13 Listed Carcinogens - University of California, Berkeley · 2017-04-03 · 13 Listed Carcinogens...
11
13 Listed Carcinogens Chemical Class Standard Operating Procedure Rev. Date: 2017-03-28 13 Listed Carcinogens Note: Due to the unique Cal/OSHA regulations in Title 8 §5209 that apply to these 13 listed carcinogens (signage, PPE, handling, disposal), any new user must be trained by an EH&S representative or a qualified designee before starting any work. This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: Thursday, March 23, 2017 Date SOP was approved by PI/lab supervisor: Friday, March 24, 2017 Principal Investigator: Name: F. Fischer Signature: ______________________________ Internal Lab Safety Coordinator or Lab Manager: Name: Stephen von Kugelgen Lab Phone: 510.301.1058 Office Phone: 510.642.8252 Emergency Contact: Name: Stephen von Kugelgen Phone Number: 510.301.1058 Location(s) covered by this SOP: Tan Hall 674, 675, 676, 679, 680, 683, 684 1. Purpose This SOP covers the precautions and safe handling procedures for the use of 13 Listed Carcinogens. For a list of 13 Listed Carcinogens covered by this SOP and their use(s), see the “List of Chemicals”. Procedures described in Section 13 apply to all materials covered in this SOP. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected]. 2. Definition of Chemical Group The term “listed carcinogen” refers to a specific list of 13 chemicals regulated by Cal/OSHA. These chemicals have specific use and handling requirements. All handling or use of the 13 “Listed”
Transcript of 13 Listed Carcinogens - University of California, Berkeley · 2017-04-03 · 13 Listed Carcinogens...
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
13ListedCarcinogens
Note:DuetotheuniqueCal/OSHAregulationsinTitle8§5209 thatapplytothese13listedcarcinogens
(signage,PPE,handling,disposal),anynewusermustbetrainedbyanEH&Srepresentativeoraqualifieddesigneebeforestartinganywork.
ThisSOPisnotasubstituteforhands-ontraining.
PrintacopyandinsertintoyourlaboratorySOPbinder.
Department: Chemistry
DateSOPwaswritten: Thursday,March23,2017
DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017
PrincipalInvestigator:Name:F.Fischer
Signature:______________________________
InternalLabSafetyCoordinatororLabManager:
Name:StephenvonKugelgen
LabPhone:510.301.1058
OfficePhone:510.642.8252
EmergencyContact:Name:StephenvonKugelgen
PhoneNumber:510.301.1058
Location(s)coveredbythisSOP: TanHall674,675,676,679,680,683,684
1. Purpose
ThisSOPcoverstheprecautionsandsafehandlingproceduresfortheuseof13ListedCarcinogens.
Foralistof13ListedCarcinogenscoveredbythisSOPandtheiruse(s),seethe“ListofChemicals”.ProceduresdescribedinSection13applytoallmaterialscoveredinthisSOP.
Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.
2. DefinitionofChemicalGroup
Theterm“listedcarcinogen”referstoaspecificlistof13chemicalsregulatedbyCal/OSHA.Thesechemicalshavespecificuseandhandlingrequirements.Allhandlingoruseofthe13“Listed”
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
carcinogensbelowrequiresevaluationbyEH&SandreportingtoCal/OSHA,evenifworkiscontainedwithinalaboratoryfumehood.
1. 2-Acetylaminofluorene
2. 4-Aminodiphenyl
3. Benzidine(anditssalts)
4. 3,3'-Dichlorobenzidine(anditssalts)
5. 4-Dimethylaminoazobenzene
6. alpha-Naphthylamine
7. beta-Naphthylamine
8. 4-Nitrobiphenyl
9. N-Nitrosodimethylamine
10. beta-Propiolactone11. bis-Chloromethylether
12. Methylchloromethylether
13. Ethyleneimine
3. PotentialHazards/Toxicity
Thetermcarcinogendenotesasubstanceoramixturewhichinducescancerorincreasesitsincidence.The13ListedCarcinogensarechemicalsthatcausecancerortumordevelopment,typicallyafterrepeatedorchronicexposure.Theireffectsmayonlybecomeevidentafteralonglatencyperiodandmaycausenoimmediateharmfuleffects.
TheGloballyHarmonizedSystemofClassificationandLabelingofChemicals(GHS)designatescarcinogenicsubstancesbyoneormoreofthefollowingHcodes:
H350Maycausecancer
H351Suspectedofcausingcancer
Carcinogensmayalsohaveotherhazardouspropertiesinadditioncarcinogenicity.Safeuserequiresassessingallpotentialhazards.ItisthePrincipal Investigator’s responsibility toensureactivity-specific laboratoryproceduresand/orprocessesaretakenintoaccountwhenusingthisChemicalClassSOP.Please,reviewtheSDSofanychemicalbeforeuse(seeSection12–SDSLocation).
4. PriortoBeginningWork
• Allhandlingoruseofthe13ListedCarcinogensrequiresevaluationbyEH&SandreportingtoCal/OSHA.ContactEH&[email protected].
• Researchersmusthavehands-ontrainingbyaknowledgeabledesignee.Worktechniquemustbeobservedandindependenthandlingofcarcinogenslimitedtoresearchersthathavedemonstratedcompetency.
• Researchersmustbeawareofthesafehandlingofthechemical,itsphysicalproperties(includingsolubility),andhealtheffectsseeninexperimentalstudiesandotherapplicablesources.
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
• Addmaterialtothechemicalinventory,andmaintainanaccurateinventoryofthematerialatalltimes.
5. EngineeringControls
Usetheengineeringcontrolslistedbelowunlessotherlab-specificinformationisincludedinSection13-Protocol/Procedure.
• Workwiththe13ListedCarcinogensmustbeconductedinafumehoodunlessothercontrolsaredesignatedinthelab-specificProtocol/Proceduresection.Sashheightmustbekeptlowtoavoidescapingfumesandprovideaphysicalbarrier.Theremustbeadesignatedareaforworkingwiththese13listedcarcinogens.Thisareamustbeappropriatelylabeled.
• Laboratoriesandroomswhereany13listedcarcinogensareusedmusthavegeneralroomventilationthatisnegativepressurewithrespecttothecorridorsandexternalenvironment.Thelaboratory/roomdoormustbekeptclosedatalltimes.
6. PersonalProtectiveEquipment
Ataminimum,thefollowingPPEmustbewornatalltimes.
EyeandFaceProtection
A. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.
• Ordinary prescription glasses will NOT provide adequate protection unless they alsomeetANSIstandardandhavecompliantsideshields.
B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.
SkinandBodyProtection
A. Glovesarerequiredwhenhandlinghazardouschemicals.
• RefertospecificchemicalSDSforinformationongloveselection.
• Foradditionalinformationongloveselection,goto:
http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.html
B. Labcoatsarerequiredwhenhandlinghazardouschemicalsinthelab.Selectthetypeoflabcoataccordingtothehazardsatthespecificworkplace.
C. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.
RespiratoryProtection
RespiratoryprotectionisnormallynotrequiredforUCBerkeleylaboratoryactivities.Anylabpersonnelconsideringtheuseofarespirator(e.g.N-95respirator,dustmask)mustcontactEH&Sforaworkplaceassessment.
7. FirstAidProceduresandMedicalEmergencies
Intheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.
GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
Call911(fromacellphone:510-642-3333)if:
• itisalifethreateningemergency;or
• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or
• thecontaminated/injuredpersonisnotbreathingorisunconscious.
Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.IncaseofskincontactIfskincontactoccurs,and/orskinorclothingareonfire,immediatelydrenchinthesafetyshowerwithcopiousamountsofwaterfornolessthan15minutestoremoveanyremainingcontaminants.Ifpossibletodosowithoutfurtherinjury,removeanyremainingjewelryorclothing.
IncaseofeyecontactRinsethoroughlywithplentyofwaterusinganeyewashstationforatleast15minutes,occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.IfswallowedDoNOTinducevomitingunlessdirectedotherwisebytheSDS.Nevergiveanythingbymouthtoanunconsciousperson.Rinsemouthwithwater.IfinhaledMoveintofreshair.Needlestick/punctureexposureWashtheaffectedareawithantisepticsoapandwarmwaterfor15minutes.
8. SpecialHandling,StorageandDisposalRequirements
Lab-specificinformationonhandlingandstoragemaybeincludedintheProtocol/Proceduresection.Ifhandlingoneofthe13ListedCarcinogens,thefollowingcontrolsapplyper8CCR5209(c)(6).
RegulatedWorkAreas
Aregulatedareacanbetheentirelaboratoryoralaboratoryhood,butmustindicateaworkareaoflimitedaccesswherespecialprocedures,knowledge,andworkskillsarerequired.Regulatedareasmustbeclearlymarkedwithsignsthatidentifythechemicalhazardandincludeanappropriatewarning:
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
PrecautionsforSafeHandling
• Eliminateorsubstituteforalesshazardousmaterialwhenpossible.• Designyourexperimenttousetheleastamountofmaterialpossibletoachievethedesired
result.• DonotexceedthescaleofproceduresspecifiedinProtocol/Proceduresectionwithoutapproval
ofthePI.• Chemicalsmustbeclearlylabeledwiththechemical’snameandhazards.• Knowthelocationofthenearesteyewash,safetyshowerandfireextinguisherbeforebeginning
work.• Laboratoryworksurfacesonwhichacarcinogenishandledmustbeprotectedfrom
contamination.Lineworksurfacewithabsorbent,removablematerial.Providesecondarycontainmentforchemicals.
• Aswithanylaboratorychemical,donotmouthpipettesolutions.• Usecontainmentdevices(suchaslabfumehoodsorgloveboxes)whenopenhandlingis
required.Ensureyourlaboratoryfumehoodisfunctioningproperly.• Forliquidtransfer,thereagentcanbedispensedusingasyringe.• Useplasticsyringesonlyonce;therubbergasketofaplasticsyringemayswellupleadingtoa
jammedsyringe.• Useventilatedcontainmenttoweighoutsolidchemicals.Alternatively,thetaremethodcanbe
usedtopreventinhalationofthechemical.Whileworkinginalaboratoryfumehood,thechemicalisaddedtoapre-weighedcontainer.Thecontaineristhensealedandcanbere-weighedoutsideofthefumehood.Ifchemicalneedstobeaddedorremoved,thismanipulationiscarriedoutinthefumehood.Inthismanner,allopenchemicalhandlingisconductedinthelaboratoryfumehood.
• Fumehoodmustbecheckedeverysix(6)months(callEH&Sat642-3073ifyourfumehoodindicatedmorethansix(6)monthshavepassedsincethelastcheck).
• Whenhandlingoneofthe13ListedCarcinogens,dailychangeofpersonalprotectiveequipmentisrequired:researchersarerequiredtoremoveandleaveprotectiveclothingandequipmentatthepointofexitfromthedesignatedworkareaand,atthelastexitoftheday,toplaceusedclothingandequipmentinimperviouscontainersfordecontaminationordisposal.Labcoatstobelaunderedmustbeplacedinaclearlylabelled,sealedplasticbag(seeSection11.HazardousWasteDisposalandLabCoatlaundering).Contaminatedequipment(gloves,wipes,disposablesyringes,etc)mustbethoroughlyrinsed,placedinsealedplasticbaganddisposedofintheregularsolidwastebin.
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
• Usehighefficiencyparticulateair(HEPA)filters,carbonfilters,orscrubbersystemswithcontainmentdevicestoprotecteffluentandvacuumlines,pumps,andtheenvironment.
• Researchersarerequiredtowashhands,forearms,faceandneckuponeachexitfromthedesignatedcarcinogenworkarea.Theuseofwetwipes(likebabywipes)isacceptableforfaceandneckwash.
ConditionsforSafeStorage
• Storecarcinogensinclosed,labeled,andchemicallycompatiblecontainersandawayfromheat,flame,andotherreactivechemicalsthatmaydispersethecarcinogenifmixedduringanaccidentalrelease.
• Alwaysplacelarge-volumecontainersonalow,protectedshelforinanotherlocationwheretheywillnotbeaccidentallyspilledorknockedover.
• 13ListedCarcinogensmustbestoredinadesignatedarea.Thelabel“carcinogen”mustbeclearlyindicatedonthecontainerorshelf.
• Storenonflammablecarcinogenswithinsecondarycontainment.• Chemicalsthatrequirerefrigerationmustbestoredappropriately.• Storeflammablecarcinogenswithinflammablestoragecabinetandsecondarycontainer.
Disposal
● Wastematerialsgeneratedmustbetreatedasahazardouswaste.● TheemptycontainermustberinsedthreetimeswithaCOMPATIBLEsolvent;leaveitopen
inthebackofthehoodovernight.Solventrinsesandwaterrinsemustbedisposedofashazardouswaste.
● Asanalternative,unrinsedemptycontainerscanbedisposedofthroughEH&Sashazardouswaste.Theunrinsedemptycontainersmustbecapped.
● Donotmixwithincompatiblewastestreams.● Decontaminationoftheemptycontainerinordertouseitforotherpurposesisnot
permitted.
9. ChemicalSpill
Spill–Assesstheextentofdanger;ifnecessaryrequesthelpbycalling911(fromacellphone:510-642-3333)foremergencyassistanceor510-642-3073fornon-lifethreateningsituations.Ifyoucannotassesstheconditionsoftheenvironmentwellenoughtobesureofyourownsafety,donotenterthearea.Ifpossiblehelpcontaminatedorinjuredpersons.Evacuatethespillarea.Avoidbreathingvaporsfromspill.Ifpossible,confinethespilltoasmallareausingaspillkitorabsorbentmaterial.Keepothersfromenteringcontaminatedarea(e.g.,usecautiontape,barriers,etc.).
• MinorSpill–Intheeventofaminorspill,ifthereisnopotentialforhazardouschemicalexposure,reportthespillto510-642-3073andifyouaretrained,proceedtocleanit.Useappropriatepersonalprotectiveequipmentandclean-upmaterialforchemicalspilled.Doublebagspillwasteinclearplasticbags,labelandrequestpick-up.
• MajorSpill–Anyhazardouschemicalspillthatinvolveschemicalexposure,anychemicalspillthatduetosizeand/orhazardrequirescapabilitiesbeyondyourtraining,oranychemicalspillthatgivestheperception(becauseofodor,forexample)thattherehasbeenahazardousrelease.Call911or510-642-3073forassistance.
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
10. CleaningandDecontamination
Lab-specificinformationondecontaminationmaybeincludedintheProtocol/Proceduresection.
• WearingproperPPE,laboratoryworksurfacesmustbecleanedattheconclusionofeachprocedureandattheendofeachworkday.
• Uponleavingthedesignatedworkarea,removeanypersonalprotectiveequipmentwornandwashhands,forearms,faceandneck.
• Attheendofeachproject,thoroughlydecontaminatethedesignatedareabeforeresumingnormallaboratoryworkintheareaandremovingcarcinogenwarningsigns.
11. HazardousWasteDisposalandLabCoatlaundering
CarcinogenWasteDisposal
• Disposableglovesslightlycontaminatedwithchemicalsmustbethoroughlyrinsedbeforebeingdiscardedintheregulartrash.
• Forheavilycontaminatedequipment(gloves,wipes,disposablesyringes,etc),placeinachemically-compatibleimperviouscontainer(i.e.sealableplasticbag,containerwithtwistonlid)andlabelclearly.Decontaminateoutsideofcontainerpriortoremovalfromtheworkarea;storewithinafumehooduntilpickupbyEH&S.
• Whenfeasible,carcinogensmustbeinactivatedpriortodisposal.• Disposeofregularlygeneratedchemicalwastewithin6months.• ContactEH&Sat642-3073ifyouneedassistance.
LabelWaste
• Label all waste containers. See the EH&S Fact Sheet, “Hazardous Waste Management” forgeneralinstructionsonproceduresfordisposingofhazardouswaste.
LabCoatLaundering
• Whenhandlingoneofthe13ListedCarcinogens,launderinglabcoatatthelastexitofthedayisrequired.Belowisanexampleoflabelthatcanbeused.
12. SafetyDataSheet(SDS)LocationSDScanbeaccessedonlineathttp://ucsds.com
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
13. Protocol/Procedure–ListedCarcinogens
Procedure/Use Scale EngineeringControls/Equipment
PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions
1.UsingListedCarcinogenicchemicalsasreagents.
Upto1gofsolidor20mLofliquidorsolutionassuppliedinthereagentbottle.RemembertoobtainPIapprovalifhigherscaleisnecessary.Documentthisapprovalinyournotebook
Allreactionsusingthesematerialsmustbeperformedinaproperlyoperatingfumehoodwiththesashaslowaspossibleorinaninertatmosphereglovebox.
Eyeprotection:WearANSIapprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Theneedforfaceprotectionisbasedonthesolventsusedorifthereactionwillbeexternallyheatedorifneeded.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-heeledshoes.
Putupanappropriatehazardsignonyourfumehoodtoalertotherlabusers.Avoidtheformationofdustswithsolids.Carefullyweighmaterialsasnormalinasealedcontainer.Transfersolidsintoatared,containerinafumehood,usingsecondarycontainmenttomovethesealedcontainertoandfromthefumehoodduringweighing.Inaproperlyfunctioningfumehood,addreagenttothereactionvessel.Ifthereagentisaliquid,dispenseandtransfertothereactionvesselvolumetricallyusingeitherasyringeorpipettor.CleanupworkareaanddisposeofcontaminatedmaterialsasoutlinedinSections10&11.
Notes AnydeviationfromthisSOPrequiresapprovalfromPI.
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
10
14. DocumentationofTraining(signatureofallusersisrequired)
• Priortoconductinganyworkwiththe13ListedCarcinogens,designatedpersonnelmustprovidetrainingtohis/herlaboratorypersonnelspecifictothehazardsinvolvedinworkingwiththissubstance,workareadecontamination,andemergencyprocedures.
• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPandacopyoftherelevantSDSsprovidedbythemanufacturer.
IhavereadandunderstandthecontentofthisSOP:
Name Signature Identifier Date
13ListedCarcinogensChemicalClassStandardOperatingProcedure
Rev.Date:2017-03-28
11
ListofChemicals
Chemical(s) Chemical(s) Chemical(s)1-Naphthylamine 2-Naphthylamine 3,3'-Dichlorobenzidine 4-Aminobiphenyl 4-Nitrobiphenyl Benzidine beta-Propiolactone bis-Chloromethyl Ether Butter Yellow Chloromethyl methyl ether Ethyleneimine N-(2-Fluorenyl)acetamide N-Nitrosodimethylamine
