7/28/2019 2008 Betterbone Flyer En

1/4

More and better bone

7/28/2019 2008 Betterbone Flyer En

2/4

Signi cantly more bone ormation and better de ect closure were observed underneathGeistlich Bio Gide.1 De ects without a membrane showed a 32.8 % de ect closure a ter12 weeks o healing, whereas similar de ects covered by Geistlich Bio Gide presented a90.0 % closure measured by microradiography and micro CT imaging in a rat model .

Geistlich Bio Gide

More bone volume

More bone volume and improved bone qualitylead to a higher implant survival rate3

Control no membrane

Synthetic test membrane

ePTFE

Geistlich Bio Gide

* The bars show the 95 % con dence intervals

De ect closure in % *

4 weeks 12 weeks2 weeks0

100

80

70

90

60

50

40

30

20

1026.9 32.8 90.088.760.222.8

7/28/2019 2008 Betterbone Flyer En

3/4

Covering the de ect with Geistlich Bio Gide increases the bone density a ter 16 weekssigni cantly by 37.3 % compared to the use o Geistlich Bio Oss alone.2 Bone density in theregenerated de ect area dog mandible was measured by CT scan and compared to the intactadjacent alveolar bone.

1 Gielkens PFM et al. Vivosorb, Geistlich Bio Gide, and Gore Tex as barrier membranes in rat mandibular de ects:an evaluation by microradiography and micro CT. Clin. Oral Implants Res. 2008 May; 19(5): 516-21.

2 Kim M et al. E ect o Bone Mineral with or without Collagen Membrane in Ridge Dehiscence De ects FollowingPremolar Extraction. In Vivo. 2008; 22(2): 231-6.

3 Norton MR, Gamble C. Bone classi cation: an objective scale o bone dentisty using the computerized tomographyscan. Clin. Oral Implants Res. 2001; 12(1): 79-84.

Improved bone quality

Control neither bone substitute nor membrane

Geistlich Bio Oss

Geistlich Bio Oss and Geistlich Bio Gide

Bone density in % *

8 weeks 16 weeks0

100

80

70

50

30

10

90

60

40

20

55.0 65.575.6 89.9

* The bars show the standard deviations

7/28/2019 2008 Betterbone Flyer En

4/4

Geistlich Bio Gide is a native, porcine,resorbable collagen membrane. Due to itstwo layers bilayer structure , it supports bothbone 1, 2and so t tissue regeneration. 3, 4 Thenatural 3D structure o Geistlich Bio Gide is degraded without infammation and thus ishighly biocompatible.5

Geistlich Bio Gide More than a Barrier

1 Wallace SS et al. Sinus Augmentation Utilizing Anorganic Bovine Bone Bio Oss

with Absorbable and Nonabsorbable Membranes Placed over the Lateral Window:Histomorphometric and Clinical Analyses. Int. J. Periodontics Restorative Dent.2005; 25(6): 551-9.

2 Wallace SS, Froum SJ. E ect o Maxillary Sinus Augmentation on the Survivalo Endosseous Dental Implants. A Systematic Review. Ann. Periodontol. 2003; 8(1):328-43.

3 Rothamel D et al. Biocompatibility o various collagen membranes in cultures o human PDL broblasts and human osteoblast like cells. Clin. Oral Implants Res.2004; 15(4): 443-9.

4 Rothamel D et al. Biodegradation o di erently cross linked collagen membranes:an experimental study in the rat. Clin. Oral Implants Res. 2005; 16(3): 369-78.

5 Zitzmann NU et al. Resorbable Versus Nonresorbable Membranes in Combinationwith Geistlich Bio Oss or guided Bone Regeneration. Int. J. Oral Maxillo ac.Implants. 1997; 12(6): 844-52.

Geistlich Bio Gide

25 x 25 mm

Geistlich Bio Gide

30 x 40 mm

Geistlich Bio Gide Perio16 x 22 mm incl. sterile templates

Geistlich Bio Gide Perio 16 x 22 mm +Geistlich Bio Oss Collagen 100 mg

3 1 2 9 6

. 1 / 0 8 0 8 / e

Geistlich Biomaterials, CH 6110 Wolhusen, www.geistlich.com