06 Schafer BariatricSurgery.ppt › 2020 › MDM20M20 › slides › 06... · bone metabolism Early...
Transcript of 06 Schafer BariatricSurgery.ppt › 2020 › MDM20M20 › slides › 06... · bone metabolism Early...
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Bariatric Surgery: What the Generalist Needs to Know
Anne Schafer, MDChief of Endocrinology & Metabolism, SFVAHCS
Associate Professor of Medicineand of Epidemiology & Biostatistics, UCSF
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DisclosuresResearch support:▫ Investigator-initiated research grant from Amgen▫ Dietary supplements for research studies
donated by Bariatric Advantage and Tate & Lyle
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Objectives• Describe the effects of bariatric surgery on
cardio-metabolic outcomes and mortality
• Identify basic eligibility criteria for surgery
• Apply recommendations for post-op medical management, monitoring
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Case 146 y.o. woman w/ severe obesity, type 2 DM, HTN, GERD•Wt increased from 240 to 280 lbs over
last 10 years (BMI 40 to 46 kg/m2)• Lost 20 lbs with Weight Watchers then
regained 10 lbs•Walks 30 min 3 times/week
Weight loss surgery?
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61 y.o. man with obesity, type 2 diabetes• 423375 lbs (BMI 5448 kg/m2)•Roux-en-Y gastric bypass surgery 240 lbs (BMI 31) Insulin discontinued
•New low back pain
Why did he fracture?
Case 2
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• 38% of US adults (Men 35%, women 40%)1
▫ Stage 3 obesity (BMI ≥40 kg/m2): 7.7%Men 5.5%, women 9.9%
• Lifestyle changes usually do not result in clinically meaningful and sustained wt loss▫ Rarely of the magnitude needed for those with
extreme obesity1Flegal, JAMA 2016
Obesity is an important and growing public health problem
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Wadden, N Engl J Med 2011
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Almost 10-fold increase in operations performed annually in the early 2000s
• 25,000 operations in 1998 220,000 in 20091
1Buchwald, Obes Surg 2009
Growing demand for bariatric surgery
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DeMaria, N Engl J Med 2007
Biliopancreatic diversion with
duodenal switch
Adjustable gastric band
Malabsorptive Restrictive
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DeMaria, N Engl J Med 2007
Roux-en-Y gastric bypass
(RYGB)
Sleeve gastrectomy
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Sjostrom, JAMA 2012
Comparative weight loss outcomes
Control
LAGB
VBG
RYGB
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Maciejewski, JAMA Surg 2016
Comparative weight loss outcomes
LAGB
Sleeve
RYGB
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• Completely resolved in 77%, and resolved or improved in 86%1
▫ 84% resolved after RYGB, 48% after gastric banding
• Resolution often occurs days after RYGB, even before marked weight loss2
• Weight-dependent and weight-independent mechanisms
1Buchwald, JAMA 2004; 2Rubino, Ann Surg 2004
Type 2 diabetes
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• All procedures: Weight loss▫Weight Insulin resistance
• RYGB: Additional endocrine effects1-3
▫ GLP-1 Insulin secretion• “Incretin effect”
▫ Ghrelin, PYY Hunger, satiety
1Rubino, Ann Surg 2004; 2Laferrere, JCEM 2008; 3Cummings, JCEM 2004
Why does diabetes improve/resolve?
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1. More diabetes remission with RYGB (75%) and BPD (95%) than conventional medical tx (0%) at 2 yrs1
2. 150 obese pts w/ uncontrolled DM underwent intensive medical therapy +/-RYGB or sleeve gastrectomy2
▫ 12% (medical tx alone) vs. 42% (RYGB) vs. 37% (sleeve) had A1c <6.0% at 12 months
1Mingrone, NEJM 2012; 2Schauer, NEJM 2012
Diabetes RCTs
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Schauer, NEJM 2012
Intensive medical therapy
Sleeve gastrectomyRoux-en-Y gastric bypass
Intensive medical therapy
Sleeve gastrectomyRoux-en-Y gastric bypass
HbA1c
# DMMeds
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• SBP and DBP as early as 1 week post-op1
▫ Weight-independent as well as -dependent mechanisms
• HTN resolves or improves in 79%2
• Complete resolution after 3 yrs in 38% of RYGB pts and 17% of LAGB pts3
1Ahmed, Obes Surg 2009; 2Buchwald, JAMA 2004; 3Courcoulas, JAMA 2013
Hypertension
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• Hypercholesterolemia improves in 71%, hypertriglyceridemia in 82%1
• Resolution of dyslipidemia after 3 yrs in 62% of RYGB pts and 27% of LAGB pts2
1Buchwald, JAMA 2004; 3Courcoulas, JAMA 2013
Dyslipidemia
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Sjostrom, JAMA 2012
• CV deaths: adjusted HR 0.47 (0.29-0.76)
Cardiovascular outcomes: Swedish Obesity Subjects Study
Fatal CV Events Total CV Events
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Sjostrom, JAMA 2012
Cardiovascular outcomes: Swedish Obesity Subjects Study
No interaction with baseline BMI
Stronger CV effect if high baseline insulin level
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• 29% reduction in risk after 10 yearsSjostrom, NEJM 2007
Mortality: Swedish Obesity Subjects
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Adams, NEJM 2007
Mortality: Utah gastric bypass study
• Covariate-adjusted mortality: 40% lower in surgery group
• Death rates for specific causes:• Lower for CVD, diabetes, cancer
• CVD: HR 0.50 (95% CI 0.36-0.69)• Higher for suicide/accidents
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Mortality: Stronger protective effect in patients with diabetes
Lent, Diabetes Care 2017
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Objectives• Describe the effects of bariatric surgery on
cardio-metabolic outcomes and mortality
• Identify basic eligibility criteria for surgery
• Apply recommendations for post-op medical management, monitoring
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Case 146 y.o. woman w/ severe obesity, type 2 DM, HTN, GERD•Wt increased from 240 to 280 lbs over
last 10 years (BMI 40 to 46 kg/m2)• Lost 20 lbs with Weight Watchers then
regained 10 lbs•Walks 30 min 3 times/week
Weight loss surgery?
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Typical criteria:•BMI ≥40 kg/m2, or BMI ≥35 kg/m2 with an obesity-related co-morbidity•Failure of lifestyle/medical weight control•Absence of psychological or medical contraindications
Undertreated psychiatric conditions Low likelihood of adherence to post-op requirements Poor coping strategies, lack of social support Eating disorders
Bariatric surgery: Eligibility criteria
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Typical criteria:•BMI ≥40 kg/m2, or BMI ≥35 kg/m2 with an obesity-related co-morbidity•Failure of lifestyle/medical weight control•Absence of psychological or medical contraindicationsPotential exclusion criteria (varies by practice):•>400 lbs, tobacco or other substance use/abuse, CHF or pulmonary HTN not responsive to medical therapy, O2-dependent COPD, cirrhosis
Bariatric surgery: Eligibility criteria
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Case 146 y.o. woman w/ severe obesity, type 2 DM, HTN, GERD•Wt increased from 240 to 280 lbs over
last 10 years (BMI 40 to 46 kg/m2)• Lost 20 lbs with Weight Watchers then
regained 10 lbs•Walks 30 min 3 times/week
Weight loss surgery?
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Objectives• Describe the effects of bariatric surgery on
cardio-metabolic outcomes and mortality
• Identify basic eligibility criteria for surgery
• Apply recommendations for post-op medical management, monitoring
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• Anticipate potentially abrupt decrease in insulin/oral diabetes med needs• Often, stop sulfonylureas at surgery• Decrease insulin doses• Metformin often continued• Self-monitoring and self-titration
Post-op management: Diabetes
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• Anti-hypertensive medications• No preemptive D/C of agents• Monitor closely at visits and adjust
• Lipid-lowering medications• Many bariatric surgery pts will continue to
meet criteria for statin use• Caution about creating expectations that
statins will be d/c’ed post-op
Post-op management
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• Oral meds: crush in initial post-op months• Avoid NSAIDs• Caution with meds dosed based on
weight (e.g., levothyroxine)• Caution about potential malabsorption of
meds
Other medication strategies
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• Weight regain• Micronutrient
deficiencies• Protein deficiency• Dumping syndrome
• Gallstones• Nephrolithiasis• Acute gout• Bone loss• Hypoglycemia
Potential metabolic and nutritional complications
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• Vitamin B12• Calcium, vitamin D• Iron• Thiamine• Folic acid• Vitamin A• Vitamin K; zinc; selenium; copper
MalabsorptionLess foodDifferent food
Micronutrient deficiencies
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• Multivitamin• 1-2 daily (often 1 bariatric-potency chewable)
• Vitamin B12• 350-1000 mcg/day po or 1000 mcg/month IM
• Vitamin D• 3000 IU daily
• Iron• Menstruating women; take with ascorbic acid
• Calcium citrate• 1200-1500 mg elemental Ca daily from diet + Ca
citrate supplement (more for BPD/DS)
Routine supplements
Parrott, Surg Obes Relat Dis 2017
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• Pre-op, q 6 months x 2 years, annually• Vitamin B12• Calcium• Intact PTH• 25(OH) vitamin D• Ferritin• Thiamine• (Folate, vitamin A, zinc, copper)
Biochemical monitoring
Heber (Endocrine Society), JCEM 2010; Mechanick (AACE/TOS/ASMBS), Surg Obes Relat Dis 2013
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• Abdominal cramping, nausea, diarrhea, lightheadedness, flushing, tachycardia
• Concentrated sweets hyperosmolarity of intestinal contents influx of fluid into intestinal lumen?
• Role of gut peptides?• Perhaps 75% of gastric bypass pts• Often transient issue, early post-op period
Dumping syndrome
Heber (Endocrine Society), JCEM 2010
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• Dx of hypoglycemia requires Whipple’s triad• Symptoms• Low glucose concentration• Resolution of sxs with glucose correction
Dumping vs HypoglycemiaDumping syndrome Hypoglycemia
Occurs early after eating (~30 min)
Occurs 1-3 hours postprandially
Develops in early post-op period, often resolving over time
Develops ≥1 year post-op
Patti, Lancet Diabetes Endocrinol 2016
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Hypoglycemia: Potential mechanisms• Overtreatment with insulin, sulfonylurea• Postprandial insulin secretion ▫ Intestinal delivery rapid glucose▫ Incretin effect (GLP-1, GIP)▫ Islet cell mass• Non-insulin dependent mechanisms▫ Dysregulated enteroendocrine secretion▫ Altered gut microbiota▫ Bile acids
Patti, Lancet Diabetes Endocrinol 2016
simple carbs;acarbose
octreotide
diazoxide; CCBs
X
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• Protein deficiency• Eat protein first; 60-120 g/d or 1.5 g/kg IBW
• Gallstones• Ursodiol, or simultaneous cholecystectomy
• Nephrolithiasis• Hydration; low oxalate diet; oral Ca; KCit
• Acute gout• Prophylactic therapy in appropriate pts
• Bone loss and fracture• Ca and vit D; consider DXA in at-risk pts
Other prevention, treatment
Heber (Endocrine Society), JCEM 2010; Mechanick (AACE/TOS/ASMBS), Surg Obes Relat Dis 2013
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Objectives• Describe the effects of bariatric surgery on
cardio-metabolic outcomes and mortality
• Identify basic eligibility criteria for surgery
• Apply recommendations for post-op medical management, monitoring
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1Compston, Gastroenterology 1984; 2Fish, J Surg Res 2010;3Dixon, Obesity 2007
•Gastric bypass induces abnormalities in bone metabolism▫ Early and sustained s in bone turnover▫ Decreases in bone mineral density (BMD)• Fewer data for other procedures▫ Biliopancreatic diversion: similar1
▫ Gastric band: less impact on bone2,3
Bariatric surgery and skeletal health
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BMD decreases substantially
-18
-16
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-10
-8
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2
6 120Month
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m b
asel
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Femoral Neck (DXA)
**
6 120Month
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m b
asel
ine
Spine (QCT)
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0
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Schafer, J Bone Miner Res 2015
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Bone loss: Potential mechanisms
•Decreased loading• Nutritional factors▫ vitamin D and Ca intake▫ Ca absorption1,2
•Changes in fat-secreted hormones▫ estradiol▫ adiponectin• Loss of muscle mass1Cifuentes, Am J Clin Nutr 2004; 2Shapses, Am J Clin Nutr 2013
DRAMATIC! RAPID!^
+ MALABSORPTION
+ RYGB-SPECIFICNEUROHORMONALEFFECTS
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Intestinal Ca absorption capacity decreases precipitously
Schafer, J Bone Miner Res 2015
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Concern for early fracture-related morbidity and mortality among bariatric
surgery patients
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61 y.o. man with obesity, type 2 diabetes• 423375 lbs (BMI 5448 kg/m2)•Roux-en-Y gastric bypass surgery 240 lbs (BMI 31) Insulin discontinued
•New low back pain
Why did he fracture?
Case 2
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• Not taking Ca or vitamin D supplements• DXA: Total hip T-score -1.8
Ca(8.5-10.5)
Alb(3.3-5.2)
Phos(2.5-4.5)
Cr(0.6-1.3)
25OH D(30-50)
PTH (12-65)
24h Uca(100-250)
8.4 3.6 2.5 1.1 17
• Vitamin D repletion course, daily Cacarbonate and vitamin D maintenance
8.5 3.5 3.0 1.1 28 80 58
• Increased Ca intake and switched to citrate
8.4 3.7 2.8 1.3 34 144
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Recommendations for bone healthCheck and replete 25(OH)D pre-opUniversal post-op supplements
• Multivitamin, calcium (dose?), vitamin DLabs q 6 mo x 2 yrs then annuallyPost-op exercise/resistance training?Monitor BMD by DXA?Pharmacologic therapy for high risk pts?
Heber (Endocrine Society), JCEM 2010; Mechanick (AACE/TOS/ASMBS), Surg Obes Relat Dis 2013
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Thank you!