7/30/2019 1977 - Persinger - Behavioral Biology - Preweaning Body Marking Reduces Brain Mast Cell Numbers in Rats

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BEHAVIORAL BIOLOGY 21 ,42 6--4 31 (1977)

B R I E F R E P O R TPr e we a n i n g Bo d y Ma r k i n g Re d u c e s B r a i n Ma s t Ce l l

N um bers in Ra ts ~MICHAEL A. P E R S I N G E R

Environmental Psychophysiology L ab, Department o f Psychology, Laurentian University,Sudbury, Ontario, CanadaIn a sp i l t - l i tt e r de s ign , r a t s (Rattus norvegieus) f r o m f o u r l i t te r s b e t w e e n 5 a n d

2 0 d a y s o f a g e w e r e g i v e n e i t h e r e l e c tr i c f o o t s h o c k o r n o s h o c k d a i l y . I d e n ti f ic a -t i o n o f t r e a t m e n t w a s m a i n t a i n e d b y d a i l y a p p l i c a t i o n s o f a p e r m a n e n t m a r k i n gp e n t o t h e d o r s a l re a r b o d y s u r f a c e a n d w a s c o u n t e r b a l a n c e d f o r t r e a t m e n t s a c r o s sf i t t e r s . E igh t 15 - and 20 -day -o ld b r a in s f rom r a t s t ha t had been marked , r ega rd l e s so f s h o c k o r n o s h o c k t r e a t m e n t s , d i s p l a y e d a s ig n i f i c a n t ( P < 0 .0 1 ) 5 0 t o 7 0 %r e d u c t i o n i n m a s t c e l l n u m b e r s w i t h i n d i e n c e p h a l i c t i s s u e r e l a t i v e t o e i g h t n o n -m a r k e d l i t te r m a t e s ; a s i m i l a r e f f e ct w a s n o t e d i n t h e a d j a c e n t l e p t o m e n i n g e s ( P