When a 5 asa agent no longer maintains remission in patients with ulcerative colitis

Post on 22-Aug-2014

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description

The goals of treatment for ulcerative colitis (UC) are to induce remission, maintain remission, and facilitate mucosal healing. Historically, a step-up approach has been used to accomplish these goals. Agents with the least toxicity are initially used, and agents are added or changed based on the treatment response or toxicity. The treatment of mild to moderate UC usually begins with 5-aminosalicylate acid (5-ASA), an anti-inflammatory agent. Corticosteroids may be used to reduce inflammation and to help induce disease remission when a flair of symptoms occurs. Other agents, such as thiopurine immunomodulator and biologic agents, are used to treat more severe disease, and surgery may be indicated if medical treatment fails.

Transcript of When a 5 asa agent no longer maintains remission in patients with ulcerative colitis

When a 5-ASA Agent No Longer Maintains Remission in a Patient

With Ulcerative Colitis

Case: A 28-Year-Old Man

Case (cont)

Sequential Therapies for UC

Case: Next Steps

Case: Next Steps

Treatment of Panulcerative Colitis That Is Unresponsive to Oral Mesalamine 2.4 g/d

Treatment of Panulcerative Colitis That Is Unresponsive to Oral Mesalamine 2.4 g/d (cont)

Treatment of Panulcerative Colitis That Is Unresponsive to Oral Mesalamine 2.4 g/d (cont)

Efficacy and Safety of Budesonide MMX

Budesonide MMX After Treatment With 5-ASA

Case: Conclusion

Options for Maintaining Remission

Patient Adherence

Adherence Is Dependent on Multiple Factors

Summary

Abbreviations

References

References (cont)