StructuresStructures

Source: Introduction to Protein Structure by Branden & Tooze

Coiled-coil structure-Coiled-coil structure-knob in holeknob in hole

Source: Introduction to Protein Structure by Branden & Tooze

Coiled-coil structure. Two Coiled-coil structure. Two helices are interwined helices are interwined and gradually coil around each other.and gradually coil around each other.

Source: Introduction to Protein Structure by Branden & Tooze

Source: Introduction to Protein Structure by Branden & Tooze

Repetitive pattern of amino acids in a coiled-Repetitive pattern of amino acids in a coiled-coil coil helix. helix.

Source: Introduction to Protein Structure by Branden & Tooze

Packing of hydrophobic side chains between Packing of hydrophobic side chains between the two the two helices in a coiled-coil structure. helices in a coiled-coil structure.

Source: Introduction to Protein Structure by Branden & Tooze

Salt bridge in a coiled-coil Salt bridge in a coiled-coil helix. helix.

Source: Introduction to Protein Structure by Branden & Tooze

““Knobs in holes” in a coiled-coil Knobs in holes” in a coiled-coil helix. helix.

Source: Introduction to Protein Structure by Branden & Tooze

Dimeric Rop molecule-Dimeric Rop molecule-“knobs in holes” + “ridges in grooves”“knobs in holes” + “ridges in grooves”

Source: Introduction to Protein Structure by Branden & Tooze

Globin DomainGlobin Domain

Source: Introduction to Protein Structure by Branden & Tooze

Ridge on grooveRidge on groove

Source: Introduction to Protein Structure by Branden & Tooze

ridges & grooves-ridges & grooves-surface of side chains of surface of side chains of helix helix

Source: Introduction to Protein Structure by Branden & Tooze

Helix packing by “ridges in grooves”Helix packing by “ridges in grooves”

Source: Introduction to Protein Structure by Branden & Tooze

Sickle-cell hemoglobinSickle-cell hemoglobin

Source: Introduction to Protein Structure by Branden & Tooze

Hemoglobin moleculeHemoglobin molecule

Source: Introduction to Protein Structure by Branden & Tooze

Sickle-cell hemoglobin molecules polymerization.Sickle-cell hemoglobin molecules polymerization.