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Parthasarathy G et al. / Pharmacie Globale (IJCP) 2011, 6 (07)

1 Pharmacie Globale(IJCP), Vol. 02, Issue 06

Available online at www.pharmacie-globale.info

PHARMACIE GLOBALE

INTERNATIONAL JOURNAL OF COMPREHENSIVE PHARMACY

FORMULATION AND CHARACTERIZATION OF TRANSDERMAL PATCHES OF NAPROXEN

WITH VARIOUS POLYMERS

G Parthasarathy*1, K Bhaskar Reddy2and V V Prasanth3

1Department of Pharmaceutics, R R College of Pharmacy, Bangalore, Karnataka, India.2Department of Pharmaceutics, Sri Venkateshwara College of Pharmacy, R V S Nagar, Chittoor, Andhra Pradesh, India.

3Department of Pharmaceutics, Gautham College of Pharmacy, Bangalore, Karnataka, India.

Received: 2 April 2011; Revised: 22 May 2011; Accepted: 29 May 2011; Available online: 5 June 2011

INTRODUCTIONNaproxen is a nonsteroidal anti-inflammatory drug, which

relieves pain and swelling. It is used to treat headaches,

muscle aches, backaches, tendonitis, dental pain,

menstrual cramps, arthritis, or gout. This drug works by

blocking the enzyme that makes prostaglandins.Decreasing prostaglandins helps to reduce pain and

swelling. The objective of the present study was to

overcome the harmful side effects of naproxen a non

steroidal anti-inflammatory drug [NSAID] which causes

severe gastro intestinal bleeding while taken orally.1 The

usage of most of the NSAIDS by oral route associated with

potential disadvantages such as peptic ulceration and

gastric bleeding. This severe drawback creates a potential

need for development of transdermal patches of NSAIDS.

The major advantage of transdermal delivery system is the

ability to avoid first-pass metabolism and also to

circumvent the hostile environment of the gastrointestinal

tract.2In the present study an attempt was made to designthe Transdermal patches of Naproxen with various

proportions of Ethyl cellulose Polymer.

MATERIALS AND METHODSNaproxen was obtained as gift sample from Brown & Berk,

Hosur. Ethyl cellulose (20cps) from Loba Chemie, Mumbai.

Hydroxy propyl methyl cellulose was procured from

Warne Hindustan Ltd, Hyderabad. The rest of the

ingredients and reagents used were of analytical grade.

Preparation of Naproxen transdermal patches

Transdermal patches of Naproxen were prepared with the

polymer Ethyl cellulose in various concentrations. The

matrix type patches were prepared by dispersing

*Corresponding Author:

G Parthasarathy

Department of Pharmaceutics, R R College of Pharmacy,

Bangalore - 560090, Karnataka, India.

Contact no: +91-9886431015; Email: mypartha@gmail.com

various proportions of Ethyl cellulose and Hydroxy propyl

methyl cellulose (10%W/V) in 30 ml of methanol. To this

dispersion weighed quantity of Naproxen (5%w/w based

on total polymer weight) is dissolved. This mixture was

stirred continuously by magnetic stirrer. After 1 hour ofstirring 10% w/w (based on total polymer weight) of

dibutylphthalate as plasticizer was added to the above

mixture as plasticizer. The stirring was continued for

another 1 hour. Then 5 ml of the sample was withdrawn

by using a pipette and slowly poured over a glass plate

covered with aluminium foil (5 x 5 cm). Care was taken to

avoid formation of air bubbles during the addition of

sample on the glass plate. The solvent was allowed to

evaporate at a controlled rate by placing an inverted glass

funnel over the glass plate. After 24 hours of drying at

room temperature, the film was removed and stored in a

desiccator.

Characterization of transdermal drug delivery system

The prepared films were characterized for thickness,

tensile strength and drug content. The thickness of the film

specimen was measured using a meter gauge. The tensile

strength of films was determined using the method

reported by Sadhana P Gupta et al3.The film was fixed to

the assembly, weights required to break the film was

noted and simultaneously film elongation was measured

with the help of a pointer mounted on assembly. Tensile

strength of the film was calculated using the formula:

Where a, b and L are the width, thickness and length of thefilm and l is the elongation of film at break point. The film

thickness and tensile strength was recorded in Table 1.

The drug content was determined by weighing the

prepared film (1cm2) and dissolving in Ethanol. The drug

concentrations were noted in Table 2.

ABSTRACTIn the present study an attempt was made to design the transdermal drug delivery system of Naproxen with

Ethylcellulose and Hydroxy propyl methyl cellulose polymer in various concentrations. Tramsdermal films were

fabricated by matrix technique with various polymer proportions using dibutylphthalate as plasticizer. Thesetransdermal drug patches were characterized for their thickness, tensile strength, content uniformity, in-vitro

release. The release profiles were found to be varied with various concentrations of Ethylcellulose Polymer. The

sample of patches prepared with 2:8 and 8:2 ratios of Ethyl cellulose and Hydroxy propyl methyl cellulose shows

highest and lowest in-vitrorelease of Naproxen respectively.

Keywords: Naproxen, Transdermal Patches, Ethyl cellulose, HPMC, NSAID.

Research Article

ISSN 0976-8157

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portion of the plot was estimated as the steady state flux

(Jss) From above studies it can be concluded that the

polymeric matrix type transdermal films of Naproxen

prepared with different grades and ratios of polymers

holds potential for transdermal delivery. The cumulative

drug release verses time plot gives a linear curve, this

supporting the test products were suitable for

transdermal patches.

CONCLUSIONFrom the above discussion it can be concluded thatnaproxen that releases from the transdermal patches of

NF-III (EC-HPMC 6:4) and NF-IV (EC-HPMC 8:2) showed

prolonged drug release. The high proportion of

hydrophobic polymer ethyl cellulose is responsible for

sustaining the drug release. This research work highlights

the best combination of drug and polymer concentrations

and also provides a rational guideline for formulating

controlled release transdermal patches. The formulated

transdermal delivery system of Naproxen can be a best

alternate to the oral formulations for effectiv therapy of

inflammatory conditions.

ACKNOWLEDGMENTThe authors are grateful to R R College of Pharmacy,Bangalore for providing research facilities and Brown &

Berk, Hosur, India for providing gift samples of the drug to

carry out this research work.

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