Curriculum vitae

Name: Prof. Jiří FRIML, Dr. rer. nat., Ph.D.

Citizenship: Czech Republic

Business Address: Institute of Science and Technology Austria (IST Austria)

Am Campus 1

3400 Klosterneuburg

Austria

Tel.: +43 2243 9000 5401

Fax: +43 2243 9000 2000

e-mail: jiri.friml@ist.ac.at

Web: http://ist.ac.at/research/research-groups/friml-group/

Education and Training

2005 P.D., Habilitation in Genetics, University of Tübingen, Tübingen, Germany

2002 Ph.D., Biochemistry, Masaryk University, Brno, Czech Republic

2000 Dr. rer. nat., Biology, summa cum laude, University of Cologne, Köln, Germany

1997 M.Sc., Biochemistry, summa cum laude, Masaryk University, Brno

1995 B.Sc., Chemistry, Masaryk University, Brno, Czech Republic

Professional Career

10/2012 - Professor; Institute of Science and Technology (IST), Austria

2011 - 2014 Associated group leader, Central Institute of Science and Technology

(CEITEC), Masaryk University, Brno, Czech Republic

2012 - 2014 Guest Professor; Ghent University, Belgium

2007 - 2012 Professor and Group leader; Plant Systems Biology Department, Flanders

Institute for Biotechnology (VIB) and Ghent University, Belgium

2006 - 2007 Professor; Plant Cell Biology Department at the University of Göttingen,

Germany

2002 - 2006 Group leader; University of Tübingen, Tübingen, Germany

2001 - 2002 Research associate; Centre for Plant Molecular Biology, University of

Tübingen, Germany

1997 - 2002 Ph.D. Student in Biochemistry; Faculty of Science, Masaryk University, Brno,

Czech Republic

1997 - 2000 Ph.D. Student in Biology; Max-Delbrück laboratory in Max-Planck-Society,

Köln, Germany

1995 - 1997 M.Sc. Student; Physical Chemistry, Biochemistry, Faculty of Science, Masaryk

University, Brno, Czech Republic

Honors and Awards

2000 Max Planck Society Award: The Otto Hahn Medal

2002 VolkswagenStiftung Award

2004 EMBO Young Investigator Award

2005 Heinz Maier-Leibnitz Prize

2007 Odysseus Award, Flanders Science Foundation

2009 2nd most cited developmental biologist and 4th most cited plant biologist in

Germany/Austria/Switzerland (Labor Journal)

2010 Olchemim Scientific Award

2010 Körber European Science Award

2010 Elected EMBO member

2011 Elected fellow of American Association for the Advancement of Science (AAAS)

2012 EMBO Gold Medal

2013 ERC Starting Grant

2014 Elected member of Junge Kurie, Austrian Academy of Science

2014 Běhounek Prize (Czech Ministry of Education)

2015 Erwin Schrödinger Prize (Austrian Academy of Science)

2015 Selected to 2015 World’s Most Influential Scientific Minds

2016 Charles Albert Shull Award (ASPB)

2017 ERC Advanced Grant

Regularly Thomson Reuters Highly Cited Researcher

Memberships

2007-current The European Plant Science Organization (EPSO)

2010-current American Society of Plant Biologists (ASPB)

2010-current American Association for the Advancement of Science (AAAS)

2010 Member of European Molecular Biology Organization (EMBO)

2011 Fellow of American Association for the Advancement of Science (AAAS)

Professional Service

- Scientific Advisory Board Member, Biological Research Centre, Hungarian Academy of Sciences

- Scientific Advisory Board Member, CEITEC, Masaryk University, Brno, Czech Rep.

- Scientific Advisory Board Member, Fujian University, Fuzhou, China

- Faculty Council Member, Department of Plant Physiology, Charles University, Prague

- Habilitation Panel Member, Agricultural University Vienna (2007), University Graz (2013)

- PhD Panel Member: Utrecht, Leiden, Ghent, Lyon, Prague, Brno, Olomouc, Tel-Aviv, Heidelberg

- Head of the interdisciplinary committee; member of the professorial and investment committees,

IST Austria

- Organizer, EMBO Plant meeting, Brno (2015)

- Organizer, Plant Systems Biology Meeting in Ghent, Belgium (2008)

- Co-organizer, Auxin and Cytokinin Meeting in Plant Development (ACPD), Prague (2009)

- Co-organizer, Summer School on Polarity and Asymmetric Cell Division in Plants at Crveni

Otok, Croatia (2009)

- Co-organizer, Vienna Plant Network (2013)

- Receiving Editor with Current Opinion of Plant Biology (2009)

- Editorial board member: Cell Research, Frontiers in Plant Science

- Grant Reviewer for funding agencies: Austria, Belgium, Czech Republic, Germany, Hungary,

Switzerland, Israel, Italy, The Netherlands, NSF, EMBO

- Reviewer for: Nature, Science, Cell, Plant Cell, Plant Journal, Plant Physiology, Current Biology,

Developmental Cell, Nature Chemical Biology, Nature Cell Biology, etc.

Invited Lectures: Invited to the international meetings about 5 times a year since 2000; regularly

plenary and key-note lectures and chairing sessions. Invited seminars at universities and research

institutes about 5 times a year.

Teaching Activities

IST Austria (2016 - ): Lecture course: Mathematics for biologists

IST Austria (2014 - ): Lecture course: Developmental and Cell biology

University Prague (2003 -): Lecture course: Developmental cell biology of plants

University Brno (2005 -): Lecture course: Modern methods in experimental Biology

Santiago, Chile (2013): Lecturer at Santander Summer School

University of Tübingen (2001 - 2006): Lecture and laboratory courses in molecular cell biology,

genetics and developmental genetics

EMBO Heidelberg (2005, 2006): Lecturer at EMBO YIP course

University Göttingen (2007): Lecture and laboratory courses in physiology, genetics

University Ghent (2007 - 2012): Lecture and practical courses in plant systems biology and

plant developmental biology

MAICH, Greece (2009, 2010, 2017): Lecture course: Hormonal regulation of plant development

By December 2017: 26 accomplished PhD graduates

Publications 2001 – 2018:

February 2018: Items: 243; Citations: 35 884; h-index: 92 according to Google Scholar

Original research articles

1. Li L, Krens SFG, Fendrych M, Friml J. (2018): Real-time Analysis of Auxin Response, Cell Wall

pH and Elongation in Arabidopsis thaliana Hypocotyls. Bio Protoc. 5;8(1):e2685

2. Prát T, Hajný J, Grunewald W, Vasileva M, Molnár G, Tejos R, Schmid M, Sauer M, Friml J.

(2018): WRKY23 is a component of the transcriptional network mediating auxin feedback on PIN

polarity. PLoS Genet. 29;14(1):e1007177.

3. Fan L, Zhao L, Hu W, Li W, Novák O, Strnad M, Simon S, Friml J, Shen J, Jiang L, Qiu QS.

(2018): NHX antiporters regulate the pH of endoplasmic reticulum and auxin-mediated

development. Plant Cell Environ. Jan 23. [Epub ahead of print]

4. Kitakura S, Adamowski M, Matsuura Y, Santuari L, Kouno H, Arima K, Hardtke CS, Friml J,

Kakimoto T, Tanaka H. (2017): BEN3/BIG2 ARF GEF is Involved in Brefeldin A-sensitive

Trafficking at the trans-Golgi Network / Early Endosome in Arabidopsis thaliana. Plant Cell

Physiol. 1;58(10):1801-1811

5. Tejos R, Rodriguez-Furlan C, Adamowski M, Sauer M, Norambuena L, Friml J. (2017): PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in

Arabidopsis thaliana. J Cell Sci. 29;131(2).

6. Von Wangenheim D, Hauschild R, Fendrych M, Barone V, Benková E, Friml J. (2017): Live

tracking of moving samples in confocal microscopy for vertically grown roots. Elife 6

7. Von Wangenheim D, Hauschild R, Friml J. (2017): Light Sheet Fluorescence Microscopy of Plant

Roots Growing on the Surface of a Gel. J Vis Exp. 119

8. Kuhn BM, Nodzyński T, Errafi S, Bucher R, Gupta S, Aryal B, Dobrev P, Bigler L, Geisler M,

Zažímalová E, Friml J, Ringli C. (2017): Flavonol-induced changes in PIN2 polarity and auxin

transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity. Sci Rep. 7:41906.

9. Steenackers WJ, Klíma P, Quareshy M, Cesarino I, Kumpf RP, Corneillie S, Araújo P, Viaene T,

Goeminne G, Nowack MK, Ljung K, Friml J, Blakeslee JJ, Novák O, Zažímalová E, Napier RM,

Boerjan WA, Vanholme B. (2017): cis-cinnamic acid is a novel, natural auxin efflux inhibitor that

promotes lateral root formation. Plant Physiol. 173(1):552-565

10. Simonini S, Deb J, Moubayidin L, Stephenson P, Valluru M, Freire-Rios A, Sorefan K, Weijers D,

Friml J, Østergaard L. (2016): A noncanonical auxin-sensing mechanism is required for organ

morphogenesis in Arabidopsis. Genes Dev.30(20):2286-2296.

11. Balla J, Medveďová Z, Kalousek P, Matiješčuková N, Friml J, Reinöhl V, Procházka S. (2016):

Auxin flow-mediated competition between axillary buds to restore apical dominance. Sci Rep.

6:35955

12. Rakusová H, Abbas M, Han H, Song S, Robert HS, Friml J. (2016): Termination of Shoot

Gravitropic Responses by Auxin Feedback on PIN3 Polarity. Curr Biol. 26(22):3026-3032.

13. Žádníková P, Wabnik K, Abuzeineh A, Gallemí M, Van Der Straeten D, Smith RS, Inzé D, Friml J,

Prusinkiewicz P, Benkova E. (2016): A Model of Differential Growth-Guided Apical Hook

Formation in Plants. Plant Cell. 28(10):2464-2477

14. Ortiz-Morea FA, Savatin DV, Dejonghe W, Kumar R, Luo Y, Adamowski M, Van den Begin J,

Dressano K, Pereira de Oliveira G, Zhao X, Lu Q, Madder A, Friml J, Scherer de Moura D,

Russinova E. (2016): Danger-associated peptide signaling in Arabidopsis requires clathrin. Proc

Natl Acad Sci U S A. 113(39):11028-33

15. Mazur E, Benková E, Friml J. (2016): Vascular cambium regeneration and vessel formation in

wounded inflorescence stems of Arabidopsis. Sci Rep. 6:33754.

16. Fendrych M, Leung J, Friml J. (2016): TIR1/AFB-Aux/IAA auxin perception mediates rapid cell

wall acidification and growth of Arabidopsis hypocotyls. Elife 5

17. Nodzyński T, Vanneste S, Zwiewka M, Pernisová M, Hejátko J, Friml J. (2016): Enquiry into the

topology of plasma membrane localized PIN auxin transport components. Mol Plant.

9(11):1504-1519

18. Łangowski Ł, Wabnik K, Li H, Vanneste S, Naramoto S, Tanaka H, Friml J. (2016): Cellular

mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells.

Cell Discov. 2:16018

19. Ugalde JM, Rodriguez-Furlán C, Rycke RD, Norambuena L, Friml J, León G, Tejos R. (2016):

Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole

morphology during Arabidopsis thaliana pollen development. Plant Sci. 250:10-9. Epub 2016 May

19.

20. Molnár G, Fendrych M, Friml J. (2016): Plasma membrane: Negative attraction. Nat Plants.

2(7):16102

21. Pernisova M, Prat T, Grones P, Harustiakova D, Matonohova M, Spichal L, Nodzynski T, Friml J,

Hejatko J. (2016): Cytokinins influence root gravitropism via differential regulation of auxin

transporter expression and localization in Arabidopsis. New Phytol. 212(2):497-509

22. Dejonghe W, Kuenen S, Mylle E, Vasileva M, Keech O, Viotti C, Swerts J, Fendrych M, Ortiz-

Morea FA, Mishev K, Delang S, Scholl S, Zarza X, Heilmann M, Kourelis J, Kasprowicz J, Nguyen

le SL, Drozdzecki A, Van Houtte I, Szatmári AM, Majda M, Baisa G, Bednarek SY, Robert S,

Audenaert D, Testerink C, Munnik T, Van Damme D, Heilmann I, Schumacher K, Winne J, Friml

J, Verstreken P, Russinova E. (2016): Mitochondrial uncouplers inhibit clathrin-mediated

endocytosis largely through cytoplasmic acidification. Nat Commun. 7:11710

23. Zemová, R., Zwiewka, M., Bielach, A., Robert, H.S., Friml, J. (2016): A Forward Genetic Screen

for New Regulators of Auxin-mediated Degradation of Auxin Transport Proteins in Arabidopsis

thaliana. Journal of Plant Growth Regulation 35 (2), 465-476

24. Simon S, Skůpa P, Viaene T, Zwiewka M, Tejos R, Klíma P, Čarná M, Rolčík J, De Rycke R,

Moreno I, Dobrev PI, Orellana A, Zažímalová E, Friml J. (2016): PIN6 auxin transporter at

endoplasmic reticulum and plasma membrane mediates auxin homeostasis and organogenesis in

Arabidopsis. New Phytol. 211(1):65-74

25. Sancho-Andrés G, Soriano-Ortega E, Gao C, Bernabé-Orts JM, Narasimhan M, Müller A, Tejos R,

Jiang L, Friml J, Aniento F, Marcote MJ. (2016): Sorting motifs involved in the trafficking and

localization of the PIN1 auxin efflux carrier. Plant Physiol. 171(3):1965-82.

26. Zhu J, Bailly AL, Zwiewka M, Sovero V, di Donato M, Ge P, Oehri J, Aryal B, Hao P, Linnert M,

Burgardt N, Lücke C, Weiwad M, Michel M, Weiergräber OH, Pollmann S, Azzarello E, Mancuso

S, Ferro N, Fukao Y, Hoffmann C, Wedlich-Söldner R, Friml J, Thomas C, Geisler M. (2016):

TWISTED DWARF1 mediates the action of auxin transport inhibitors on actin cytoskeleton

dynamics. Plant Cell. 28(4):930-48

27. Michalko J, Glanc M, Perrot-Rechenmann C, Friml J. (2016): Strong morphological defects in

conditional Arabidopsis abp1 knock-down mutants generated in absence of functional ABP1

protein. F1000Res. 5:86

28. Karampelias M, Neyt P, De Groeve S, Aesaert S, Coussens G, Rolčík J, Bruno L, De Winne N, Van

Minnebruggen A, Van Montagu M, Ponce MR, Micol JL, Friml J, De Jaeger G, Van Lijsebettens

M. (2016): ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of

auxin transporter recycling. Proc Natl Acad Sci U S A. 8;113(10):2768-73

29. Marhavý P, Montesinos JC, Abuzeineh A, Van Damme D, Vermeer JE, Duclercq J, Rakusová H,

Nováková P, Friml J, Geldner N, Benková E. (2016): Targeted cell elimination reveals an auxin-

guided biphasic mode of lateral root initiation. Genes Dev. 30(4):471-83

30. Michalko J, Dravecká M, Bollenbach T, Friml J. (2015): Embryo-lethal phenotypes in early abp1

mutants are due to disruption of the neighboring BSM gene. F1000Res. 4:1104. eCollection 2015.

31. Wang HZ, Yang KZ, Zou JJ, Zhu LL, Xie ZD, Morita MT, Tasaka M, Friml J, Grotewold E,

Beeckman T, Vanneste S, Sack F, Le J. (2015): Transcriptional regulation of PIN genes by FOUR

LIPS and MYB88 during Arabidopsis root gravitropism. Nat Commun. 6:8822

32. Chen Q, Liu Y, Maere S, Lee E, Van Isterdael G, Xie Z, Xuan W, Lucas J, Vassileva V, Kitakura S,

Marhavý P, Wabnik K, Geldner N, Benková E, Le J, Fukaki H, Grotewold E, Li C, Friml J, Sack F,

Beeckman T, Vanneste S. (2015): A coherent transcriptional feed-forward motif model for

mediating auxin-sensitive PIN3 expression during lateral root development. Nat Commun. 6:8821

33. Šimášková M, O'Brien JA, Khan M, Van Noorden G, Ötvös K, Vieten A, De Clercq I, Van Haperen

JM, Cuesta C, Hoyerová K, Vanneste S, Marhavý P, Wabnik K, Van Breusegem F, Nowack M,

Murphy A, Friml J, Weijers D, Beeckman T, Benková E. (2015): Cytokinin response factors

regulate PIN-FORMED auxin transporters. Nat Commun. 6:8717

34. Jia Y, Tian H, Li H, Yu Q, Wang L, Friml J, Ding Z. (2015): The Arabidopsis thaliana elongator

complex subunit 2 epigenetically affects root development. J Exp Bot. 66(15):4631-42. Epub 2015

May 21.

35. Grones P, Chen X, Simon S, Kaufmann WA, De Rycke R, Nodzyński T, Zažímalová E, Friml J.

(2015): Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental

roles. J Exp Bot. 66(16):5055-65. Epub 2015 Apr 28.

36. Zwiewka M, Nodzyński T, Robert S, Vanneste S, Friml J. (2015): Osmotic stress modulates the

balance between exocytosis and clathrin-mediated endocytosis in Arabidopsis thaliana. Mol Plant.

8(8):1175-87. Epub 2015 Mar 17

37. Perez Sancho J, Vanneste S, Lee E, McFarlane H, Esteban Del Valle A, Valpuesta V, Friml J,

Botella MA, Rosado A. (2015): The Arabidopsis SYT1 is enriched in ER-PM contact sites and

confers cellular resistance to mechanical stresses. Plant Physiol. 168(1):132-43. Epub 2015 Mar 19.

38. Sasse J, Simon S, Gübeli C, Liu GW, Cheng X, Friml J, Bouwmeester H, Martinoia E, Borghi L.

(2015): Asymmetric Localizations of the ABC Transporter PaPDR1 Trace Paths of Directional

Strigolactone Transport. Curr Biol. 25(5):647-55. Epub 2015 Feb 12

39. Doyle SM, Haeger A, Vain T, Rigal A, Viotti C, Łangowska M, Ma Q, Friml J, Raikhel NV, Hicks

GR, Robert S. (2015): An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is

essential for basal polarity establishment in Arabidopsis thaliana. Proc Natl Acad Sci U S A.

112(7):E806-15. Epub 2015 Feb 2.

40. Robert HS, Grunewald W, Sauer M, Cannoot B, Soriano M, Swarup R, Weijers D, Bennett M,

Boutilier K, Friml J. (2015): Plant embryogenesis requires AUX/LAX-mediated auxin influx.

Development 142(4):702-11. Epub 2015 Jan 23

41. Ivanchenko MG, Zhu J, Wang B, Medvecká E, Du Y, Azzarello E, Mancuso S, Megraw M,

Filichkin S, Dubrovsky JG, Friml J, Geisler M. (2015): The cyclophilin A DIAGEOTROPICA gene

affects auxin transport in both root and shoot to control lateral root formation. Development

142(4):712-21. Epub 2015 Jan 23

42. Hazak O, Obolski U, Prat T, Friml J, Hadany L, Yalovsky S.(2014): Bimodal regulation of ICR1

levels generates self-organizing auxin distribution. Proc Natl Acad Sci U S A. 111(50). Epub 2014

Dec 2

43. Viaene T, Landberg K, Thelander M, Medvecka E, Pederson E, Feraru E, Cooper ED, Karimi M,

Delwiche CF, Ljung K, Geisler M, Sundberg E, Friml J. (2014): Directional Auxin Transport

Mechanisms in Early Diverging Land Plants. Curr Biol. Nov 24(23):2786-2791. Epub 2014 Nov 13.

44. Chen X, Grandont L, Li H, Hauschild R, Paque S, Abuzeineh A, Rakusová H, Benkova E, Perrot-

Rechenmann C, Friml J. (2014): Inhibition of cell expansion by rapid ABP1-mediated auxin effect

on microtubules. Nature 516(7529):90-3. Epub 2014 Nov 17.

45. Sassi M, Ali O, Boudon F, Cloarec G, Abad U, Cellier C, Chen X, Gilles B, Milani P, Friml J,

Vernoux T, Godin C, Hamant O, Traas J. (2014): An Auxin-Mediated Shift toward Growth Isotropy

Promotes Organ Formation at the Shoot Meristem in Arabidopsis. Curr Biol. 24(19):2335-42

46. Naramoto S, Otegui MS, Kutsuna N, de Rycke R, Dainobu T, Karampelias M, Fujimoto M, Feraru

E, Miki D, Fukuda H, Nakano A, Friml J. (2014): Insights into the Localization and Function of the

Membrane Trafficking Regulator GNOM ARF-GEF at the Golgi Apparatus in Arabidopsis. Plant

Cell 26(7):3062-76.

47. Tejos R, Sauer M, Vanneste S, Palacios-Gomez M, Li H, Heilmann M, van Wijk R, Vermeer JE,

Heilmann I, Munnik T, Friml J. (2014): Bipolar Plasma Membrane Distribution of

Phosphoinositides and Their Requirement for Auxin-Mediated Cell Polarity and Patterning in

Arabidopsis. Plant Cell. 26(5):2114-2128.

48. Marhavý P, Duclercq J, Weller B, Feraru E, Bielach A, Offringa R, Friml J, Schwechheimer C,

Murphy A, Benková E. (2014): Cytokinin Controls Polarity of PIN1-Dependent Auxin Transport

during Lateral Root Organogenesis. Curr Biol. 24(9):1031-7.

49. Xu T, Dai N, Chen J, Nagawa S, Cao M, Li H, Zhou Z, Chen X, De Rycke R, Rakusová H, Wang

W, Jones AM, Friml J, Patterson SE, Bleecker AB, Yang Z. (2014): Cell surface ABP1-TMK

auxin-sensing complex activates ROP GTPase signaling. Science 343(6174):1025-8

50. Nováková P, Hirsch S, Feraru E, Tejos R, van Wijk R, Viaene T, Heilmann M, Lerche J, De Rycke

R, Feraru MI, Grones P, Van Montagu M, Heilmann I, Munnik T, Friml J. (2014): SAC

phosphoinositide phosphatases at the tonoplast mediate vacuolar function in Arabidopsis. Proc Natl

Acad Sci U S A. 111(7):2818-23.

51. Gadeyne A, Sánchez-Rodríguez C, Vanneste S, Di Rubbo S, Zauber H, Vanneste K, Van Leene J,

De Winne N, Eeckhout D, Persiau G, Van De Slijke E, Cannoot B, Vercruysse L, Mayers JR,

Adamowski M, Kania U, Ehrlich M, Schweighofer A, Ketelaar T, Maere S, Bednarek SY, Friml J,

Gevaert K, Witters E, Russinova E, Persson S, De Jaeger G, Van Damme D. (2014): The TPLATE

Adaptor Complex Drives Clathrin-Mediated Endocytosis in Plants. Cell. 156(4):691-704

52. Mazur E, Kurczyńska EU, Friml J. (2014): Cellular events during interfascicular cambium

ontogenesis in inflorescence stems of Arabidopsis. Protoplasma 251(5):1125-39. Epub 2014 Feb 14.

53. Le J, Liu XG, Yang KZ, Chen XL, Zou JJ, Wang HZ, Wang M, Vanneste S, Morita M, Tasaka M,

Ding ZJ, Friml J, Beeckman T, Sack F. (2014): Auxin transport and activity regulate stomatal

patterning and development. Nat Commun. 5:3090

54. Naramoto S, Nodzynski T, Dainobu T, Takatsuka H, Okada T, Friml J, Fukuda H. (2014): VAN4

Encodes a Putative TRS120 that Is Required for Normal Cell Growth and Vein Development in

Arabidopsis. Plant Cell Physiol. 55(4):750-63. Epub 2014 Jan 18.

55. Tanaka H, Nodzynski T, Kitakura S, Feraru MI, Sasabe M, Ishikawa T, Kleine-Vehn J, Kakimoto T,

Friml J. (2013): BEX1/ARF1A1C is required for BFA-sensitive recycling of PIN auxin transporters

and auxin-mediated development in Arabidopsis. Plant Cell Physiol. 55(4):737-49. Epub 2013 Dec

24.

56. Bailly A, Wang B, Zwiewka M, Pollmann S, Schenck D, Lüthen H, Schulz A, Friml J, Geisler M.

(2013): Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to

increased cell elongation and hypermorphic growth. Plant J. 77(1):108-18. Epub 2013 Dec 9.

57. Wabnik K, Robert HS, Smith RS, Friml J. (2013): Modeling Framework for the Establishment of

the Apical-Basal Embryonic Axis in Plants. Curr Biol. 23(24):2513-8. Epub 2013 Nov 27.

58. Robert HS, Grones P, Stepanova AN, Robles LM, Lokerse AS, Alonso JM, Weijers D, Friml J.

(2013): Local Auxin Sources Orient the Apical-Basal Axis in Arabidopsis Embryos. Curr Biol.

23(24):2506-12. Epub 2013 Nov 27

59. Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzi F. (2013): Inter-regulation of the

unfolded protein response and auxin signaling. Plant J. 77(1):97-107. Epub 2013 Dec 3.

60. Grunewald W, De Smet I, De Rybel B, Robert HS, van de Cotte B, Willemsen V, Gheysen G,

Weijers D, Friml J, Beeckman T. (2013): Tightly controlled WRKY23 expression mediates

Arabidopsis embryo development. EMBO Rep. 14(12):1136-42

61. Péret B, Middleton AM, French AP, Larrieu A, Bishopp A, Njo M, Wells DM, Porco S, Mellor N,

Band LR, Casimiro I, Kleine-Vehn J, Vanneste S, Sairanen I, Mallet R, Sandberg G, Ljung K,

Beeckman T, Benkova E, Friml J, Kramer E, King JR, De Smet I, Pridmore T, Owen M, Bennett

MJ. (2013): Sequential induction of auxin efflux and influx carriers regulates lateral root

emergence. Mol Syst Biol. 9:699.

62. Boutté Y, Jonsson K, McFarlane HE, Johnson E, Gendre D, Swarup R, Friml J, Samuels L, Robert

S, Bhalerao RP. (2013): ECHIDNA-mediated post-Golgi trafficking of auxin carriers for differential

cell elongation. Proc Natl Acad Sci U S A. 110(40):16259-64.

63. Bargmann BO, Vanneste S, Krouk G, Nawy T, Efroni I, Shani E, Choe G, Friml J, Bergmann DC,

Estelle M, Birnbaum KD. (2013): A map of cell type-specific auxin responses. Mol Syst Biol. 9:688.

64. Di Rubbo S, Irani NG, Kim SY, Xu ZY, Gadeyne A, Dejonghe W, Vanhoutte I, Persiau G, Eeckhout

D, Simon S, Song K, Kleine-Vehn J, Friml J, De Jaeger G, Van Damme D, Hwang I, Russinova E.

(2013): The Clathrin Adaptor Complex AP-2 Mediates Endocytosis of BRASSINOSTEROID

INSENSITIVE1 in Arabidopsis. Plant Cell. 25(8):2986-97

65. Kim SY, Xu ZY, Song K, Kim DH, Kang H, Reichardt I, Sohn EJ, Friml J, Juergens G, Hwang I.

(2013): Adaptor Protein Complex 2-Mediated Endocytosis Is Crucial for Male Reproductive Organ

Development in Arabidopsis. Plant Cell. 25(8):2970-85

66. Tian H, Wabnik K, Niu T, Li H, Yu Q, Pollmann S, Vanneste S, Govaerts W, Rolcík J, Geisler M,

Friml J, Ding Z. (2013): WOX5-IAA17 feedback circuit mediated cellular auxin response is crucial

for the patterning of root stem cell niches in Arabidopsis. Mol Plant. 7(2):277-89. Epub 2013 Aug

12.

67. Cazzonelli CI, Vanstraelen M, Simon S, Yin K, Carron-Arthur A, Nisar N, Tarle G, Cuttriss AJ,

Searle IR, Benkova E, Mathesius U, Masle J, Friml J, Pogson BJ. (2013): Role of the Arabidopsis

PIN6 Auxin Transporter in Auxin Homeostasis and Auxin-Mediated Development. PLoS One.

8(7):e70069

68. Simon S, Kubeš M, Baster P, Robert S, Dobrev PI, Friml J, Petrášek J, Zažímalová E. (2013):

Defining the selectivity of processes along the auxin response chain: a study using auxin analogues.

New Phytol. 200(4):1034-48. Epub 2013 Aug 5.

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B, and Benková

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technique for mRNA detection in whole mount Arabidopsis samples. Nat Protoc. 1(4):1939-46

154. Brewer P, Heisler

M, Hejátko

J, Friml J, and Benková

E. (2006): In situ hybridization for mRNA

detection in Arabidopsis tissue sections. Nat Protoc. 1(3):1462-7

155. Sauer M, Paciorek T, Benková E, and Friml J. (2006): Immunocytochemical techniques for whole

mount in situ protein localization in plants. Nat Protoc. 1(1):98-103

156. Dhonukshe P, Aniento F, Hwang I, Robinson D, Mravec J, Stierhof Y-D, and Friml J. (2007):

Clathrin-mediated constitutive endocytosis of PIN auxin efflux carriers in Arabidopsis. Curr Biol.

17(6):520-7

157. Blakeslee J, Bandyopadhyay A, Lee O-K, Mravec J, Boosaree Titapiwatanakun B, Sauer M, Makam

S, Cheng Y, Bouchard R, Adamec J, Geisler M, Nagashima A; Sakai T, Martinoia E, Friml J, Peer

W , and Murphy A. (2007): Interactions among PIN-FORMED and P-Glycoprotein Auxin

Transporters in Arabidopsis. Plant Cell. 19(1):131-47

158. Kleine-Vehn J, Dhonukshe P, Swarup R, Bennett M, Friml J. (2006): Subcellular trafficking of the

Arabidopsis auxin influx carrier AUX1 uses a novel pathway distinct from PIN1. Plant Cell.

18(11):3171-81

159. Sauer M, Balla J, Luschnig C, Wiśniewska J, Reinöhl V, Friml J, Benková E. (2006): Canalization

of auxin flow by Aux/IAA-ARF-dependent feed-back regulation of PIN polarity. Genes Dev.

20(20):2902-11

160. Scarpella E, Marcos D, Friml J and Berleth T. (2006): Control of leaf vascular patterning by polar

auxin transport. Genes Dev. 20(8):1015-27

161. Wiśniewska J, Xu J, Seifertová

D, Brewer P, Růžička K, Blilou

I, Roquie

D, Benková

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Friml J. (2006): Polar PIN localization directs auxin flow in plants. Science. 312(5775):883

162. Petrášek J, Mravec J, Bouchard R, Blakeslee J, Abas M, Seifertová D, Wiśniewska J, Tadele Z,

Čovanová M, Dhonukshe P, Skůpa P, Benková E, Perry L, Křeček P, Lee O. R, Fink G, Geisler M,

Murphy A, Luschnig C, Zažímalová E, Friml J. (2006): PIN proteins perform a rate-limiting

function in cellular auxin efflux. Science. 312(5775):914-8

163. Paciorek T, Sauer M, Balla J, Wiśniewska J, and Friml J. (2006): Immunocytochemical technique

for protein localization in sections of plant tissues. Nat Protoc. 1(1):104-7

164. Abas L, Benjamins

R, Malenica

N, Paciorek

T, Wisniewska

J, Moulinier-Anzola

J.C, Sieberer

T,

Friml J, Luschnig C. (2006): Intracellular trafficking and proteolysis of the auxin efflux facilitator

PIN2 in Arabidopsis is proteasome-dependent and involved in root gravitropism. Nat Cell Biol.

8(3):249-56

165. Xu J, Hofhuis H, Heidstra R, Sauer M, Friml J, Scheres B. (2006): A molecular framework for root

regeneration. Science. 20;311(5759):385-8

166. Dhonukshe P, Baluska F, Schlicht M, Hlavacka A, Samaj J, Friml J, Gadella TW Jr. (2006):

Endocytosis of Cell Surface Material Mediates Cell Plate Formation during Plant Cytokinesis. Dev

Cell. 10(1):137-50

167. Vieten A, Vanneste S, Wiśniewska J, Benková E, Benjamins E, Beeckman E, Luschnig C, Friml J.

(2005): Functional redundancy of PIN proteins is accompanied by auxin-dependent cross-regulation

of PIN expression. Development. 132(20):4521-31

168. Weijers D, Sauer M, Meurette O, Friml J, Ljung K, Sandberg G, Hooykaas P, Offringa R. (2005):

Maintenance of Embryonic Auxin Distribution for Apical-Basal Patterning by PIN-FORMED-

Dependent Auxin Transport in Arabidopsis. Plant Cell. 17(9):2517-26

169. Blilou I, Xu J, Wildwater M, Willemsen V, Paponov I, Friml J, Heidstra R, Aida M, Palme K and

Scheres B. (2005) The PIN auxin efflux facilitator network controls growth and patterning in

Arabidopsis roots, Nature 433, 39-44.

170. Paciorek T, Zažímalová

E, Ruthardt

N, Petrášek

J, Stierhof

Y-D, Kleine-Vehn J, Morris

DA, Emans

N, Jürgens G, Geldner

N, and Friml J. (2005): Auxin inhibits endocytosis and promotes its own

efflux from cells. Nature. 435(7046):1251-6

171. Sauer M and Friml J. (2004): In vitro Culture of Arabidopsis Embryos within their Ovules. Plant J.

40(5):835-43

172. Duroux M, Houben

A, Růžička

K, Friml J, and Grasser

K. (2004): The chromatin-remodelling

complex FACT associates with actively transcribed regions of the Arabidopsis genome. Plant J.

40(5):660-71

173. Friml J, Yang X, Michniewicz M, Weijers D, Quint A, Tietz O, Benjamins R, Ljung K, Sandberg

G, Hooykaas P, Palme K and Offringa R. (2004): A PINOID-dependent binary switch in apical-

basal PIN polar targeting directs auxin efflux. Science. 306(5697):862-5

174. Benková E, Michniewicz M, Sauer M, Teichmann T, Seifertová D, Jürgens G and Friml J. (2003):

Local, efflux-dependent auxin gradients as a common module for plant organ formation. Cell.

115(5):591-602

175. Reinhardt D, Pesce E, Stieger P, Mandel T, Baltensperger K, Bennett M, Traas J, Friml J and

Kuhlemeier C. (2003): Regulation of phyllotaxis by polar auxin transport. Nature. 426(6964):255-

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176. Friml J, Vieten A, Sauer M, Weijers D, Schwarz H, Hamann T, Offringa R and Jürgens G. (2003):

Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis. Nature.

426(6963):147-53

177. Friml J, Benkova E, Mayer U, Palme K, and Muster G. (2003): Automated whole-mount

localisation techniques for plants. Plant J. 34(1):115-24.

178. Willemsen V, Friml J, Grebe M, van den Toorn A, Palme K, and Scheres B. (2003): Cell polarity

and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function.

Plant Cell. 15(3):612-25

179. Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, and Lindsey K. (2002):

hydra mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signalling.

Plant Cell. 14(5):1017-31

180. Friml J, Benková E, Blilou I, Wisniewska J, Hamann T, Ljung K, Woody S, Sandberg G, Scheres

B, Jürgens G, and Palme K. (2002): AtPIN4 mediates sink driven auxin gradients and patterning in

Arabidopsis roots. Cell. 108(5):661-73

181. Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett M, and Scheres B.

(2002): Cell Polarity Signaling in Arabidopsis Involves a BFA-Sensitive Auxin Influx Pathway. Curr Biol. 12(4):329-34

182. Friml J, Wisniewska J, Benková E, Mendgen K, and Palme K. (2002): Lateral relocation of auxin

efflux regulator AtPIN3 mediates tropism in Arabidopsis. Nature. 415(6873):806-9

183. Swarup R and Friml J, Marchant A, Ljung K, Sandberg G, Palme K, and Bennett M. (2001):

Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport

pathways operate in the Arabidopsis root apex. Genes Dev. 15(20):2648-53

184. Geldner N and Friml J, Stierhof Y-D, Jürgens G, and Palme K. (2001): Polar auxin transport

inhibitors block PIN1 cycling and vesicle trafficking. Nature. 413(6854):425-8

185. Gil P, Dewey E, Friml J, Zhao Y, Snowden KC, Putterill J, Palme K, Estelle M, and Chory J.

(2001): BIG: a calossin-like protein required for polar auxin transport in Arabidopsis. Genes Dev.

15(15):1985-97

186. Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, and Palme K. (2001):

Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth.

EMBO J. 20(11):2779-88

187. Trnková L, Friml J, and Dracka O. (2001): Elimination voltammetry of adenine and cytosine

mixtures. Bioelectrochemistry. 54(2):131-6

Review articles and book chapters

188. Mazur E, Friml J (2017): Vascular Tissue Development and Regeneration in the Model Plant

Arabidopsis, Intech, Nov 17 (Book chapter "Plant Engineering", book edited by Snježana Jurić,

ISBN 978-953-51-3608-8)

189. Chen X, Wu S, Liu Z, Friml J. (2016): Environmental and Endogenous Control of Cortical

Microtubule Orientation. Trends Cell Biol. 26(6):409-19

190. Himschoot E, Beeckman T, Friml J, Vanneste S. (2015): Calcium is an organizer of cell polarity in

plants. Biochim Biophys Acta. 1853(9):2168-72. Epub 2015 Feb 25.

191. Grones P, Friml J. (2015): ABP1: Finally Docking. Mol Plant. 8(3):356-8. Epub 2015 Jan 13

192. Adamowski M, Friml J. (2015): PIN-Dependent Auxin Transport: Action, Regulation, and

Evolution. Plant Cell. 27(1):20-32. Epub 2015 Jan 20

193. Grones P, Friml J. (2015): Auxin transporters and binding proteins at a glance. J Cell Sci. 1;128(1).

194. Rakusová H, Fendrych M, Friml J. (2014): Intracellular trafficking and PIN-mediated cell polarity

during tropic responses in plants. Curr Opin Plant Biol. 23:116-23. Epub 2014 Dec 29.

195. Chen X, Friml J. (2014): Rho-GTPase-regulated vesicle trafficking in plant cell polarity. Biochem

Soc Trans. 42(1):212-8

196. Kania U, Fendrych M, Friml J. (2014): Polar delivery in plants; commonalities and differences to

animal epithelial cells. Open Biol. 4(4):140017

197. Sauer M, Friml J. (2014): Plant biology: gatekeepers of the road to protein perdition. Curr Biol.

24(1):R27-9.

198. Simon S, Skůpa P, Dobrev PI, Petrášek J, Zažímalová E, Friml J. (2014): Analyzing the In Vivo

Status of Exogenously Applied Auxins: A HPLC-Based Method to Characterize the Intracellularly

Localized Auxin Transporters. Springer, Methods Mol Biol. 1056:255-64

199. Vanneste S, Friml J. (2013): Calcium: The Missing Link in Auxin Action. Plants. 2(4):650-675

200. Viaene T, Delwiche CF, Rensing SA, Friml J. (2013): Origin and evolution of PIN auxin

transporters in the green lineage. Trends Plant Sci. 18(1):5-10

201. Tejos R and Friml J (2012): Cell Polarity and Endocytosis. Springer

202. Nodzynski T, Vanneste S, Friml J. (2012): Endocytic Trafficking on PIN Proteins and Auxin

Transport. Springer

203. Beeckman T, Friml J. (2012): Plant biologists meet on stairways in Matera. Development.

139(20):3677-82

204. Li H, Friml J, Grunewald W. (2012): Cell polarity: stretching prevents developmental cramps. Curr

Biol. 22(16):R635-7

205. Zwiewka M, Friml J (2012): Fluorescence imaging-based forward genetic screens to identify

trafficking regulators in plants. Front Plant Sci. 3:97

206. Vanneste S, Friml J. (2012): Plant signaling: Deconstructing auxin sensing. Nat Chem Biol.

8(5):415-6

207. Dettmer J, Friml J. (2011): Cell polarity in plants: when two do the same, it is not the same.... Curr

Opin Cell Biol. 23(6):686-96

208. Chen X, Irani NG, Friml J. (2011): Clathrin-mediated endocytosis: the gateway into plant cells.

Curr Opin Plant Biol. 14(6):674-82

209. Wabnik K, Govaerts W, Friml J, Kleine-Vehn J.(2011): Feedback models for polarized auxin

transport: an emerging trend. Mol Biosyst. 7(8):2352-9

210. Sauer M, Friml J. (2011): Fleeting hormone cues get stabilized for plant organogenesis. Mol Syst

Biol. 7:507

211. Friml J, Jones AR. (2010): Endoplasmic reticulum: the rising compartment in auxin biology. Plant

Physiol. 154(2):458-62

212. Beeckman T and Friml J (2010): Nitrate Contra Auxin: Nutrient Sensing by Roots. Dev Cell.

18(6):877-8

213. Grunewald W, Friml J. (2010): The march of the PINs: developmental plasticity by dynamic polar

targeting in plant cells. EMBO J. 29(16):2700-14

214. Sauer M, Friml J. (2010): Immunolocalization of proteins in plants. Methods Mol Biol. 655:253-63

215. Křeček P, Skůpa P, Libus J, Naramoto S, Tejos R, Friml J, Zažímalová E. (2009): The PIN-

FORMED (PIN) protein family of auxin transporters. Genome Biol. 10(12):249

216. Schumacher K, Friml J. (2009): Cell biology. Curr Opin Plant Biol. 12(6):651-2

217. Friml J. (2010): Subcellular trafficking of PIN auxin efflux carriers in auxin transport. Eur J Cell

Biol. 89(2-3):231-5

218. Petrasek J, Friml J. (2009): Auxin transport routes in plant development. Development.

136(16):2675-88

219. Robert HS, Friml J. (2009): Auxin and other signals on the move in plants. Nat Chem Biol.

5(5):325-32

220. Weijers D, Friml J. (2009): SnapShot: Auxin Signaling and Transport. Cell. 136(6):1172, 1172.e1

221. Vanneste S, Friml J. (2009): Auxin: Trigger of Change in Plant Development. Cell. 136(6):1005-16

222. Benková E, Ivanchenko MG, Friml J, Shishkova S, Dubrovsky JG. (2009): A morphogenetic

trigger: is there an emerging concept in plant developmental biology? Trends Plant Sci. 14(4):189-

93

223. Kleine-Vehn J, Friml J. (2008): Polar targeting and endocytic recycling in auxin-dependent plant

development. Annu Rev Cell Dev Biol. 24:447-73

224. Feraru E, Friml J. (2008): PIN Polar Targeting. Plant Physiol. 147(4):1553-9

225. Friml J, Sauer M. (2008): Plant biology: in their neighbour's shadow. Nature. 453(7193):298-9

226. Sauer M, Friml J. (2008): Visualization of auxin gradients in embryogenesis. Methods Mol Biol.

427:137-44

227. Sauer M, Friml J. (2008): In vitro culture of Arabidopsis embryos. Methods Mol Biol. 427:71-6

228. Michniewicz M, Brewer P, Friml J. (2007): Polar Auxin Transport and Asymmetric Auxin

Distribution, in The Arabidopsis Book, American Society of Plant Biologists.

229. Bandyopadhyay A, Blakeslee J, Lee O, Mravec J, Sauer M, Titapiwatanakun B, Makam S, Bouchard

R, Geisler M, Martinoia E, Friml J, Peer W, Murphy A. (2007): Interactions of PIN and PGP auxin

transport mechanisms. Biochem Soc Trans. 35(Pt 1):137-41

230. Dhonukshe P, Samaj J, Baluska F, Friml J. (2007): A unifying new model of cytokinesis for the

dividing plant and animal cells. Bioessays. 29(4):371-81

231. Friml J (2007) Auxin – univerzální vývojový signál v životě rostlin, Ziva 1, 65-68.

232. Vieten A, Sauer M, Brewer P.B, Friml J. (2007): Molecular and cellular aspects of auxin transport-

mediated development. Trends Plant Sci. 12(4):160-8

233. Tanaka H, Dhonukshe P and Friml J. (2006): Spatio-temporal asymmetric auxin distribution:

Means to coordinate plant development. Cell Mol Life Sci. 63(23):2738-54

234. Paciorek T and Friml J. (2006): Auxin signalling. J Cell Sci. 119(Pt 7):1199-202

235. Sauer M and Friml J. (2005): In vitro culture of Arabidopsis embryos in "Somatic embryogenesis:

new approaches", Springer.

236. Friml J, Benfey P, Benková E, Bennett M, Berleth T, Geldner N, Grebe M, Jürgens G, Laux T,

Lindsey K, Lukowitz W, Luschnig C, Offringa R, Scheres B, Swarup R, Torres Ruiz R, Weijers D,

Zažímalová E. (2005): Apical/basal polarity: Why plant cells do not stand on their heads. Trends

Plant Sci. 11(1):12-4

237. Dhonukshe P, Kleine-Vehn J and Friml J. (2005): Cell polarity, auxin transport and cytoskeleton

mediated division planes: who comes first? Protoplasma. 226(1-2):67-73

238. Dubová J, Hejátko, J, Friml J. (2005) Reproduction, Plants. In: Meyers R.A. (Ed.): Encyclopedia of

Molecular Cell Biology and Molecular Medicine, Vol. 12, 2nd. Ed., Wiley - VCH Verlag GmbH &

Co, KGaA Weinheim, s. 249 - 295. ISBN-13: 978-3-527-30649-7, ISBN-10: 3-527-30649-8.

239. Friml J and Wisniewska J. (2005) Auxin as an Intercellular Signal. In: Fleming A. (Ed.):

Intercellular Communication in Plants, Blackwell Publishing, s. 1 - 26. ISBN: 1405120681

240. Morris D, Friml J, Zažímalová E. (2004) The Transport of Auxins. In: Davies P.J. (Ed.): Plant

Hormones: Biosynthesis, Signal Transduction, Action, Kluwer Academic Publishers. s. 437 - 470,

ISBN: 1-4020-2685-4. (Textbook)

241. Sauer M and Friml J. (2004) The Matryoshka Dolls of Plant Polarity, Development 131, 5774-5.

242. Friml J. (2003): Auxin transport - shaping the plant. Curr Opin Plant Biol. 6(1):7-12

243. Friml J and Palme K. (2002): Polar auxin transport - old questions and new concepts? Plant Mol

Biol. 49(3-4):273-84