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Medicinal Chemistry 535: Laboratory Diagnostics Introduction Lecture

1) Class Goals (Get smart and have some fun figuring out how

stuff works) a) Familiarize you with the standard laboratory testing

techniques that are used in patient care.

b) Understand what it means when test values are out of range and how to develop a clinical picture.

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c) Be able to intelligently discuss lab report values with other health care providers and provide input on care.

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d) Be able to discuss various types of lab results with patients and teach them how to use home devices.

2) Where are diagnostic or screening tests performed? a) Hospitals and commercial reference laboratories with totally

awesome sophisticated equipment and dedicated technicians. Samples are submitted and results returned in lab reports.

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b) Point of Care Testing (POC) Smaller devices even hand held, more limited tests, modular and more expensive per test. Does not require a technician. Very common in intensive care, emergency rooms and large clinics. These can be used for basic metabolic panels, ABG’s, coagulation tests, MI injury markers etc

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c) Home Testing. Here the patient collects the sample and may (a) analyze it directly with a device or a test strip (b) collects a sample and sends it off to a lab or (c) both of the above (drugs of abuse testing).

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3) Apply basic disease and physiology concepts to interpretation of lab tests and drug treatment.

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4) Read a laboratory report and know values for major clinical tests.

See below

https://labtestsonline.org/assets/static-pages/Sample.html

5) Sometimes Handy Oneline References. a) Mayo Clinic Site (really good, download the phone app):

Mayo Clinic Site (Definitely Poke Around Here) Massive national reference lab. By far the best authoritative website on a particular test as well as a host of other information on disease.

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http://www.mayomedicallaboratories.com/index.html Mobile Mayo Clinic Test Reference Data Base App: http://www.mayomedicallaboratories.com/mobile-apps/

Some info even in airplane mode. More when connected to internet.

b) UW Site (not so handy but here it is).

http://depts.washington.edu/labweb/referencelab/index.htm

c) Labtests Online (good) Site for the American Association

of Clinical Chemistry

https://labtestsonline.org

d) Wikipedia Site (really great for poking around and background stuff)

Reference Ranges for Blood Tests Gets You Started: https://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests The good: Clickable Links to info about each test. Some really cool charts and graphs. A great start to a deep dive into an issue. Literature references often cited. The bad: Highly detailed in some cases, not comprehensive, sometimes questionable peer review of content, really difficult to stop clicking on neat stuff.