University of Guanajuato

Campus Celaya Salvatierra

Division of Health Sciences and Engineering

Department of Nursing and Obstetrics

Dr. Nicolas Padilla Raygoza

Medical Doctor, University Autonomous of Guadalajara and University National Autonomous of Mexico, 1984

Pediatrician, Mexican Council of Certification of Pediatrics, N° 2870, 1986

Postgrade in Epidemiology. University of London, 2002

Master and Doctorate in Sciences in focus in Epidemiology, Atlantic International University, 2006

Professor Associate C and Coordinator of Support to Research and Postgraduate Studies, Department of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya Salvatierra University of Guanajuato

To describe main characteristics of rotavirusTo identify susceptible people to rotavirusTo identify the symptoms and signs from

rotavirus infectionTo describe laboratory studies to diagnosis of

rotavirus infectionTo identify and describe the treatment

Rota= wheelFamily ReoviridaeDiscovery in 1973 by Dra. Ruth BishopIt appear as a bicycle wheelSeven groups: A, B, C, D, E, F, G.Only A, B. C cause enteritis.Resistant

They will survive in the environment

UnwrappedDouble capsuleMeasure 70 nmGenome

11 RNA segmentsEncode six structural proteins and five non-

structural.Group A

14 serotypes accord to VP7 protein (G)20 serotypes accord protein VP4 (P)G and P have multiple combinations

Cause more severe and acute diarrhea in children:111 millions of cases require ambulatory care25 millions of medical consultations2 millions of hospitalized patientsFrom 352,000 to 592,000 deaths of children.

Children from 6 months to 2 yearsPre term newbornsElderlyImmunocompromisedTraveler diarrhea or sub clinic disease in

adults

World wide distribution

Peaks in winter and summerNovember - DecemberApril-May

Fecal oralPerson to person,Foods,Food handlers,Fomites

Airway

Infectiousness period 1 – 3 díasContagiousness

8 days>30 days in immunocompromised

Sudden onset with (6 days):Vomit, disappear in 24-48 hoursFever, disappear suddenlyProfuse watery diarrheaDehydrationDiminish the activity of lactase

Detection of antigen of Rotavirus in fecesImmunoassay quick testElectrophoresis of RNA from genome viralStaining with silver nitrateImmunosobernt assay

There is not a specific treatmentNon- suspend feedingTo change at soy formulaOral rehydrationNON-ANTIBIOTICS

To change at soy formulaSoy with fiber for 5 daysOnly soy for 15 daysComeback to habitual milk

Oral rehydration100 – 120 ml/kg/during 6 hours in low or

absent dehydration120 ml/kg/during 6 hours in moderate

dehydrationIV rehydration in severe dehydration

NON-ANTIBIOTICSAminoglycosides

Lactase deficiency aggravatesDiarrhea aggravatesIncrease the anxiety of familyIncrease needed of hospitalization

Thank you