10a dev. ug
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Transcript of 10a dev. ug
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Development of
UROGENITAL SYSTEM
Dr mohan angadi
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HIGHLIGHTS-functionally divided
• Urinary system
• Genital system
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Introduction
2 embryonic structures that play an imp role in dev of UG system
1. Intermediate mesoderm &
2. Primitive Urogenital Sinus(UGS)-a part of cloaca.
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Second Outline Level
Third Outline Level Fourth Outline
Level Fifth
Outline Level
Sixth Outline Level
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Eighth Outline Level
Ninth Outline LevelClick to edit Master text styles
Intermediate mesoderm
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Second Outline Level
Third Outline Level Fourth Outline
Level Fifth
Outline Level
Sixth Outline Level
Seventh Outline Level
Eighth Outline Level
Ninth Outline LevelClick to edit Master text styles
Urogenital ridge
Nephrogenic cord
Gonadal ridge
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Cloaca
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Development of KIDNEY Three sets of kidneys develop in human embryos-evolution
1. Pronephroi – in cyclostomes & fishes
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2. Mesonephroi
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3. Metanephroi
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ampulla
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Development of NEPHRONS
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Ascent of kidneys:• Positional changes
• Changes in blood supply
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Anomalies of kidneys • Accessory(supernumerary)renal arteries
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• Polar renal artery/ aberrant renal artery - hydronephrosis
Accessory renal artery
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• Renal agenesis/hypoplasia/ /
hyperplasia
– Unilateral • 1:1000 newborn• Males• Left kidney• Suspected in infants with single
umbilical artery
– Bilateral • 1:3000 newborn• Ass with oligohydromnios • Incompatible with life
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• Abnormal rotation/Malrotated kidney :– Nonrotation– Incomplete rotation– Reverse rotation
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Second Outline Level
Third Outline Level Fourth Outline
Level Fifth
Outline Level
Sixth Outline Level
Seventh Outline Level
Eighth Outline Level
Ninth Outline LevelClick to edit Master text styles
• Anomalies of position/ Ectopic kidneys :
– - Pelvic kidney– - Crossed renal ectopia
with or without fusion
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• Anomalies of shape– Horseshoe kidney
– Pancake kidney
– Lobulated kidney
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• Cystic kidney diseases– Autosomal recessive polycystic kidney
disease
– Multicystic dysplastic kidney disease
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Development of ureter
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1
• Bifid & duplicate ureter
Anomalies of ureter
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Level Third Outline
Level Fourth Outline
Level Fifth
Outline Level
Sixth Outline Level
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Eighth Outline Level
• Ninth Outline LevelClick to edit Master text styles
– Second level• Third level
– Fourth level» Fifth level
Ectopic ureter-urinary incontinence
• Male • Female
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Second Outline Level Third Outline Level
Fourth Outline Level
Fifth Outline Level
Sixth Outline Level
Seventh Outline Level
Eighth Outline Level
• Ninth Outline LevelClick to edit Master text styles
– Second level• Third level
– Fourth level» Fifth level
Click to edit the outline text format
Second Outline Level Third Outline Level
Fourth Outline Level
Fifth Outline Level
Sixth Outline Level
Seventh Outline Level
Eighth Outline Level
Ninth Outline LevelClick to edit Master text styles
Click to edit the outline text format
Second Outline Level Third Outline Level
Fourth Outline Level
Fifth Outline Level
Sixth Outline Level
Seventh Outline Level
Eighth Outline Level
• Ninth Outline LevelClick to edit Master text styles
– Second level• Third level
– Fourth level» Fifth level
Development of urinary bladder
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Anomalies of urinary bladder • Urachal anomalies
• Congenital megacystis & bladder diverticula
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• Exstrophy of bladder/Ectopia vesicae
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Click to edit the outline text format Second Outline
Level Third Outline
Level Fourth Outline
Level Fifth
Outline Level
Sixth Outline Level
Seventh Outline Level
Eighth Outline Level
• Ninth Outline LevelClick to edit Master text styles
– Second level• Third level
– Fourth level» Fifth level
Development of urethra
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DEVELOPMENT OF MALE URETHRA
1.Prostatic urethra: Above opening of ejaculatory duct
VUC (vesicourethral canal)
Below ejaculatory ducts: DUGS (definitive urogenital sinus.)
2.Membranous urethra: DUGS
3.Penile urethra: DUGS
4.Glandular urethra: Surface ectoderm
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It is homologous to upper part of prostatic urethra i. e. above the opening of ejaculatory ducts.
DEVELOPMENT OF FEMALE URETHRA
Anomalies of urethra:
• Urethral diverticula• Duplication• Abnormal commu with rectum• Hypospadiasis • Epispadiasis
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Development of suprarenal glands:
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Applied aspects
• Ectopic adrenal tissue• Deep to capsule of kidney• Congenital adrenal hyperplasia
– adrenogenital syndrome-in male– Pseudohermaphroditism-in female
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Thanku