- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Socioeconomic position Socioeconomic position (SEP) (SEP)

and ageingand ageing

Why do we age so differently?

Merete OslerResearch Centre for Prevention and Health

&Insitute of Public Health, University of Copenhagen

VELUX FONDEN

Funded by:

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Socioeconomic position (SEP) Socioeconomic position (SEP) and ageing and ageing

Copenhagen-Odense SEP and ageing- selection or causation

Copenhagen-Aarhus SEP and molecular biomarkers

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Socioeconomicposition

Health

Familiar factors(genetics and rearing environment)

Ageing(longevity,chronic disease,Disability)

• Twin register/-cohorts• Metropolit 1953- male birth cohort

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Limitations in running 100 m Dental status General health Fatigue

The Metropolit cohort6,292 men born in 1953 in Copenhagen who participatedin a follow-up survey in 2004

Middle-aged Danish Twins (the MADT study)2,198 male twins born 1931-1952 who participated in a health survey in 1995.

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Metropolit MADTORPer unit decrease ORPer unit decrease

Limited in running Childhood SEP 1.03 (1.00-1.08) 1.08 (1.00-1.17)Adult SEP 1.61 (1.49-1.73) 1.24 (1.16-1.36)

Poor dental status Childhood SEP 1.25 (1.08-1.43) 1.06 (0.98-1.10)Adult SEP 3.06 (2.24-4.09) 1.37 (0.96-1.30)

Poor self-rated health Childhood SEP 1.07 (1.01-1.15) 1.12 (0.96-1.28)Adult SEP 1.66 (1.48-1.86) 1.12 (1.00-1.10)

Fatigue Childhood SEP 1.10 (1.04-1.17) 1.03 (0.95-1.12)Adult SEP 1.47 (1.32-1.62) 1.18 (1.09-1.23)

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Socioeconomicposition

Familiar factors(genetics and rearing environment)

Ageing(longevity,chronic disease)

• Twin register- linked to health and social registers in Statistics DenmarkMia Madsen’ PhD-study

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Socioeconomicposition

Molecular biomarker(telomer length, mitochondrial expression)

Subsample of the Metropolit cohort examinedCAMB high and low adult SEPLaila Bendix’- post-doc study

- D A N I S H A G I N G R E S E A R C H C E N T E R -www.sdu.dk/darc

Socioeconomicposition

Familiar factors(genetics and rearing environment)

Ageing(longevity,chronic disease)

Sibling cohort study- linking family database-to health and social registers in Statistics DenmarkNew PhD-study/post doc?

Social status and telomeres in a longitudinal design