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YY Oscars 2013Oscars 2013M.H.C.M.H.C. TLRsTLRs Presenting...Presenting...an antigen!an antigen!

Most antibodies Most antibodies are found in the are found in the

this group of this group of globulins which globulins which

are the 3are the 3rdrd fastest fastest migrating.migrating.

What are gamma What are gamma globulins?globulins?

IgG molecules IgG molecules are cleaved by are cleaved by this enzyme to this enzyme to

form 2 Fab form 2 Fab fragments and 1 fragments and 1

Fc fragment.Fc fragment.

What is papain?What is papain?

These two These two antibodies are the antibodies are the best complement best complement

activators.activators.

What are IgM and What are IgM and IgG?IgG?

This heavy chain is This heavy chain is expressed on the expressed on the surface of pre-B surface of pre-B cells, associated cells, associated

with surrogate light with surrogate light chains, and is chains, and is absent in an absent in an

autosomal recessive autosomal recessive form of form of

agammaglobulinemiagammaglobulinemia.a.

What is the What is the μμ heavy chain?heavy chain?

This is the CDR This is the CDR with the most with the most

variability.variability.

What is CDR3?What is CDR3?

This Best Picture This Best Picture nominee was nominee was

based on a fable based on a fable by Yann Martel by Yann Martel

that stars a tiger that stars a tiger and a 16 year old and a 16 year old

boy.boy.

What is The Life of What is The Life of Pi?Pi?

This Best Picture This Best Picture nominee was nominee was

based on a novel based on a novel by Victor Hugo by Victor Hugo

and stars a and stars a reluctant reluctant criminal.criminal.

What is Les What is Les Misérables?Misérables?

This Best Picture This Best Picture nominee stars the nominee stars the

youngest Best youngest Best Actress nominee in Actress nominee in

history.history.

What is Beasts of What is Beasts of the Southern Wild?the Southern Wild?

This 2013 Best This 2013 Best Picture nominee Picture nominee

stars “Katniss” from stars “Katniss” from the Hunger Games the Hunger Games and “Phil” from the and “Phil” from the

Hangover. Hangover.

What is Silver What is Silver Linings Playbook?Linings Playbook?

This Best Picture This Best Picture nominee chronicles nominee chronicles the hunt for Osama the hunt for Osama Bin Laden and stars Bin Laden and stars

Jessica Chastain.Jessica Chastain.

What is Zero Dark What is Zero Dark Thirty?Thirty?

This is the name This is the name of the set of MHC of the set of MHC alleles present on alleles present on each chromosome.each chromosome.

What is a What is a haplotype?haplotype?

These two chains These two chains make up MHC class make up MHC class

I.I.

What is an What is an αα chain and chain and ββ2 2

microglobulin?microglobulin?

Peptides are Peptides are transported into transported into the ER for Class I the ER for Class I

loading by this loading by this moleculemolecule

What is TAP?What is TAP?

This segment of This segment of class II molecules class II molecules

contain the binding contain the binding site for CD4.site for CD4.

What is the What is the ββ2 2 segment?segment?

This cytokine is This cytokine is encoded in the encoded in the

MHCMHC

What is TNF What is TNF αα, , lymphotoxin lymphotoxin αα or or lymphotoxin lymphotoxin ββ??

This TLR binds This TLR binds LPS.LPS.

What is TLR4?What is TLR4?

These 4 TLRs These 4 TLRs are expressed on are expressed on

endosomes.endosomes.

What are What are TLRs 3, 7, 8, 9?TLRs 3, 7, 8, 9?

This TLR does not This TLR does not signal through signal through

MyD88.MyD88.

What is TLR3?What is TLR3?

Polymorphisms in Polymorphisms in this “CARD this “CARD

carrying” member carrying” member of the NLRs is of the NLRs is

associated with associated with Crohn’s disease. Crohn’s disease.

What is NOD2?What is NOD2?

  

This enzyme is This enzyme is induced after induced after

ligation of TLRs ligation of TLRs and functions to and functions to reduce oxygen in reduce oxygen in reactive oxygen reactive oxygen

species.species.

What is NADPH What is NADPH (or phagocyte) (or phagocyte)

oxidase?oxidase?

It is an accessory It is an accessory molecule on this molecule on this cell that binds to cell that binds to

CD80/CD86.CD80/CD86.

What is CD28 on T What is CD28 on T cells?cells?

Cytokine Cytokine receptors signal receptors signal

through this through this pathway.pathway.

What is What is Jak/STAT?Jak/STAT?

In TCR signaling, In TCR signaling, Lyk Lyk

phosphorylates phosphorylates ITAMs on ITAMs on ζζ chains chains

in order to in order to provide a docking provide a docking

site for this site for this tyrosine kinase.tyrosine kinase.

What is ZAP-70?What is ZAP-70?

The B cell The B cell equivalents of equivalents of Lck/ZAP-70 are Lck/ZAP-70 are

these.these.

What are What are Lyn/Syk?Lyn/Syk?

After IP3 mediated After IP3 mediated calcium liberation calcium liberation

from the ER, STIM1 from the ER, STIM1 induces the induces the

opening of this opening of this channel to allow channel to allow

calcium influx into calcium influx into the cell.the cell.

What is the What is the CRAC channel?CRAC channel?