2006 Catholic University Presentation
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Transcript of 2006 Catholic University Presentation
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Explorations in bioinformatics
Division of Computational Biosciences
Douglas James Joubert, MLISBiomedical InformationistNational Institutes of Health Library
May 10, 2006
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EXPLORATIONS IN BIOINFORMATICS
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EXPLORATIONS IN BIOINFORMATICS
Bioinformatics is multi-faceted
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EXPLORATIONS IN BIOINFORMATICS
Bioinformatics – My Approach
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EXPLORATIONS IN BIOINFORMATICS
Bioinformatics – My Approach
Formal and informal educational opportunities
MS in bioinformatics NIH SIGs
ACM & IEEE SIGs AMIA Working Groups
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EXPLORATIONS IN BIOINFORMATICS
Bioinformatics – My Approach
Formal and informal educational opportunities
MS in bioinformatics NIH SIGs
…Talk the talk
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EXPLORATIONS IN BIOINFORMATICS
What is “Familiar” About MSCL – Informationist Collaboration
Primary role is data and text mining Evaluate resources - resources typically text
mining tools and database interfaces Conduct searches, subject terms are gene sets
and microarray probe IDs; methods of database access are unique
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EXPLORATIONS IN BIOINFORMATICS
What is Unique About MSCL – Informationist Collaboration
MSCL does not use “library resources” in the traditional sense of the word
50% work commitment in lab Office space @ DCB, access to the NIH
mainframe through HELIX MSCL collaborative efforts are intermittent, and
project bound MSCL has been working with some core groups
for 5+ years
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Primary Roles with MSL
SequenceAnalysis
Intermolecular &Biological Pathways
Data andText Mining
Genes &Proteins
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SequenceAnalysis
Intermolecular &Biological Pathways
Data andText Mining
Genes &Proteins
Roles linked to a clear vision
MSCL DLS
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EXPLORATIONS IN BIOINFORMATICS
What Tools do I use?
Use bioinformatics tools to explore modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases
Focus on information about gene function, metabolic, signaling, and canonical pathways
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Sequence Analysis
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subject terms
Sequence Analysis
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EXPLORATIONS IN BIOINFORMATICS
Phylogenetic Analysis
Origins of a genetic disease
At sequence level looking for unique and non-unique characters
S. Wain-Hobson. (1998). 1959 and all that Nature 391: 531-532.
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EXPLORATIONS IN BIOINFORMATICS
Protein Structure Analysis and Protein-Protein Interactions
Field of structural biology Moving from Sequence to
3-D modeling Good tutorial available at:
http://www.usm.maine.edu/~rhodes/SPVTut/
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EXPLORATIONS IN BIOINFORMATICS
Pathway Analysis
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EXPLORATIONS IN BIOINFORMATICS
Contact Information
Douglas J. Joubert, MLISBiomedical InformationistNational Institutes of Health LibraryBldg. 10, Room 1L09ABethesda, MD 20906-1150Phone: 301.594.6282E-mail: [email protected]: [email protected]