matlab.iis.u-tokyo.ac.jp Overview 3D microvessel model

1
Center for International Research on Integrative Biomedical Systems http://matlab.iis.u-tokyo.ac.jp An-512 DISEASE Overview HEALTHY Bundled gel as cell scaffold Y.J. Kim and Y. Takahashi et al., J. Mater. Chem. B, 3, 8154-8161 (2015), Y.J. Kim et al., Biomater. Sci., 4, 1197-1201 (2016). 2.5 mm 200 μm Colormap image ROI microvessel PDMS channel Fluorescence image PDMS channel Bars= 100 μm OCT image 3D image by OCT Fluorescence image leakage FITC-dextran Inflammatory factor Barrier-strengthening compound Endothelial Barrier Function Assay 3D microvessel model Vascular permeability assay 3D imaging of angiogenesis J. Pauty, R. Usuba et al., Nanotheranostics, 1, 103-113 (2017). H. Takahashi et al., Sci. Rep., 7, 42426 (2017).

Transcript of matlab.iis.u-tokyo.ac.jp Overview 3D microvessel model

Center for International Research on Integrative Biomedical Systems

http: / /mat lab. i is .u-tokyo.ac. jp

An-512

DISEASE

Overview

HEALTHY

Bundled gel as cell scaffold

Y.J. Kim and Y. Takahashi et al., J. Mater. Chem. B, 3, 8154-8161 (2015), Y.J. Kim et al., Biomater. Sci., 4, 1197-1201 (2016).

2.5 mm

200 μm

Colormap imageROI

microvessel

PDMS channel

Fluorescence image

PDMS channel

Bars= 100 µm

OCT image 3D image by OCT

Fluorescence image

leakage

FITC-dextran

Inflammatory factor

Barrier-strengthening compound

Endothelial Barrier

Function Assay

3D microvessel model

Vascular permeability assay

3D imaging of angiogenesis

J. Pauty, R. Usuba et al., Nanotheranostics, 1, 103-113 (2017).

H. Takahashi et al., Sci. Rep., 7, 42426 (2017).