Parkinson’s Disease (PD) -progressive neurodegenerative disease affecting motor ability -third...
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Parkinson’s Disease (PD)
-progressive neurodegenerative disease affecting motor ability
-third most common neurologic disorder of older adults
Population at risk: Male> Female Two types 1) 21- 40 yrs. of age (young onset)
Michael J. Fox at age 30 2) 40- 70 yrs. of age (idiopathic)
over 1 million affected in US with 50,000 -60,000 new cases each year
http://www.parkinson.org/parkinson-s-disease.aspx
Presence of motor dysfunction with 4 cardinal symptoms
resting tremor akinesia (slowness of body movement) rigidity Postural instabilityNO PREVENTION, NO CURE
Degeneration of dopamine-producing neurons in the substantia nigra of the midbrain› Disrupts the balance of:
dopamine (DA) – neurotransmitter for normal functioning of the extrapyramidal motor system
Acetylcholine (Ach)
Symptoms do not occur until 80% of the neurons in the substantia nigra are lost
Fatigue Problems with manual dexterity Slight tremor Rigidity Changes in facial expression Uncontrolled drooling