Unravelling the biological characteristics of MammaPrint ... · normalized enrichmet score ul gsea...

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70-gene MP

22

UH

-lo

g 1

0(a

dj.

P.V

al)

log2FLC

UH vs. HR

log2FLC

UL vs. LR

-lo

g 1

0(a

dj.

P.V

al)

Activating Invasion & metastasis

Deregulating cellular energetics

Enabling replicative immortality

Evading growth suppressors

Genome instability and mutation

Immune response

70-gene MP UL

546

Department of Research and Development, Agendia, Amsterdam, the Netherlands;

Contact: rajith.bhaskaran@agendia.com

Hallmarks of Cancer

Unravelling the biological characteristics of MammaPrint extreme risk subgroups