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17th C-HPP Symposium 27-28 April 2017

Tehran, Iran

Jointly Organized by Royan Institute and IPS (Prof. Ghasem Hosseini Salekdeh) and HUPO C-HPP Consortium (Prof. Young-Ki Paik)

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Resalat Highway, Banihashem St., Shaghayegh Alley, No: 9. Tel/Fax: +98-21- 23562178; Email: info@royancongress.com; www.royaninstitute.org

April 27-28, 2017; Conference Hall of University of Science & Culture, Tehran, Iran

Conference venue: University of Science & Culture, Bahar Ave, Shahid Ghomoushi Ave, Hemmat Highway, Ashrafi Esfehani Blvd, Tehran, Iran

Date & Venue

Registration

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Professor Young-Ki Paik

Yonsei University, Korea Chair-Chromosome Centric Human Proteome Project Principal Investigator-Chromosome 16 of Human Proteome Project Director of the Yonsei Proteome Research Center Talk Title: Functional Validation of the Previous Missing Proteins Involved in Human Reproductive Disease: Experimental Strategy and Pitfall

After earning his bachelor’s in Biochemistry at Yonsei University in 1975, Seoul, Korea, Young-Ki Paik briefly held a Research Associate position for the Agency for Defense Development, Daejeon, Korea, before moving to the United States in order to pursue his doctorate at the University of Missouri-Columbia. Achieving this goal in 1983, he held a postdoctoral position at the Gladstone Institute of Cardiovascular Diseases until 1986 when he became a Staff Research Investigator. After leaving the Gladstone Institute in 1989, he returned to Seoul and had an associate professorship at the Department of Biochemistry, Hanyang University (1989-1993) and the Department of Biochemistry, Yonsei University (1993-95). In 1995, Paik became a full Professor, and in 2000 was appointed Director of the Yonsei Proteome Research Center (www.proteomix.org), a flagship proteome center in Asia where he performs research on the discovery of disease biomarkers. Paik is currently Professor of Dept. of Biochemistry and Director of Yonsei Proteome Research Center. He is the former President of HUPO, AOHUPO, KHUPO and KSBMB. Paik has been named as “Underwood Distinguished Professor” since 2009 and has authored or co-authored over 180 scientific journal publications and has been awarded several prestigious Awards including Kyung-Am Awards, HUPO distinguished service award, Scientist of the Month and dozens of international patents for his discoveries of biomarkers of liver cancer and pancreatic cancer, dauer pheromone and cholesterol regulators. Paik served chair of Basic Science Division of the Korean Academy of Science and Technology (2013-2014). He was one of the key founders of international consortium of ‘Chromosome-centric Human Proteome Project’ and serves currently Chair of this global project (www.c-hpp.org). He is also senior/associate editor for multiple peer-reviewed international journals including Proteomics, Proteomics: Clinical Applications and BMC Cancer. His research is focused on C-HPP, biomarkers of HCC and pancreatic cancer, and dauer pheromone signaling in C. elegans.

Invited Speakers

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Professor Christopher Overall University of British Columbia Co-Chair-Chromosome Centric Human Proteome Project Canada Research Chair in Metalloproteinase Biology and Proteomics Oral Biological and Medical Sciences Talk Title: Antiviral Immunity Cellular Substrates revealed by TAILS Terminomics Dr. Overall is a Professor and Tier 1 Canada Research Chair in Protease Proteomics and Systems Biology at the University of British Columbia (UBC), Life Sciences Institute, and Canadian Institutes of Health Research (CIHR) Foundation Grant holder. With 23 Nature Review, Science, and Nature/Cell/Science-sister journal papers, he is a pioneer of degradomics, a term he coined. His 240 papers have been cited over 15,558 times (16 over 200 citations) and has an h index of 67. He completed his Honors Science and Masters degrees at the University of Adelaide, South Australia; his Ph.D. at the University of Toronto; and MRC Centennial Fellow with Dr. Michael Smith, Nobel Laureate, UBC. He was a Visiting Senior Scientist at British Biotech Pharmaceuticals, Oxford (1997/1998) and Visiting Senior Scientist Novartis, Basel (2004/2008), External Senior Fellow, Freiburg Institute for Advanced Studies, and in 2014 was appointed as Honorary Professor, Albert-Ludwigs Universität Freiburg. Awarded the 2002 CIHR Scientist of the Year, the UBC Killam Senior Researcher Award 2005, and was the Chair of the 2003 Matrix Metalloproteinase and the 2010 Protease Gordon Research Conferences. Elected to HUPO Council and as Co-Chair of the Chromosome–Centric Human Proteome Project (C-HPP) in 2014. He was recognized by the International Society of Proteolysis (2011 Lifetime Achievement Award); by the Matrix Biology Society of Australia and New Zealand (2012 Barry Preston Award); by the IADR Distinguished Scientist Award for Research in Oral Biology (2013); and in 2014 by the Tony Pawson Canadian National Proteomics Network Award for Outstanding Contribution and Leadership to the Canadian Proteomics Community. He is an Associate Editor of the Journal of Proteome Research, Editor of mSystems and on the Executive Committee of HUPO and co-chair of the Chromosome Centric Human Proteome Project of HUPO.

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Professor Pengyuan Yang Fudan University, China Principal Investigator-Chromosome 8 of Human Proteome Project Deputy Director of Institutes of BioMedical Sciences, Shanghai Medical College, Fudan University Talk Title: Progress in Chr 8 with Disease Implications

Chairman/Chairman of Department of Chemistry (2000-2002/2003-2006), and currently is the Deputy Director of Institutes of BioMedical Sciences (2005-), Shanghai Medical College, Fudan University. He gained Ph D from the University of Massachusetts at Amherst (USA，1987), with Prof. R.M. Barnes in Analytical Chemistry. He was Postdoc Fellow in Indiana University at Bloomiongton (USA) with Prof. G.M. Hieftje（1987-1989）and in Xiamen University with Prof. BL. Huang（1989-1991.

Dr. Pengyuan Yang is very active in bio-mass spectrometry for protein analysis, glycoproteomics and disease proteome areas. He is specialized in Mass-Spectrometry based technology and methodology, especially in the field of Biomass Spectrometry and its application in Glycoproteome and Cancer-proteome. He was the Principal Scientist for National 973 Project “Proteomics for disease study”(2002-2006), and for“Micro-fluidics and its application in chemistry and bio-medicine” (2007-2011), and is the Principal Scientist for National 863 Project “Instrumentation and reagent for proteomics”, supported by Ministry of Science and Technology. He is the Council Member of Chinese Mass Spectrometry Society, and is the President of Chinese HUPO (human proteome organization, 2011-2015) and Past- President of Chinese HUPO now. He is also a member of editorial board of Proteomics, and J Proteome Res. Currently, He is the PI in charge of Proteome of Chromosome 8, in coordination with Chinese colleagues for Ch#1, 8, and 20 in C-HPP plan. Dr. Yang has published a number of scientific papers on many important journals, including Anal Chem, Mass Spectrom Rev, Ripad Commun Mass Spectr,Proteomics, J Res Proteome, Mol Cell Proteomics, Nat Commun, Hypatoogy, Adv Mater, Angrew Chem Int Ed., Chem Comm, and etc.

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Professor Je-Yoel Cho Seoul National University, Korea Principal Investigator-Chromosome 9 of Human Proteome Project President of Korean Human Proteome Organization (KHUPO) Talk Title: C-HPP Project (Chr 9): Proteogenomic Study in Human Lung Cancer

Je-Yoel Cho, DVM, PhD is currently associate professor in the Department of Biochemistry, College of Veterinary Medicine, Seoul National University. He was an assistant and associate professor at the Kyungpook National University, Daegu, Korea from 2003 to 2011. He has been working in proteomics research field since his postdoctoral researcher at the BIDMC genomics center in Harvard Medical School (2001-2003). He received his Ph.D. degree in Physiology and Cell Biology from the Ohio State University. He served as a secretary general of KHUPO (2012-2013) and elected as 10th President of KHUPO (2018-2019). He is currently the PI of Chromosome #9 team in the international chromosome-based human proteome project (C-HPP). His current researches include the development of cancer biomarkers by glycoproteome and low molecular weight proteome analyses using LC-ms/ms-based mass spectrometry. One of the main approaches for the biomarker development is based on the comparative medicine between companion animals and humans in the similar environment. He validates the biomarkers by MRM technologies and further develops multiplexed point of care testing (POCT) kit useful for cancer diagnosis. Another research area is cardiovascular regeneration using stem cells combined with biomaterials. In this project, stem cells are modified to be functional by delivering the therapeutic genes into safe harbor site and protected by biocompatible materials.

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Professor Charles Pineau IRSET institute, France Principal Investigator-Chromosome 14 of Human Proteome Project Research Director at the French National Institute of Health and Medical Research (Inserm) Talk Title: Looking for missing proteins in the testicular germ cell lineage: new insights into normal and pathological spermatogenesis

Dr Pineau currently serves as Research Director at the French National Institute of Health and Medical Research (Inserm). He is team leader at the IRSET institute (www.irset.org) and is heading the Protim Core Facility (www.protim.eu) at Rennes, France.

Charles Pineau received his Ph.D. degree from University of Rennes 1 in 1990. Following a post doctoral stay at the Population Council, Rockefeller University, New York, USA (1990-1993), he was recruited as a permanent senior staff scientist at Inserm. Over the past thirty years, Dr Pineau has been working in the field of reproductive biology and is a renowned specialist of spermatogenesis. He has heavily invested in the development of proteomics, integrative proteomics, bioinformatics and imaging mass spectrometry technologies and his applying these to answer biological and clinically relevant problems in the field of testicular pathophysiology and reproductive toxicology.

Dr Pineau’s team focuses on the deciphering of the testicular proteome in mammals with a priority given to the identification of novel germ cell proteins that play a key role in the normal and pathological spermatogenesis. His recent breakthrough work identifies novel testicular germ cell proteins using a proteogenomics approach. C. Pineau's team is part of the Chromosome-centric Human Proteome Project and is tackling the characterization of "missing proteins" in the human spermatozoa. Among applications of its fundamental work to clinics, the team also uses germ cell-specific proteins markers identified by integrative proteomics for developing a diagnostic multiplex test of infertilities in men (FertichipTM assay).

Dr Pineau is also keenly interested in biotechnology and was the co-founder of Innova Proteomics, a Contrat Research Organization (2003-2012). Dr Pineau serves as a recognized scientific expert in the field of male reproduction, proteomics and reproductive toxicology for national and international funding agencies. He is a scientific consultant for several pharmaceutical companies and past President of the French Proteomics Society (SFEAP). Finally, among other activities, Charles Pineau is Vice-President of the French Society for Reproductive Medecine (SMR) and PI of the Chromosome 14 initiative of Human Proteome Project (C-HPP).

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Professor Fernando J Corrales CIMA, University of Navarra , Spain Principal Investigator -Chromosome 16 of Human Proteome Project Head of the Proteomics Laboratory at the Centro Nacional de Biotecnología Talk Title: Searching for missing proteins: Update on chromosome 16 activity

Fernando J Corrales received the BSc degree in Biological Sciences (1986) and the PhD degree in Biochemistry and Molecular Biology (1992) from the University Autónoma of Madrid. After a Postdoctoral period at the University of Cambridge (UK), he joined the CIMA, University of Navarra where he has been Professor of Biochemistry and head of the Proteomics, Genomics and Bioinformatics Facility. He is currently Senior Scientist and head of the Proteomics Laboratory at the Centro Nacional de Biotecnología. He is an active researcher in the field of Biochemistry. His interest is now focused on the study of the mechanisms associated to liver function as well as those involved in the progression of liver diseases using proteomics and genomics approaches, which are then combined in a systems biology-based strategy. His research activity has been regularly founded by regional, national and international grants and lead to the publication of more than 130 scientific articles. He is member of the editorial board of different journals specialized in proteomics and hepatology, General Coordinator of the Molecular and Bioinformatics resources Platform and ProteoRed-ISCIII (Spanish Proteomics Network) and is member of the Executive Councils of the European Proteomics Association and the BD and C-Human Proteome Project as well as PI of the Human Liver Proteome Project and the chromosome 16 Spanish Human Proteome Project.

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Professor Alexander Ivanovich Archakov Institute of Biomedical Chemistry, Moscow, Russia Principal Investigator-Chromosome 18 of Human Proteome Project Director of the V.N. Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences (RAMS) Talk Title: SRM-based ‘missing’ proteins of UPS2 (sigma) and Chr18 expressed in human liver, HepG2 cells and in plasma

Full member of the RAS, Professor, Scientific Advisor of Institute of Biomedical Chemistry, Was born January 10, 1940, in Kashin, Kalinin (Tver) region – scientist, biochemist.A.I. Archakov had organized a scientific school to study molecular organization and functioning of oxygenase cytochrome P450-containing systems, molecular mechanisms of the structure and function of membranes and biological oxidation. Under the guidance of A. I. Archakov, the institute’s members have developed a fundamentally new pharmaceutical composition “Phosphogliv” with antiviral activity for the treatment of liver diseases of various etiology. A.I. Archakov’s present-day/current areas of expertise relate to research in the field of post-genomic technologies, nanobiotechnologies, proteomics, development of approaches to create personalized medicine of the future. A.I. Archakov is the pioneer in the development of proteomics in Russia. Currently, he is the international “Human proteome” project coordinator in Russia/ the coordinator representing Russia in the international “HP” project (http://www.proteom.ru). A.I. Archakov is one of the Russia’s top 100 scientists by Hirsch number-27. He is the author of more than 700 scientific works including about 482 scientific articles, 6 monographs, 30 patents and author’s certificates. He was scientific adviser for 15 doctor’s and more than 60 Ph.D. thesis. Winner of three State Prizes of the USSR, the RSFSR and of the Russian Federation, the Russian Federation Government Award, the Bach Prize of the USSR Academy, the Order "For Merit to the Fatherland» (IV, III, II class).

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Professor Gong Zhang Jinan University, Guangzhou, China Co-Principal Investigator -Chromosome 20 of Human Proteome Project Team leader, translatome sequencing as the 4th resource pillar of the C-HPP Talk Title: The hidden human proteome: the protein-coding "lncRNAs"

Dr. Gong Zhang completed his PhD in 2009 in Germany. Now he is a professor in Jinan University, Guangzhou, China. His major research interest is in translatomics, proteomics and bioinformatics. His group accomplished the first full-length translating RNA sequencing (RNC-seq) in human cells and the first genome-wide translation speed evaluation under physiological condition, providing an in-depth and global view on translation regulation. These technologies were applied in cancer research, antibiotic resistance and protein engineering. He and his group also developed several accurate algorithms for next-generation sequencing and proteomics analysis, including the hyper-accurate mapping algorithm FANSe series with extremely high robustness and experimental verifiability, which has been successfully applied in clinical diagnosis. Dr. Gong Zhang and his colleagues are involved in the Human Proteome Project (HPP) with the translatome sequencing as the 4th resource pillar of the Chromosome-centric HPP, identifying missing proteins and the new proteins encoded by “long non-coding RNAs” in an unprecedented efficiency.

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Professor Tadashi Yamamoto Niigata University Co-Chair-Chromosome X Human Proteome Project Director of ”All-in-One Urine Test” project Institute for Social Innovation and Corporation Talk Title: Identification of Missing Proteins Encoded in Chromosome X Dr. Yamamoto is a Research Professor and Director of “All-in-One Urine Test” Project at the Niigata University. He is a pioneer of Kidney and Urine Proteomics with the background of nephrology and kidney and pathology and molecular biology. He has published more than 200 papers regarding from basic researches on kidney glomerular diseases to clinical researches for urine biomarker discovery and kidney tissue proteomics. He graduated at the School of Medicine, Niigata University (1974) and completed his PhD, Degree of Medical Sciences (D.M.Sc.) degrees at the Niigata University (1981). He was a Visiting researcher at the Scripps Research Institute, La Jolla (1984/1992) He became the Professor of Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University (1999), the Director of Institute of Nephrology (2011) and the Director of Niigata University satellite Center of Innovation Program (2013). He organized the HUPO Kidney and Urine Initiative as the chair (2005) and also chaired the Chromosome X project (Japan). He was elected to the HUPO council (2011) and the President of Japan HUPO (Japanese Proteomics Society, JProS) (2012). He was recognized by the Japanese Proteomics Society (2012 Japanese Proteomics Society Award). He is on the Executive Committee of Biology/Disease Centric Human Proteome Project of HUPO.

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Professor Ghasem Hosseini Salekdeh Royan Institute for Stem Cell Biology and Technology, Tehran, Iran Principal Investigator-Chromosome Y of Human Proteome Project Talk Title: Heart of Y Chromosome: Searching for Functions of Missing Proteins Involved in Disease

Dr. Salekdeh joint Agricultural Biotechnology Research Institute of Iran in 2002 after receiving his PhD in Genetics. He started his collaboration with Department of Stem Cells at Royan Institute, Tehran in 2005. His researches focus on discovery novel pathways and genes involved in embryonic cell proliferation and differentiation using proteomics and genomics approaches. He is co-founder of Iranian Proteomics Society (IPS) and president elect of the society from 2004 till 2015. He is council member of Asian Oceanian Human Proteome Organization (AOHUPO) and Human Proteome Organization (HUPO). He is also vice-president of AOAPO and Middle East Coordinator of INPPO. He is also Principal Investigator of Human Y Chromosome Proteome Project. He is on a number of editorial boards, including Nature Scientific Reports, Journal of Proteome Research and Proteomics journal. He received several awards and honors including National Biotechnology Award (2007), National Razi Medical Science award for advance technologies (2009), the Khwarizmi International Award for fundamental research (2010), and Hadavi award from Iranian Academy of Medical Sciences (2010 and 2014), National Distinguished Scientist in Biotechnology (2013), Best National Researcher Award (2015), and National Distinguished Scientist in Genetics (2016). He has published over 140 peer-reviewed papers in international journals such as Nature Biotechnology, Nature Protocol, Molecular Cellular Proteomics, Stem Cells, Journal of Hepatology, and Journal of Proteome Research.

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Professor Andrea Urbani University of Rome “Tor Vergata”, Rome, Italy

Principal Investigator- Human Proteome Project- Mitochondria Head of the Analytical Biochemistry and Proteomics facility in the Centre of Study on Aging Talk Title: Mitochondrial Proteome-Completion of Missing Protein Annotation

Prof. Andrea Urbani is the Head of the Analytical Biochemistry and Proteomics facility in the Ce.S.I., (Centre of Study on Aging) University Foundation “G. D’Annunzio” of Chieti-Pescara where he investigates Proteomics and Metabonomics by mass spectrometry. He is also Head of Proteomics and Metabonomics Laboratory at the IRCCSFondazione Santa Lucia – Rome which supports the research of CNR Istitute for Neurobiology & Molecular Medicine as well as the European Brain Reasearch Istitute – Rita Levi Monatalcini Foundation. He is also Associate Professor in Clinical Biochemistry and Molecular Biology, and Faculty Chair at the University of Rome “Tor Vergata.” Since 2009, he has been the organiser of the National Congress of the Italian Proteomics Association (ItPA, www.itpa.it) and is the President of ItPA for the 2009-2012 period. Since his PhD in 1998, he has authored over 180 papers in the field of proteomics and metabonomics investigations. He is currently the President of European Proteomics Aocossiation.

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Professor Paola Roncada Istituto Spallanzani , Italy Co-Principal Investigator- Human Proteome Project- Mitochondria chair of the international program FOOD AND NUTRITION PROTEOMICS Talk Title: Update on the Food and Nutrition Initiative

Professor Paola Roncada received her PhD in Biochemistry from Faculty of Medicine, Università degli Studi di Sassari. Dr Roncada is responsible, from 2001, of Proteomic Research of Istituto Spallanzani, (www.istitutospallanzani.it) and her major interests of scientific activity are foodomics, food safety, food quality through proteomics, peptidomics and metaproteomics. Her research lines are realized in the topics related to proteomics applied to one health approach. She is the chair of the international program FOOD AND NUTRITION PROTEOMICS, an initiative of the Human Proteome Project - Biology and Disease (HPP/BD). https://www.hupo.org/Food-and-Nutrition-Initiative.

This action was also recently approved in European Proteomics Association. She is the President of Italian Proteomics Association Foundation. She served for six years the Italian Proteomics Association Council. From 2015 she is elected member of Council of Human proteome Organization. (HUPO). From 2014 She is also co-PI of the international program chromosome Centric Human Proteome Project- Mitochondria. She published more than 120 papers.

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Ph. D Heeyoun Hwang Korea Basic Science Institute Biomedical OMICS Research Group Senior Post-Doc Talk Title: Updates of missing proteins and novel variants findings from chromosome 11 Dr. Hwang is a senior postdoc supervised with Dr. Jong Shin Yoo and Dr. Jin Young Kim, in Korea Basic Science Institute, Biomedical OMICS Research Group. He completed his Masters degrees at Yonsei University, South Korea; his Ph.D. at the KyungHee University. Awarded the Young Scientist Award of KHUPO 2009, 2013, and 2016, the Young Scientist Award of ICAST 2015, The Excellent Contribution for KBSI Award 2015, C-HPP Young Investigator Award of HUPO 2014 and 2016, The Clinicians and Clinical Scientist Travel Award of HUPO 2015, and PhD Abstract Competition Finalist of HUPO 2016. As a first author, he has participated to publish the papers of Proteogenomics and Glycoproteomics field; In-depth Analysis of Site-Specific N-Glycosylation in Vitronectin from Human Plasma by Tandem Mass Spcetrometry with Immunoprecipitation (ABC 2014), Chromosome-Based Proteomic Study for Identifying Novel Protein Variants from Human Hippocampal Tissue using Customized neXtProt and GENCODE Databases (JPR 2015), Analysis of fucosylation in liver-secreted N-glycoproteins from human hepatocellular carcinoma plasma using liquid chromatography with tandem mass spectrometry (ABC 2016), Integrated Proteomic Pipeline Using Multiple Search Engines for a Proteogenomic Study with a Controlled Protein False Discovery Rate (JPR 2016). Recently, he designed the cover of Journal of Proteome Research, 2016 15(11) C-HPP Special Issue.

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Ph. D. Seul-Ki Jeong Yonsei Proteine Research Center, Yonsei University. Talk Title: Bioinformatic tools of Chromosome 13 team for finding missing protein Dr. Jeong got his Ph.D in biochemistry at Yonsei University and now, working at Yonsei Proteme Research Center as research professor. He contributed to writing 1st Nature Biotechnology paper about C-HPP with Prof. Young-Ki Paik and William Hancock in 2012. And also, He contribute to setting up 1st standard guideline for the C-HPP in 2012, JPR. His major topics are creating bioinformatics tools for analyzing biological data and constructing databases. He published 28 papers about protein function prediction, statistics analysis of expression data, proteome database and biomarker discovery. He made C-HPP homepage (C-HPP.org) and GenomewidePDB, the chromosome centric proteome database containing comprehensive information.

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Dr. Fan Zhong Institutes of Biomedical Science, Fudan University, China leads the analysis of chromosome 8 and contributes to the analyses of chromosomes 1 and 20 for the Chromosome-centric Human Proteome Project Talk Title: Probable Physicochemical and Epigenetic Causes of Missing Proteins

Dr. Fan Zhong is Associate Researcher of Institutes of Biomedical Science, Fudan University, China. As a member of the bioinformatics and data analysis faculty of the CNHUPO, he is mainly focussed on proteomics data processing including mass spectrometry signal processing, database searching, QC, quantification, post-translational modifications (PTMs) finding, differential protein screening, network analysis and pattern discovery. Dr. Zhong has developed new proteomics data processing methodologies, including data standards, label-free quantification, data integration (with transcriptome), and pathway / network analysis. he has also discovered evolutionary, structural and functional-associated protein abundance distribution patterns among multiple species by integrating multiple proteomics data. These are successful examples of deep mining and meta-analysis of proteomics data in knowledge discovery. Dr. Zhong has contributed expert bioinformatics analyses in the Human Liver Proteome Project (HLPP), which generated the first global human organ proteome. He leads the analysis of chromosome 8 and contributes to the analyses of chromosomes 1 and 20 for the Chromosome-centric Human Proteome Project (C-HPP). By using multiple-omics methods, Dr. Zhong has carried out systems biology research in hepatocellular carcinoma (HCC) metastasis, and screened out several biomarker and drug target candidates for further clinical intervention. Based on the construction of the largest integrated human protein interaction database, PathPPI, which includes pathway flows and protein-protein interaction (PPI) pairs, he has also developed novel methods in network pattern discovery. In addition to research activity, he is active in knowledge transfer and outreach activities, especially promoting proteomics and systems biology in China. He introduced and participated in the translation of the leading European-authored book “Systems Biology in Practice: Concepts, Implementation and Application” (Edda Klipp et al., Wiley, 2008) into Chinese.

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Program

Thursday, April 27th

08:00-08:50 Registration 08:50-09:00 Welcome Message: Prof. Hamid Gourabi (President of Royan Institute) Plenary Lecture Chair: Hamid Gourabi 09:00-09:20 Prof. Reza Malekzadeh- Deputy Minster for Research and Technology, Ministry of Health and Medical Education, Iran) Invited Session I: Introduction and Overview C-HPP- Direction, Importance, Data Guidelines and Technology Resources Chair: Young-Ki Paik 09:30-10:00 C-HPP: Past, Present and Future: Young-Ki Paik (C-HPP Chair, Korea) 10:00-10:20 JPR Special Issue and MP50 Campaign with HPP Data Guidelines Chris Overall (C-HPP Co-Chair, Associate Editor for JPR) 10:20-10:40 Link between C-HPP and Biology/Disease HPP Fernando Corrales, Spain 10:40-11:10 Coffee Breaks

Invited Session II: Uncovering Missing Proteins by Using Various Biological and Clinical Samples Chair: Chris Overall 11:10-11:30 Searching for missing proteins: Update on chromosome 16 activity Fernando Corrales, Spain

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11:30-11:50 Looking for missing proteins in the testicular germ cell lineage: new insights into normal and pathological spermatogenesis Charles Pineau, France 11:50-12:10 Identification of Missing Proteins Encoded in Chromosome X

Tadashi Yamamoto, Japan

12:10-12:30 Mitochondrial Proteome-Completion of Missing Protein Annotation

Andrea Urbani, Italy

12:30-12:50 Updates of missing proteins and novel variant findings from chromosome 11 Heeyoun Hwang, Korea 12:50-13:10 SRM-based ‘missing’ proteins of UPS2 (sigma) and Chr18 expressed in human liver, HepG2 cells and in plasma Alexander Archakov, Russia 13:10-14:30 Lunch Break Invited Session III: Functional Study of Missing Proteins with Disease Implication Chair: Fernando Corrales 14:30-14:50 Functional Validation of the Previous Missing Proteins Involved in Human Reproductive Disease: Experimental Strategy and Pitfall Young-Ki Paik, Korea 14:50-15:10 Heart of Y Chromosome: Searching for Functions of Missing Proteins Involved in Disease Ghasem Hosseini Salekdeh, Iran 15:10-15:30 C-HPP Project (Chr 9): Proteogenomic Study in Human Lung Cancer

Je-Yoel Cho, Korea

15:30-15:50 Progress in Chr 8 with Disease Implications (tentative) Pengyuan Yang, China 15:50-16:10 Update on the Food and Nutrition Initiative

Paola Roncada, Italy

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16:10-16:30 The hidden human proteome: the protein-coding "lncRNAs" Gong Zhang. China 16:30-17:00 Coffee Breaks Invited Session IV: Invited Special Lectures Chair: Fernando Corrales 17:00-17:30 Antiviral Immunity Cellular Substrates revealed by TAILS Terminomics Chris Overall, Canada 17:30-18:00 General Discussion on All Pending Issues Chairs: Young-Ki Paik, Chris Overall, Fernando Corrales 19:00-21:00 Milad Tower (PIs and Co-PIs) Friday, April 28th

Young Investigator Invitation Session Chair: Pengyuan Yang, Fudan Univ., China 08:30-08:45 Identifying 17000 human proteins in a single MS experiment using high throughput de novo identification aided by translatome sequencing Dehua Li, China 08:45-09:00 Human Y chromosome genes regulate Human Embryonic Stem Cell Differentiation to cardiac cell Anna Meyfour, Iran 09:00-09:15 Probable Physicochemical and Epigenetic Causes of Missing Proteins Fan Zhong, China 09:15-09:30 Human Y chromosome proteome project and male infertility Mehdi Alikhani, Iran 09:30-09:45 Bioinformatic tools of Chromosome 13 team for finding missing proteins Seul-Ki Jeong, Korea

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09:45-10:00 Human Membrane proteomics: searching for missing proteins Faezeh Shekari, Iran

10:00-10:30 Coffee Breaks Working Group Formation: Networking and Interaction through the C-HPP Clusters

Co-Chairs: Young-Ki Paik and Chris Overall

10:30-12:00 Organization of Intra C-HPP Cluster Groups Rare Tissues and Cell Lines Cluster Olfactory Receptor Cluster Novel Protein Cluster PTM Cluster IVTT Cluster Infertility cluster lnc RNA Cluster Call-In: Gil Omenn 12:00-13:30 Future Directions Chair: Charles Pineau Update on the 18th C-HPP Workshop in Dublin (Young-Ki Paik and Fernando Corrales) Update on the JPR Special Issue (Chris Overall, Co-Chair & JPR AE) Planning on the 19th C-HPP Workshop in Santiago (Fernando Corrales) Planning on the 20th C-HPP Workshop in St. Malo (Charles Pineau) Planning on the Collaboration with B/D-HPP Group (Fernando Corrales) End of Symposium