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Transcript of 1 5/8/2015 Tissues of the Immune Response Tissues of the Immune Response Hugh B. Fackrell...
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Tissues of the Immune Response
Tissues of the Immune Response
Hugh B. FackrellHugh B. Fackrell
Filename:tissuesv7Filename:tissuesv7
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Structure and Function of the Lymphatic SystemStructure and Function
of the Lymphatic System Lymphatic systemLymphatic system Primary Lymphoid tissuesPrimary Lymphoid tissues Secondary Lymphoid TissuesSecondary Lymphoid Tissues
NextNext
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Lymphatic System: FunctionLymphatic System: Function
Generate lymphocytesGenerate lymphocytes committed to a committed to a particular antigenic specificityparticular antigenic specificity
Create an environment to Create an environment to trap antigenstrap antigens from from various tissues, spaces or fluidsvarious tissues, spaces or fluids
Provide sites where the committed Provide sites where the committed lymphocytes interact with the trapped lymphocytes interact with the trapped antigensantigens
NextNext
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Committed LymphocytesCommitted Lymphocytes
Immature lymphocytesImmature lymphocytes generated by hematopoiesis of pleuripotent stem generated by hematopoiesis of pleuripotent stem
cells within the bone marrow.cells within the bone marrow. Lymphocytes mature in the primary lymphoid Lymphocytes mature in the primary lymphoid
organsorgans Bone Marrow, Thymus, Bursa (in birds)Bone Marrow, Thymus, Bursa (in birds)
Mature lymphocytes migrate to the secondary Mature lymphocytes migrate to the secondary lymphoid organslymphoid organs Lymph nodes, spleen, mucosal associated lymphoid Lymph nodes, spleen, mucosal associated lymphoid
tissuestissues
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Primary Lymphoid TissuesPrimary Lymphoid Tissues
B cellsB cells BirdsBirds
Bursa of FabriciusBursa of Fabricius MammalsMammals
Fetal LiverFetal LiverBone MarrowBone Marrow
T CellsT Cells ThymusThymus
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BursaBursa
LocationLocation StructureStructure FunctionFunction
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Avian Lymphoid SystemAvian Lymphoid System
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Bursa of Fabricius:FolliclesBursa of Fabricius:Follicles
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Bursa of Fabricius: X-SectionBursa of Fabricius: X-Section
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Bursa: B cell germinal centersBursa: B cell germinal centers
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B cell OriginsB cell Origins
Hemopoietic stem cells develop in the fetal Hemopoietic stem cells develop in the fetal liverliver
Later they are produced in the Bone Later they are produced in the Bone MarrowMarrow
““Bursal equivalent”Bursal equivalent” NextNext
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Fetal liver: HematopoiesisFetal liver: Hematopoiesis
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Bone Marrow Scanning EMBone Marrow Scanning EM
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Bone Marrow DifferentiationBone Marrow Differentiation
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ThymusThymus
LocationLocation StructureStructure CirculationCirculation FunctionFunction Summary DiagramSummary Diagram
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Thymus: LocationThymus: Location
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Thymus: LobulesThymus: Lobules
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Thymus: X sectionThymus: X section
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Thymus: DevelopmentThymus: Development
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Thymus: EmbrogenisisThymus: Embrogenisis
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Thymus: Summary DiagramThymus: Summary Diagram
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Athymic MouseAthymic Mouse
““Nude” mouse - lacks hair folliclesNude” mouse - lacks hair follicles Lacks developed thymusLacks developed thymus few circulating T cellsfew circulating T cells No cell mediated immunityNo cell mediated immunity
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“Nude Mouse”“Nude Mouse”
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Lymph NodesLymph Nodes
DistributionDistribution StructureStructure CirculationCirculation FunctionFunction Summary DiagramSummary Diagram
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Lymphatic SystemLymphatic System
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Node: CirculationNode: Circulation
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Node: TD & TI areasNode: TD & TI areas
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Node: X sectionNode: X sectionCapsule
Cortex
MedullaParacortex
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Node: Diagram 2Node: Diagram 2
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CortexCortex
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Node: DiagramNode: Diagram
Efferent lymphatic
Afferent lymphatic
Primary Follicle
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Node: B cells in cortexNode: B cells in cortex
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Node: Germinal CenterNode: Germinal Center
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Node: Reticular networkNode: Reticular network
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Node Follicle: Mantle of lymphocytesNode Follicle: Mantle of lymphocytes
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ParacortexParacortex
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Node T Cells Diffuse cortexNode T Cells Diffuse cortex
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Node: T Cells in ParacortexNode: T Cells in Paracortex
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Node: T cell depletionNode: T cell depletion
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MedullaMedulla
Thymic Dependent areaThymic Dependent area
T cells localizeT cells localize
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Lymph Node: MedullaLymph Node: Medulla
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Node: LM MedullaNode: LM Medulla
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Node: Medullary SinusNode: Medullary Sinus
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Node: Subcapsular SinusNode: Subcapsular Sinus
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Node: EM of MedullaNode: EM of Medulla
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Node: Primary FollicleNode: Primary Follicle
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Node: Diffuse CortexNode: Diffuse Cortex
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Node: HEVNode: HEV
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Node: Diagram summaryNode: Diagram summary
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SpleenSpleen
LocationLocation StructureStructure CirculationCirculation Immunological functionImmunological function Summary DiagramSummary Diagram
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Spleen: Connective TissueSpleen: Connective Tissue
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Spleen: X section low magSpleen: X section low mag
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Spleen : X section higher magSpleen : X section higher mag
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Spleen: circulationSpleen: circulation
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Spleen EM: Marginal zoneSpleen EM: Marginal zone
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Marginal zone B cellsMarginal zone B cells
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Antigen localization in SpleenAntigen localization in Spleen
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Spleen: Summary DiagramSpleen: Summary Diagram
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The EndThe End