08-Genomic Integrity and Cancer

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    The Biology of CancerFirst Edition

    Chapter 12:

    Maintenance of Genomic Integrity

    and the Development of Cancer

    Copyright Garland Science 2007

    Robert A. Weinberg

    Figure 12.1 The Biology of Cancer( Garland Science 2007)

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    Figure 12.2a The Biology of Cancer( Garland Science 2007)

    Figure 12.2b The Biology of Cancer( Garland Science 2007)

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    Figure 12.2c The Biology of Cancer( Garland Science 2007)

    Figure 12.3a The Biology of Cancer( Garland Science 2007)

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    Figure 12.3b The Biology of Cancer( Garland Science 2007)

    Figure 12.3c The Biology of Cancer( Garland Science 2007)

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    Figure 12.4 The Biology of Cancer( Garland Science 2007)

    Figure 12.5a The Biology of Cancer( Garland Science 2007)

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    Figure 12.5b The Biology of Cancer( Garland Science 2007)

    Figure 12.5c The Biology of Cancer( Garland Science 2007)

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    Figure 12.5d The Biology of Cancer( Garland Science 2007)

    Figure 12.5e The Biology of Cancer( Garland Science 2007)

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    Figure 12.5f The Biology of Cancer( Garland Science 2007)

    Figure 12.6 The Biology of Cancer( Garland Science 2007)

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    Figure 12.6 (part 1 of 2) The Biology of Cancer( Garland Science 2007)

    Figure 12.6 (part 2 of 2) The Biology of Cancer( Garland Science 2007)

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    Figure 12.7 The Biology of Cancer( Garland Science 2007)

    Figure 12.8a The Biology of Cancer( Garland Science 2007)

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    Figure 12.8b The Biology of Cancer( Garland Science 2007)

    Figure 12.8c The Biology of Cancer( Garland Science 2007)

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    Figure 12.8d The Biology of Cancer( Garland Science 2007)

    Figure 12.9 The Biology of Cancer( Garland Science 2007)

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    Figure 12.10 The Biology of Cancer( Garland Science 2007)

    Figure 12.11a The Biology of Cancer( Garland Science 2007)

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    Figure 12.11b The Biology of Cancer( Garland Science 2007)

    Figure 12.12a The Biology of Cancer( Garland Science 2007)

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    Figure 12.12b The Biology of Cancer( Garland Science 2007)

    Figure 12.13 The Biology of Cancer( Garland Science 2007)

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    Figure 12.14a The Biology of Cancer( Garland Science 2007)

    Figure 12.14b The Biology of Cancer( Garland Science 2007)

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    Figure 12.15b The Biology of Cancer( Garland Science 2007)

    Figure 12.16 The Biology of Cancer( Garland Science 2007)

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    Figure 12.17 The Biology of Cancer( Garland Science 2007)

    Figure 12.18a The Biology of Cancer( Garland Science 2007)

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    Figure 12.18b The Biology of Cancer( Garland Science 2007)

    Figure 12.19a The Biology of Cancer( Garland Science 2007)

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    Figure 12.19b The Biology of Cancer( Garland Science 2007)

    Figure 12.20 The Biology of Cancer( Garland Science 2007)

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    Figure 12.21a The Biology of Cancer( Garland Science 2007)

    Figure 12.21b The Biology of Cancer( Garland Science 2007)

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    Figure 12.21c The Biology of Cancer( Garland Science 2007)

    Figure 12.22a The Biology of Cancer( Garland Science 2007)

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    Figure 12.22b The Biology of Cancer( Garland Science 2007)

    Figure 12.22c The Biology of Cancer( Garland Science 2007)

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    Figure 12.22d The Biology of Cancer( Garland Science 2007)

    Figure 12.23a The Biology of Cancer( Garland Science 2007)

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    Figure 12.23b The Biology of Cancer( Garland Science 2007)

    Figure 12.24 The Biology of Cancer( Garland Science 2007)

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    Figure 12.27 The Biology of Cancer( Garland Science 2007)

    Table 12.1 The Biology of Cancer( Garland Science 2007)

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    Figure 12.28 The Biology of Cancer( Garland Science 2007)

    Table 12.2 The Biology of Cancer( Garland Science 2007)

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    Figure 12.32 The Biology of Cancer( Garland Science 2007)

    Figure 12.32 part 1 of 2 The Biology of Cancer( Garland Science 2007)

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    Figure 12.32 part 2 of 2 The Biology of Cancer( Garland Science 2007)

    Figure 12.33 The Biology of Cancer( Garland Science 2007)

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    Figure 12.36b The Biology of Cancer( Garland Science 2007)

    Figure 12.37a, b The Biology of Cancer( Garland Science 2007)

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    Figure 12.37c The Biology of Cancer( Garland Science 2007)

    Figure 12.38a The Biology of Cancer( Garland Science 2007)

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    Table 12.3 The Biology of Cancer( Garland Science 2007)

    Figure 12.39 The Biology of Cancer( Garland Science 2007)

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    Key Concepts

    Structural integrity, mutability two barriers to cancer occurrence

    Stem cell, transit-amplifying cell, differentiated cell

    DNA replication, error-correction, MMR, HNPCC

    Mutagenesis mechanisms- internal and exogenous, oxidativephosphorylation, ROS, detoxifying enzymes, xenobiotics

    Base excision repair, nucleotide excision repair

    Double strand break, chromosomal scrambling, chromosomal numberchange

    Cancer Genome

    Analysis

    Copy number change

    CGH

    Gene expression pattern

    Microarray, qPCR

    DNA sequence alteration

    NGS

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    Figure 11.20 The Biology of Cancer( Garland Science 2007)


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