10. What are the indications to refer Mrs. Melan to specialist?When there are signs of it become malignant which include: A (Asymmetry) : Malignant mole tends to be asymmetrical B (Border) : The borders tend to be unevenC (Color) : There are variety of colors such as different shades of brown, tan or black, also red, white or blueD (Diameter) : Malignant moles tend to have larger diameterE (Evolving) : Any change — in size, shape, color, elevation, or another trait, or any new symptom such as bleeding, itching or crusting — points to danger

11. What are the possible diagnoses for Mrs. Melan and the three siblings from TV? Mrs. Melan is diagnosed with either Actinic Keratosis or Seborrheic Keratosis on her chest with Nevus Pigmentosus as differential diagnose. And Basal Cell Carsinoma on her nostril with Squamous Cell Carcinoma and Melanoma Malignant as differential diagnoses. While the three siblings on TV are diagnosed with Xeroderma Pigmentosum.