.

Welcome to Izmir – Turkey

Venue LocationSet in 12,000 m2 of landscaped gar-dens overlooking the spectacular Kor-don on the Aegean Sea, the Swissotel Grand Efes Izmir is conveniently locat-ed right in the centre of the commer-cial district and just a few steps away from the heart of the city.

Travel and TransportationAdnan Menderes Airport (ADB) is less than 15 km or 20 minute drive away from the Hotel Swissotel. For more information please visit: www.adnan-menderesairport.com

• Taxi The cost of taxi is of around US$ 28 from the airport to downtown hotels. Arrangements for a private lim-ousine transfer can be made through concierge.izmir@swissotel.com

• Public Transportation Take the Havas Airport Shuttle Bus with a stop right in front of the Hotel Swissotel. The trans-fer time takes around 45 minutes and has a cost of around 6 US$. Time ZoneStandard time zone daylight saving: UTC/GMT +2 hours.Time zone abbreviation: EEST – East-ern European Summer Time

LanguageThe official congress language is Eng-lish. No simultaneous translation will be provided. The official country lan-guage, Turkish, is the first language in the country. However many people in the city centres and resort areas also speak English, to some degree.

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ClimateThe Aegean type Mediterranean cli-mate of Izmir can be easily charac-terised by its lengthy, sunny summer months and mild, winter weather. Many tourists favour visiting Izmir during the spring or fall seasons, when the climate is pleasantly warm and dry. Between September and October, temperatures in Izmir regularly exceed 25°C / 76°F and can often top 30°C / 85°F.

Credit Cards / Cash MachinesAll major credit cards are widely ac-cepted. Bank cash machines (ATM) can be found easily and debit cards are also widely used. If you are using a foreign card at a bank machine, your money will be disbursed in Turkish funds. There is also an ATM machine in the lobby of the Swissotel.

CurrencyThe currency in Turkey is Turkish Lira.1 € Euro ≈ 2.30 TL (Date of printing, De-cember 2012)Euros and US dollars are also accepted in many hotels and tourist areas, but you will save money by converting some funds into Turkish liras at one of the many exchange offices or banks in the city. They typically offer competi-tive rates and charge no fees.

TippingService charges are typically not in-cluded in the bills in Turkey. Please add 10 % for restaurants and bars or add 1–5 US$ for a friendly service. This applies to waiters, barbers and hair-dressers, taxi drivers, etc. Tips should rather be given in cash Turkish liras and not be added to the credit card charge on the bills.

Health CareSpecial Vaccinations are not required for entry into Turkey but an individual travel & health insurance is highly rec-ommended because health insurance plans often do not extend full coverage for medical services received outside the country of residence.

Entry Formality / VisaWe strongly recommend that all par-ticipants needing a visa to attend the Congress in Turkey start their applica-tion process as soon as possible by contacting the local Turkish Consu-lates to obtain and follow instructions. http://www.mfa.gov.tr/visa-informa-tion-for-foreigners.en.mfa.

Citizens of the following countries can enter Turkey with a valid passport (at least 90 days) and either do not need a visa at all or can obtain a visa on arrival at the airport or border.

Albania, Andorra, Antigua-Barbuda, Argentina, Armenia, Australia, Austria, Azerbaijan, Bahamas, Bahrain, Barba-dos, Belarus, Belgium, Bolivia, Bosnia-Herzegovina, Brazil, Brunei, Bulgaria, Turkey, Chile, Costa Rica, Croatia, Cuba, Czech, Denmark, Dominica, Dominican Republic, Ecuador, El Salvador, Esto-nia, Finland, France, Georgia, Germany, Greece, Grenada, Haiti, Honduras, Hong Kong, Hungary, Iceland, Indonesia, Iran, Ireland, Israel, Italy, Jamaica, Japan, Jordan, Kazakhstan, Kosovo, Kuwait, Kyrgyzstan, Latvia, Lebanon, Libya, Liechtenstein, Lithuania, Luxembourg, Macao, Macedonia, Malaysia, Maldives, Malta, Moldova, Monaco, Mongolia, Montenegro, Morocco, Netherlands, New Zealand, Nicaragua, Norway, Oman,

General Information

Paraguay, Poland, Portugal, Qatar, Ro-mania, Russia, St. Kitts Nevis, St. Lucia, St. Vincent and Grenadines, San Marino, Saudi Arabia, Serbia, Singapore, Slova-kia, Slovenia, South Africa, South Korea, Spain, Sweden, Switzerland, Syria, Tajik-istan, Trinidad and Tobago, Tunisia, Turk-menistan, Ukraine, United Arab Emir-ates, United Kingdom, USA, Uruguay, Uzbekistan, Vatican and Venezuela. As laws may change without notice it is rec-ommended to recheck this information before travelling at www.mfa.gov.tr .

DisclaimerICRS and the congress organizer can-not accept any liability for the acts of any suppliers to this meeting nor of the safety of any attendee while in transit to or from this event. Participants are strongly advised to carry proper travel and health insurance as the ICRS can-not accept liability for any accidents or injuries that may occur. Information in this programme is subject to change without prior notice. For updated in-formation please visit frequently our congress website at www.cartilage.org

Cancellation of the Congress by the OrganizerCongress fees will be reimbursed if the congress is cancelled for other reasons than war, warlike events, and acts of terrorism or sickness epidem-ics. In the latter circumstances only a proportion of the congress fee would be refundable.

Technical Industry ExhibitionA technical industry exhibition with will take place at the Swissotel Grand Efes Convention Centre. It will be open every day throughout the meeting and ex-hibitors will present a wide range of or-

General Information/ Registration

thopaedic- and cartilage repair related products. Participants are encouraged to take advantage of this unique op-portunity to be updated with the most recent advances and latest news from our industry partners. Interested com-panies may contact the ICRS Executive Office for further exhibit- and sponsor-ing information.

IntermissionsDuring intermissions, coffee, tea and refreshments will be served in the exhi-bition area as a courtesy from the ICRS.

Services for Persons with DisabilitiesPlease inform the ICRS office or indi-cate on the accommodation online booking form any special require-ments you may have to allow us to best serve you. The Swissotel Grand Efes has international-standard facili-ties for the physically challenged, in-cluding access ramps, elevators and toilets for people with special needs.

Security / BadgesThe safety of all congress attendees is of utmost importance to our society. The ICRS and the Swissotel Grand Efes have taken security precautions to en-sure the maximum possible safety for all participants. Identity check controls may occur at any time by the security staff. Congress badges are personal-ized, not transferable and guarantee individual access to different section of the event. For organizational and se-curity reasons, badges have to be worn all the time at the congress venue.

Electricity, Weights and Measures• Electricity: 220 volts 60 hz• Weights: Kilo/Gramm system• Measures: Metric system

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WaterTurkish tap water is generally not safe to drink. We recommend drinking bot-tled water.

Complimentary Internet/WLANAs a special courtesy, ICRS will provide free WLAN Hot Spots and a public In-ternet Corner to all attendees and ex-hibitors in the convention area.

SmokingThe ICRS World Congress is a non-smoking congress. Smoking is not per-mitted at the Swissotel Grand Efes and its Conference Centre except in desig-nated smoking areas.

Mobile PhonesAll attendees will be requested to turn off their mobile phones during all sci-entific sessions.

Recording/PicturesTaking photos or video/ audio record-ing during the scientific presentations or from the poster area is strictly pro-hibited. Note that the majority of the Presentations, posters and many of-ficially recorded sessions will become available online after the congress at the ICRS website in the members’ area. Therefore there is no need to take pic-tures during the sessions or from the poster exhibits.

Registration Fees All attendees must register online for the congress at www.cartilage.org Students, Residents, Physiotherapists and Nurses must provide a proof of their training /residency or profession-al status to receive our highly reduced registration rates. This document must be sent to office@cartilage.org imme-diately after registration to confirm the specially reduced fee. Register un-til June 15, 2013 in order to receive a highly reduced registration fee!

Early - Prior to June 15, 2013Resident/Students* € 290.00*Physiotherapists/Nurses* € 290.00*ICRS – Members € 390.00Non – Members € 550.00Industry Representatives € 650.00Accompanying Person € 90.00

Late – June 16 – August 20, 2013Resident/Students* € 390.00*Physiotherapists/Nurses* € 390.00*ICRS – Members € 490.00Non – Members € 650.00Industry Representatives € 750.00Accompanying Person € 100.00

On-Site – as from August 21, 2013Resident/Students* € 450.00*Physiotherapists/Nurses* € 450.00*ICRS – Members € 550.00Non – Members € 690.00Industry Representatives € 850.00Accompanying Person € 110.00

*Registrations to be accompanied by a certificate signed by the head of department or valid student or profes-sional ID

Join ICRS Now!Non-member attendees who apply for ICRS membership 2013 right before their congress registration will imme-diately profit from our highly reduced members’ fee. ICRS Members who are not in good-standing with their membership dues 2012 / 2013 will au-tomatically be charged with the non-member fee.

Included in your registration fee:• Access to all scientific sessions (except early morning workshops)• Access to the technical industry exhibition• Access to the scientific poster exhibition• Welcome Reception, Poster Cocktail & Coffee Breaks• Free Internet Access (Internet Corner & WLAN available)• Congress Bag with Main Programme & Abstract Book• Badge and Certificate of Attendance• CME Credits (to be confirmed)

Congress Registration/Cancellation

Cancellation of Congress Registrations – Name ChangesWritten notification is required for all congress cancellations and name changes. Notifications should be sent to the Cartilage Executive Office of-fice@cartilage.org

Refunds for congress cancellations are as follows:• 80 % refund for cancellations until June 15, 2013• 50 % refund for cancellations until August 20, 2013• No refund thereafter

Name changes will be charged with a fee of € 100.00

In case of a congress cancellation due to rejection of an abstract, the full amount of the paid registration fee will be refunded.

Izmir by Night

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Important: The ICRS has made a major commitment to the Swissotel Grand Efes and to the Izmir Hilton in order to secure a sufficient block of qual-ity hotel rooms at competitive rates in walking distance. We kindly ask partic-ipants and industry partners to book their hotel rooms either at the Swis-sotel Grand Efes or the Izmir Hilton through the official reservation links on our website. There is no extra han-dling charge for this service and we guarantee excellent discounted rates in both properties.

Rooms will be allocated on a first-come, first-serve basis. If you wish to extend your stay, hotel rooms at both Hotels are available up to three nights prior and three nights after the con-gress dates for the same special con-gress rates.

Individual Reservations - ParticipantsFor individuals online booking only will be accepted through www.carti-lage.org. Online reservations should be submitted as early as possible, lat-est until August 12, 2013. Reservations thereafter are only confirmed upon availability and the hotel may charge a significantly higher rate.

Group Reservations – IndustryThe Swissotel Grand Efes reservation department is pleased to receive group reservations (10 Rooms or more). Please contact the Convention Service Manag-er, Mr. Ali Yazicioglu, for assistance and details at Ali.Yazicioglu@swissotel.com or call +90 232 414 50 80 (direct)

Accomodation

Credit Card Guarantee / PaymentA credit card guarantee for the entire reservation period is required to con-firm and secure your hotel room res-ervation. Please note that your Hotel invoice shall be settled directly to the hotel upon your check-out.

Hotel Room CancellationCancellations are to be addressed to the Hotels directly in writing. The fol-lowing cancellation fees will apply: For cancellations until August 12, charge of 1 night. For cancellations af-ter August 12 and No-Shows, charge of the entire reservation period.

Hotel Reservation ChangesHotel reservation changes must be di-rected to the individual hotels in writ-ten. Room night reductions of existing reservations are subject to the cancel-lation conditions as described above.

Swissotel Izmir

Hilton Izmir

Official Congress Hotels

Swissotel Grand Efes (Congress Venue)Gaziosmanpasa Bulvari No:135210 Alsancak, Izmir, Turkeyizmir@swissotel.com www.swissotel.com/izmir

The Swissôtel Grand Efes is promi-nently located in the heart of Izmir’s commercial hub and set in 12,000 m2 of landscaped gardens overlooking the spectacular Kordon on the Aegean Sea. The hotel is within walking dis-tance of the city centre and the airport is less than 15 km away. 402 luxurious-ly appointed guest rooms including 55 spacious suites feature state-of-the-art technology.

Special Courtesy: As a special cour-tesy, the hotel offers exclusively to ICRS congress attendees, complimen-tary health club access and free high speed internet access in the hotel rooms. Children under 12 years, shar-ing the room with their parents are free of charge.

Room Rates (incl. Breakfast buffet and Service Charges, VAT excl.)

• Classic & Swiss Advantage Room: SGL € 150.00 DBL € 170.00• Business Suite Room SGL € 300.00 DBL € 320.00• Executive Suite Sea View Room: SGL € 450.00 DBL € 450.00

Hilton IzmirGazi Osmanpasa Bulvari No:7 35210 Izmir, Turkeyderya.ficici@hilton.comwww.izmir.hilton.com

Enjoy the dramatic setting with stag-gering views of Izmir Bay and the sur-rounding mountains from the Izmir Hilton hotel. Spanning 34 floors, the hotel is one of the tallest buildings in the region, offering superior views in every single guest room and suite. Lo-cated in the heart of the city, near to the Old town, the hotel is within walk-ing distance of shopping, entertain-ment and dining.

Special Courtesy: Early Check-in and Late Check-out upon availability. Free Health Club and WLAN access for ICRS participants. Fitness center, heated in-door pool, squash and tennis courts, etc.

Room Rates (incl. Breakfast buffet and Service Charges, VAT excl.) • Hilton Superior Room SGL € 110.00 Dbl € 130.00• Hilton Sea View Room SGL € 130.00 Dbl € 150.00• Hilton Executive Floor Sea View SGL € 144.00 Dbl € 155.00

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Accomodation / Social Events

Reservation Departments

1. Swissotel Grand Efes Izmirc/o Ms. Zeren OzturkPhone: +90 232 414 00 00 Ext. 5071Direct Line: +90 232 414 50 71Email: reservations.izmir@swissotel.comToll Free Reservation: 800 6379 47 71Online Reservation: www.cartilage.org

2. Hilton IzmirC&E DepartmentMs. Derya FiciciPhone: +90 232 49760 60Direct Line: +90 232 497 60 22Email: derya.ficici@hilton.comOnline Reservation: www.cartilage.org

Social Events

ICRS supports compliance with inter-national ethical standards and there-fore emphasizes that participants who would like to attend tours or so-cial events shall bear all related costs themselves.

Sunday, September 15

Opening Ceremony & Cocktail19.00 PM – 20.30 PMParticipants, industry representatives and accompanying persons are invited to join the opening ceremony and wel-come cocktail at the Swissotel Grand Efes. This reception is offered to you by the ICRS. After the cocktail, par-ticipants have free time for their own leisure to discover Izmir and enjoy one of the many nice restaurants / bars at the harbour promenade right in front of the Swissotel.

Monday, September 16

ICRS Fun Run for Healthy Joints (3-4 km) 06.15 AM– 07.00 AMICRS and the Hotel Swissotel Grand Efes understand that maintaining a fitness routine while traveling is dif-ficult. Congress participants wanting to get off the treadmill and take their workout outside can join the compli-mentary ICRS Fun Run led by members of the ICRS & Swissotel Grand Efes management teams. Runners meet at 6:00 a.m. in the Lobby for a four-mile beachside jog returning by 6:45 a.m.

Monday, September 16

Free evening for participants’ individ-ual programmes and for industry re-lated events. The Hotel Concierge and/or our official agent Venus Tourism will be pleased to recommend and book at table for you at one of your favourite restaurants in town.

1001 Turkish Nights19.30 PM – 23.00 PMGreat Turkish style entertainment for everyone! Join us for a magic evening with mouth watering oriental cuisine, drinks and assist amazing folkloric presentations such as belly dancers, whirling dervishes and much more. Let you be immersed in a magical 1001 night atmosphere together with your colleagues from all around the world. Here, you can look forward to delicious specialties, regional beverages and enjoy typical music and cultural show acts. Price per person: (incl. dinner, drinks & entertainment) Individual Par-ticipants: € 75.00 (partly sponsored by ICRS) Industry Representatives: € 95.00

Venus Tourism (Official ICRS Agency)1374 Sok. Mab Ishani No: 4/203 Cankaya35210 Izmir – Turkey

Contact: Mr. Serhat KUTLU or Mr Suha SunayPhone: +90 232 484 8485Fax: +90 232 484 5576 Email: serhat@venus-tourism.comEmail: suha@venus-tourism.comWeb: www.venusdmc.com

Sunday, September 15, 201309:30 AM – 12:00 PM13:30 PM – 16:00 PM

Historical Izmir – Half Day TourThe 5,000 year-old city of Izmir is one of the oldest cities of the Mediterrane-an basin. The original city was estab-lished in the third millennium BC (at present day Bayraklı), at which time it shared with Troy the most advanced culture in Anatolia. Rich in history and archaeological remains, Izmir is also widely regarded as the most western-ized city of Turkey in terms of values, ideology and lifestyle. Nicknamed “the pearl of Aegean,” Izmir is home to wide palm-lined boulevards, smart shops, hotels and restaurants, a busy port and exotic old quarter.

Tour Description: Pick-up from your hotel and start your half day city tour of Izmir including the Roman Agora, which was used as a square shaped market place during the Roman rule of the city; Archaeological museum, which houses several Hellenistic and Roman findings from Izmir and surrounding area, including roman mosaics, sar-cophagi, statues. The tour ends with a visit to the historic Elevator with a great view of Izmir. Return to Swissotel. Price per Person: 30 Euros

Tours & Social Event Information

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Saturday September 15, 2013 & Monday September 16, 2013from 09:00 AM – 16:00 PM

Pergamum – Full Day TourMost of the buildings and monu-ments in Pergamum date to the time of Eumenes II (197-159 BC). Built on a conical hill rising 1,000 feet above the surrounding valley, Pergamum (also spelled Pergamon, from the Greek for “citadel”) was an important capital city in ancient times. Its modern successor is the Turkish city of Bergama. Bergama is home to two of the country’s most celebrated archaeological sites: Perga-mum’s acropolis and Asclepion are both listed among the top 100 historical sites on the Mediterranean.

Tour Description: Drive to PERGAMUM. Visit the ACROPOLIS, the TEMPLE OF ATHENA, the famous LIBRARY, the ROY-AL PALACES, the TEMPLE OF TRAJAN, the steepest THEATRE of the world, the TEMPLE OF DIONYSOS, the ALTAR OF ZEUS (Seat of Satan), and the view of the RED BASILICA (St. John’s church). Visit the ruins of ASCLEPION. The AS-CLEPION is a famed ancient medical center built in honor of Asclepius, the god of healing. It was also the world’s first psychiatric hospital. Time permit-ting shopping opportunities will be of-fered and lunch is included. Return to Swissotel. Price per Person 65 Euros.

Tuesday, Sept. 17, 2013from 09:00 AM – 17:00 PM

Ephesus – Full Day TourEphesus dates back to 2000 B.C. but the historical period probably remembered most is during the Roman rule of the city which began in 190 B.C.The ancient city of Ephesus (Turkish: Efes), located near the Aegean Sea in modern day Turkey, was one of the great cities of the Greeks in Asia Minor and home to the Temple of Artemis, one of the Seven Wonders of the World. Today, the ruins of Ephesus are a major tourist attraction, especially for travelers on Mediterranean cruises. Ephesus is also a sacred site for Chris-tians due to its association with several biblical figures, including St. Paul, St. John the Evangelist and the Virgin Mary.

Tour Description: Drive to EPHESUS. Visit the HOUSE OF THE VIRGIN MARY where she supposedly spent her later days. Pro-ceed to Ephesus and see the spectacular ruins some of which have recently been excavated. See the ODEON, the BOULE-TERION, FOUNTAINS, the TEMPLES, the BROTHEL, the LIBRARY, the AGORAS, the GREAT THEATRE, the ROMAN BATHS, the GYMNASIUMS. After lunch visit TEMPLE OF ARTEMIS (one of the Seven Wonders of the ancient world) and ST JOHN BASILICA. Time permitting, shopping opportunities will be offered. (Lunch included) Return to Swissotel. Price per Person 65 Euros.

Tours & Social Event Information

Wednesday, Sept. 18, 2013from 13:30 PM - 19:30 PM

Alacati – Half Day TourAlacati, a unique Mediterranean town on the Western coast of Turkey, which has been famous for its architecture, vine-yards and windmills for over 150 years has now made its name in the world of Wind- and Kite surfing, with its crystal clear water, consistent and steady wind (for an average of 300 days a year) and well acclaimed Turkish hospitality.

Tour Description: Drive to Alacati. Visit the small village with its Greek & Turk-ish style houses. You will have some free time for shopping or a Turkish Cof-fee or famous Ice Cream in the village. Then continue to a beach resort and

enjoy a leisurely sun & sea afternoon on the sand beach (admission fee and food & drinks are not included). Return to Swissotel. Price: 40 Euro per person

Important InformationAll tours are conducted in modern private A/C vehicles. English speak-ing tour guide, entry fees and lunches (for full day tours only) are included. A minimum of 10 Persons is required for the above mentioned tours. If a mini-mum participation is not reached 2-3 weeks prior to the excursion date, a tour may be cancelled and registered participants would be reimbursed in full. All tours can also be organized on private basis and in other languages. Please contact Venus Tourism for more information and prices.

Tours & Social Event Information

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Price p/Person Price p/Person Price p/Person in Single Room in Double Room in Triple Room

Germir Hotel 4* www.germirpalas.com € 485.00 Euros € 335.00 Euros € 315.00 Euros

The Marmara 5*www.themarmarahotels.com € 980.00 Euros € 575.00 Euros € 515.00 Euros

Prices are including:• 3 nights hotel accommodation, incl. breakfasts, taxes, service and local charges• 2 airport transfers (arrival & departure)• 2 full day excursions including English speaking guide, A/C transportation and entry fees to museums mentioned in the programme

Pre- & Post Congress Programme

Istanbul Pre- & Post Congress Tours (4 days, 3 nights)

Sept. 13 – 15, 2013 or Sept. 18 -21, 2013

In the past known as Constantinople today Istanbul with its 15 million peo-ple is one of the world’s largest cities. Istanbul is now a huge metropolis con-necting cultures, continents and reli-gions. Thanks to its atypical geograph-ic location on the Bosporus, Istanbul is the only city in the world which is located on two different continents. The western part is in Europe while the eastern portion is in Asia. Istanbul is certainly an amazing place to be vis-ited before or after the ICRS Congress.

DAY 01Arrival in Istanbul, the only city in the world built on two continents. Transfer to your hotel. Free day & overnight in Istanbul.

DAY 02Full day historical Istanbul tour; visit of the Hagia Sophia Church (built in the 6th century, once it was the biggest

Christian church in the world), Topkapi Palace (Imperial Residence of Otto-man Sultans, with displays of priceless world-class collections of artifacts, jewelry and rare porcelain), the Blue Mosque (unique with its 6 minarets, and famous for its blue Iznik tiles), the Hippodrome Square where ancient chariot races were held, and then visit the world famous Grand Bazaar. Free evening at your leisure.

DAY 03Full day Bosphorus & Asia Tour; visit the Egyptian Spice Market, and then take a Bosphorus boat tour, viewing the beauty of the European and Asian shorelines on either side. After lunch at a local fish restaurant, cross to the Asian side to visit the Camlica Hill and tour the Beylerbeyi Palace, the sum-mer residence of the Ottoman Sultans with its magnificent gardens. Free evening at your leisure.

DAY 04Transfer to Istanbul Ataturk Airport as per your departure time.

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