Definition Hypersensitivity of the nasal mucosa due to exposure to allergens Acute and seasonal or...
Transcript of Definition Hypersensitivity of the nasal mucosa due to exposure to allergens Acute and seasonal or...
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Definition Hypersensitivity of the nasal mucosa due to
exposure to allergens
Acute and seasonal or chronic and perennial
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What happens in allergic rhinitis?1. Exposure to allergen 2. IgE production by the body3. Formation of allergen IgE complex4. Binding of the complex to mast cells5. Degranulation of the mast cells and
release of inflamatory mediators including histamine.
6. Vasodilation 7. Increase in capillary permability.
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Exposure of genetically predisposed individuals to allergens (pollen, animal dander, (pollen, animal dander,
fur)fur)
Activation of T-lymphocytes
Stimulates IgE production by B-lymphocytes
IgE coat mast cells [on re-exposure mast cell degranulation]
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1. Mast cells ◦ Contain
Granules (histamine) Other mediators (leukotrienes and PGs)
2. Lymphocytes◦ T cells◦ Increased mobilisation of inflammatory cells
Eosinophils, macrophages, neutrophils
3. Eosinophils◦ Major basic protein, Eosinophilic Cationic
Protein(epithelial injury, nasal block)
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Released by inflammatory cells (mast cells, eosinophils, lymphocytes)
1. Leukotrienes◦ hypersecretion of mucus◦ oedema (Increased vascular permeability)
2. Histamine◦ itching, rhinorrhea (Allergic rhinitis)
3. Cytokines◦ Interleukins (IL) ◦ IL-4 (IgE production)◦ IL-3 and IL-5 (eosinophil, mast cell recruitment /
activation)
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CLASSIFICATION OF ALLERGIC RHINITIS (AR)
Intermittent AR• < 4 days per week• or < 4 weeks
Mild Intermittent AR Moderate-Severe Intermittent AR
• Normal Sleep • No impairment of daily activities• Normal work and school • No troublesome symptoms
• Abnormal Sleep • Impairment of daily activities• Problem at work and school• Troublesome symptoms
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CLASSIFICATION OF ALLERGIC RHINITIS (AR)
Persistent AR• > 4 days per week• or > 4 weeks
Mild Persistent AR Moderate-Severe Persistent AR
• Normal Sleep • No impairment of daily activities• Normal work and school • No troublesome symptoms
• Abnormal Sleep • Impairment of daily activities• Problem at work and school• Troublesome symptoms
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2 Types: Seasonal (summer, spring, early autumn) tree pollens, grass pollens, mold spores lasts several weeks, disappears and recurs
following year at the same time Perennial -inhaled: house dust, wool, feathers, foods,
tobacco, hair -ingested: wheat, eggs, milk, nuts occurs intermittently for years with no
pattern or may be constantly present
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Clinical features Nasal obstruction with pruritis, sneezing Clear rhinorrhea (containing increased
eosinophils) Itching of eyes with tearing Frontal headache and pressure Mucosa edematous, pale or violet in color Allergic salute transverse nasal skin
crease from rubbing the nose
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Diagnosis History (don’t forget to ask about atopy &
family history) Physical examination: 1. look for redness ,swelling of the mucosa
(particularly the turbinates) &mucoid discharge. 2.check for structural anomalies such as
septal deviation or nasl polyps. Sensitivity test for specific allergen ( skin
prick tests)
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Treatment 1. identification and avoidance of allergen 2.during the acute attach: -antihistamine (systemic or intranasal) -local steroids -decongestant( ephedrine) 3.sodium cromoglycate mast cell stabilizer used as prophyaxis 4. desensitization we keep exposing the body to gradually
increased amounts of allergen until the body fails to produce IgE as a result to exposure.
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Drug type Itch / sneezing
Discharge Blockage Impaired smell
Nasal preparations
Antihistamines +++ ++ + _
AZELASTINE
Anticholinergics _ +++ _ _ Ipratropium
Decongestants _ + +++ _ Xylometazoline
Oxymetazoline
Mast Cell Stabilizers
+ + + _ Sodium cromoglycate
Topical
Corticosteroids +++ +++ ++ +
Fluticasone
Nometasone
2 sprays/nostril OD
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Antihistamines◦ Oral: Most common form of Treatment. (Drowsiness
/ Dryness of mouth / Urinary retention / Blurred vision / appetite +).Cetrizine, Rupatidine
◦ Nasal Spray : Azelastine. Potent H1 blocker with immediate effect / Also blocks other mediators (LT, PAF)
Corticosteroids◦ Nasal Sprays: Most effective treatment of AR /
certain types of perennial rhinitis (Beclomethasone / Budesonide / Fluticasone / Mometasone.
◦ Block both EAR / LAR : Reduce swelling & secretions in nasal mucosa (anti-inflammatory)
◦ Oral Corticosteroids: Short term
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Complications - chronic sinositis - polyps( swollen edematous nasal mucosal
tissue , they can cause complete nasal obstruction)
- serous otitis media
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- It is a very common type of non-inflammatory, non-allergic rhinitis
-Characterized by a combination of symptoms that includes nasal obstruction and rhinorrhea
-vasomotor rhinitis is a diagnosis of exclusion reached after taking a careful history, performing a physical examination, and, in select cases, testing the patient with known allergens
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Caused by: -temperature change -alcohol, dust, smoke -stress, anxiety, neurosis -endocrine – hypothyroidism, pregnancy,
menopause -parasympathomimetic drugs
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Clinical features: -Chronic intermittent nasal obstruction -Rhinorhea (thin, watery) -Mucosa and turbinates : swollen, pale
between exposure
We have 2 types ; eosinophilic & non eosinophilic (according to the number of eosinophils found in the nasal secretion)
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TYPES 1.Eosinophilic &
2.Non eosinophilic (according to the number of eosinophils found in the nasal secretion)
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Treatment:-Elimination of irritant factor-Parasympathetic blocker-Steroids-Surgery -Symptomatic relief with exercise