TDMS No. 20307 - 04 P09: NON-NEOPLASTIC …...TDMSE Version: 2.4.2.1_003 PWG Approval Date: NONE...

F1_M3C Number: C20307

Lock Date: 12/28/2009

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Both

TDMSE Version: 2.4.2.1_003

PWG Approval Date: NONE

TDMS No. 20307 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 07/27/2011Test Type: 90-DAY Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E

Super)Time Report Requested: 12:17:04

Route: SKIN APPLICATION CAS Number: 54464-57-2 First Dose M/F: 12/14/06 / 12/15/06Species/Strain: MICE/B6C3F1 Lab: MBA

DAY ON TEST

B6C3F1 MICE MALE

untreatedANIMAL ID

00010 * TOTALS

ALIMENTARY SYSTEM

Esophagus I + + + + + + + + + 9

Gallbladder + + + + + + + + + + 10

Intestine Large, Cecum + + + + + + + + + + 10

Intestine Large, Colon + + + + + + + + + + 10

Intestine Large, Rectum + + + + + + + + + + 10

Intestine Small, Duodenum + + + + + + + + + + 10

Intestine Small, Ileum + + + + + + + + + + 10

Intestine Small, Jejunum + + + + + + + + + + 10

Liver + + + + + + + + + + 10

Oral Mucosa + + + + + + + + + + 10

Pancreas + + + + + + + + + + 10

Salivary Glands + + + + + + + + + + 10

Stomach, Forestomach + + + + + + + + + + 10

Stomach, Glandular + + + + + + + + + + 10

Tongue + + + + + + + + + + 10

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

DAY ON TEST

B6C3F1 MICE MALE

untreatedANIMAL ID

00010 * TOTALS

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + 10

Adrenal Medulla + + + + + + + + + + 10

Parathyroid Gland + M + + + + + + + + 9Cyst X 1

Pituitary Gland + + + + + + + + + + 10

Thyroid Gland + + + + + + + + + + 10Follicle, Degeneration 2 1 2.0

GENERAL BODY SYSTEM

GENITAL SYSTEM

Epididymis + + + + + + + + + + 10

Preputial Gland + + + + + + + + + + 10

Prostate + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

untreatedANIMAL ID

00010 * TOTALS

Seminal Vesicle + + + + + + + + + + 10

Testes + + + + + + + + + + 10

HEMATOPOIETIC SYSTEM

Bone Marrow + + + + + + + + + + 10

Lymph Node, Mandibular + + + + + M + + + + 9

Lymph Node, Mesenteric + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

INTEGUMENTARY SYSTEM

Mammary Gland M + M M + M + M M + 4

Skin + + + + + + + + + + 10

Skin, Site Of Application + + + + + + + + + + 10

MUSCULOSKELETAL SYSTEM

Bone + + + + + + + + + + 10

NERVOUS SYSTEM

Brain + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

untreatedANIMAL ID

00010 * TOTALS

RESPIRATORY SYSTEM

Larynx + + + + + + + + + + 10

Lung + + + + + + + + + + 10

Nose + + + + + + + + + + 10

Trachea + + + + + + + + + + 10

SPECIAL SENSES SYSTEM

Eye + + + + + + + + + + 10Retrobulbar, Inflammation, Neutrophil 1 1 1.0

Harderian Gland + + + + + + + + + + 10

URINARY SYSTEM

Kidney + + + + + + + + + + 10

Urinary Bladder + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

vehicleANIMAL ID

00020 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + 10

Gallbladder + + + + + + + + + + 10

Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 3 1 3.0

Oral Mucosa + + + + + + + + + + 10

Pancreas + + + + + + + + + + 10

Salivary Glands + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

vehicleANIMAL ID

00020 * TOTALS

Tongue + + + + + + + + + + 10

Blood Vessel + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + 10

Adrenal Medulla + + + + + + + + + + 10

Parathyroid Gland + + + + + + + + + + 10Cyst X X 2

Pituitary Gland + + + + + + + I + + 9

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEM

GENITAL SYSTEM

Epididymis + + + + + + + + + + 10

Preputial Gland + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

vehicleANIMAL ID

00020 * TOTALS

Prostate + + + + + + + + + + 10

Seminal Vesicle + + + + + + + + + + 10

Testes + + + + + + + + + + 10

Bone Marrow + + + + + + + + + + 10

Lymph Node, Mandibular + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Mammary Gland M + + + M + M M M M 4

Skin + + + + + + + + + + 10

Bone + + + + + + + + + + 10

Skeletal Muscle + 1

DAY ON TEST

B6C3F1 MICE MALE

vehicleANIMAL ID

00020 * TOTALS

NERVOUS SYSTEM

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM

Larynx + + + + + + + + + + 10

Lung + + + + + + + + + + 10

Nose + + + + + + + + + + 10

Trachea + + + + + + + + + + 10

Eye + + + + + + + + + + 10Retina, Dysplasia 2 1 2.0

Harderian Gland + + + + + + + + + + 10Inflammation, Neutrophil 2 1 2 1.5

URINARY SYSTEM

Kidney + + + + + + + + + + 10Inflammation, Chronic 1 1 1.0

Urinary Bladder + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

6.25%ANIMAL ID

00030 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Skin + + + + + + + + + + 10

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1 4 1.5

DAY ON TEST

B6C3F1 MICE MALE

6.25%ANIMAL ID

00030 * TOTALS

Hyperkeratosis 1 1 2 1.0Hyperplasia 2 2 2 1 2 2 1 1 2 9 1.7Inflammation, Chronic Active 1 2 1 2 2 1 1 7 1.4Hair Follicle, Hyperplasia 1 1 1 3 1.0

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE MALE

12.5 %ANIMAL ID

00040 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 1 1 2 1.0

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Skin + + + + + + + + + + 10Control, Hyperplasia 2 1 2 1.5Control, Inflammation, Chronic Active 2 1 2 1.5

DAY ON TEST

B6C3F1 MICE MALE

12.5 %ANIMAL ID

00040 * TOTALS

Control, Hair Follicle, Hyperplasia 2 1 2.0

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 3 2.0Hyperkeratosis 1 1 2 2 1 5 1.4Hyperplasia 2 2 3 2 1 2 1 3 1 2 10 1.9Inflammation, Chronic Active 1 2 2 2 2 2 1 2 1 2 10 1.7Hair Follicle, Hyperplasia 2 1 2 1.5

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE MALE

25 %ANIMAL ID

00050 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + I + + + + + 9Centrilobular, Hypertrophy 1 2 1 3 1.3

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + I + + + + + 9

Skin + + + + I + + + + + 9Control, Fibrosis 1 1 1.0Control, Hyperplasia 1 1 1 1 4 1.0

DAY ON TEST

B6C3F1 MICE MALE

25 %ANIMAL ID

00050 * TOTALS

Control, Inflammation, Chronic Active 1 1 2 1 4 1.3

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1 2 2 2 2 8 1.8Hyperkeratosis 1 1 2 1 2 5 1.4Hyperplasia 1 1 1 2 2 2 2 2 3 9 1.8Inflammation, Chronic Active 1 1 1 2 2 2 2 2 2 9 1.7Epidermis, Inflammation, Suppurative 1 1 1.0Hair Follicle, Hyperplasia 1 3 3 3 2.3

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE MALE

50 %ANIMAL ID

00060 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Skin + + + + + + + + + + 10Control, Fibrosis 2 1 2 1.5Control, Hyperkeratosis 2 2 2 2.0Control, Hyperplasia 3 2 1 3 2.0

DAY ON TEST

B6C3F1 MICE MALE

50 %ANIMAL ID

00060 * TOTALS

Control, Inflammation, Chronic Active 2 2 2 2.0Control, Epidermis, Inflammation, Suppurative 2 1 2.0Control, Hair Follicle, Hyperplasia 2 1 2.0

Skin, Site Of Application + + + + + + + I + + 9Fibrosis 1 2 2 2 2 1 2 1 8 1.6Hyperkeratosis 1 1 1 2 1 2 1 2 8 1.4Hyperplasia 2 3 2 3 2 3 2 2 2 9 2.3Inflammation, Chronic Active 1 1 2 2 2 2 2 2 1 9 1.7Epidermis, Inflammation, Suppurative 2 1 2.0Hair Follicle, Hyperplasia 1 1 2 1 1 1 1 7 1.1

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE MALE

100 %ANIMAL ID

00070 * TOTALS

ALIMENTARY SYSTEM

Esophagus + I + + + + + + + + 9

Gallbladder + + + + + + + + + + 10

Liver + + + + + + + + + + 10Centrilobular, Hypertrophy 3 1 2 2 4 2.0

Oral Mucosa + + + + + + + + + + 10

Pancreas + + + + + + + + + + 10

Salivary Glands + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

100 %ANIMAL ID

00070 * TOTALS

Tongue + + + + + + + + + + 10

Blood Vessel + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + 10

Adrenal Medulla + + + + + + + + + + 10

Parathyroid Gland + + + + + + + + + + 10

Pituitary Gland + + + + + + + + + + 10

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEM

GENITAL SYSTEM

Epididymis + + + + + + + + + + 10

Preputial Gland + + + + + + + + + + 10

Prostate + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE MALE

100 %ANIMAL ID

00070 * TOTALS

Seminal Vesicle + + + + + + + + + + 10

Testes + + + + + + + + + + 10

Bone Marrow + + + + + + + + + + 10

Lymph Node, Mandibular + + + + + + + M + + 9

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Mammary Gland M M + M + M + M + M 4

Skin + + + + + + + + + + 10Control, Fibrosis 1 2 1 2 1 5 1.4Control, Hyperkeratosis 2 2 1 1 2 5 1.6Control, Hyperplasia 2 3 2 2 2 3 2 2 8 2.3Control, Inflammation, Neutrophil 1 1 1.0Control, Inflammation, Chronic Active 2 2 2 1 2 2 2 1 8 1.8Control, Epidermis, Inflammation, Suppurative 1 1 1 1 4 1.0Control, Hair Follicle, Hyperplasia 2 1 2 2 1 5 1.6

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 2 2 2 2 2 2 2 10 2.0

DAY ON TEST

B6C3F1 MICE MALE

100 %ANIMAL ID

00070 * TOTALS

Hyperkeratosis 2 2 2 2 2 2 1 1 2 1 10 1.7Hyperplasia 2 3 3 3 2 3 3 3 3 3 10 2.8Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 1 1 1 1 5 1.0Hair Follicle, Hyperplasia 2 2 1 1 2 2 2 2 8 1.8

Bone + + + + + + + + + + 10

NERVOUS SYSTEM

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM

Larynx + + + + + + + + + + 10

Lung + + + + + + + + + + 10

Nose + + + + + + + + + + 10

Trachea + + + + + + + + + + 10

Eye + + + + + + + + + + 10

Harderian Gland + + + + + + + + + + 10Inflammation, Neutrophil 1 1 1.0Inflammation, Chronic 2 1 2.0

DAY ON TEST

B6C3F1 MICE MALE

100 %ANIMAL ID

00070 * TOTALS

URINARY SYSTEM

Kidney + + + + + + + + + + 10

Urinary Bladder + + + + + + + + + + 10

*** END OF MALE DATA ***

DAY ON TEST

B6C3F1 MICE FEMALE

untreatedANIMAL ID

00080 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + 10

Gallbladder + + + + + + + + + + 10

Liver + + + + + + + + + + 10

Oral Mucosa + + + + + + + + + + 10

Pancreas + + + + + + + + + + 10

Salivary Glands + + + + + + + + + + 10

Tongue + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

untreatedANIMAL ID

00080 * TOTALS

Blood Vessel + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + 10

Adrenal Medulla + + + + + + + + + + 10

Parathyroid Gland + + + + + + + + M + 9

Pituitary Gland + + + + + + + + + + 10

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEM

GENITAL SYSTEM

Clitoral Gland + + + + + + + + M + 9

Ovary + + + + + + + + + + 10

Uterus + + + + + + + + + + 10

Vagina + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

untreatedANIMAL ID

00080 * TOTALS

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Mammary Gland + + + + + + + + + + 10

Skin + + + + + + + + + + 10

Bone + + + + + + + + + + 10

NERVOUS SYSTEM

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM

Larynx + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

untreatedANIMAL ID

00080 * TOTALS

Lung + + + + + + + + + + 10

Nose + + + + + + + + + + 10

Trachea + + + + + + + + + + 10

Eye + + + + + + + + + + 10

Harderian Gland + + + + + + + + + + 10

URINARY SYSTEM

Kidney + + + + + + + + + + 10

Urinary Bladder + + + + + + M + + + 9

DAY ON TEST

B6C3F1 MICE FEMALE

vehicleANIMAL ID

00090 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + 10

Gallbladder + + + M + + + + + + 9

Liver + + + + + + + + + + 10

Oral Mucosa + + + + + + + + + + 10

Pancreas + + + + + + + + + + 10

Salivary Glands + + + + + + + + + + 10

Tongue + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

vehicleANIMAL ID

00090 * TOTALS

Blood Vessel + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + 10

Adrenal Medulla + + + + + + + + + + 10

Parathyroid Gland + + M M + + M + + + 7

Pituitary Gland + + + + + + + + + + 10

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEM

GENITAL SYSTEM

Clitoral Gland M + M M + + + + + M 6

Ovary + + + + + + + + + + 10

Uterus + + + + + + + + + + 10

Vagina + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

vehicleANIMAL ID

00090 * TOTALS

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Mammary Gland + + + + + + + + + + 10

Skin + + + + + + + + + + 10

Skin, Site Of Application + + + + + + + + + + 10Ulcer 4 1 4.0

Bone + + + + + + + + + + 10

NERVOUS SYSTEM

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM

DAY ON TEST

B6C3F1 MICE FEMALE

vehicleANIMAL ID

00090 * TOTALS

Larynx + + + + + + + + + + 10

Lung + + + + + + + + + + 10

Nose + + + + + + + + + + 10

Trachea + + + + + + + + + + 10

Eye + + + + + + + + + + 10

Harderian Gland + + + + + + + + + + 10

URINARY SYSTEM

Kidney + + + + + + + + + + 10Nephropathy 1 1 1.0

Urinary Bladder + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

6.25 %ANIMAL ID

00100 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Skin + + + + + + + + + + 10Control, Hyperplasia 1 1 1 1 4 1.0

DAY ON TEST

B6C3F1 MICE FEMALE

6.25 %ANIMAL ID

00100 * TOTALS

Control, Inflammation, Chronic Active 1 1 1 2 4 1.3

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 1 2 1.5Hyperkeratosis 2 1 1 1 1 5 1.2Hyperplasia 3 2 2 2 2 2 2 2 2 2 10 2.1Inflammation, Chronic Active 2 2 2 1 2 2 2 1 2 2 10 1.8Hair Follicle, Hyperplasia 1 2 1 3 1.3

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE FEMALE

12.5 %ANIMAL ID

00110 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Skin + + + + + + + + + + 10Control, Fibrosis 1 1 2 3 1.3

DAY ON TEST

B6C3F1 MICE FEMALE

12.5 %ANIMAL ID

00110 * TOTALS

Control, Hyperkeratosis 1 1 1.0Control, Hyperplasia 2 1 2 3 1.7Control, Inflammation, Chronic Active 2 1 1 2 4 1.5

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 1 2 2 1 1 2 2 2 1 2 10 1.6Hyperkeratosis 2 1 1 1 1 5 1.2Hyperplasia 1 2 2 1 2 2 2 2 1 3 10 1.8Inflammation, Chronic Active 1 2 2 2 1 2 2 2 1 2 10 1.7Epidermis, Inflammation, Suppurative 1 1 1.0

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE FEMALE

25 %ANIMAL ID

00120 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10

Skin + + + + + + + + + + 10Control, Hyperplasia 1 1 2 1.0

DAY ON TEST

B6C3F1 MICE FEMALE

25 %ANIMAL ID

00120 * TOTALS

Control, Inflammation, Chronic Active 2 1 2 1.5Control, Hair Follicle, Hyperplasia 1 1 1.0

Skin, Site Of Application + + + + + + + + + + 10Fibrosis 2 2 2 1 2 2 2 1 2 1 10 1.7Hyperkeratosis 2 2 3 2 1 2 1 2 1 1 10 1.7Hyperplasia 2 2 2 2 2 2 2 2 2 2 10 2.0Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 2 1 1 4 1.3Hair Follicle, Hyperplasia 2 3 3 3 4 2.8

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE FEMALE

50 %ANIMAL ID

00130 * TOTALS

ALIMENTARY SYSTEM

Liver + + + + + + + + + + 10

Heart I + + + + + + + + + 9

ENDOCRINE SYSTEM

GENERAL BODY SYSTEM

GENITAL SYSTEM

Bone Marrow + + + + + + + + + + 10

Spleen I + + I + + + + + + 8

Thymus I I + + + + + + + + 8

Skin I + + I + + + + + + 8Control, Hyperplasia 1 1 1 3 1.0

DAY ON TEST

B6C3F1 MICE FEMALE

50 %ANIMAL ID

00130 * TOTALS

Control, Inflammation, Chronic Active 1 2 1 3 1.3

Skin, Site Of Application I I I I + + + + + + 6Fibrosis 1 1 1 2 4 1.3Hyperkeratosis 2 1 2 2 2 2 6 1.8Hyperplasia 3 3 2 2 2 2 6 2.3Inflammation, Chronic Active 2 2 2 2 2 2 6 2.0Ulcer 2 1 2.0Epidermis, Inflammation, Suppurative 1 1 1 2 4 1.3Hair Follicle, Hyperplasia 3 1 2 3 2.0

NERVOUS SYSTEM

RESPIRATORY SYSTEM

URINARY SYSTEM

DAY ON TEST

B6C3F1 MICE FEMALE

100 %ANIMAL ID

00140 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + 10

Gallbladder + + + + + + + + + + 10

Liver + + + + + + + + + + 10

Oral Mucosa + + + + + + + + + + 10

Pancreas + + + + + + + + + + 10

Salivary Glands + + + + + + + + + + 10

Tongue + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

100 %ANIMAL ID

00140 * TOTALS

Blood Vessel + + + + + + + + + + 10

Heart + + + + + + + + + + 10

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + 10

Adrenal Medulla + + + + + + + + + + 10

Parathyroid Gland + + + + + M + + M + 8Cyst X 1

Pituitary Gland + + + + + I + + + + 9

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEM

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + 10

Ovary + + + + + + + + + + 10

Uterus + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

100 %ANIMAL ID

00140 * TOTALS

Vagina + + + + + + + + + + 10

Bone Marrow + + + + + + + + + + 10

Lymph Node + 1

Spleen + + + + + + + + + + 10

Thymus + + + + + + + + + + 10Atrophy 2 2 2 2.0

Mammary Gland + + + + + + + + + + 10

Skin + + + + + + + + + + 10Control, Fibrosis 2 2 1 1 1 2 6 1.5Control, Hyperkeratosis 2 1 2 2 2 2 3 7 2.0Control, Hyperplasia 3 1 2 3 2 1 2 1 3 3 10 2.1Control, Inflammation, Chronic Active 2 1 2 2 2 2 2 2 8 1.9Control, Ulcer 2 1 2.0Control, Epidermis, Inflammation, Suppurative 1 1 2 2 2 2 1 2 8 1.6Control, Hair Follicle, Hyperplasia 1 2 3 3 2.0

DAY ON TEST

B6C3F1 MICE FEMALE

100 %ANIMAL ID

00140 * TOTALS

Fibrosis 3 2 2 2 1 2 2 2 2 9 2.0Hyperkeratosis 3 2 1 3 2 1 2 2 2 3 10 2.1Hyperplasia 3 3 3 3 3 3 2 2 3 3 10 2.8Inflammation, Chronic Active 2 2 2 2 2 2 2 2 2 2 10 2.0Epidermis, Inflammation, Suppurative 1 1 2 1 2 1 1 7 1.3Hair Follicle, Hyperplasia 1 1 2 2 1 3 2 2 3 3 10 2.0

Bone + + + + + + + + + + 10

NERVOUS SYSTEM

Brain + + + + + + + + + + 10

RESPIRATORY SYSTEM

Larynx + + + + + + + + + + 10

Lung + + + + + + + + + + 10

Nose + + + + + + + + + + 10

Trachea + + + + + + + + + + 10

Eye + + + + + + + + + + 10Retrobulbar, Inflammation, Neutrophil 1 1 1.0

Harderian Gland + + + + + + + + + + 10

DAY ON TEST

B6C3F1 MICE FEMALE

100 %ANIMAL ID

00140 * TOTALS

URINARY SYSTEM

Kidney + + + + + + + + + + 10

Urinary Bladder + + + + + + + + + + 10

*** END OF REPORT ***

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