Ultrasensitive monitoring of geographic atrophy (GA) progression

K . Gocho, V. Sarda, S. Falah, J.-A. Sahel M. Benchaboune, M. Ullern, and M. Paques

Clinical Investigation Center 503, INSERM, Quinze-Vingts National Eye Hospital, Paris, France

rtx1 clinical case report: dry AMD

Geographic atrophy: 5 months follow up

Imagine Eyes rtx1 clinical case report: dry AMD

66 year old female patient with dry age related macular degeneration (AMD).

Adaptive optics (rtx1)

at T0

Geographic atrophy: 5 months follow up

Imagine Eyes rtx1 clinical case report: dry AMD

66 year old female patient with dry AMD.

Adaptive optics (rtx1)

at T0 + 2 weeks

Geographic atrophy: 5 months follow up

Imagine Eyes rtx1 clinical case report: dry AMD

66 year old female patient with dry AMD.

Adaptive optics (rtx1)

at T0 + 1 month

Geographic atrophy: 5 months follow up

Imagine Eyes rtx1 clinical case report: dry AMD

66 year old female patient with dry AMD.

Adaptive optics (rtx1)

at T0 + 3 months

Geographic atrophy: 5 months follow up

Adaptive optics (rtx1)

at T0 + 5 months

Imagine Eyes rtx1 clinical case report: dry AMD

66 year old female patient with dry AMD.

Geographic atrophy: 5 months follow up

AO with border

positions

Imagine Eyes rtx1 clinical case report: dry AMD

Successive border positions at each visit.

Geographic atrophy: 5 months follow up

Successive border positions at each visit.

AO close-up of border positions

2W: +7 µm

T0 1M: +25 µm

3M: +12 µm

5M: +15 µm

Imagine Eyes rtx1 clinical case report: dry AMD

Conclusion

• Adaptive optics allows to detect the progression of atrophic lesions in as small time scale as a couple of weeks.

• Such small changes are not visible with conventional imaging techniques

• See also:

• K. Gocho, V. Sarda, S. Falah, J.-A. Sahel, M. Benchaboune, M. Ullern, and M. Paques, "Adaptive optics imaging of geographic atrophy," Investigative Ophthalmology & Visual Science, Vol.54. May 2013.

Imagine Eyes rtx1 clinical case report: dry AMD

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