10 - examples
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110 - examples
10 - examples -density growth
2example - adaptation in bone
different load cases
Carter & Beaupré [2001]
[1][2][3]
midstance phase of gaitextreme range of abductionextreme range of adduction
2317 N1158 N1548 N
24˚-15˚56˚
703 N351 N468 N
28˚-8 ˚35˚
3example - adaptation in bone
different load cases
Carter & Beaupré [2001]combination of all load cases
necessary
4example - adaptation in bone
experiment vs simulation
• dense system of compressive trabaculae carrying stress into calcar region• secondary arcuate system, medial joint surface to lateral metaphyseal region• ward‘s triangle, low density region contrasting dense cortical shaft Carter & Beaupré [2001]
5example - adaptation in bone
node point based - h-refinement
6example - adaptation in bone
node point based - p-refinement
7example - adaptation in bone
integration point based - p-refinement
8example - adaptation in bone
parameter sensitivity - instabilities
certain parameters induce checkerboard modes Harrigon & Hamilton [1992],[1994]
9example - adaptation in bone
comparison with x-rays
excellent agreement of simulation and x-ray pattern
Pauwels [1973]
coxa norma
coxa valga
coxa vara
10example - hip replacement
total hip replacement vs hip resurfacing
• about 120,000 artificial hip replacements in us per year• aseptic loosening caused by adaptive bone remodeling• goal prediction of dredisctribution of bone density
11example - hip replacement
convential total hip replacement
ward‘s triangle • trabeculae • dense cortical shaft
12example - hip replacement
convential total hip replacement
stress shielding • bone resorption • implang loosening
13example - hip replacement
new birmingham hip resurfacing
ward‘s triangle • trabeculae • dense cortical shaft
14example - hip replacement
new birmingham hip resurfacing
improved ingrowth • anatomic situation • less resorption
15example - hip replacement
computer tomography of human femur
patient specific medical treatment
16example - wound healing
wound healing
• epidermal migration / spreading of existing cells• increase of mitotic activity of about15 times in 1mmwide zone @wound edge
Murray [2003]
17example - wound healing
wound healing
„…thou shouldst bind it with fresh meet the first day, and thou shouldst treat afterword with grease and honey every day until he recovers…“ Breadsted [1930]
Edwin Smith Surgical Papyrus [13th Dynasty]
18example - wound healing
tension - single edge notched specimen
19example - wound healing
tension - single edge notched specimen
increased cell activity @wound edge
20example - wound healing
tension - surface cut specimen
increased cell activity @wound edge
21example - wound healing
tension - crack mouth opening displacement
increased cell activity - wound healing & closure
22example - wound healing
bending - single edge notched specimen
increased cell activity @wound edge
23example - wound healing
bending - surface cut specimen
increased cell activity @wound edge
24example - wound healing
bending - crack mouth opening displacement
increased cell activity - wound healing & closure
25example - topology
optimization
form follows function
structural design
load case I load case IIoptimalmaterial distribution I
26example - topology
optimization
form follows function
bicycle frames 1817-2005
27example - topology
optimization
form follows function
design of bicycle frameArmstrong
[2005]Kuhl
[2005]