UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM

Mochamad Fahlevi Rizal

Infeksi akibat biofilm

Perkembangan teori biofilm

Skema biofilm

Properti biofilmGeneral property Dental plaque example

Open architecture Presence of channels and voids

Protection from host defences, desiccation etc.

Production of extracellular polymers to form a functional matrix

Enhanced resistance to antimicrobials

Increased resistance to chlorhexidine and antibiotics

Neutralization of inhibitors Β-lactamase production by neighbouring cells to protect sensitive organisms

Novel gene expression Synthesis of novel proteins; up-regulation of gtfBC

Co-ordinated gene responses Production of cell-cell signaling molecules (e.g. CSP, autoinducer 2)

Spatial and environmental heterogeneity

pH and O2 gradients; co-adhesion

Broader habitat range Obligate anaerobes in an overtly aerobic environment

More efficient metabolism Complete catabolism of complex host macromolecules (e.g. mucins) by consortia

Host•Saliva•Struktur Gigi•dll

Agent

•Bakteri

Fungsi komponen saliva

Jalur metabolik spesifik dan mekanisme transport S. mutans

Salivary Mucin MG2

deft

1614121086420-2

.5

.4

.3

.2

.1

0.0

-.1

Observed

Cubic

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