2004 FBIRN Meeting FIRST BIRN: Challenges of Collaborative Multi- site, Multi-discipline Research...
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Transcript of 2004 FBIRN Meeting FIRST BIRN: Challenges of Collaborative Multi- site, Multi-discipline Research...
2004 FBIRN Meeting
FIRST BIRN: Challenges of Collaborative Multi-site, Multi-discipline Research
Steven Potkin, MD
Gary Glover, PhD
Gregory McCarthy, PhD
OutlineOutline
Why is this important Our vision Clinical Aims Challenges Accomplishments
Gary Glover: Calibration Experience
Gregory McCarthy: Cognitive Challenges
Why Is This ImportantWhy Is This ImportantWhy Is This ImportantWhy Is This Important
Schizophrenia - • Cause unknown • No cure but treatable
Neuroimaging is critical to understanding• Gross structural and functional abnormalities
(e.g., frontal and temporal)
Statistical Parametric MapStatistical Parametric MapMai et al Human Atlas, 2001Mai et al Human Atlas, 2001
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Why Is This ImportantWhy Is This Important
Research hampered by • Spatial distortions (Morph BIRN)• Inconsistent data & lack of replications• Noncomparable imaging techniques • Small and diverse patient populations
Solution: Queryable Federated DatabasesSolution: Queryable Federated Databases
fMRI
Are chronic, but not first-onset patients, associated with Are chronic, but not first-onset patients, associated with superior temporal gyrus dysfunction (MMN)?superior temporal gyrus dysfunction (MMN)?
IntegratedIntegrated ViewView
Receptor Density ERP
WebWeb
PubMed, Expasy
Wrapper
WrapperWrapper
Wrapper
Structure
Wrapper
Clinical
Wrapper
MediatorMediator
0.150.18
0.140.11
-0.14-0.10-0.06-0.020.020.060.100.140.180.220.260.30
ARIP - 20MG ARIP - 30MG RISP - 06MG PLACEBOTreatment Group
Functional Imaging Research Schizophrenia Testbed = First BIRN: Operational for 17 months
Builds on and extends the mouse BIRN and morphometry BIRN
Extend morphology BIRN technology• Into 4D (time)• During sensory and cognitive tasks• Tackle schizophrenia
FIRST BIRN: Clinical AimsFIRST BIRN: Clinical Aims
Study brain functioning in schizophrenia with fMRI• Dorsolateral pre-frontal cortex (working memory)• Superior temporal gyrus (early cortical auditory
processing)• Site-specific cognitive tasks activating DLPFC
and STG.
Develop infrastructure to understand the development & progression of schizophrenia
Sensitive to alteration by treatment
FBIRN: Patient PopulationsFBIRN: Patient Populations
Childhood schizophrenia Elderly onset First episode Chronic baseline and after treatment
• Atypical antipsychotic• Cognitive enhancers
Prodromal Normal healthy volunteers
First BIRN SitesFirst BIRN Sites
• Brigham & Women’s
• Duke • Iowa • MGH • Minnesota • New Mexico
• UCI
• UCLA
• UCSD
• UNC
• Stanford
Experienced imaging sites
Well developed ideas on how imaging should be done
Challenges: Creating a New CultureChallenges: Creating a New Culture
How to get competitors to cooperate• Will this project decrease the RO1 $ pool• How to share glory, work and $• Governance - who makes and keeps the rules
How to avoid “What’s mine is mine and what’s yours is mine” How to communicate across fields efficiently:
• Clinician scientists Computer scientists• Experimental psychologists MRI physicists• Statisticians Database engineers
How to show a clear scientific benefit from cooperation• Efficiency of multiple studies in parallel; quick revisions • Different perspectives create new ideas or achieve the lowest
common denominator “designed by committee”
ChallengesChallenges
How to incorporate HIPAA regulations• Security - paperless/wireless & audit • Confidentiality & IRB - what do subject need to know
and agree to• Rules of upload and down. access to data
How to develop a new model for data sharing How to meet technological challenges:
• Space for storage• Tools for manipulation• Ability to transfer gigabytes of data around the country• Assume that soft and hardware changes are inevitable
How to show usefulness outside of BIRN
Inter-site variabilityInter-site variability
Different scanners = different raw images
How bad it is?
Inter-site variabilityInter-site variability
Different scanners = different raw images
How bad it is?
A Unique Dataset: A Unique Dataset: Human Calibration SubjectsHuman Calibration Subjects
5 healthy, right handed males Between 18 and 40 years old College students or graduates Traveled around the country from late July
to mid September, 2003
100 scanning sessions: over 800 different scans
Technology: HID GUITechnology: HID GUI
Federated Imaging DatabasesFederated Imaging Databases
Solution: Federated DatabaseSolution: Federated Database
fMRI
Are chronic, but not first-onset patients, associated with superior temporal gyrus dysfunction (MMN)?
Integrated View
Receptor Density ERP
Web
PubMed, Expasy
Wrapper
WrapperWrapper
Wrapper
Structure
Wrapper
Clinical
Wrapper
MediatorMediator
0.150.18
0.140.11
-0.14-0.10-0.06-0.020.020.060.100.140.180.220.260.30
ARIP - 20MG ARIP - 30MG RISP - 06MG PLACEBOTreatment Group
Accomplishments: To Date
Common image translation method: XML Common Database Schema for fMRI: HID (not yet
federated) Queryable clinical and imaging database: GUI Initial phantom protocol and assessments: QA Initial human calibration study Analysis of same data with different methods Initial calibration methods for multi-site fMRI studies
These methods are: Flexible, Expandable, and Adaptable to other types of data and fields of study
Major Accomplishments
Cultural change A new way to do science that is both
creative and exciting, and works• Willingness to have others analyze your
data with their methods
• To facilitate use of your methods on their data
• Sharing concepts as well as data
• Solving common problems –rapid turn around time, new perspectives
Why are we here today?Why are we here today?
WE NEED FEEDBACK FROM YOU:
Which developments are useful for your projects?
Which developments are we missing?
How can we build better bridges to your projects?