1471-2466-12-13-3
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Timeline Questionnai re & physical exam Serum Dust sample Blood RNA Blood DNA Stool Meconiun & Stool Mother n = 326 n = 326 n = 200 Newborns n = 326 n = 326** n = 71** n = 90 Child (3-6 months) n = 286* n = 78 n = 272‡ n = 245 n = 45 Child (12 months) n = 280 n = 205 n = 9 n = 272 n = 178 n = 57 Child (24 months) n = 274 n = 169 n = 82 n = 153 n = 51 Measurement s & Analyses Demographic s, exposures & clinical outcomes * (x2) sIgE, IgA IgG levels **from Allergen s & endotoxi n levels ‡House floors (n = 232) Gene expressi on Genotypin g & re-seq Parasite analysis & Kato Katz Molecula r analysis of gut microflo ra
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TimelineQuestionnaire
& physical exam
SerumDust
sampleBlood RNA
Blood DNA Stool Meconiun
&Stool
Mother n = 326 n = 326 n = 200
Newborns n = 326 n = 326** n = 71** n = 90
Child (3-6 months)
n = 286* n = 78 n = 272‡ n = 245 n = 45
Child(12 months)
n = 280 n = 205 n = 9 n = 272 n = 178 n = 57
Child (24 months)
n = 274 n = 169 n = 82 n = 153 n = 51
Measurements & Analyses
Demographics,exposures &
clinical outcomes
* (x2) validation of lifestyle +
follow-up
sIgE, IgA IgG
levels
**from cord blood
Allergens & endotoxin
levels
‡House floors
(n = 232)child’s bed(n = 347)
Gene expression
**from cord blood
Genotyping& re-seq
Parasite analysis & Kato Katz
Molecular analysis of
gutmicroflora
