Post on 30-Dec-2016
Population
Characteristics # %
Gender
Male 91 25,6%
Female 165 64,4%
Age
�55 30 11,7%
55-65 36 17,9%
66-75 118 46,09%
76-85 57 22,2%
>86 13 5,07%
Scholarity
< 5 years 19 7,4%
5-11 yrs 97 37,89
12-15 yrs 51 19%
>16 yrs 97 37,98%
Diagnostic
Healthy 118 46%
DCL 44 36,7%
Dementia 94 44,1%
Total 256 100%
Poster Presentations: P2 P453
(p <0.0001). A sensitivity of 75% was established to detect MCI and of
94.4% for MD and the value of specificity was 79% with a cutting point
� 24. The relationship between the sensitivity and specificity was optimized
with cutoff point of�24, was established a p ositive predictive value of 83%
and a negative predictive value of 90%. Conclusions: The translation of
MoCA test is valid for application in Colombiawith fine psychometric prop-
erties such as internal consistency, interrater reliability and convergent val-
idity. The cutting point� 24 reaches 89% sensitivity and 79% specificity for
the detection of DCL and DL. The sensitivity for detecting DCL is 75% and
95.4% for DL.
P2-258 WITHDRAWN
P2-259 NEUROPSYCHOLOGICAL PROFILE AND
NEUROPSYCHOLOGICAL MARKERS OF
DEMENTIA IN OLDER PEOPLE IN RIO DE
JANEIRO CITY, BRAZIL
Helenice Charchat-Fichman1, Camila Faria1, Conceic~ao Fernandes2,
Luciana Brooking2, Daniele Lima3, Regina Novaes3, 1PUC-Rio, Rio de
Janeiro, Rio de Janeiro, Brazil; 2UERJ, Rio de Janeiro, Rio de Janeiro,
Brazil; 3HFSE, Rio de Janeiro, Rio de Janeiro, Brazil. Contact e-mail:
camila_psic@yahoo.com.br
Background: The identification of preclinical stages of dementia is impor-
tant for early intervention and prevention. Many studies analyze the predic-
tive biomarkers of dementia process before the manifestation of the disease,
but few studies investigating the clinical and cognitive factors involved in
the same process. Methods: The sample consisted of 43 older patients
with MCI (15 male and 28 female) between 66 and 89 years old, four years
period. All patients were submitted to clinical evaluation. 17 older people
were reassessed after two years. The instruments used were: Pfeffer, De-
mentia Rating Scale (DRS), Digits Forward and Backward, Spatial Span
Forward and Backward, Phonemic Verbal Fluency (PVF), Categorical Ver-
bal Fluency, Animal Naming, Memory Figures, RAVLT, Rey complex fig-
ure, Trail A and B, Codes, Cubes and Clock Drawing. Results: Most
participants received a MCIamnestic diagnosis 68.6%, mean age 76.9 (65.2) and mean education level 4.9 (6 4.5) years. 31.4% of participants
had a MCInon amnestic diagnosis, mean age 73.3 (6 5.2) and mean educa-
tion level 5.1 (6 4.1) years. More than half of participants showed impair-
ment in executive functions (55.6%) and instrumental activities of daily
living (51.4%) andmuch of the sample showed impairment in delayed recall
(44.4%) and global cognitive functioning (44.1%). After two years, 29.4%
of participants reassessed changed the diagnosis for dementia. 64.7% of re-
assessed participants showed decline in the recognition process and others
64.7% showed decline in delayed recall. 58.8% showed a decline in learning
process and 50%, in attention. The neuropsychological tests considered
markers of preclinical dementia were: delayed recall and recognition of
Memory Figures test; learning score and recognition of RAVLT and Digits
Forward and Backward. Conclusions: The results show that delayed recall,
learning, recognition and working memory tests are important markers of
conversion to dementia, confirming the literature data. The neuropsycholog-
ical markers identification is important for early intervention and prevention
of dementia.
P2-260 DISEASE PROGRESSION MARKERS FROM
CONNECTED SPEECH
Samrah Ahmed1, Celeste de Jager2, Anne-Marie Haigh2, Peter Garrard3,1St George’s University of London, London, England, United Kingdom;2University of Oxford, Oxford, England, United Kingdom; 3St George’s,
University of London, London, England, United Kingdom. Contact e-mail:
sahmed-a@sgul.ac.uk
Background:Our group recently described syntactic simplification and im-
pairments in lexico-semantic processing in samples of connected speech
samples obtained at the time of diagnosis from patients in whom AD was
subsequently confirmed at post mortem. In this study we set out to identify
features of connected speech that: i) had been abnormal during the MCI
phase of these patients’ illness; and ii) showed consistently greater deviation
from normal performance with disease progression.Methods:Members of
the OPTIMA cohort, in whom diagnoses of both MCI and probable AD had
been made during longitudinal evaluation, were selected for the study. Tran-
scripts of the Cookie Theft picture description task were subjected to anal-
ysis using the Quantitative Production Analysis (QPA) approach. QPA
produces a series of measurements and error counts that can be grouped un-
der four broad descriptive domains: syntactic complexity, lexical content,
speech production and fluency. Semantic content was quantified by identi-
fying and counting semantic units. Variables on which the majority of cases
showed a linear decline between the MCI and early AD stages and were
taken as potential markers of progression. These were then applied to tran-
scripts obtained from the same patients at a uniform stage of moderate dis-
ease severity. Results: There were significant linear trends over the three
stages of the disease (MCI, early and moderate AD) for: syntactic complex-
ity (F(1,8)¼12.304, p<0.01), semantic content (F(1,8)¼8.627, p<0.05),
and lexical content (F(1,8)¼9.273, p<0.05), but not for speech production
(F(1,8)¼0.031, p>0.05) or fluency errors (F(1,8)¼2.735, p>0.05).Conclu-
sions: The study found that subtle changes in language function typical of
AD are evident during the preclinical stage, and that a number of these in-
dices showed a progressive decline through later clinical stages of the dis-
ease. Translation of these striking observations into simple and specific
markers, of language change in AD could have far-reaching clinical conse-
quences.
P2-261 PREDICTING DEMENTIA IN DOWN SYNDROME:
STUDY OFA PORTUGUESE COHORT
Paula Breia1, Ros�ario Mendes1, Ana Silvestre1, Maria Jo~ao Goncalves2,
Maria Jo~ao Figueira2, Regina Bispo3, 1Hospital Garcia de Orta, Almada,
Portugal; 2Cercizimbra, Sesimbra, Portugal; 3ISPA - Instituto Universit�ario
de Ciencias Psicol�ogicas, Sociais e da Vida, Lisboa, Portugal. Contact
e-mail: apaulabreia@hotmail.com
Background: Adults with Down syndrome (DS) may frequently present
cognitive deterioration, personality, mood and behavior changes, which
are often related to early signs of dementia.Methods: The aim of this study
is to determine the presence of early signs of dementia in a Portuguese sam-
ple of institutionalized DS patients. The sample comprises 16 adults with
DS, aged between 26 and 50 years. They were initially assessed using the
Plymouth Dementia Screening Checklist (PDSC) and the Global Deteriora-
tion Scale (GDS) with follow-up 12 months later. Collected data were sta-
tistically analyzed. Results: The results of the initial assessment show