003 Replicação.pdf
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Transcript of 003 Replicação.pdf
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2. DNA replication
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Dogma central da Biologia Molecular
Francis Crick 1958
(autoreplicao) Transcrio Traduo Protena
DNA
Gentipo Fentipo
(RNA)
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MeselsonStahl experiment 1958
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MeselsonStahl experiment 1958
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Circular Linear
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No replicons tamnaho velocidade
E.Coli 1 4,200 kb 50 kb/min
Drosophila 3,500 40 kb 3,6 kb/minRatinho 25,000 150 kb 2,2 kb min
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Replication Timing: pulse-chase experiments
-Early Single copy-Mid Single copy + moderate repeats-Late Heterochromatin
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ORC Origen recognition complex
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DNA polymerases 53
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DNA polimerase 5 -> 3Elongao
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Primer synthesis
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Polimerizao
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DNA polymerase
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Okazaki fragmentsRemoval RNA
Extension DNALigation
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E.coli
Sliding clamp hypothesis
E.Coli PCNA
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O replissoma
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Replicao em bactria e mamferos e semelhante
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Replicao em bactria e mamferos e semelhante
Old histones distributed randomlyand new ones added by specific chaperones
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A=TG=C
A..C
G..T
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Replication errors 1-5 x 10 -9 / nucleotide
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Supercoiling +
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Topoisomerase II
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Origens de replicao e metilao
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Replicao do fago lambda
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Telomere length is genetically controlled in yeast
