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A NOVEL FRAMEWORK OF MAKING PLA/PLGA POLYMER MICRO NEEDLES PATCH FOR BETTER SKIN PIERCING AND DRUG RELEASE

LIGA and Biophotonics Lab

NTHU

Institute of NanoEngineering and MicroSystem

Speaker：Wen Cheng Yang

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Outline

Introduction Fabricated polymer micro needles

array PLA/PLGA soft micro needles Flexible membrane substrate Conclusion

LIGA and Biophotonics Lab

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Introduction Fabricated polymer micro needles

array PLA/PLGA soft micro needles Flexible membrane substrate Conclusion

Outline

LIGA and Biophotonics Lab

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Introduction

Many reports have been published to fabricate micro needles over the past ten years. One of the most important potential applications is the patch with micro needles array on it for efficient drug delivery purpose.

LIGA and Biophotonics Lab

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Introduction

Fabrication micro needles ： 1. solid micro needles array

2. hollow needle array

3. polymer needles patch on flexible

membrane

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Introduction Fabricated polymer micro needles

array PLA/PLGA soft micro needles Flexible membrane substrate Conclusion

Outline

LIGA and Biophotonics Lab

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Fabricated polymer micro needles array

Fabricated polymer micro needles array by the purposed back-side exposure method.

Out-of-plane polymer micro needles with a height of 65 ~ 210 um and an outer diameter between 20 ~ 100 um have been successfully realized.

LIGA and Biophotonics Lab

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Fabricated polymer micro needles array

An example result made by the combinational method. The outside wall had a larger tilting angle, while the internal wall had a smaller tilting angle (nearly vertical) can be made by one lithography step.

LIGA and Biophotonics Lab

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Fabricated polymer micro needles array

Different kinds of hollow polymer micro needles can be fabricated through the purposed method.

LIGA and Biophotonics Lab

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Introduction Fabricated polymer micro needles

array PLA/PLGA soft micro needles Flexible membrane substrate Conclusion

Outline

LIGA and Biophotonics Lab

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Poly lactic acid （ PLA,聚乳酸） Poly lactide-co-glycolide

（ PLGA,聚甘醇酸共聚物）

PLA/PLGA soft micro needles

LIGA and Biophotonics Lab

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PLA/PLGA soft micro needles

PDMS intermediate

PLA powder spread over the PDMS mold

PLGA + Albumin

LIGA and Biophotonics Lab

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Introduction Fabricated polymer micro needles

array PLA/PLGA soft micro needles Flexible membrane substrate Conclusion

Outline

LIGA and Biophotonics Lab

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Flexible membrane substrate

The needles array fabricated on a flexible membrane substrate. The substrate employed here was PDMS.

LIGA and Biophotonics Lab

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Flexible membrane substrate

PLA micro needles array ( 900 needles in 0.5×0.5 mm2 area) fabricated by replication through a PDMS intermediate mold

LIGA and Biophotonics Lab

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Flexible membrane substrate

(a)

(b)

(c)

(d)

Optical micrographs showing piercing experiments. (a) The human skin of hand back

of an Asian people before piercing.

(b) After piercing by a fabricated PLA needles array.

(c) Test result using artificial skin: Cica-Caretm from Smith+Nephew Corp

(d) Test result using simulated agarose gel with the standard hardness range of human skin.

LIGA and Biophotonics Lab

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Introduction Fabricated polymer micro needles

array PLA/PLGA soft micro needles Flexible membrane substrate Conclusion

Outline

LIGA and Biophotonics Lab

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In this paper, we introduced our fabrication approach, preparation methods and the produced patches. We have also executed piercing experiments on artificial skin and real human skin.

LIGA and Biophotonics Lab

Conclusion

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LIGA and Biophotonics Lab

Thanks for your attendance .