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pcHy. Q)ar,rr-' uio sriKopiic.rilua Axl ito:jpax).dkiB r,id_icrb 3aAoiiijrbF{o oirtlc}e clicrrepriil,ri:urutlgj ;:iui, ex:l_sye iia cyr.f€Bc :6i,rr,ucHrrg a,Kr- rip!i Alr;Kd lit43bKllxrl'crtrl{a.l{ sn'g3.,,aanu:i ni.ii Aicto r:i,TC!tot^",, r.\1ic,-,,glccnipti,nr,lti{x crpvKryp a ptlK. i gal.i i;eii lr"ricr.rf:ixo :j;i,{e;(jii.L EIij l-yrlTtiliii 3e

, j;l-j,,",;i;r}irr,f r;I-ra,rcii v...

B i gi:,rro, rrlo c"pt' KT \/ c:i c,l ilo-rya jiLi rcr c i,rl ".( 1e1.epo-no,'iiui,r<-lcoru.qiB, iilo 3Haxor-,rrt)cJr 1i pcs,iltai, 3ar3ij;igBrrnnBy Ar{r{at,rlqnij-\ :r.tiii .vrllprriu i pcsrall, rjfn}l_xci ;<i,:t xocTi "{ir-irtjori 3 riilc,fiaoEC}o ricirf njiclvie;i-i.Zi_r-iil*i': i12 l. 3a .aar.iti:: l/!icB Tii,lollc;;, il.rcpxa,iriorudri;.:i'fl)ri fiiipar,i;{ ociloR ;eocni;;ii.,iilii1x !i;.i}iHoti, ilit .ri,ti,*r.a-lto J/TF cp;Jxi.ictl, 3cyBa s jJnlli1i,ii.,;e-,, pi ;.ri,rl il rv cii c_Teuli CSiv{e .8 5ix gai<onl iileHirri EK33aF;iIX ,q::.ocni_parbr{;rx if pa rt r eiiri n, E }tc,i}, n,i to iir+- I pc-ni ;;ecpig, I or..:<<:expil;lloua.ra> Tafioi cTp), K"li pl{. ij.sol,r1, rdo)i{ tr cilpri_sr;r i ra oScraeliria, rlc tjo3l{Tirintiii 3:ip,{A ,rr{jlcpcilyse "tora;ri3crraunii Ha iipoMaTi.rlulolriy xpo,.,lcdtrrpi i0 j,a npr{eAHar{i qo Nr,oro 6croui ;Tfi}{]{}c|t4 lio.}(ir.r}, n0_renqiiirro rrpocKrynarrca rr, do;:i ::1x:r 4ei;cnip.l,.riluorct-roj'rlHyKreorl*gy, s5 ilnI]rv!.] lrii eiiep rirc as' I 3-va 3un*3a pallyiicK ri,rpocbcSnor re aeuc,rii lS, 6 ].

Eiqouc, rqo iurep$eilouofeui{a sqa.rtir;t.l iu;yx_ropis uyx;reoruAr{oi upiipoilti 3&,-ie)(,rirj} nepc;},ctiyi r{i(nig t*axeuocr.i n cx,ra,qi ix uouolaepil?rX Koivrcolrr)ir.rirrpir60;rr, rc< i si,1 eroDr:Hl;cl {-ri;yfi;./pil nc,.i;r:cp;; _npficv"Hocri qocr.a.rni,ol xlryr,roc.li gi:ocnip:;ii,trNx 4i-,irqr{oK i12}. Canre ra.xi cradirlni gaccnipa,:r,ui gt_,TsliKX i<opln-,-rexcie qpixcqxona pHK _,rn,.lopon ri{o_xy'rb syMoBirK)BarH irlrep$tcpoHorerlrrlr qi;c r 1,r,roaa_rin vivt; ra in vitro, jrKs Bi{fiBr-rerra panirte i?, g j.

.,4. R. Kapnext, C_ .{i. Xpanyncc, ,i. B. C*oo,to|

i4syue;tne Ko,tl.trjecrDeHt{bix -xapilr:r cp;1ij.i}1K KoMii_,ieKcoofpa:claealrHJlopolra c nonpil ryKleor[AaMt.I pa3n h LilioFo ltpot4cxo].KAeHH'

Fe3ror.ic

C namctzaa uiex*tporlsor*t.vtcrti.pr!tt ,.rrr,ro,u'ir,r-,,"otir,tL{}:tiu,tccKuena.pd.\rcn!.pbt cqjtlbrcaglut" r.]utudpoxttopucrr-Loti cunu 2,T_1itci2-(Erts-rtut-ax.txa ) uno x cu J -Q.;tyo peu-9 -o t a { zut) p oxnc p uo m1Lp porLLt ) cHypleuHaauiltt Kuctonl&+uL ()ttpc}ctauo, ttilLij tcotictrtulLtnln acJ.3r)r_aanua d,.,a [t{K u poly(U) pciatttt 5,3.i0' ti 4,f . jAt M-l r,r,t,t-aeftLcinqcHuo, 6 irlo gpeila KaK pe3J,iep *tisrtot: caq|uecxut d.laimi$ tlO.rtUH.frLleontuAoi cacma(t"qntnl. ttSsu6:,LuJutttznou.o 2 ttQpuocnaeeuu:7 u. i ttyx-,teot;ttj taorii(rJtitcti,atHt:c. .\Hq,ttu3 u:j'iilepJtctit.ibtBaHun ltn natnuc;toi Apc;ii;xreoi pl{K notasu:t, 4tio Kai{.-Ltttuttltltt Ctb(3t,16.t!rtLa r)-lx O0nOU,eriO't( tttLolX U CAl,Ctt-tipU-,iAt6L1 y,it1_cnltal palttbr 1,3.10' u l,t.l0' iv{-' cooniaenicnrceat*. [o.n:tJltycttupo;r::trat.r v\af,nKOa 3 ciltpyKtti|pe F.{! ji ac:nui.zttitt: 32 cL,i/nC 3Hii)i.Unieltt,tLO AbLI!.Le ),Kd.:j(utiLG:A iiA-Ikii:i:jn6e, pAHi{ 0)tpr(E_tienleJo d;t::. mex :t:e o6pct:+4oe pl{t( s otncTncfi6ur ili.Ltr,taponc.Coe,,iatt atrca} a attcoxoi cnacolnocitiLt rr!u,\opat:,a t:nr.15rLr:.u3upo,dlrb dotcnr.pii,,tbHbe yiutc.niil G cocntlttlt ?IIK. C0c",lxda*tticz6tto.tit.lItt,icct:ue ccneKtLbt InaIa ccoicnitla niu:n!),Ir{.j. e tl,7clt1to_cft!!t, Jzo 3itateHuc C,,Ln utll'r4tttt utLrnapt!:epauz

45

,\. V. Ktirpov, .\. N. i.{t:r:i;:t:iicv, A. T . Si',,s16i1

StLrtiy rri ihc trtn{it:ilive ..:irar:lciel-lsllcs ti iiio;-onit aoinpiexatiolr u,illrn::-r il;cis..ii.l. s r)i t..,:J-_. ()it^in

Suininan'

"l'i-rinoir,:ttt.rt:iL: ijruji;riars t"i ii!orcitt i:,:.:iroc!;loride (tlihl,cjro-cltLoritic s:tlt,tj 2,7-l;ij;f.?-(dicti;.;,/-Qrri.iitt)tiltoxyj-jluoren-9-one)bitlrliJ;li irt nuci.t!c ti::Js:trt t;;ttt;urad.;;;::i:ircplioioinetrica!/1,. !l is.{o'ittd .t,ii.l tii: b:naitg. corsla:tts {or f ;i,ri end, poiy( t/1 areJ J ll ,'.; ' ..11- 1.;-: : ,i: /,:rI. r.i." ,,- ,i.iir ti,: bi;;JinS sittslzas Ji;r liia:;L ;tcl;:iitit!ac;!iJLs o a, rcs;;:c:iilt!y, abaut 2 bo u-ul !ttuclcc:!t!c. l|fil: .:ita;.;r's :,,i itt:tl j::g itotiyrrr: lor nr;tivo 3,east R.i'iAiirct1,.t !i:a:: ili.e i;iii.|ing. riri-iidr:Is ft1t. ct,:i;lt- ti.ri singlc-sirancitirtgictts tuc l,J..lA' th' uti .l ,:']0" i,,{' reir-(c.;1ys!.t...i{iJVacliottetf CoLtti.e-slrat:drt:i rtt,J;ir ii;;it iiN;t i; yourtl to bc 32.1o, tltevniue wiiicii u'e consiricrabi; iiigircr llicti tltcd rclue previousiy!'tporial fc: ili; sdnie Ri{A te;npb !:t ti:.t ctrse:;ce cf liloronc. A'iiiorci.e ii:gi: ,tbil;::;' c1' ;tl.i;ilizirig 7o;ij;::;-:!ra:icl RhrA regians issii.ggeirtri ritw bioicgi.ct:! a,trfic:.ttia,l"s {)! :Eis ai)ility, espcci,il!1, lari t,,! e rf ct' c lt | ;:.i xt it, r,, ar t ii i: J.is :i c d.

Cill{COK ;iITIPATr FX1. Md_t;er G. f)., i?i.ieger 11. .F. Tilorc:rl hlTcrocitloi-irie: mcCe cf

r.,ttiait / / Sci;::ce.-r t7*.-;59, FJ :it5i.--;t. iZI4-I2iS.2. i\,1a3'ct'{.:. i}., )irue$r n. ll Tiicl.i;.:s i1ir.:'--g' O- -- and reiirted

ri{ilecuics ll In'-c:i:ra:t a;:i lrict-f*.oit iricecers ,/ Ed. D. A.Sirirrgicliow.-New ?crir: Ookker, ; t8C.-p. iE7-ZZt.

3. CkriftCrg I'", -/ui:;;ia j:-, dicuy ,'. F. ?! al :\4o<je of liloronehydrcchicrlde irieracilJn io Dlitr i;;c poij'dec_xyribonucieo-i:J:s / i FSBS lri!.-i9?2.-:8.-;i. i-9.

4. Cin:ilrc P,, Zut:ittc ;;., 3scca,-$ A. st.:i. infiuerce of iiiorcneiti,drochici'ide cii Ljte sacondafy sriuriilrc ai:d tenrplale aciivir;,cl DNA /l lr:d.-i972.-?3.-t. i,4i--i4g

5. Duutw |vi., Stuitn i., Zatia ,e. Tcmpei.aiiirc-jump study oilrlcrorre binriing orr poilt dA poii,cj'I',// Siud. biophys.*1976.-5?.-p. t39-i4q.

6. Wright R. G. htclt., Waielh L. p. {}., Fieldes A. e/ a/. Effecrsoi rirrg subsriluerits ai:i iirrker chliiis on ile bifurrctionalinlcrcajirlon of ciiacr?Cii:es irto. Cerxyribonucleic asid //Iliochcmistly.-1 t80.*it, N 5.-p. 58:S-S836.

7. Kapnat ,4. R., )firt;ia1aK i:!. !if. l}-pc71yr.riNc r.rurep$epouor ITlina :1 OltiS;ii43Me ilon ;ICj.J.-TE fi gI; M CnCKyrt plt brx 4.Otr,,{il,l1excCllApox(xeBnr PFIK - rft,,toporr // nonp. Bi4pycojlofxl.i._igqb.- i .-C. :3- i o.

8. !(apnoe A. ii., ,\Katxda;< H. .V/. jzisyceHii'e= urrrep<lrepoxc-leHHiri.\ ccoiicta Ko[{iut-xcoB ApoiK]ieirat FHK - IpLrlCpCH BRylti,rypc x,rercx /rr ha.ru1wrs.txxit nr xrrMrjurt:priilltrr.*i995.*j,.i, \.i 5.-C. 7J-23. ;

9. Crathcrs D. l,!. {,ticsiation oi binciiig iscthems ior hetcro-geneous poiyrcar-s r/,/ Bicpolyrners.-1 969.-6.-p. 57 S*594.

lA. McGlice J. D., van ]ijt:t;e! p. l:', Theci'etlcal aspccts ofDNi\-pi-otcin i/ttcraciioris: cccpera iir/c an rj r:on-coopere,tjve bin-clirg of large ligands ro a circ-dilrelsiona) honrogenecus iatilce/ / J. NLoi. tsicl.-l9'i4.-86, i{ 2.-p. .1b9-439.

't\, At.cet{}G O. A., io:Losuii E. 17., Cna;tcA,_lit4cs,4. .4. AHrr-B,{pvctoc ;e iic'rarre ;tpc?43ccljHi,r;d,1pox;<eso:i pHK l.r s,,rns -liHC ira ilcrO il0,,7'{Kat:Nt,i.iOE i / Be;ru. ,L\iH CCCP.-i 970._Ne B.-C. Jt*5t"

12. Tgrrencc P. '1-,, De Clercq E. Inlerfs:-oli incuction by nucicicacids: slructui{r-actjviiy r-Jiaiionsl-ijps /l inierferon and theirappiicaricns / Ec'. P. E. Came, W. A. Ca::ter.-Berlin:Springe;-, i 98'i.-P. 371_-3r\3.

iia;iii:u"':a ;o pegarqii 26.A5.97