1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician...
-
Upload
felix-newman -
Category
Documents
-
view
216 -
download
1
Transcript of 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician...
![Page 1: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/1.jpg)
1
Migraine in children and adolescents What is different?
Ishaq Abu-ArafehConsultant PaediatricianStirling Royal Infirmary
andHeadache ClinicRHSC, Glasgow
![Page 2: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/2.jpg)
2
Headache is common in children and adolescents
![Page 3: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/3.jpg)
3
Prevalence of headache in schoolchildren
≥ 1 headache over 1 year 50-70%
Migraine 10.6%
Chronic TTH 0.9%
Episodic TTH 18-25% Several European studies 5 6 7 8 9 10 11 12 13 14 15
Age in years
0%
20%
40%
60%
80%
100%
Migraine
Severe headache
Mild headache
No headache
Aberdeen schoolchildren (Abu-Arafeh and Russell, BMJ, 1994)
![Page 4: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/4.jpg)
4
Headache in specialist clinics
Study No. MO MA ETTH CTTH Other
Abu-Arafeh, McLeod 2005 815 227
(27%)
39
(5%)
128
(16%)
178
(22%)
243
(30%)
Wober Bangol, et al, 1995 437 127 51 86 30 143
Gallai et al 1994 719 176 118 244 181
Jay & Tomassi, 1981 116 42 12 33 29
TOTAL 2087 572
(27%)
220
(11%)
699
(33%)
596
(29%)
![Page 5: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/5.jpg)
5
![Page 6: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/6.jpg)
6
Evaluation of the child with headache:The Clinical History
Disease and headache
Characteristics
Duration of illness
Frequency of attacks
Duration of each attack
Severity of pain (interference
with activities)
Location of maximal pain
Quality of pain
Trigger factors
Warning symptoms
Symptoms during attacks Anorexia
Nausea
Vomiting
Light intolerance
Noise intolerance
Pallor
Physical activities
Relieving factors
Symptoms between attacks
![Page 7: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/7.jpg)
7
Evaluation of the child with headache:The Clinical Examination
General examination should include• Weight• Height• Head circumference• BP
Neurological examination should include:• Cranial nerves and optic disc inspection• Eye movement, nystagmus• Muscle co-ordination, ataxia, tremor etc.
![Page 8: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/8.jpg)
8
Name: Date of birth: Address: Sex:
Attack number 1 2 3 4
Date
Time started
Time resolved
Severity of headache*
Type of headache**
What may started it?
Any loss of appetite?
Nausea?
Vomiting?
Does light make it worse?
Does noise make it worse?
I s it worse by walking?
Does rest make it better?
Does sleep make it better?
I s it better af ter paracetamol?
Throbbing, hitting, banging, Tightness, pressure, squeeze, sharp, stab, dull, or can’t describe
1 normal activities2 stop some
activities3 stops all activities
Prospective Headache diary
www.bpna.org.uk
![Page 9: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/9.jpg)
9
Excluding brain tumours
Luckily IT IS RARE
1-5 /100,000 children/yearMiltenburg etal. CJNS, 1996
2000-5000/100,000 have migraine
≈1/1000 of children with chronic headache as the only symptom, attending a specialist clinic
Abu-Arafeh & McLeod, ADC, 2005
![Page 10: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/10.jpg)
10
Relationship between headache and brain tumour?
• Almost all children with brain tumour have headache at some stage
• The vast majority of children with headache have no brain tumour
• Childhood Brain Tumor Consortium– 3291 children with brain tumors– 62% had headache prior to diagnosis
– 98% had > 1 other associated sign or symptom– >50% had > 3 other associated signs or symptoms
J Neurooncol. 1991
![Page 11: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/11.jpg)
11
Frequency of symptoms in 200 children with brain tumours
Wilne et al, ADC, 2006
![Page 12: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/12.jpg)
12
SymptomHeadache<4 months
(n = 68)Headache 4 months
(n = 38)
Vomiting 87% 76%
Vision 53 63
Unsteadiness 49 45
Education /behavioural
37 45
Disturbed sleep 26 31
Growth/fluid balance 7 21
Seizures 7 8
None 0 0
Associated symptoms in children with headache
Wilne et al, ADC, 2006
![Page 13: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/13.jpg)
13
So, what are the indications for neuroimaging
![Page 14: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/14.jpg)
14
Indications for Neuroimaging
Features of cerebellar dysfunction: Ataxia Nystagmus Intention tremor
Increased intracranial pressure: PapilloedmaNight/early morning vomiting Large head
Focal new neurological deficits: Recent squintFocal seizures
Personality change
Deterioration in school work
Atypical headaches or migraine
![Page 15: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/15.jpg)
15
Chronic sinusitis and headache
Common misdiagnosis
Sinusitis as detected on cranial CT scan is mostly a coincidental finding in adolescents with chronic primary headache
Treatment of sinusitis did not improve headache
Şenbil et al. J headache Pain 2008
![Page 16: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/16.jpg)
16
Childhood Migraine
![Page 17: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/17.jpg)
17
Classification of migraine ICHD-II, Cephalalgia, 2004
1.1 Migraine without aura
1.2 Probable migraine without aura
1.3 Migraine with aura
1.3.1 Typical aura with migraine headache
1.3.2 Typical aura with non-migraine headache
1.3.3 Typical aura without headache
1.3.4 Familial hemiplegic migraine
1.3.5 Sporadic hemiplegic migraine
1.3.6 Basilar artery migraine
1.4 Probable migraine with aura
1.5 Childhood periodic syndromes
1.5.1 Cyclical vomiting
1.5.2 Abdominal migraine
1.5.3 Benign Paroxysmal vertigo of childhood
1.6 Retinal Migraine
1.7 Complications of migraine
1.7.1 Chronic migraine
1.7.2 Status migrainosus
1.7.3 Persistence aura without infarction
1.7.4 Migraine infarction
1.7.5 Migraine triggered seizures
![Page 18: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/18.jpg)
18
Childhood migraine – what is different Diagnostic criteria, ICHD-II, Cephalalgia, 2004
Migraine without aura
A. At least 5 attacks fulfilling B-D
B. Headache lasting 1-72 in children
C. Headache has at least two of the following characteristics:
1. Unilateral location
2. Pulsating quality
3. moderate or severe intensity
4. Aggravation by walking or similar routine activity.
D. During headache at least one of the following:
1. Nausea and/or vomiting.
2. Photophobia and phonophobia.
![Page 19: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/19.jpg)
19
Childhood migraine – what is different Reasons for seeking medical advice:
• Children should not have headache
• Time lost off school
• Treatment is not helpful
• Headache has been going on for a
long time
• Worry about a serious disease?
![Page 20: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/20.jpg)
20
Childhood migraine – what is different
Duration of migraine attacks
• Variable, but generally
shorter than in adults
• Around 10% of migraine
attacks are less than 2
hours
Abu-Arafeh, Cephalalgia, 2001
![Page 21: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/21.jpg)
21
Childhood migraine – what is different
Site of maximum pain
• Unilateral headache is less
common than in adults
• Frontal headache in at least 50% of
patients
![Page 22: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/22.jpg)
22
Childhood migraine – what is different
Quality of pain
• Allow children to use their own
words
• Most children under the age of 8
can’t describe pain
• Good description of pain can be
expected in majority of children
over 12 years
![Page 23: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/23.jpg)
23
Childhood migraine – what is different
Severity of pain
• best assessed by behaviour during
attacks
• Mild: Does not interfere with activities
• Moderate: Stops some but not all
activities
• Severe: Stops all activities (child lies in
bed)
![Page 24: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/24.jpg)
24
Childhood migraine – what is different
Trigger factors
• None identifiable in the majority of
children
• Food trigger are uncommon
• Missing meals and sleep, stress and
anxiety are likely
![Page 25: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/25.jpg)
25
Childhood migraine – what is different
Mixed headaches:
• Migraine with aura and migraine
without aura can coexist
• 10-20% of patient with migraine
also have tension type headache
![Page 26: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/26.jpg)
26
Childhood migraine – what is different
Associated symptoms:
• Nausea is common in children
(90% of attacks)
• Vomiting is also common and an
early feature (60%)
• Dizziness reported by more than
50% of children with migraine
• Abdominal pain also common
(25%)
![Page 27: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/27.jpg)
27
Migraine with aura“Alice in wonderland”
•Distorsion of images
•Micropsia
•Macropsia
•Déja vu
Childhood migraine – what is different
![Page 28: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/28.jpg)
28
Childhood migraine – what is different
Response to treatment
• Unpredictable
• Attack to attack variation
• Large placebo effect
![Page 29: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/29.jpg)
29
Principles of pharmacologic treatment
• As early as possible after onset
of symptoms
• Most suitable drug
• Most effective dose
• Most reliable route of
administration
![Page 30: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/30.jpg)
30
Response to Acute treatment AAN, Neurology, 2004
![Page 31: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/31.jpg)
31
Other drugs used in treatment of acute migraine, but no clinical studies …..
NSAIDDiclofenacMefenamic acidApirin (over 15 years age)Naproxen
OpiateCodeine ± paracetamol, aspirinMeperadine
Other triptans
Naratriptan Naramig (GSK)
Rizatriptan Maxalt (MSD)
Zolmtriptan Zomig (Astra Z)
Eletriptan Relpax (Pfizer)
![Page 32: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/32.jpg)
32
ADC, 2007
Pediatrics, 2005
Neurology, 2004
![Page 33: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/33.jpg)
34
Preventative treatment of migraine, AAN, Neurology, 2004
![Page 34: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/34.jpg)
35*Cochran-Mantel-Haenszel analysis, stratified by number of migraine days at baseline.
Topiramate trial: Monthly Migraine Days (ITT Population)
-2.0
-2.6-3.0
-2.5
-2.0
-1.5
-1.0
-0.5
0.0
Change in Change in Mean Mean
Monthly Monthly Migraine Migraine
Days*Days*
PlaceboPlacebo(n = 49)(n = 49)
TopiramateTopiramate(n = 108)(n = 108)
P = 0.061
Double-Blind PhaseDouble-Blind Phase
-2.3
-3.1-3.5
-3.0
-2.5
-2.0
-1.5
-1.0
-0.5
0.0
Change in Change in Mean Mean
Monthly Monthly Migraine Migraine
Days*Days*
PlaceboPlacebo(n = 44)(n = 44)
TopiramateTopiramate(n = 95)(n = 95)
P = 0.026
Maintenance PhaseMaintenance Phase
![Page 35: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/35.jpg)
36
Pharmacological prophylaxis
All are DB, XO and placebo controlled studies
Drug Dose No. Result
Propranolol 60-120mg/d 28 less frequency, nausea
40 mg/d 39 No difference
3 mg/kg/d 28 No difference
Pizotifen 1-1.5 mg/d 39 No difference
2.5-3.75 mg/d 14 Fewer symptoms
Flunarizine 5 mg/d 63 Reduced frequency & duration
Clonidine 25-75 mg/d 43 No difference
![Page 36: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/36.jpg)
37
Other drugs used in migraine prophylaxis
• Magnesium oxide• Sodium Valproate• Gabapentin• Cyproheptadine• Other beta blockers (Atenalol)• Other calcium channels blockers (verapamil)• Vitamin B2• Fever few• Botulinum toxin• Montelukast, etc
![Page 37: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/37.jpg)
38
Childhood migraine – what is different
Childhood Syndromes Related to Migraine
• Benign Paroxysmal Torticollis
• Benign paroxysmal Vertigo
• Cyclical Vomiting Syndrome
• Abdominal Migraine
![Page 38: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/38.jpg)
39
Migraine - “More than a Headache”
27.5
4
30.5
5.5
0 5 10 15 20 25 30 35
Abdominalpain
Vomitingattacks
Dizziness
Limb pains
Percent
Abdominal migraine
Cyclical vomiting syndrome
Benign paroxysmal vertigo
Recurrent limb pains of childhood
‘Related’ syndromeNon-headache symptomsin 200 children with migraine
1
![Page 39: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/39.jpg)
40
Psychotherapy:Useful, regardless of the type of headache
• Physical - behavioural component
• Cognitive therapy
• Behavioural therapy
• Cognitive Behavioural Therapy
![Page 40: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/40.jpg)
41
Alternate or complementary medicine
• Acupuncture
• Acupressure
• Aroma therapy
• Reflexology
• Chiropractice
• Osteopathy
![Page 41: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/41.jpg)
42
Alternate or complementary medicine
![Page 42: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/42.jpg)
43
![Page 43: 1 Migraine in children and adolescents What is different? Ishaq Abu-Arafeh Consultant Paediatrician Stirling Royal Infirmary and Headache Clinic RHSC,](https://reader036.fdocuments.us/reader036/viewer/2022062421/56649dac5503460f94a9bbf5/html5/thumbnails/43.jpg)
44