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    Cell Structure and

    Function

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    Concepts of the Cell Theory

    A cell is the basicstructural and functional

    unitof living organisms.The activity of anorganism depends on thecollective activities of itscells.

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    Concepts of the Cell Theory

    According to theprincipleof complementarity, the

    biochemical activities ofcells are dictated by therelative number of their

    specic subcellularstructures.

    Continuity of life has a

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    Chemical Components of Cells

    Most cells are composedof the following four

    elementsCarbon

    Hydrogen!ygen

    "itrogen

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    Cells and Tissues

    Carry out all chemicalactivities needed to

    sustain life Cells are the building

    bloc#s of all livingthings.

    Tissues are groups of

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    Anatomy of the Cell

    Cells are not all the same. All cells share generalstructures.

    All cells have three main regions

    "ucleus

    Cytoplasm$lasma membrane

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    Anatomy of the Cell

    The nucleoplasm andcytosol ma#e up the

    intracellular %uid.

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    Nucleus

    Cytoplasm

    Plasmamembrane

    (a)

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    The "ucleus

    Control center of the cellContains genetic material&'"A(

    Three regions

    "uclear envelope &membrane(

    "ucleolus

    Chromatin

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    Nucleus

    Nuclear envelope

    Chromatin

    Nuclearpores

    Nucleolus

    Rough ER

    (b) Figure 3.1b

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    The "ucleus

    "uclear envelope &membrane()arrier of the nucleus

    Consists of a doublemembrane

    Contains nuclear pores that

    allow for e!change of materialwith the rest of the cell

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    The "ucleus

    "ucleoli"ucleus contains one or

    more nucleoliSites of ribosomeassembly

    *ibosomes migrate intothe cytoplasm through

    nuclear ores

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    The "ucleus

    Chromatin

    Composed of DNA andprotein

    $resent when the cell isnot dividing

    Scattered throughout thenucleus

    Condensesto form

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    $lasma Membrane

    )arrier for cell contents Double phospholipid

    layerHydrophilic heads

    Hydrophobic tails Also contains proteins,

    cholesterol, and

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    $lasma Membrane

    Glycoproteins-Themolecules that ma#e the

    cell surface fu++y, stic#y,and sugar-rich

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    $lasma Membrane

    A( it consists of two lipid layers

    )( its lipid components areprimarily phospholipids and

    cholesterolC( it contains proteins for

    speciali+ed functions

    '( it regulates the entry and e!itof cell materials

    ( it does not allows watersoluble molecules to ass

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    Figure 3.2

    Extracellular uid(watery environment)

    ugargroup

    Polar hea!s o"phospholipi!molecules

    #imolecularlipi! layercontainingproteins

    Nonpolar tails

    o" phospholipi!molecules

    $lycoprotein

    Proteins Filaments o"

    cytos%eleton Cytoplasm(watery environment)

    Channel

    Cholesterol

    /lycolipid

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    $lasma Membrane 0unctions

    Membrane 1unctions2. Tight 1unctions

    3. 'esmosomes4. /ap 1unctions

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    $lasma Membrane 0unctions

    Membrane 1unctions2. Tight 1unctions

    5mpermeable 1unctions

    )ind cells together into

    lea#proof sheets membrane connections

    that prevent the lea#ing of

    %uid between cells

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    Plasmamembranes o"a!&acent cells

    'esmosome(anchoring

    &unction)

    ight(impermeable)&unction

    icrovilli

    $ap(communicating)

    &unction

    E*tracellularspace bet+een

    cells

    ,n!erlyingbasement

    membrane

    Conne*on

    Figure 3.3

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    $lasma Membrane 0unctions

    Membrane 1unctions3. 'esmosomes

    Anchoring 1unctions thatprevent cells from beingpulled apart

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    Plasmamembranes o"a!&acent cells

    'esmosome(anchoring

    &unction)

    ight(impermeable)&unction

    icrovilli

    $ap(communicating)

    &unction

    E*tracellularspace bet+een

    cells

    ,n!erlyingbasement

    membrane

    Conne*on

    Figure 3.3

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    $lasma Membrane 0unctions

    Membrane 1unctions4. /ap 1unctions

    Allow communicationbetween cells

    Allows Nutrients andions pass directly

    from cell to cell

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    Plasmamembranes o"a!&acent cells

    'esmosome(anchoring

    &unction)

    ight(impermeable)&unction

    icrovilli

    $ap(communicating)

    &unction

    E*tracellularspace bet+een

    cells

    ,n!erlyingbasement

    membrane

    Conne*on

    Figure 3.3

    C t l

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    Cytoplasm

    The material outsidethe nucleus and inside

    the plasma membraneSite of most cellular

    activities

    C t l

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    Cytoplasm

    Contains threema1or elements

    2.Cytosol

    3.rganelle4.5nclusions

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    Cytoplasm

    Contains three ma1orelements

    2. CytosolFluid that suspends

    other elements

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    Cytoplasm

    Contains three ma1orelements

    3. rganellesMetabolic machineryof the cell

    67ittle organs8 thatperform functions for

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    Cytoplasm

    Contains three ma1orelements

    3. rganellesThe speciali+ed cellularcompartments withinthe cytosol of the cell

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    Cytoplasm

    Contains three ma1orelements

    4. 5nclusionsChemical

    substances such asstored nutrients or

    Chromatin

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    Ribosomes

    $olgi apparatus

    ecretion being release!

    "rom cell by e*ocytosisicrotubule

    Centrioles

    itochon!rion

    -ysosome

    Cytosol

    mooth en!oplasmicreticulum

    Chromatin

    Nucleolus

    Nuclear envelope

    Nucleus

    Plasmamembrane

    Roughen!oplasmicreticulum

    5ntermediate

    laments

    $ero!isome

    Figure 3.

    C t l i ll

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    Cytoplasmic rganelles

    Mitochondria6$owerhouses8 of the cell

    Change shapecontinuously

    Carry out reactions whereo!ygen is used to brea#down food

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    Cytoplasmic rganelles

    *ibosomesMade of protein and

    *"ASites of proteinsynthesis

    Found at two locations

    Free in the

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    Cytoplasmic rganelles

    ndoplasmic reticulum &*(

    Fluid-lled tubules forcarrying substances

    Two types of *

    2. Rough endoplasmic

    reticulumStudded with ribosomes

    Synthesi+es proteins

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    Cytoplasmic rganelles

    ndoplasmic reticulum&*(

    Two types of *

    3. moothendoplasmic

    reticulumFunctions in lipid

    metabolism and

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    Figure 3./

    0n the cistern the protein "ol!s into its"unctional shape. hort sugar chainsmay be attache! to the protein ("orminga glycoprotein).

    he protein is pac%age! in a tinymembranous sac calle! a transportvesicle.

    he transport vesicle bu!s "rom therough ER an! travels to the $olgiapparatus "or "urther processing.

    s the protein is synthesie! on theribosome it migrates into the rough ERcistern.

    32

    1

    Ribosome mRN

    Rough ER

    ransportvesicle bu!s o""

    Protein insi!etransport vesicle

    Protein

    3

    2

    1

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    Figure 3./ step 1

    Ribosome mRN

    Rough ER

    Protein

    s the protein is synthesie! on theribosome it migrates into the rough ERcistern.

    1

    1

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    Figure 3./ step 2

    0n the cistern the protein "ol!s into its"unctional shape. hort sugar chainsmay be attache! to the protein ("orminga glycoprotein).

    s the protein is synthesie! on theribosome it migrates into the rough ERcistern.

    2

    Ribosome mRN

    Rough ER

    Protein

    21

    1

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    Figure 3./ step 3

    0n the cistern the protein "ol!s into its"unctional shape. hort sugar chainsmay be attache! to the protein ("orminga glycoprotein).

    he protein is pac%age! in a tinymembranous sac calle! a transportvesicle.

    s the protein is synthesie! on theribosome it migrates into the rough ERcistern.

    32

    1

    Ribosome mRN

    Rough ER

    ransportvesicle bu!s o""

    Protein

    3

    2

    1

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    Figure 3./ step

    0n the cistern the protein "ol!s into its"unctional shape. hort sugar chainsmay be attache! to the protein ("orminga glycoprotein).

    he protein is pac%age! in a tinymembranous sac calle! a transportvesicle.

    he transport vesicle bu!s "rom therough ER an! travels to the $olgiapparatus "or "urther processing.

    s the protein is synthesie! on theribosome it migrates into the rough ERcistern.

    32

    1

    Ribosome mRN

    Rough ER

    ransportvesicle bu!s o""

    Protein insi!etransport vesicle

    Protein

    3

    2

    1

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    Cytoplasmic rganelles

    Golgi apparatusModies and pac#ages

    proteins$roduces di9erent typesof pac#ages

    ecretory vesicles

    Cell membrane

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    Figure 3.4

    $olgi vesicle containing!igestive enymesbecomes a lysosome

    Path+ay 3

    Path+ay 2

    ecretory vesicles

    Proteins

    ecretion bye*ocytosis

    $olgi vesicle containingproteins to be secrete!becomes a secretoryvesicle

    $olgiapparatus

    Path+ay 1

    ransportvesicle

    embrane

    Proteins in cisternaCisternaRough ER

    -ysosome "uses +ith

    ingeste! substances

    $olgi vesicle containingmembrane components"uses +ith the plasma

    membrane

    Plasma membrane

    Extracellular fluid

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    Cytoplasmic rganelles

    7ysosomesContain en+ymes

    produced by ribosomes$ac#aged and secretedby the /olgi apparatus

    'igest worn-out ornonusable materials

    within the cell

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    Cytoplasmic rganelles

    $ero!isomesMembranous sacs ofo!idase en+ymes

    'eto!ify harmfulsubstances such as

    alcohol and formaldehyde)rea# down free radicals&highly reactive chemicals(

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    Cytoplasmic rganelles Cytos#eleton

    "etwor# of protein structuresthat e!tend throughout thecytoplasm

    $rovides the cell with aninternal framewor#

    Three di9erent types ofelements

    Microlaments &largest(

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    Figure 3.5a6c

    (a) icro"ilaments (b) 0nterme!iate "ilaments (c) icrotubules

    ctin subunit

    5 nm 17 nm

    Fibrous subunits ubulin subunits

    2/ nm

    icro"ilaments "orm the bluenet+or% surroun!ing the pin%nucleus.

    0nterme!iate "ilaments "ormthe purple batli%e net+or%.

    icrotubules appear as gol!net+or%s surroun!ing thecells8 pin% nuclei.

    l i ll

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    Cytoplasmic rganelles

    Centrioles*od-shaped bodies

    made ofmicrotubules

    'irect the formationof mitotic spindle

    C ll l 1 i

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    Cellular $ro1ections

    "ot found in all cells

    Ciliamove materialsacross the cell surface

    7ocated in the respiratorysystem to move mucus

    "lagellapropel the cell

    The only %agellated cellin the human body is

    sperm

    C ll l $ 1 i

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    Cellular $ro1ections

    "ot found in all cells

    #icrovilliare tiny,ngerli#e e!tensions of

    the plasma membrane5ncrease surface area

    for absorption

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    Figure 3.9a

    Fibroblasts

    Rough ER an! $olgiapparatus No organelles

    Nucleus

    Erythrocytes

    (a) Cells that connect bo!y parts

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    Figure 3.9b

    Epithelialcells

    Nucleus

    0nterme!iate

    "ilaments

    (b) Cells that cover an! line bo!y organs

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    Figure 3.9c

    %eletalmuscle cell

    Nuclei

    Contractile

    "ilaments

    mooth

    muscle cells

    (c) Cells that move organs an! bo!y parts

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    Figure 3.9!

    Fat cell -ipi! !roplet

    (!) Cell that stores

    nutrients

    Nucleus

    -ysosomes

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    -ysosomes

    acrophage

    (e) Cell that "ights

    !isease

    Pseu!o6po!s

    Figure 3.9e

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    Figure 3.9"

    ProcessesRough ER

    Nerve cell

    Nucleus

    (") Cell that gathers in"ormation an! controls bo!y "unctions

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    Nucleus Flagellum

    perm

    (g) Cell o" repro!uction