Top Top Performing Performing Biotechs ~ Biotechs ~

20122012AVERAGE GAIN AVERAGE GAIN

314% 314%

Average Gain Average Gain 314%314%

1. Arena Pharmaceutical (ARNA) +560%1. Arena Pharmaceutical (ARNA) +560%

2. Celsiun Corp (CLSN) +438%2. Celsiun Corp (CLSN) +438%

3. Acadia Pharmaceutical (ACAD) +369%3. Acadia Pharmaceutical (ACAD) +369%

4. Sarepta Theraputics (SRPT) +360%4. Sarepta Theraputics (SRPT) +360%

5. BioMimetic Therpapiutics (BMTI) +309%5. BioMimetic Therpapiutics (BMTI) +309%

6. Repros Theraputics (RPRX) +259%6. Repros Theraputics (RPRX) +259%

7. Orexigen Therputics (OREX) +223%7. Orexigen Therputics (OREX) +223%

8. Sunesis Pharmaceuticals (SNSS) +216%8. Sunesis Pharmaceuticals (SNSS) +216%

9. Threshold Pharmaceuticals (THLD) +208%9. Threshold Pharmaceuticals (THLD) +208%

10. Affymax Inc. (AFFY) +204%10. Affymax Inc. (AFFY) +204%

1. Arena (ARNA) 1. Arena (ARNA) +560%+560%

2. Celsion (CLSN) 2. Celsion (CLSN) +438%+438%

3. Acadia (ACAD) 3. Acadia (ACAD) +369%+369%

4. Sarepta (SRPT) 4. Sarepta (SRPT) +360%+360%

5. BioMimetic 5. BioMimetic (BMTI) +360%(BMTI) +360%

6. Repros (RPRX) 6. Repros (RPRX) +259%+259%

7. Orexigen 7. Orexigen (OREX) +223%(OREX) +223%

8. Senesis (SNSS) 8. Senesis (SNSS) +216%+216%

9. Threshold 9. Threshold (THLD) +216%(THLD) +216%

10. Affymax 10. Affymax (AFFY) +216%(AFFY) +216%