2003-2004 Hematopoiesis Pharmacology Review 28 August 2015 7:22 AM.

2003-2004Hematopoiesis

Pharmacology Review

April 19, 202310:05 AM

Abciximab

Antiplatelet

Anti-GPIIb/IIIa receptor antibody

Acetaminophen

Analgesic, Antipyretic

Adalimumab

TNF inhibitor

Anti-TNF antibodyUsed in rheumatoid arthritis

Alemtuzumab

Antineoplastic

Anti-CD52 antibody

Allopurinol

AntigoutAntineoplastic (supporting

agent)

Folic acid analogueXanthine oxidase inhibitor

Aminocaproic acid (EACA)

Procoagulant

Inhibitor of plasminogen activation

(decreases fibrinolysis)

Aminoglutethimide

AntineoplasticImmunosuppressive

Glucocorticoid antagonistAromatase inhibitor

(decreases steroid synthesis)

Angiostatin

Antineoplastic

Angiogenesis inhibitor

Anistreplase

Thrombolytic

Streptokinase + plasminogen

Anti-thymocyte globulin

Immunosuppressive

Anti-T cell antibody

Aprotinin

Procoagulant

Fibrinolytic inhibitorSerine protease inhibitor

(“serpin”)Streptokinase inhibitor

Argatroban

Anticoagulant

Direct thrombin inhibitor

L-asparaginase

Antineoplastic

Protein synthesis inhibitor

Aspirin(Acetylsalicylic acid, ASA)

NSAID (acetylsalicylate)Analgesic, Anti-inflammatory

Antipyretic, Antiplatelet

Irreversible cyclooxygenase inhibitor

Azathioprine

ImmunosuppressiveAntineoplastic

Antimetabolite(“pseudofeedback inhibition” of

HGPRT and PRP)

Basiliximab

Immunosuppressive

Anti-CD25 (interleukin 2 receptor)

Organ transplant (antirejection)

Betamethasone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidNot by inhalation

Bivalirudin

Anticoagulant

Direct thrombin inhibitor

Bortezomib

Antineoplastic

Proteosome inhibitor

Bradykinin

Inflammatory mediator

Plasma, hypotension, pain

C3a, C5a

Inflammatory mediators

Anaphylatoxins Low molecular weight

complement cleavage products

Celecoxib

NSAIDAnti-inflammatory

Cyclooxygenase 2 (COX-2) inhibitor

Cetirizine

Antihistamine

H1 antagonist Non-sedating

Chlorpheniramine

Classical antihistamine

H1 antagonist

Clopidogrel

Antiplatelet

ADP receptor antagonist

Cobalamin(cyanocobalamin, hydroxocobalamin)

Vitamin

Treatment forvitamin B12 deficiency

Cortisol (Hydrocortisone)


Anti-inflammatory steroid

Cyclosporine


Binds cyclophilinInhibits calcineurin

Cytarabine (AraC)

Antineoplastic

Antimetabolite

Daclizumab

Immunosuppressive

Anti-CD25 (interleukin 2 receptor) antibody

Organ transplant (anti-rejection)

Dalteparin

Anticoagulant

LMW HeparinATIII activator

Desmopressin acetate

Synthetic analogue ofarginine vasopressin

Used in treatment of bleeding disorders

Dexamethasone

AdrenocorticosteroidGlucocorticoidAntineoplastic

Antiemetic


Diflunisal

NSAIDAnalgesic, Anti-inflammatory

Antipyretic

Cyclooxygenase inhibitor

Diphenhydramine

Classical antihistamineAntiemetic

H1 antagonist

Dipyridamole

Antiplatelet

Phosphodiesterase inhibitor(increases cAMP)

Drotrecogin alfa(Activated Protein C)

Anticoagulant

Many actionsTreatment for septic shock

Edrecolomab

Antineoplastic

Anti-17-1A antibody

Enoxaparin

Anticoagulant

LMW HeparinATIII activator

Eptifibatide

Antiplatelet

GPIIb/IIIa antagonist

Erythropoietin (EPO)

Cytokine

Primary regulator of RBC synthesis

Etanercept

TNF inhibitor

Tumor necrosis factor receptor+ Fc portion of IgG

Used in rheumatoid arthritis

Fexofenadine

Antihistamine

H1 antagonistNon-sedating

5-Fluorouracil

Antineoplastic

AntimetaboliteThymidylate synthase inhibitor

Folic acid

Vitamin

Treatment for folicacid deficiency

Gefitinib

Antineoplastic

MiscellaneousTyrosine kinase inhibitor

Gemcitabine

Antineoplastic

Antimetabolite

Gemtuzumab

Antineoplastic

Anti-CD33 antibody

Heparin

Anticoagulant

ATIII activator

Hirudin

Anticoagulant

Direct thrombin inhibitor(DTI)

Histamine


Stored in mast cells and basophils

Hydrocortisone


Anti-inflammatory steroid

4-Hydroxycoumarin

Oral anticoagulant

Vitamin K synthesis inhibitor

Hydroxyurea

Antineoplastic

MiscellaneousRibonucleotide reductase

inhibitor

Hydroxyzine


H1 antagonist

Ibritumomab

Antineoplastic

Anti-CD20 antibody

Ibuprofen

NSAIDAnalgesic, Anti-inflammatory

Antipyretic

Reversible cyclooxygenase inhibitor

Imatinib

Antineoplastic

MiscellaneousTyrosine kinase inhibitor

Indomethacin

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitorTocolytic

Uterine relaxant

Infliximab

TNF inhibitor

Anti-TNF monoclonal antibodyTreatment of IBD

Interferon alpha

Antiviral for hepatitisAntineoplastic

Cytokine

Anti-angiogenesis

Interleukin 2

Cytokine Antineoplastic

Interleukin 11

Cytokine Antineoplastic (supporting

agent)

Interleukin 12

Cytokine Antineoplastic (supporting

agent)

Kallidin


Plasma, hypotension, pain

Ketoprofen


Antipyretic


Lepirudin

Anticoagulant

Direct thrombin inhibitor (DTI)

Leucovorin

Antineoplastic (supporting agent)

Folic acid analogue(used in methotrexate rescue)

Leukotriene B4 (LTB4)


Lipoxygenase productof arachidonate metabolism

Chemotactic

Leukotrienes C4, D4, E4

(LTC4, LTD4, LTE4)

Inflammatory mediators

Cysteinyl leukotrienesPeptidyl leukotrienes

SRS-ALipoxygenase products ofarachidonate metabolism

Loratidine

Antihistamine

H1 antagonistNon-sedating

Meclofenamate


Antipyretic


6-Mercaptopurine

Antineoplastic

Antimetabolite(“pseudofeedback inhibition” of

HGPRT and PRP – purine synthesis)

Methotrexate


Folic acid antagonistDihydrofolate reductase

inhibitor

Methylprednisolone



Montelukast

Leukotriene inhibitor

LTR1 and LTD4 antagonistAsthma treatment

Muromonab-CD3

Immunosuppressive

Mouse monoclonal anti-CD3 antibody

Organ transplant (anti-rejection)

Mycophenolate

Immunosuppressive

Inhibits inosine monophosphate dehydrogenase activity

Naproxen


Antipyretic


Non-steroidalAnti-inflammatory Drugs

(NSAIDs)

Analgesic, Anti-inflammatory, Antipyretic

Cyclooxygenase inhibitors

Omalizumab

Anti-asthma

Anti-IgE antibody

Palivizumab

Antiviral

Monoclonal antibody againstthe surface of

respiratory syncytial virus

Pentostatin

Antineoplastic

MiscellaneousEnzyme inhibitor

(blocks purine synthesis)

Phytonadione

Vitamin K

Warfarin antagonist

Piroxicam


Antipyretic


Platelet Activating Factor (PAF)


LipidHypotensive

Prednisone

AdrenocorticosteroidGlucocorticoid Antineoplastic

Anti-inflammatoryNot by inhalation

Promethazine

Classical antihistamineAntipsychotic

Antiemetic

H1 antagonist

Prostaglandin D2 (PGD2)

Bronchoconstrictor

Cyclooxygenase product of arachidonate metabolism

Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)

Oxytocic prostaglandinInflammatory mediator


Uterine stimulantCervical ripener

Prostaglandin F2 (PGF2)



Prostaglandin I2 (PGI2)


Inhibits platelet aggregation


Prostacyclin

Protamine Sulfate

Heparin antagonist

Rituxumab

Antineoplastic

Anti-CD20 antibody

Rofecoxib

NSAIDAnti-inflammatory

Cyclooxygenase 2 (COX-2) inhibitor

Sargramostim(GM-CSF)

Colony stimulating factor

WBC (granulocyte and macrophage)

stimulant

Sirolimus

Immunosuppressive

Binds FKBP, inhibits mTOR (mammalian kinase target of

rapamycin) & cell cycle progression

Rapamycin

Streptokinase

Thrombolytic

Sulindac


Antipyretic


Tacrolimus


Binds FKBP (FK506 binding protein)

Inhibits calcineurin

Thalidomide

AntineoplasticLeprosy treatment

Anti-angiogenicAnti-TNF

6-Thioguanine

Antineoplastic

Antimetabolite (“pseudofeedback inhibition” of

HGPRT and PRP – purine synthesis)

Thromboxane A2 (TXA2)

Autacoid

Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

Ticlopidine

Antiplatelet

ADP receptor antagonist

Tissue plasminogen activators

Thrombolytics

alteplase, reteplase, tenecteplase

Tositumomab

Antineoplastic

Anti-CD20 antibody

Trastuzumab

Antineoplastic

Anti-HER2 antibody

Tripelennamine


H1 antagonist

Tumor necrosis factor

CytokineAntineoplastic

Urokinase

Thrombolytic

Warfarin

Anticoagulant

Vitamin K synthesis inhibitor

Zafirlukast


LTR1 and LTD4 antagonistAsthma treatment

Zileuton


5-lipoxygenase inhibitorUsed in asthma

2003-2004 Hematopoiesis Pharmacology Review 28 August 2015 7:22 AM.

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Transcript of 2003-2004 Hematopoiesis Pharmacology Review 28 August 2015 7:22 AM.