03 vaccinationstrategieslast herin
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Transcript of 03 vaccinationstrategieslast herin
PCV2 vaccination strategies
Jean-Bernard HERIN,Merial France
Agenda
• PCV2 characteristics• PCVD: the disease has changed over time• PCV2 control strategies
« How to optimize PCVD control according to what we currently know and the available
tools? »
PCV2 characteristics and image
• PMWS raised in 1995• PCV2 : a worrying virus…
– Stable and resistant virus / disinfection difficult – Found everywhere / unlikely to eradicate– Impact on piglet immunity and farmer’s revenue
• Still considered as a major threat by pig farmers
« What we currently know »
PCVD: 3 risk factors
• High PCV2 pressure in the herd• Poor passive immunity• Young age of piglets at exposure
Will lead to PCVD any time in the life of the pigs due to triggering co-factors
Courtesy: Dr K. Mc Cullough
Immunostimulation
« What we currently know »
Evolution of the disease
SporadicSporadic AcuteAcute ChronicChronic
In France Very rare ≈ 80% Quite all
1995-2002
Mortality PCVD
< 1 % Up to 35 % 5 to 15 %
Control measures None Management Medication
Genetic
Before 1995 Since 2002
Vaccination: sow/pigletsManagement Medication
Genetic
« What we currently know »
PMWS in 1995-2000
« What we currently know »
PCVD in 2005-2010
« What we currently know »
In pigs, has the disease changed? Yes
• Later – Move from postweaning to finishing period– Extended period for clinical signs– Mixed with other diseases
• Milder – Lower mortality, sometimes at a “residual” level– Less typical acute forms– Increased impact on performances (growth, homogeneity)
• Influenced by control measures applied since late 90’s – Management and hygiene improvement (MADEC’s rules)– Pig genetic lines(?)– Massive vaccination (sows and/or piglets)
« What we currently know »
Mortality rate in Brittany
2
2,5
3
3,5
4
4,5
5
5,5
6
1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
%
% fattening period % post weaning period
Zootechnical measures, genetic changes and vaccination allowed to control PCVD
Data from GTE –GTTT : source IFIP- EDE Bretagne 2010
Sow vaccination
Piglet/Sow vaccination
Madec’s rulesGenetic
«How to control this changing disease»
ADWG (8 to 115 kg)
620
630
640
650
660
670
680
690
700
710
1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
g/d
ADG 8-115
Growth performance improved with PCV2 vaccination
Sow vaccination
Piglet/Sow vaccination
Madec’s rulesGenetic
Data from GTE –GTTT : source IFIP- EDE Bretagne 2010
«How to control this changing disease»
PCV2 vaccination challenges
• Limiting the impact of environmental risk factors and co infections (E.Coli,Lawsonia,Flu ,PRRS)
• Assessing the infectious dynamics at herd level (necropsy, IHC, serology, PCR)
• Optimizing the vaccination strategy
«How to control this changing disease»
PCV2 Vaccination options
• Sow vaccination– Transmission of passive immunity
to offspring– Viral pressure decreased:
herd stabilization– Best ROI– Benefits on reproductive
parameters
– Long term impact: booster vaccination needed
– Passive immunity related to colostrum intake
– Interference between passive and active immunity
• Piglet vaccination– Active immunization before clinical
signs– Fast answer– « Demonstrative » vaccination
– Herd stabilization ?– One injection more– Cost– Need for combined vaccination
with Myco hyo
«Optimizing the vaccination strategy»
Possible synergy ?
« Assault program » : piglets vaccination
• Objective: – Fast protection of the piglets after 3 weeks of age
• Active immunization of piglets.• Target herds :
• post-weaning or fattening units with piglets from multi-origines,
• Farrowing units with bad colostral intake management.
«Optimizing the vaccination strategy»
« Complete program »: sow and piglets
• Objective: – Maximum security for the whole herd.
• Sow active immunization and passive of piglets, then relay with active immunization of piglets.
• Target situations : – Large size farm with management at risk,– Multiple co-infections, high pig density, – Stabilization needed during sow herd repopulation,– Optimization of reproductives performance
«Optimizing the vaccination strategy»
« Basic program » : sows
• Objective: – PCV2 herd protection with the best ROI of vaccination
• Active immunization of sows and passive of piglets.
• Target situations : – Improvement of piglet viability,– Good colostral intake management,– Introduction of naïves gilts,– Optimisation of reproductive performances,– Early form of PMWS,– Multiple co-infections in farrowing units.
«Optimizing the vaccination strategy»
Dynamics of the programsChoice of the program
COMPLETE program :Sow + piglets
Novaccination
BASIC program:Sow + gilts
ASSAULT program :piglets
ClinicalPMWS
SubclinicalSubclinicalPMWSPMWS
Demonstrative? (Show)vaccination
CoinfectionsBad colostrum intake
The best security
Better coinfections management To reduce vaccination costOptimal colotrum intake
«Optimizing the vaccination strategy»
Slaughter age (115 kg) /PCV2 vaccination program
199
193
180 179
165
170
175
180
185
190
195
200
205
Day
s
during PMWSAssaultBasicComplete
18 herds, 63 500 piglets
«Field results of Circovac programs »
Mortality rate / PCV2 vaccination program
Mortality
10,1
5,7 5,6
3,8
0
2
4
6
8
10
12
%
Acute PMWSAssaultBasicComplete
***
**
***p<0,001 **p<0,05
18 herds, 63 500 piglets
«Field results of Circovac programs »
19
Baromètre 2010 de la Baromètre 2010 de la
Evolution of the PCV2 vaccinationEvolution of the PCV2 vaccination
33
35
21
15
19
21
16
14
2
2
0 5 10 15 20 25 30 35 40
2010 (301 herds)
2009 (313 herds)
2007 (304 herds)
% of herds
Vaccination rate (%) Sow vaccination only (%)
Piglet vaccination only (%) Sow and/or piglet vaccination (%)
Evolution of the vaccination rate
PCV2 Vaccination farmer phone survey : 301 FTF herds PCV2– July – Aug 2010
21
(*) technical level evaluated by the number of weaned piglets/sow/year: bottom group less than 23 piglets, Average group between 23 and 27, top group more than 27.
PCV2 Vaccination farmer phone survey : 301 FTF herds PCV2– July – Aug 2010
Evolution of the vaccination rate
33,2
27
34,8
61,5
31
36,1
44
26,2
32
0 10 20 30 40 50 60 70
Top group (*)
Average group (*)
Bottom group (*)
Other areas
Brittany
300 sows and +
200-299 sows
100-199 sows
Farrow-to-finish farms
Fréquence en % des éleveurs de chaque classe
Basic(Sow)
Assault(Piglets)
Complete(Sow+Piglets)
Gilts acclimatization
++ 0 ++(+)
Sow reproduction ++ 0 ++(+)
Post weaning ++ + ++(+)
Fattening +(+) ++ ++(+)
Vaccination cost 100 250-300 350-400
ROI 9 4 (3 or more !)
Expected benefits of the different programs
French exampleCIRCOVAC Programs
Brittany (Density,PRRSV and
SIV +++)
Other regions(Low density,PRRS and
FLU -)
300 sows FTF farms(1-2 FTE)
1. Assault2. Basic
Basic
Large multisite herds (600 to 2000 sows, FTF or FTW)(2-7 FTE, excellent performances needed, security
+++)
Complete(sow + piglets)
Basic
Collectives farrowing units(< 860 sows)(2-3 FTE, excellent performances needed, security
+++)
Assault (piglets) Or Complete if reproductive
problems
Basic if possible
Possible herd segmentation* in 2015
* Source : C Roguet IFIP – JRP 09
Conclusion
• It is essential to adapt the vaccinal program – epidemiology, – Farm by farm
CIRCOVAC®, 1st sow and piglet PCV2 vaccine: for a tailor-made protection in pigs farms
CIRCOVAC benefits…
• Thank you for your attention.