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Choices Affecting Regenerative Outcomes

Cheryl Bagley

April 2017

Helping Stem Cells through Nutrition

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MY STORY

• IT band injury long-distance cycling 2009, and

subsequent partial ACL tear

• Intention to avoid surgery at any cost– Elected PRP & BMAC

– 45-50 yrs. old - focused on whole dense nutrient rich foods and

working on improving digestion

• Completed Pittsburgh to DC bike trip again, painlessly,

last summer (4th time)

• Completed Mud on the Mountain 2013

• Hiked all over Utah summer of 2014

• Mud on the Mountain 2015

• Hiked with grandchild in the Adirondacks 2017

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HOWDY

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• I’m back - again

• Quick review – nutrition matters

• Specific foods enhance the

generation of new stem cells

• What a day might look like

• Two ways to implement

• Case studies for nutrition

• A take home for you

DISCUSSION

https://fineartamerica.com/featured/bone-marrow-stem-cell-on-cartilage-science-photo-library.html

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OUR 13 TIPS

1. Stop sugar

2. Anti-inflammatory diet

3. Eliminate food sensitivities

4. Sleep

5. Digestion

6. Hydration/minerals

7. Bone broth

8. Fermented foods

9. Get moving

10. Mindfulness

11. Infrared heat

12. Supplements

13. Laughter

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OUR 13 TIPS

1. Stop sugar

2. Anti-inflammatory diet

3. Eliminate food sensitivities

4. Sleep

5. Digestion

6. Hydration/minerals

7. Bone broth

8. Fermented foods

9. Get moving

10. Mindfulness

11. Infrared heat

12. Supplements

13. Laughter

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What’s stopping YOU?

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• More peer reviewed articles

• FDA changing the food pyramid

• Wellness centers prospering

• $33.9 Billon spent in 2009 on

alternative health care

• Stem cell therapy increasing

• Paleo choices

• Cross Fit

ARE YOU STARTING TO BELIEVE?

More & more people believe

that food matters

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Body Nutritional Composition

Water 60% Carbs 2%

Protein 18% Vitamins <1%

Fats 15% Minerals 4%

QUICK REVIEW

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ROLES NUTRIENTS PLAY IN HEALING

WATER• Transports nutrients

• Oxygen delivery & hydration to cells

• Lubricates tissues

PROTEINS• Building blocks for cellular-level response

• Helps tissue regeneration

• Oxygen for tissues and energy

• Enzymes help convert essential fatty acids

FATS• Building blocks for cell membranes

• Prostaglandins for inflammation processes

• Required for adequate use of proteins

• Provide a source of long burning energy

CARBOHYDRATES• Help regulate protein and fat metabolism

• Help fight infection

• Promote growth of tissue

• Lubricate joints

VITAMINS• Essential for growth and vitality

• Aide in digestion

• Co-enzymes in metabolism

MINERALS• Maintain pH

• Contract and relax muscles

• Regulate tissue growth

• Structural and functional support

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NUTRITION MATTERS

Cell components come from food

• Nutrients are converted to a usable

from of energy

• Ingredients we need to repair muscles

organs and skin

• Continual cell turnover creates state of

health and resilience

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• Cellular regeneration happens

continually

• 50-75 trillion in the body

• Bones and ligaments are breathing

living cells that regenerate

• RBC every 4 mos.

• WBC about 1/yr.

CELL REGENERATION

What do you and your patients

want cells replaced with?

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PLEASE, NOT THIS!

This is not food

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• Food choices are like selecting

building materials

• Quality matters

• Combinations matter

• Nutrients must be available

when cells are regenerating

NUTRIENTS, NOT CALORIES

http://odranoel.eu/human-tissues/close-to-the-bone-by-odra-noel/

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PARTS IS PARTS

• Inadequate nutrition prolongs wound

healing, increasing risk factors

• Malnutrition linked to decreased tensile

wound strength and higher infection rates

• Vigor of patients affects recuperative

activity and psychological factors

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• Angiogenesis

• Inflammation reduction

• Bio-availability

• Growth factors

• Cytokines, etc.

NUTRIENTS AFFECT HEALING

http://journals.sagepub.com/doi/abs/10.1177/14

7323000903700531?journalCode=imra

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Berries. Blueberries, raspberries, blackberries all help build up the powerful antioxidant superoxide dismutase (SOD).

This is excellent for reducing oxidative stress, a key factor in liver support and the prevention of joint pain. Berries are also

rich in flavonoids that reduce inflammation and repair cellular damage.

Broccoli. Broccoli may not be a kid-favorite, but this cruciferous vegetable is rich in sulforaphane, a chemical that

increases enzymes in the liver, which work to neutralize the harmful toxins we breathe. Further, all cruciferous vegetables

are packed with a unique molecule called indole-3-carbinol that reduces inflammatory agents in the blood.

Ginger root. Ginger root does more than settle stomach issues. The knobby root combats painful inflammation by

inhibiting the effects of arachidonic acid, a necessary fat that triggers the inflammatory response.

Nuts and seeds. These handy snacks have healthy fats and protein to keep your full longer and satisfy your

cravings. Their benefits don’t end there: Nuts like walnuts and almonds, and seeds such as flax, hemp and chia are high in

alpha-linolenic acid, a type of anti-inflammatory omega-3 fat. Seeds also contain plant sterols, also reputed for their anti-

inflammatory properties.

Mushrooms. Long a staple in traditional medicine, mushrooms like shiitake and maiitake are high in polyphenols.

These are nutrients known to help protect liver cells from damage. Supporting the liver is critical in fighting inflammation,

because this is where we filter out toxins and break down our hormones.

Fatty fish and seafood. A must for any healthy diet, seafood contains eicosapentaenoic acid, a powerful anti-

inflammatory type of omega-3 fatty acid. Studies show the oil in fish can act in an anti-inflammatory manner. Also great for

the brain and heart!

“EYE OF NEWT?” NO…

BUT REAL FOODS DO MATTER

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WHAT SCAFFOLDING FOODS DO YOU WANT?

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• Blueberries (wild) – Anthocyanosides

(antioxidants catalysts for bio-

flavinoids)

• Increased neurogenesis

• Purifies blood

• Slows aging on cells and organs

• Tissue regeneration-SOD and

catalase

SPECIFIC FOODS TO ENHANCE HEALING

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• L-Carnosine- amino acid functions in

the skeletal, muscles, brain and

nervous system

• Rejuvenate cells approaching

senescence (aging)

• Restoring normal appearance and

extending cellular life span

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SPECIFIC FOODS TO ENHANCE HEALING

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Bone broth is Rich Food

– Nutrient dense and soluble

– Easy to digest

– Boost immune system

– Loaded with minerals

– Collagen-19 amino acids 2nd to H20 most

plentiful substance in our body-gelatin-

glycine-hyaluronic acid

• Calcium

• Phosphorous

• Magnesium

• Potassium

EASY TO MAKE. CHEAP. TASTY.

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SPECIFIC FOODS TO ENHANCE HEALING

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• Green tea-bio-active components

polyphenols-catechins (antioxidants)

• Reactivate dying skin cells

• Accelerate wound healing and decrease

scarring

• Mitigate bone loss

SPECIFIC FOODS TO ENHANCE HEALING

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• Vitamin A - carrots, sweet potatoes dark leafy greens

– Epithelial/bone formation, cellular differentiation and immune function

• B-Vitamins – calf’s liver, dark leafy greens, lentils, beets

– Convert our food into fuel, reduces stress, provides antioxidants, and boosts HDL

• Vitamin C- strawberries, oranges, RBP, kale, broccoli

– Collagen formation, immune function and a tissue antioxidant

• Vitamin D3 - sunlight, sardines, yogurt, kefir

– Absorb calcium and bone growth

• Zinc – oysters, spinach, beef

– aides in nutrient absorption and digestion, helps with muscle growth and repair

VITAMINS = FOOD

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• Brown vs. White rice

• Bone broth

• Form the building blocks of proteoglycans

which are the major building blocks of the

extracellular matrix.

• Vital in determining the cellular activities such

as cell division because the cell division

machinery has to attach itself to the

extracellular matrix before the division process

is initiated.

• Dependent on fluid intake for availability

BONE BROTH = GLYCOSAMINOGLYCANS

GAGs are good

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• Granulocyte-macrophage colony stimulating factor (GM-

CSF)

• Produced naturally by bone marrow to stimulate cell

activity

• Single nutrients showed no results

• Synthetic GM-CSF 46%

• Combinations of nutrients 62-83%

– Blueberries; green tea extract

– Blueberries; green tea extract; D3

– Blueberries; L-carnosine

NUTRIENTS TESTED TOGETHER

Bickford, Paula C., et al. "Nutraceuticals synergistically promote proliferation of human stem cells." Stem cells

and development 15.1 (2006): 118-123.

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• Broccoli -rich in folic acid (helps bone

marrow cells to differentiate into mature

WBC

• Broccoli sprouts-high in glucoraphanin

precursor to sulforphane (SGS)

antioxidant 30-50 x more than broccoli

• Mushrooms - Chaga (SOD and sterols)

block oxidative damage of tissues - very

new studies

MORE SPECIFIC FOODS

Sim, Y. C., et al. "Effects of polysaccharides isolated from Inonotus obliquus against hydrogen peroxide-induced oxidative damage in RINm5F pancreatic β-

cells." Molecular medicine reports 14.5 (2016): 4263.

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• 78 participants

• 113 degree stimulus to the leg twice

– Book on tape 3%

– Placebo analgesic cream 1%

– Shamatha meditation 22% = morphine

– Mindfulness meditation 44% = dbl morphine

MINDFULNESS

Zeidan, Fadel, et al. "Mindfulness-meditation-based pain relief is not mediated

by endogenous opioids." Journal of Neuroscience 36.11 (2016): 3391-3397.

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WHAT A DAY MIGHT LOOK LIKE

– Wake up- mindfulness

– Green tea-polyphenols

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BREAKFAST

Morning smoothie

Blueberry Energizer

Yogurt, almond milk and or kefir, hemp

protein powder and or gelatin and

greens

Blueberries, chia seeds, flax and or

hemp and coconut milk

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MORNING BREAK

Chaga tea with coconut milk

Apple-nut butter

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LUNCH

Kale and broccoli salad with

grilled salmon and EVOO

dressing, topped with a

fermented veggie, broccoli &

sprouts

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AFTERNOON SNACK

1-2 cups of bone broth Avocado with olive oil

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DINNER

• Grass fed flank steak

• Spinach

• Sweet potatoes and or roasted carrots

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NO EXCUSES

=

$8 lb. $16 lb.

$2/burger $4/burger

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DESSERT

Coconut Ice Cream

This might be a little much

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WATER

Dehydration delays

tissue recovery

Drink half body weight in ounces. Quality matters.

No more than 100 ounces each day.

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• Omega 3’s (fish oil)

• B-Vitamins

• Vitamin C

• Vitamin D3

• Zinc (if needed)

• Turmeric (pre-procedure)

SUPPLEMENTS

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SIDE EFFECTS OF REGENERATIVE

MEDICINE AND HEALTHY FOOD

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AND FOOD IS SAFE

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SIDE EFFECTS OF THE STANDARD

AMERICAN DIET

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Female 40 yo (vegetarian), professional

• Complaints: Idiopathic migraines, over-weight, fatigue, stressed;

bloating with stomach pain.

• Bio-individual Plan:

– Sugar control food plan reduce inflammation & adrenal fatigue

– MRT – Remove sensitive foods

– Bone broth

– Digestion protocol

– Traveling food plan

– Hydration

– Activity calendar

• Post Report: weight loss, eliminated stomach issues, overall

stress reduction, more energy sleeps all night feels great when

wakes up

BIOINDIVIDUAL CASE STUDY - 1

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Male 60 yo athlete; peak form-cyclist; long-term

• Complaints: muscle cramps, bloating, GERD, fatigue,

frequent steroid injections and brain fog

• Bio-individual Plan:

– Remove sensitive foods

– Sugar control food plan

– Replaced all energy boots with natural options

– Digestive supplemental program

– Hydration and natural minerals

– Remove amalgam fillings

– PRP

• Post Report:– Steroid injections

– GERD and bloating gone

– Muscle cramping eliminated

– Brain fog much better

BIOINDIVIDUAL CASE STUDY - 2

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Female, 50 yo active business owner

• Complaints: IBS, bloating and chronic knee pain and stress

• Bio-individual Plan:

– Remove sensitive foods

– Anti-inflammatory food plan

– Healing gut foods

– PRP

– Mindfulness

– Bio-individual supplemental program

• Post Report:– IBS controlled

– Bloating totally eliminated

– Knee pain reduced

– Stress reduction

BIO-INDIVIDUAL CASE STUDY - 3

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Female 62 yo active teacher

• Complaints: Rosacea, GERD, constipation and poor bone health

• Bio-individual plan

– Gallbladder cleanse

– Castor packing

– Lymph drainage massage monthly

– Food plan with fermented and cultured foods

– Supplemental program

• Post report

– Rosacea eliminated

– GERD and constipation gone

– Osteopenia under control

– Weight loss

– More energy, skin is clearer, better sleep and bone health improving

BIO-INDIVIDUAL CASE STUDY - 4

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TWO WAYS TO GET STARTED

2. BIO-INDIVIDUAL – CONCIERGE PRACTICE

1. COOKIE CUTTER – STANDARD PLANS

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Generic plan

1. Pre-procedure– Anti-inflammatory food plan for at

least 2 weeks

2. Post-op– Give a list of foods post

procedure

– Supplements for post procedure

1. COOKIE CUTTER – STANDARD PLANS

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STANDARD ORTHOPEDIC FOOD LIST

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2. FOR THE CONCIERGE PRACTICE

1. Run an MRT

2. Create a personal anti-inflammatory food plan

3. Short term plan and long term plan

4. Supplemental protocol based on your findings

5. Hire or associate with an NTP, RD, CN & make

them a part of your practice

6. Create bio-individual culinary program for each

client based on their personal needs

YOU MIGHT:

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BIO-INDIVIDUAL PROCESS EXAMPLE

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TIP 3 - FOOD SENSITIVITIES

• Mediated response

• Inflammation

• Digestive issues

• Bio-Individual food sensitivities

WE RUN AN MRT ON EVERY PATIENT

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1. Short term plan

– Hydration recommendation

– Make “sole” mineral water

– Make digestive tea with slippery elm bark and marshmallow root

– Start each morning with sole ACV water 16 oz.

– Have goat yogurt 4 x each week

2. Long term plan

– Take MRT

– Activate digestion to function optimally

– Gallbladder cleanse

– Correct EFA imbalance

– Address Immune system

– Support adrenals with food plan, supplements and mindfulness

– Create bio-individual food plan

PERSONAL PLAN

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Does nutrition matter?

Can foods enhance outcomes?

Ways to get started

Why not?

WRAP-UP

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MEET SOLE’

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MY WORK

• “Rejuvitrition” is about how to rejuvenate the body through

nutritional and lifestyle choices.

• Rejuvitrition Pillars:

– Nourish

– Cleanse

– Renew

– Move

– Live

• Certified Nutritional Therapy Practitioner; GAPs Practitioner;

Restorative Wellness Practitioner; Certified Healing Food

Specialist, Culinary degree from The Art Institute of Pittsburgh.

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FOR MORE…

1. Greco, Whitney B., and Nancy McLaughlin. "Orthopedic uses of stem cell therapy."

Journal of the American Academy of Physician Assistants 28.4 (2015): 58-62.

2. Smith, T. K. "Nutrition: its relationship to orthopedic infections." The Orthopedic clinics

of North America 22.3 (1991): 373-377.

3. Enig, Mary G., PhD. “Know Your Fats – The Complete Primer for Understanding the

Nutrition of Fats, Oils, and Cholesterol. Bethesda Press 2008

4. Campbell-McBride, Natasha. "Gut and psychology syndrome." Journal of

Orthomolecular Medicine 23.2 (2008): 90-94

5. Vartanian, Arsy, and Amy Kubal. The Paleo Slow Cooker: Healthy, Gluten-free Meals

the Easy Way. Race Point Pub, 2013.

6. Huang, Shurong, et al. "Saturated fatty acids activate TLR-mediated proinflammatory

signaling pathways." Journal of Lipid Research 53.9 (2012): 2002-2013.

7. Ozkalkanli, Murat Y., et al. "Comparison of tools for nutrition assessment and

screening for predicting the development of complications in orthopedic surgery."

Nutrition in Clinical Practice 24.2 (2009): 274-280.