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    dbee ew 3

    th ue of dbee voe ke u noher e n he

    long que o reel he myere of ye 2 bee. the

    o y colgu W t of h uy o

    o of ol n eonom hory n he ny ln non

    of nuu, wh ll mo h 10,000 h,

    lk xml of h olly ou mg -

    w g voml fo h uoof y 2 . i h of h nuu, hou

    of y of ol Mo souh pf lfyl,

    fhng n gherng fru n oonu, ene when he

    hoh wlh of h l w ov h ly

    20h uy. th lfyl w vy uly l y

    wz, y o, lug hgh-gy

    (hgh n ugr, f n l) of more foo.

    the ubequen exloon n he number of eole wh

    obey-ren ye 2 bee, o 34.4% by 1975,

    mjor omonen n he me nghmrh rgm of

    ho ll-hlh h h lgh igou ommu

    oh of h wol aogl aul h

    pm inn n arzon, Usa, for exmle. a rou

    ombnon of gene reononng n weernze

    lfeyle n uh nen n for mny hunre of gen-

    eron ole oulon h been exlne n he

    hrfy gene hyohe.

    aog o h hoy, hum g volv h

    llow hu-gh oulo o ul u o -

    gy v qukly ffvly wh foo lful,

    lg hm o uvv m of fm. Howv,

    wh u of foo y hvou, h

    m goy h om vly jul, lg ooy omlo. th ulul o, low

    oo-oom u gogh olo h h-

    z my uh igou ommu hm h ovo

    of qu o uo.

    th uo Mhl po, who vl wh h

    royl Flyg doo sv of aul, o-

    vv oj h, y lg wh oul

    fmwok h fml o aogl ol, lv

    ulully o uo o oulyg ommu.

    th sugm oj u ol oy-llg

    v-lg oh whh l o wlk

    ou h sugm oy o myfy . al

    fom c hghlgh h ffo of h Fh- eglh-

    kg oo h xll wok o

    omo h, w, ov uo gul, mov h gh of ol wh

    lug F no ol h v ouy.

    a o fom h nhl y Juh Ku rkk

    bog, g 11 uy- fom ou h wol,

    l wh h mg u ou h mu-

    m o of Ha1

    . i 2007, h ul of h

    glol a1

    -dv avg Gluo (adaG) uy ouly

    mo h m vg gluo, lul

    ung he Hba1

    y, orrele ery loely wh bloo

    glucoe reading obtained by repeated meaurement

    (ung fnger k n onnuou gluoe monorng)

    oer he ero of url of hemoglobn-berng re

    bloo ell roun 100 y, hu gn jufyng he

    lly of Ha1

    g h mol mmoy

    of he nermee .

    th uy w neery n reul egerly we

    n he enf bee ommuny. i houl be noe,

    howeer, h he adaG uy w rere o eole

    l mol ool houghou h uy o;

    eole wh fluung bloo gluoe leel, he adaG

    lulon my well le o fferen reul. the adaG

    fg uo h og o of Ha1

    lue rnle no erge bloo gluoe luethat allow people with diabete to better undertand

    her urren mebol onon. the reee reom-

    menon reulng from he uy re l ou n he

    2007 conenu tatement (cited in the article) by the

    leng bee orgnzon roun he worl idF,

    h euo aoo fo h suy of d h

    am d aoo, h cou sm

    on the Worldwide standardization of the Hemoglobin

    a1c

    Meuremen.

    Helmut R Henrichs

    is Professor of

    internal medicine

    and diabetologist.

    He founded the

    Quakenbrck

    Diabetes Centre

    and the German

    Diabetes

    Technology study

    group, and served

    as president of the

    German Diabetes

    Association

    and German

    Diabetes Union.

    Further puzzles and uncertainties and some progress

    March 2009 | Volume 54| Issue 1