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INFORMATII PERSONALE Srtefana-Maria Petrescu

9 lnstitutul de Biochimie, Academia Romana, Splaiul lndependentei 296, 060031 Bucuresti(Romdnia)

LE (*+o) 212239069

)!K stefana.petrescu@biochim.ro

@ http:/Aarww. biochim. ro

POZITIA Director lnstitutul de Biochimie

EXPERI ENTA P RO FESI ONALA

19g7-Prezent Cercetator stiintific gr. l, Director

lnstitutul de Biochimie, Bucuresti (RomAnia)

Research coordinator, Educational activities, PhD Supervision since 2000

1992-1997 Cercetator stiintific gr. ll

lnstitutul de Biochimie, Bucuresti (Romdnia)

Research coordi nator, Educational activities

1983-1992 Cercetator stiintific gr lll

lnstitutul de Biochimie, Bucuresti (RomAnia)

Research

EDUCATTE $r FORMARE

NivelulS CEC

Stagii de cercetare in strainatate:

- 1997 -2007, Departamentul de Biochimie, Universitatea Oxford, 3-6 luni pe an

- 1999, Universitatea Washington, USA:

-- 1993, Royal Society Fellowship, Universitatea Oxford

- 1991, Departamentul de Biochimie, Facultatea de Farmacie, Universitatea Wurtzburg

1995-1997 Post Doc Nivetut 8 CEC

Glicobiologie, Departamentul de Biochimie, U.Oxford, UK, 19931995

1989-1992 Doctorat in Biologie Nivetut 7 CEC

lnstitutul de Biochimie, Academia Romana, Bucuresti (RomAnia)

Paginal l4

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13/1/16 O Uniunea Europeand, 2002-201 5 | http://europass.cedefop.europa.eu

197+-1979 Licenta si specializare in Biochimie, Facultatea de Biologie, Universitatea Bucuresti Nivelul 6 CEC

COMPETENTE PERSONALE

Limba(i)maternd(e) romdnd

Alte limbistrdine cunoscute intftfCfRf VORBTRE SCRTERE

Ascultare citire Participare.la Discurs oral

@nversalle

franenzd C2 C2 C2 C1 C1

englezd C2 C2 C2 C2 C2

Niveluri: 41 gi 42: Utilizator elementar - Bl gi 82: Utilizator independent - C1 9i C2: UtilizatorexperimentatCadrul european comun de referintd pentru limbi strdine

Competenle de comunicare

Competenle - Granturi lntema[ionale (UE, SEE/RO-CH , Wellcome Trust UK, NATO, NlH,): 7

organizalionale/manageriale -Granturi Nalionale (PCE, Academia Romana, Proiecte Complexe etc): >20

Exemple: FP6-EU - lP FOOD-CT-200$51 3959; FPS-EU QLK5-1 999-01 501 ; Wellcome Trust, UK,

CRIG 067361 2002; CEEXMATNANTECH 2006, CEEX /IASAN 2006, CEEX/RELANSIN,

CEEXCERES2007, PNlll-P3-5312016; PNll&lll:|D-PCE-201G0650;ID-PCE-2011-3'03/,2; lD-PCE-

16812007.

Proiecte coordonate Fondui europene:

POSDRU Biotehnologiicelularc cu aplicatiiin medicina,2010-2013,7.5 mileuro

POSCCE Dezvoltarea infnstructuii de cercetarc a IBAR,2010-2013.4.5 mil euro

Competenle dobAndite la locul de Domenii expertiza:

muncd Biologia Moleculard a Celulei - investigarea plieii sitraficului intncelular al proteinelor mecanisme

si puncte de control pe calea secrctoie, caile de degrcdare si relatia lorcu prezentarea antigenica,

Medicini Moleculari - metode de diagnostic si tmtament al cancerului de piele bazate pe utilizarea

antigenelor tumomle din familia tirozinazei;

Glicobiologie Moleculari - biosinteza glicoproteinelorsi interactia cu chaperonii moleculai din ER,

investigarea raportului specificitate/divercitate in distibutia microhetercgenitatii de glucid a

glicoproteinelorin functie de specie si oryan;

Biologie Celulari, Biochimie Analitici 9i Preparativi; Enzimologie

t,t,"lt'J !,

f I i Paginaztq13t1t16 O Uniunea Europeand, 2002-201 5 | http:iieuropass.cedefop.europa.eu

-\YmU Wffi#ffiffi curricurum vitaen

Competen{i digitali

Procesarea

informalieiComunicare

AUTOEVALUARE

Creare de

continutSecuritate

Rezolvarea

de probleme

tNFORMATil SUPLTMENTARE

l.Jtilizator Utilizator UtilizatorUtilizator elementar Utilizator elementarexperimentat independent independent

Competentele diqitale - Gril6 de auto-evaluare

Premii

FEBS fellowship 1990

DMD fellowship 1990

Wdlcome Trust lnternational Grant CRIG 1995, 1998

PremiulAcademiei RomAne "E.Racovi[d", 2002, pentru "Contibulli in Plierea Tirozinazel'

Premiul de Excelen[d al Ministerului Educatiei gi Cercetdrii, 2008

Alte responsabilitil$

Conducator Doctorcte, SCOSMR - $coala de Studii Avansate a Academiei RomAne

Membru al Comitetului Infnstructui Eurcpene de Cercetare - ESFRI 2007-2008

Membru in panelul european de evaluare ERC- Development and Cell Biology 2008-2015

Expert European FP EU ( Impact assessment FP prcjects) din 2001

Memb ru CNADTCU 201 0-2016

Membru CCCDI- Coordonator Bioeconomie, (20'1 S-prezent)

Membruin Comitetulde Redactie alRevisteiMdecular Life din 2016

Membru in Comisii de Doctorat din 1997

Pregedinte al Societd[ii Romane de Biochimie gi Biologie Moleculad din 2000

Activitatestiintifica lndexHirsch: 21

>1600

>270

>125

Citdri lSl-WoS, fdra autocitdri:

Factorul lmpact total al publica{iilor lSl

Scorulde lnfluentd (Al) al publicaliilor lSl

Lucrari stiintifice relevante

l.Mustata RC, Grigorescu A, Petrescu SM. "Encapsulated cargo intemalized by fusogenic liposomespaftially overlapsthe endoplasmic reticulum;' J Cell Mol Med 13(98):3110-21 Q009).

2.Popescu Cl, MaresA, ZdrentuL,Zitzmann N, Dwek RA, Petrescu SM."Productivefolding of

1311116 O Uniunea Europeand, 2002-201 5 I http://europass.c€defop.europa.eu Pagina3l 4

tyrosinase ectodomain is controlled by the tnnsmembrcne anchor."J Biol Chem.281:21682-9 (2006)

3.Popescu Cl, Paduraru C, Dwek RA, Petrescu SM. "So/uble tyrosinase is an endoplasmic reticulum(ER)-associated degradation subsfrafe rctained in the ER by calrcticulin and B|P/GRP78 and notcalnexin;' J. Biol. Chem.280,13833-40 (2005)

4.Petrescu SM, Branza-Nichita N, Negroiu G, PetrescuAJ, Dwek R, "Tyrosinase and GlycoprcteinFoldinS', Biochemistry 39; 5229-5237, (2000)

S.ZapunA, Petrescu SM, Rudd PM, Dwek RA., Thomas DY, Bergeron JJM"Conformation -independent binding of monoglucosylated ibonuclease B to calnexin", Cell, 88,29-38 (1994

Speaker invitat la conferinte internationale

1999 Godon Conference on Glycobiology, Ventura, USA "Folding of metalloenzyme tyrosinase is

calnexin/calreticulin dependent'

1999 Eurcpean Research Confercnces, Biology of MolecularChaperones, Aquafredda di Maratea,

Italy " lnteraction of tyrosinase with calnexin prevents folding and is essential for aclivity"

200018th Intemational Congress of Biochemistry and Molecular Biology,

Beyond the Genome, Birmingham, "Folding of glycoenzymes in the

endoplasmic reticulum "

20026th Jenner confercnce Glycoimmunology, Seillac, Frcnce "fhe

glycosylationof tyrosinase in melanoma cells and the effecl on Ag

presentation"

2O03NATO Advanced Workshop "ER metabolism", Siena, /faly "Glycoprotein

folding in the ER"

2005GLYCO XVill Florence, ltaly,,New strategies for a melanoma varcine"

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