Fiona NielsenApril 18 - 2016

BioSB PhD Retreat in Lunteren

Tweet me @glyn_dk

Why I left my job in genomic

R&D

The frustrated researcher!

How did this happen?

The long road to resultsRaw reads

Read QC

Variant calling

Analysis-readyreads

Analysis-readyvariants

Variant Annotation Genotype

Refinement Raw Indels

Raw SVs

Raw SNPs

Mapping

External Data

What do you do?

Sequence Read Archive

What do you do?

What do you do?

Yikes

What do you do?

PubMed?

What do you do?

What do you do?

Ask your PI

Write application

Apply for access

Wait…Wait…Wait…Wait…

Access requests can take months

https://www.flickr.com/photos/blackzack00/10205948476/

How did I end up here?

• Masters in bioinformatics, Odense, Denmark• Masters project in Nijmegen, CMBI• Continued as Phd student (junior onderzoeker) with

CMBI and Molecular biology

Then my mother got cancer

Access requests can take months

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Genomes Sequenced~400k genomes produced

And how do you keep up?

More projects launched every day

And how do you keep up?

Data is uploaded to repository

Data is discovered by potential user

Data is accessed by potential user

https://www.flickr.com/photos/blackzack00/10205948476/

It has taken a while…

DNAdigest was founded in March 2013

Working out what to do

Making data discoverable and shareable

Realising the scope of the problem

T. A. van Schaik et alThe need to redefine genomic data sharing: a focus on data

accessibility, Applied & Translational Genomics, 2014

10.1016/j.atg.2014.09.013

Researchers spend months to find and access genomic data, and often choose to not access

data at all

What IF?You could easily search and

discover data?

You could rank data by relevance?

Registering data was simple to do?

Search would be easy

Collaboration would be simple

You would discover new resources you did not

know existed

Building through collaboration

DNAdigest organises hackathons/workshops 4 times a year

We founded Repositive

To make genomic data accessible for research

Adrian Alexa CTO & Data Scientist

Fiona NielsenFounder & CEO

A portal to search for data

Interested? Sign up for our beta at repositive.io

To make your data visible

Interested? Sign up for our beta at repositive.io

To collaborate

Interested? Sign up for our beta at repositive.io

But we are not done yet

https://www.flickr.com/photos/blackzack00/10205948476/

Now I am an entrepreneur

The future is always uncertain

https://www.flickr.com/photos/f4/12652885873

I am just doing what it takes

Team effort

Presenting to the world

Reaching out

ConsultingFundraisingMarketingBrandingPublic EngagementFinancial forecastsPlanningSoftware developmentScienceLong daysLittle financial returnBig satisfaction

Questions? I would love to hear from you , drop me a line at fiona@dnadigest.org

https://www.flickr.com/photos/matthewpaulson/7185380311/

Life as an entrepreneur

Read more at http://repositive.io and http://DNAdigest.org

Thanks for listening!

repositive [ re-poz-i-tiv ], noun; 1. a positive experience of accessing

genomic data repositories

Read more at http://repositive.io and tweet us @repositiveio